EG24000A - N-(3-ethynylphenylamino) 6,7-bis (2-methoxye-thoxy) -4-quinazolinamine mesylate anhydrate and monohydrate - Google Patents

N-(3-ethynylphenylamino) 6,7-bis (2-methoxye-thoxy) -4-quinazolinamine mesylate anhydrate and monohydrate

Info

Publication number: EG24000A
Authority: EG; Egypt
Prior art keywords: methoxye; ethynylphenylamino; thoxy; monohydrate; bis
Prior art date: 1998-04-29

Application number

EG48299A

Other languages

English (en)

Inventor

Douglas J Allen

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-29

Filing date

1999-04-29

Publication date

2008-03-19

1999-04-29 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2008-03-19 Application granted granted Critical

2008-03-19 Publication of EG24000A publication Critical patent/EG24000A/xx

Links

FITYFYMINUEMHW-UHFFFAOYSA-N 6,7-bis(2-methoxyethoxy)quinazolin-4-amine Chemical compound C1=NC(N)=C2C=C(OCCOC)C(OCCOC)=CC2=N1 FITYFYMINUEMHW-UHFFFAOYSA-N 0.000 title 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title 1
150000004682 monohydrates Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EG48299A 1998-04-29 1999-04-29 N-(3-ethynylphenylamino) 6,7-bis (2-methoxye-thoxy) -4-quinazolinamine mesylate anhydrate and monohydrate EG24000A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US8344198P	1998-04-29	1998-04-29

Publications (1)

Publication Number	Publication Date
EG24000A true EG24000A (en)	2008-03-19

Family

ID=22178359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG48299A EG24000A (en)	1998-04-29	1999-04-29	N-(3-ethynylphenylamino) 6,7-bis (2-methoxye-thoxy) -4-quinazolinamine mesylate anhydrate and monohydrate

Country Status (41)

Country	Link
EP (1)	EP1076652B1 (bs)
JP (1)	JP4652569B2 (bs)
KR (1)	KR100668412B1 (bs)
CN (2)	CN1298396A (bs)
AP (1)	AP1252A (bs)
AR (1)	AR018201A1 (bs)
AT (1)	ATE295839T1 (bs)
AU (1)	AU759691C (bs)
BR (1)	BR9910025A (bs)
CA (1)	CA2330447C (bs)
CO (1)	CO5060467A1 (bs)
CZ (1)	CZ298230B6 (bs)
DE (1)	DE69925366T2 (bs)
DZ (1)	DZ2777A1 (bs)
EA (1)	EA002836B1 (bs)
EG (1)	EG24000A (bs)
ES (1)	ES2238825T3 (bs)
GT (1)	GT199900063A (bs)
HN (1)	HN1999000057A (bs)
HU (1)	HU227569B1 (bs)
ID (1)	ID27198A (bs)
IL (1)	IL139172A0 (bs)
MA (1)	MA26624A1 (bs)
ME (1)	MEP42008A (bs)
MX (1)	MXPA00010610A (bs)
MY (1)	MY136033A (bs)
NO (1)	NO317301B1 (bs)
NZ (1)	NZ508154A (bs)
OA (1)	OA11769A (bs)
PA (1)	PA8471001A1 (bs)
PE (1)	PE20000441A1 (bs)
PL (1)	PL196940B1 (bs)
RS (1)	RS50081B (bs)
SA (1)	SA99200216B1 (bs)
TN (1)	TNSN99079A1 (bs)
TR (1)	TR200003166T2 (bs)
TW (1)	TWI248437B (bs)
UA (1)	UA60363C2 (bs)
UY (1)	UY26099A1 (bs)
WO (1)	WO1999055683A1 (bs)
ZA (1)	ZA992972B (bs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6706721B1 (en)	1998-04-29	2004-03-16	Osi Pharmaceuticals, Inc.	N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
RS49836B (sr)	1999-03-31	2008-08-07	Pfizer Products Inc.,	Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
UA74803C2 (uk) *	1999-11-11	2006-02-15	Осі Фармасьютікалз, Інк.	Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en)	1999-11-11	2006-08-08	Osi Pharmaceuticals, Inc.	Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA73993C2 (uk) *	2000-06-06	2005-10-17	Астразенека Аб	Хіназолінові похідні для лікування пухлин та фармацевтична композиція
WO2003000188A2 (en)	2001-06-21	2003-01-03	Ariad Pharmaceuticals, Inc.	Novel quinazolines and uses thereof
US7078409B2 (en)	2002-03-28	2006-07-18	Beta Pharma, Inc.	Fused quinazoline derivatives useful as tyrosine kinase inhibitors
GB0223854D0 (en) *	2002-10-12	2002-11-20	Astrazeneca Ab	Therapeutic treatment
US7148231B2 (en) *	2003-02-17	2006-12-12	Hoffmann-La Roche Inc.	[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
AU2004291709C1 (en)	2003-05-30	2010-03-11	Astrazeneca Uk Limited	Process
EP1680426B1 (en)	2003-06-10	2007-09-19	F. Hoffmann-La Roche Ag	1.3.4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives
GB0403744D0 (en)	2004-02-20	2004-03-24	Astrazeneca Ab	Chemical process
BRPI0510717B8 (pt)	2004-05-06	2021-05-25	Bioresponse Llc	uso de 3,3' diindolilmetano (dim) ou 2-(indol-3-ilmetil)-3,3´-diindolilmetano (ltr)
WO2006083458A2 (en)	2004-12-30	2006-08-10	Bioresponse Llc	Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions
CA2659307A1 (en)	2006-07-28	2008-01-31	Synthon B.V.	Crystalline erlotinib
BRPI0717753B1 (pt)	2006-10-27	2022-04-12	Bioresponse, Llc	Uso de uma composição compreendendo 50-250 mg de um ou mais indóis relacionados com dim e um ou mais agentes anti-protozoários, e, composição
WO2008122776A2 (en) *	2007-04-04	2008-10-16	Cipla Limited	Process for preparation of erlotinib and its pharmaceutically acceptable salts
WO2009007984A2 (en)	2007-07-11	2009-01-15	Hetero Drugs Limited	An improved process for erlotinib hydrochloride
WO2009024989A2 (en)	2007-08-17	2009-02-26	Hetero Drugs Limited	A novel hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form b
KR101132937B1 (ko) *	2008-10-01	2012-04-06	주식회사종근당	Ｎ-(3-에티닐페닐)-6,7-비스(2-메톡시에톡시)-4-퀴나졸린아민 납실레이트 염
EP2411373B1 (en)	2009-03-26	2015-10-21	Ranbaxy Laboratories Limited	Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
WO2011068404A2 (en)	2009-12-02	2011-06-09	Ultimorphix Technologies B.V.	Administration of n-(3-ethynylphenylamino)-6,7-bis(2- methoxyethoxy)-4-quinazolinamine mesylate salt by inhalation
DE202010006543U1 (de)	2010-05-07	2010-09-09	Ratiopharm Gmbh	Erlotinibresinat
HU230483B1 (hu)	2011-10-10	2016-07-28	Egis Gyógyszergyár Nyrt.	Erlotinib sók
US9593083B2 (en)	2012-09-04	2017-03-14	Shilpa Medicare Limited	Crystalline erlotinib hydrochloride process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ243082A (en) *	1991-06-28	1995-02-24	Ici Plc	4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
JP2994165B2 (ja) *	1992-06-26	1999-12-27	ゼネカ・リミテッド	キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤
GB9323290D0 (en) *	1992-12-10	1994-01-05	Zeneca Ltd	Quinazoline derivatives
DE69536015D1 (de) *	1995-03-30	2009-12-10	Pfizer Prod Inc	Chinazolinone Derivate
US5747498A (en) *	1996-05-28	1998-05-05	Pfizer Inc.	Alkynyl and azido-substituted 4-anilinoquinazolines

1999
- 1999-04-08 IL IL13917299A patent/IL139172A0/xx not_active IP Right Cessation
- 1999-04-08 MX MXPA00010610A patent/MXPA00010610A/es active IP Right Grant
- 1999-04-08 JP JP2000545843A patent/JP4652569B2/ja not_active Expired - Lifetime
- 1999-04-08 PL PL343766A patent/PL196940B1/pl not_active IP Right Cessation
- 1999-04-08 EA EA200001112A patent/EA002836B1/ru not_active IP Right Cessation
- 1999-04-08 CA CA002330447A patent/CA2330447C/en not_active Expired - Lifetime
- 1999-04-08 OA OA1200000300A patent/OA11769A/en unknown
- 1999-04-08 ID IDW20002186A patent/ID27198A/id unknown
- 1999-04-08 TR TR2000/03166T patent/TR200003166T2/xx unknown
- 1999-04-08 HU HU0101818A patent/HU227569B1/hu unknown
- 1999-04-08 AU AU28509/99A patent/AU759691C/en not_active Expired
- 1999-04-08 CZ CZ20003974A patent/CZ298230B6/cs not_active IP Right Cessation
- 1999-04-08 AT AT99909165T patent/ATE295839T1/de not_active IP Right Cessation
- 1999-04-08 ME MEP-420/08A patent/MEP42008A/xx unknown
- 1999-04-08 KR KR1020007011998A patent/KR100668412B1/ko not_active Expired - Lifetime
- 1999-04-08 RS YUP-661/00A patent/RS50081B/sr unknown
- 1999-04-08 CN CN99805497A patent/CN1298396A/zh active Pending
- 1999-04-08 WO PCT/IB1999/000612 patent/WO1999055683A1/en not_active Ceased
- 1999-04-08 ES ES99909165T patent/ES2238825T3/es not_active Expired - Lifetime
- 1999-04-08 CN CNA2008100051101A patent/CN101219999A/zh active Pending
- 1999-04-08 BR BR9910025-8A patent/BR9910025A/pt not_active Application Discontinuation
- 1999-04-08 NZ NZ508154A patent/NZ508154A/en not_active IP Right Cessation
- 1999-04-08 EP EP99909165A patent/EP1076652B1/en not_active Expired - Lifetime
- 1999-04-08 DE DE69925366T patent/DE69925366T2/de not_active Expired - Lifetime
- 1999-04-23 TW TW088106555A patent/TWI248437B/zh not_active IP Right Cessation
- 1999-04-26 HN HN1999000057A patent/HN1999000057A/es unknown
- 1999-04-27 PA PA19998471001A patent/PA8471001A1/es unknown
- 1999-04-27 AR ARP990101942A patent/AR018201A1/es active IP Right Grant
- 1999-04-27 MY MYPI99001636A patent/MY136033A/en unknown
- 1999-04-28 DZ DZ990077A patent/DZ2777A1/xx active
- 1999-04-28 ZA ZA9902972A patent/ZA992972B/xx unknown
- 1999-04-28 MA MA25557A patent/MA26624A1/fr unknown
- 1999-04-28 TN TNTNSN99079A patent/TNSN99079A1/fr unknown
- 1999-04-29 EG EG48299A patent/EG24000A/xx active
- 1999-04-29 CO CO99026003A patent/CO5060467A1/es unknown
- 1999-04-29 GT GT199900063A patent/GT199900063A/es unknown
- 1999-04-29 PE PE1999000356A patent/PE20000441A1/es not_active Application Discontinuation
- 1999-04-29 AP APAP/P/1999/001523A patent/AP1252A/en active
- 1999-06-02 SA SA99200216A patent/SA99200216B1/ar unknown
- 1999-08-04 UA UA2000116681A patent/UA60363C2/uk unknown
2000
- 2000-04-05 UY UY26099A patent/UY26099A1/es not_active Application Discontinuation
- 2000-10-27 NO NO20005453A patent/NO317301B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
HN1999000057A (es)	1999-09-29
CA2330447A1 (en)	1999-11-04
TR200003166T2 (tr)	2001-02-21
AP1252A (en)	2004-02-25
ES2238825T3 (es)	2005-09-01
DE69925366T2 (de)	2006-03-09
DZ2777A1 (fr)	2003-12-01
TNSN99079A1 (fr)	2005-11-10
WO1999055683A1 (en)	1999-11-04
NZ508154A (en)	2003-07-25
RS50081B (sr)	2009-01-22
CN101219999A (zh)	2008-07-16
HUP0101818A1 (hu)	2002-03-28
UA60363C2 (uk)	2003-10-15
ZA992972B (en)	2000-10-30
TWI248437B (en)	2006-02-01
OA11769A (en)	2005-07-25
JP2002513009A (ja)	2002-05-08
PL196940B1 (pl)	2008-02-29
KR100668412B1 (ko)	2007-01-12
DE69925366D1 (de)	2005-06-23
ATE295839T1 (de)	2005-06-15
CA2330447C (en)	2009-06-30
NO20005453L (no)	2000-12-20
MEP42008A (en)	2011-02-10
BR9910025A (pt)	2000-12-26
PL343766A1 (en)	2001-09-10
MY136033A (en)	2008-07-31
MXPA00010610A (es)	2002-07-02
PE20000441A1 (es)	2000-05-23
IL139172A0 (en)	2001-11-25
NO20005453D0 (no)	2000-10-27
CZ298230B6 (cs)	2007-08-01
AU759691C (en)	2004-04-29
JP4652569B2 (ja)	2011-03-16
EA200001112A1 (ru)	2001-04-23
AU759691B2 (en)	2003-04-17
NO317301B1 (no)	2004-10-04
CO5060467A1 (es)	2001-07-30
CZ20003974A3 (en)	2001-05-16
HU227569B1 (en)	2011-08-29
GT199900063A (es)	2000-10-20
PA8471001A1 (es)	2000-09-29
AU2850999A (en)	1999-11-16
UY26099A1 (es)	2001-12-28
YU66100A (sh)	2003-07-07
KR20010078710A (ko)	2001-08-21
AP9901523A0 (en)	1999-06-30
MA26624A1 (fr)	2004-12-20
EA002836B1 (ru)	2002-10-31
ID27198A (id)	2001-03-08
HK1037180A1 (en)	2002-02-01
EP1076652A1 (en)	2001-02-21
CN1298396A (zh)	2001-06-06
SA99200216B1 (ar)	2006-06-04
AR018201A1 (es)	2001-10-31
EP1076652B1 (en)	2005-05-18
HUP0101818A3 (en)	2002-05-28

Publication	Publication Date	Title
PL343766A1 (en)	2001-09-10	N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
EP1066039A4 (en)	2003-02-26	SUBSTITUTED QUINAZOLINE AND THEIR ANALOGS AND USES
GB2332993B (en)	2002-03-13	Fully integrated ballast ic
HUP9904631A3 (en)	2001-05-28	Fine-grained caoutchouc-powders, procedure for making them and the use thereof
HUP0203430A3 (en)	2003-07-28	Quinazolinones and their use
DK0901487T3 (da)	2003-08-25	2,3,6-trisubstituerede 4(3H)-quinazolinoner
DE69833751D1 (de)	2006-05-04	IN POSITION 5 UND 6 MODIFIZIERTE GONADOTROPIN FREISETZENDES HORMON (GnRH)-ANTAGONISTEN
ATE417847T1 (de)	2009-01-15	Chinazolin- und pyridopyrimidinderivate
GB9607729D0 (en)	1996-06-19	Quinazoline derivatives
AU1047402A (en)	2002-03-22	Quinoline and quinazoline derivatives
ATE448238T1 (de)	2009-11-15	3-beta-d-ribofuranosylthiazolo(4,5- delta)pyridimin-nucleoside und ihre verwendung
HUP0102831A2 (hu)	2001-12-28	Új, helyi érzéstelenítő vegyületek és azok alkalmazásai
ATE227724T1 (de)	2002-11-15	Muscarinagonisten und antagonisten
DE59903751D1 (de)	2003-01-23	2',2'-difluornucleoside zur immunosuppressiven therapie und kombinationspräparate
NO20004274D0 (no)	2000-08-25	Proteaseaktivert reseptor 4 og anvendelse derav
IL143095A0 (en)	2002-04-21	3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
PL336481A1 (en)	2000-06-19	Method of obtaining (1,2,3,4- tetrahydroisoquinolin -6-yl) amide of 4'-trifluoromethylbiphenyl-2-carboxylic acid and intermediate compounds
PL346759A1 (en)	2002-02-25	Carbamate and urea compositions and neurotrophic uses
ATE282015T1 (de)	2004-11-15	Rheologieänderung und rheologiemodifiziermittel
ZA985326B (en)	1999-03-23	Aminospiropiperidine quinazoline derivatives
MXPA02005731A (es)	2003-10-14	Moleculas similares al antagonista del receptor de interleucina-1 y usos de las mismas.
DE69839570D1 (de)	2008-07-10	Halbleiteranordnung und dessen betriebsverfahren
DE69928166D1 (de)	2005-12-15	Integrierte Leitungssyteme und Cross Connect
SI1140835T1 (en)	2004-08-31	3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
PL105028U1 (en)	1998-01-19	Clothing hander