EP0308736A3 - Mévalonolactones du type pyrimidine - Google Patents

Mévalonolactones du type pyrimidine Download PDF

Info

Publication number: EP0308736A3
Authority: EP; European Patent Office
Prior art keywords: alkyl; hydrogen; independently; bromo; fluoro
Prior art date: 1987-09-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP88114705A

Other languages

German (de)

English (en)

Other versions

EP0308736A2 (fr

Inventor

Yoshihiro c/o NISSAN CHEMICAL IND.Ltd. Fujikawa

Hiroshi c/o Nissan Chemical Ind. Ltd. Iwasaki

Mikio c/o NISSAN CHEMICAL IND.Ltd. Suzuki

Mitsuaki c/o NISSAN CHEMICAL IND.Ltd. Sakashita

Masaki c/o Nissan Chemical Ind.Ltd. Kitahara

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nissan Chemical Corp

Original Assignee

Nissan Chemical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-12

Filing date

1988-09-08

Publication date

1990-02-14

1988-08-16 Priority claimed from JP20338188A external-priority patent/JPH01294665A/ja

1988-09-08 Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp

1989-03-29 Publication of EP0308736A2 publication Critical patent/EP0308736A2/fr

1990-02-14 Publication of EP0308736A3 publication Critical patent/EP0308736A3/fr

Status Withdrawn legal-status Critical Current

Links

CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 13
239000001257 hydrogen Substances 0.000 abstract 13
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 8
-1 n-butoxy, i-butoxy, sec-butoxy Chemical group 0.000 abstract 6
150000002431 hydrogen Chemical class 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
150000003973 alkyl amines Chemical class 0.000 abstract 3
125000001246 bromo group Chemical group Br* 0.000 abstract 3
125000001309 chloro group Chemical group Cl* 0.000 abstract 3
125000001153 fluoro group Chemical group F* 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
125000006592 (C2-C3) alkenyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical group N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
229910003202 NH4 Inorganic materials 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
239000011591 potassium Chemical group 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
239000011734 sodium Chemical group 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP88114705A 1987-09-12 1988-09-08 Mévalonolactones du type pyrimidine Withdrawn EP0308736A3 (fr)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
JP229357/87		1987-09-12
JP22935787		1987-09-12
JP1402788		1988-01-25
JP14027/88		1988-01-25
JP142695/88		1988-06-11
JP14269588		1988-06-11
JP20338188A JPH01294665A (ja)	1987-06-11	1988-08-16	ピリジン系メバロノラクトン類
JP203381/88		1988-08-16

Publications (2)

Publication Number	Publication Date
EP0308736A2 EP0308736A2 (fr)	1989-03-29
EP0308736A3 true EP0308736A3 (fr)	1990-02-14

Family

ID=27456120

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP88114705A Withdrawn EP0308736A3 (fr)	1987-09-12	1988-09-08	Mévalonolactones du type pyrimidine

Country Status (3)

Country	Link
US (1)	US5026708A (fr)
EP (1)	EP0308736A3 (fr)
WO (1)	WO1990010624A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3854854D1 (de) *	1987-07-10	1996-02-15	Hoechst Ag	3-Desmethyl-mevalonsäurederivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen, ihre Verwendung sowie Zwischenprodukte
KR900701778A (ko) *	1988-10-06	1990-12-04	예안 크라머, 한스 루돌프 하우스	피리미디닐- 치환된 하이드록시산, 락톤 및 에스테르, 및 이를 함유하는 약학적 조성물
FI94339C (fi)	1989-07-21	1995-08-25	Warner Lambert Co	Menetelmä farmaseuttisesti käyttökelpoisen /R-(R,R)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
JP2648897B2 (ja)	1991-07-01	1997-09-03	塩野義製薬株式会社	ピリミジン誘導体
NZ525150A (en) *	2000-10-12	2004-10-29	Kowa Co	Preventives and remedies for complications of diabetes
US8455489B2 (en) *	2003-11-10	2013-06-04	Exelixis, Inc.	Substituted pyrimidine compositions and methods of use
US8372877B2 (en)	2010-04-16	2013-02-12	Cumberland Pharmaceuticals	Stabilized statin formulations
WO2012046772A1 (fr)	2010-10-06	2012-04-12	国立大学法人東京大学	Médicament destiné à la prévention et au traitement d'un lymphœdème
RU2019121534A (ru)	2016-12-16	2021-01-18	Басф Се	Пестицидные соединения
CN108689926A (zh) *	2018-06-26	2018-10-23	山东齐都药业有限公司	匹伐他汀钙5-氧代杂质的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4681893A (en) *	1986-05-30	1987-07-21	Warner-Lambert Company	Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
EP0307342A2 (fr) *	1987-07-10	1989-03-15	Hoechst Aktiengesellschaft	Dérivés d'acide 3-déméthyl-4-fluoro-mévalonique, procédé pour leur préparation, préparations pharmaceutiques à base de ces composés, leur utilisation et intermédiaires

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4735958A (en) *	1986-12-22	1988-04-05	Warner-Lambert Company	Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis
DE3823045A1 (de) *	1987-07-10	1989-01-19	Hoechst Ag	3-desmethyl-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung sowie zwischenprodukte
US4868185A (en) *	1987-12-10	1989-09-19	Warner-Lambert Company	6-[[Substituted)pyrimidinyl)ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis

1988
- 1988-09-08 EP EP88114705A patent/EP0308736A3/fr not_active Withdrawn
- 1988-09-12 US US07/243,468 patent/US5026708A/en not_active Expired - Fee Related
1989
- 1989-03-08 WO PCT/JP1989/000250 patent/WO1990010624A1/fr not_active Ceased

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4681893A (en) *	1986-05-30	1987-07-21	Warner-Lambert Company	Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
EP0307342A2 (fr) *	1987-07-10	1989-03-15	Hoechst Aktiengesellschaft	Dérivés d'acide 3-déméthyl-4-fluoro-mévalonique, procédé pour leur préparation, préparations pharmaceutiques à base de ces composés, leur utilisation et intermédiaires

Also Published As

Publication number	Publication date
WO1990010624A1 (fr)	1990-09-20
EP0308736A2 (fr)	1989-03-29
US5026708A (en)	1991-06-25

Legal Events

Date	Code	Title	Description
1989-02-11	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1989-03-29	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE
1989-12-28	PUAL	Search report despatched	Free format text: ORIGINAL CODE: 0009013
1990-02-14	AK	Designated contracting states	Kind code of ref document: A3 Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE
1990-05-16	17P	Request for examination filed	Effective date: 19900320
1992-02-05	17Q	First examination report despatched	Effective date: 19911223
1992-11-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1992-12-30	18D	Application deemed to be withdrawn	Effective date: 19920703

Publication	Publication Date	Title
EP0308736A3 (fr)	1990-02-14	Mévalonolactones du type pyrimidine
JPS57167974A (en)	1982-10-16	Preparation of 4-phenylphthalazine derivative
EP0234910A3 (fr)	1988-09-14	Procédé pour augmenter la production d'hydrocarbures à partir de formations souterraines
EP0220878A3 (fr)	1988-06-01	Composés d'éthanolamine
EP0183280A3 (fr)	1988-06-08	Composés siloxa-cycliques
GB1423376A (en)	1976-02-04	Herbicidal ethers
EP0096903A3 (fr)	1984-02-01	Composés intermédiaires dans la préparation de dérivés céphèmes et leur procédé de préparation
EP0031801A3 (fr)	1981-09-16	Diesters de l'acide 4-(2',3'-dichlorophényl)-2-méthyl-1,4-dihydropyridine-3,5-dicarboxylique substitués en position 6, possédant des propriétés hypotensives, procédé pour leur préparation ainsi que compositions pharmaceutiques les contenant
SE9000872L (sv)	1990-10-01	Sulfonylderivat av tieno-triazolo-diazepiner, ett foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande dem
EP0024888A3 (fr)	1981-10-07	Insecticides à base d'éthers de cétoxime
EP0004733A3 (fr)	1979-10-31	Pyrazolines-1-carboxanilides diaryl substituées, procédés pour leur préparation, compositions insecticides, leurs emplois et leurs intermédiaires
SU1591803A3 (ru)	1990-09-07	СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 2-АРИЛПРОНИЛОВОГО простого эфира
EP0137163A3 (fr)	1987-04-15	Dérivés de 3-indolecarboxamide
EP0303466A3 (fr)	1990-04-25	Dérivés d'éthanolamine
KR850002094A (ko)	1985-05-06	나프탈레닐 이미다조피리딘 및 그의 유도체의 제조방법
JPS6452753A (en)	1989-02-28	Prostaglandin e and antiulcer agent containing same
EP0143630A3 (fr)	1986-04-23	Composés chimiques
JPS5246095A (en)	1977-04-12	Preparation of novel thienopyrimidine derivatives
DE3484365D1 (de)	1991-05-08	Pheromonaktive zusammensetzungen.
JPS5233627A (en)	1977-03-14	Preparation of novel o,o-dialkyl-o-(n-alkoxy-halogeno-acycimidoyl) pho sphates or thionophosphates
JPS5528907A (en)	1980-02-29	Novel 5-(pyridyl)-2-mercaptoimidazole derivative, its preparation,and medicine containing thereof as effective component
EP0149341A3 (fr)	1986-02-19	Silalactones et méthodes de leur préparation et usage
NO852618L (no)	1985-12-30	Aroyl-substituerte dihydro-1,4-tiaziner.
JPS5629504A (en)	1981-03-24	Antibacterial for agriculture and horticulture
EP0109299A3 (fr)	1984-08-15	Dérivés de l'éthanol-1,1- disubstitué-2-hétérocyclique