Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
  • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
  • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
  • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/04—Centrally acting analgesics, e.g. opioids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/06—Antimigraine agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/20—Hypnotics; Sedatives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/22—Anxiolytics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
  • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
  • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
  • C07D451/06—Oxygen atoms
  • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
  • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Definitions

• the present invention relates to heterocyclic compounds having a serotonin-3 (hereafter referred to as 5-HT3) antagonizing activity which compounds are useful as antiemetics and suppressants of migraine.
• 5-HT3 serotonin-3
• 5-HT3 antagonists exhibit an antiemetic activity, an antianxious activity, a suppressing activity of mental disorders, a suppressing activity of migraine, etc. [Trends in Pharmacological Sciences, 8 , 501 (1987); hereafter referred to as TIPS].
• 5-HT3 antagonists are effective against carcinostatic agent-induced vomiting, which has not been cured by dopamine antagonists. The 5-HT3 antagonists are thus expected to be antiemetics of new type [Br. J. Cancer, 56 , 159 (1987)].
• an indole derivative ICS205-930 an indazole derivative, BRL43694: and the like are described in TIPS supra .
• novel 2-quinolone and 1,8-naphthyridin-2-one derivatives are provided and which have 5-HT3 antagonizing activity.
• Both types of derivative may be represented collectively by the formula (I): wherein R1 represents hydrogen, lower alkyl or aryl; R2 represents hydrogen, hydroxyl or lower alkyl; A represents CH or N; X represents -O- or -NH-; R3 represents hydrogen, hydroxyl or lower alkyl; R4 represents lower alkyl; and n represents 0 or 1.
• compositions of formula (I) are also included within the scope of the invention.
• pharmaceutically acceptable salts of the compounds of formula (I) and pharmaceutical preparations comprising such a compound or salt in admixture with a pharmaceutically acceptable carrier or diluent.
• lower alkyl means a straight or branched alkyl having 1 to 6 carbon atoms and includes, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, neopentyl, hexyl, etc;
• aryl means an aryl group having 6 to 10 carbon atoms such as phenyl, naphthyl, etc; whilst the pharmaceutically acceptable salts include acid addition salts, metal salts and amino acid addition salts of the compounds of formula (I).
• the pharmaceutically acceptable acid addition salt of Compound (I) mention may be made of inorganic acid salts such as hydrochlorides, sulfates, phosphates, etc; organic acid salts such as acetates, maleates, fumarates, tartarates, citrates, etc.
• the pharmaceutically acceptable metal salts mention may be made of alkali metal salts such as sodium salts, potassium salts and alkaline earth metal salts such as magnesium salts, calcium salts, etc.
• aluminum salts and zinc salts As the pharmaceutically acceptable amino acid salts, mention may be made of addition salts to lysine, glycine, phenylalanine, etc.
• the group may be treated in a manner conventional to organic synthetic chemistry, for example, protection of a functional group, removal of protection, etc. so that the processes may be easily carried out.
• Compounds of formula (I) can generally be obtained by reacting a compound of formula (II) with a compound of formula (III) in a solvent, preferably in the presence of a base, according to the following reaction scheme: wherein R1, R2, R3, R4, A, X and n have the same significances as defined above; and L represents a displaceable group e.g. halogen such as chlorine, bromine, iodine, etc; alkoxy such as methoxy, ethoxy, etc; aryloxy such as phenoxy, etc; alkoxycarbonyloxy such as ethoxycarbonyloxy, etc; aroyloxy such as benzoyloxy, etc.
• halogen such as chlorine, bromine, iodine, etc
• alkoxy such as methoxy, ethoxy, etc
• aryloxy such as phenoxy
• alkoxycarbonyloxy such as ethoxycarbonyloxy, etc
• aroyloxy such as be
• Compound (II) can be prepared in a conventional manner, for example, the method as described in J. Org. Chem., 39 1803 (1974), Compound (III) is commercially available or can be prepared by the method as described in J. Am. Chem. Soc., 79 4194 (1957).
• any solvent may be used singly or in combination, so long as it is inert to the reaction. Mention may be made of ethers such as tetrhydrofuran, dioxane, etc; amides such as dimethylformamide, dimethylacetamide, etc; ketones such as acetone, methyl ethyl ketone, etc; alcohols such as methanol, ethanol, isopropyl alcohol, etc; halogenated hydrocarbons such as methylene chloride, chloroform, dichloroethane, etc; esters such as ethyl acetate, etc; aromatic hydrocarbons such as benzene, toluene, xylene, etc; and dimethylsulfoxide, etc.
• ethers such as tetrhydrofuran, dioxane, etc
• amides such as dimethylformamide, dimethylacetamide, etc
• ketones such as acetone, methyl ethyl ketone, etc
• alkali metal bicarbonates such as sodium bicarbonate, potassium bicarbonate, etc
• alkali metal carbonates such as sodium carbonate, potassium carbonate, etc
• alkali metal hydrides such as sodium hydride, etc.
• alkali metal alkoxides such as sodium methoxide, sodium ethoxide, etc.
• alkali metal salts such as n-butyl lithium, etc.
• the reaction is carried out at -30 to 150°C, preferably at -10 to 100°C and generally completed in 30 minutes to 20 hours.
• the intermediates and the desired products in the processes described above may be isolated and purified by subjecting these compounds to purification means conventionally used in organic synthetic chemistry, for example, filtration, extraction, washing, drying, concentration, recrystallization, various chromatographies, etc.
• the intermediates may also be provided for the next reaction without particularly purifying them.
• Compound (I) may be purified as it is in case that Compound (I) is obtained in a form of salt. In case that Compound (I) is obtained in a free form, the salts may be formed in a conventional manner.
• Compound (I) and its pharmaceutically acceptable salts may also be present in the form of addition products to water or various solvents. These addition products are also included in the present invention.
• Compound (I) includes all possible steric isomers including its optical isomers and a mixture thereof.
• rat neutroblastoma-glyoma NG108-15 cell membrane fraction Using rat neutroblastoma-glyoma NG108-15 cell membrane fraction, the binding activities of the test compounds to 5-HT3 receptor were examined.
• a membrane fraction of NG108-15 cells was prepared according to the method of Neijt et al . [Naunyn-Schmiedeberg's Arch. Pharmacol., 337 , 493 (1988)].
• the receptor binding experiment was performed using [3H] quipazine [J. Neurochem., 52 , 1787 (1989)], a high affinity ligand to 5-HT3 receptor.
• a membrane fraction obtained from 3 X 105 NG108-15 cells was suspended in 1 ml of 20 mM Tris-hydrochloride buffer (pH 7.5) (hereafter referred to as Buffer) containing 154 mM sodium chloride. Then, 2 nM [3H] quipazine (2519.7 GBq/mmol; Du Pont Co., Ltd.) and various concentrations of the test coumpound were added to the suspension followed by incubating at 37°C for 60 minutes. 4 ml of ice-cold Buffer was added to terminate the reaction and then the mixture was filtered through GF/C glass filter (Whatmann Co., Ltd.).
• the filter was washed 5 times with 2 ml of ice-cold Buffer, and put in scintillation vial containing 8 ml of Scintisol EX-H (Wako Pure Chemicals, Inc.). Radioactivity on the filter was counted in a liquid scintillation counter (TRI-CARB 2200CA; Packard Co., Ltd.).
• Total binding is [3H] quipazine-binding in the absence of test compound and "non-specific binding” is [3H] quipazine-binding in the presence of 10 ⁇ M MDL7222 5-HT3 antagonist [Naunyn-Schmiedeberg's Arch. Pharmacol., 326 , 36 (1984)].
• a time period (latency) for the first vomiting and the number of frequencies (episodes) of vomiting caused in the period of 5 to 120 minutes after administration were determined.
• the latency and the number of frequencies in the test compound administered group were compared with those in the control group.
• the test of significance was performed by Student's t-test.
• test compound was orally and intraperitoneally administered to ddY strain male mice weighing 20 to 25g.
• MLD Minimum Lethal Dose
• Compound (I) has an excellent 5-HT3 antagonizing activity and is useful for the treatment of nausea and vomiting which are side effects caused by chemotherapy and radiotherapy of cancer, and for the treatment of anxiety, mental disorders (for example, schizophrenia and mania), migraine, pains, etc.
• Compound (I) or a pharmaceutically acceptable salt thereof may be used as it is or in various preparation forms.
• the pharmaceutical composition of the present invention can be prepared by uniformly mixing Compound (I) or a pharmaceutically acceptable salt thereof with pharmaceutically acceptable carriers.
• the pharmaceutical composition may be desirably in a single dose unit which is suited for oral or parenteral administration.
• any pharmaceutically acceptable carriers may be used.
• Liquid preparations for oral administration for example, a suspension and a syrup, may be prepared using water; sugars such as sucrose, sorbitol, fructose, etc,; glycols such as polyethylene glycol, propylene glycol, etc.; oils such as sesami oil, olive oil, soybean oil, etc.; preservative such as alkyl p-hydroxybenzoic acid esters, etc,; flavors such as strawberry flavor, peppermint, etc.
• Powders, pills capsules and tablets may be prepared using excipients such as lactose, glucose, sucrose, mannitol, etc,; disintegrators such as starch, sodium alginate, etc,; lubricants such as magnesium stearate, talc, etc.; binders such as polyvinyl alcohol, hydroxypropyl cellulose, gelatin, etc.; surfactants such as fatty acid esters, etc.; plasticizers such as glycerine, etc. Tablets and capsules are the most useful single dose unit for oral administration since their administration is easy. When tablets or capsules are prepared, solid pharmaceutical carriers are used. Furthermore, a solution for parenteral administration may be prepared using carriers composed of distilled water, saline, a glucose solution or a mixture of saline and a glucose solution.
• the effective dose of Compound (I) or its pharmaceutically acceptable salt and the number of administration may vary depending upon form of administration, age, body weight, condition, etc. of a patient but it is generally preferred to administer in a dose of 0.01 to 25 mg/kg/day by dividing into 3 to 4 times.
• Compound (I) may also be administered by inhalation in the form of aerosol, finely divided powders or spray solution.
• the present compound When administered in the form of aerosol, the present compound is dissolved in an appropriate solvent which is pharmaceutically acceptable, for example, ethyl alcohol or in combination with a miscible solvent and the resulting solution may be mixed with a pharmaceutically acceptable propellant.
• an appropriate solvent which is pharmaceutically acceptable, for example, ethyl alcohol or in combination with a miscible solvent
• Such aerosol composition is filled up in a pressure container equipped with an aerosol valve suited to release a pressurized composition, which is then provided for use.
• 1-(n-Hexyl)-2-oxo-1,2-dihydro-4-quinolinecarboxylic acid was obtained (yield, 46%, 99%) in a manner similar to Refernce Example 1 except for using n-hexyl bromide instead of n-butyl iodide, and changing the reaction time from one day to 3 hours and the reaction temperature from room temperature to 80°C.
• the obtained carboxylic acid in place of Compound a was treated in a manner similar to Example 1 to give Compound 17 as the hydrochloride (yield, 42%).
• Ethyl 1-(n-butyl)-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (yield, 100%, 69%) was obtained in a manner similar to Reference Example 2 except for using methyl 2-(n-butylamino)nicotinate as synthesized according to the method described in J. Org. Chem., 39 , 1803 (1974) instead of methyl 2-anilinonicotinate. Then, a mixture of 1.45g (5.00 mmols) of the carboxylate, 6.10g (43.20 mmols) of tropine and 100 ml of xylene was heated under reflux for 20 minutes.
• Compound 29 was obtained as the fumarate (yield, 42%, 73%) in a manner similar to Example 6 except for using 1-(n-butyl)-3-hydroxy-2-oxo-1,2-dihydro-4-quinolinecarboxylic acid as synthesized according to the method described in Chem. Ber., 96 , 1234 (1963) instead of Compound a .
• Ethyl 4-hydroxy-2-oxo-1-phenyl-1,2-dihydro-3-quinolinecarboxylate was obtained (yield, 97%, 84%) in a manner similar to Reference Example 2 except for using methyl N-phenylanthranilate instead of methyl 2-anilinonicotinate.
• the obtained carboxylate in place of ethyl 1-(n-butyl)-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate was treated in a manner similar to Example 11 to give Compound 30 as the fumarate (yield, 75%, 63%).
• Ethyl 4-hydroxy-2-oxo-1-phenyl-1,2-dihydro-3-quinolinecarboxylate was obtained (yield, 97%, 84%) in a manner similar to Reference Example 2 except for using methyl N-phenylanthranilate instead of methyl 2-anilinonicotinate.
• the obtained carboxylate in place of ethyl 1-(n-butyl)-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate was treated in a manner similar to Example 11 except for using Endo-9-methyl-9-azabicyclo[3.3.1]non-3-yl-amine [Japanese Published Unexamined Patent Application No.
• Compound 33 was obtained as the fumarate (yield, 21%, 72%) in a manner similar to Example 11 except for using ethyl 4-hydroxy-2-oxo-3-quinolinecarboxylate [J. Pharm. Sci., 54 , 792 (1965)] instead of ethyl 1-(n-butyl)-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate and tropine instead of Endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-amine.
• Compound 35 was obtained as the fumarate (yield, 41%, 87%) in a manner similar to Example 11 except for using ethyl 4-hydroxy-2-oxo-3-quinolinecarboxylate [J. Pharm. Sci., 54 , 792 (1965)] instead of ethyl 1-(n-butyl)-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylate and Endo-9-methyl-9-azabicyclo[3.3.1]non-3-yl-amine [Japanese Published Unexamined Patent Application No. 67284/84] instead of Endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-amine.
• Tablet having the following composition is prepared in a conventional manner.
• Powder having the following composition is prepared in a conventional manner.
• Syrup having the following composition is prepared in a conventional manner.
• Water is added to the composition to make the whole volume 20 cc.
• Capsule having the following composition is prepared in a conventional manner.
• the above composition is mixed and filled up in a gelatin capsule.
• Injection having the following composition is prepared in a conventional manner.
• Water is added to the composition to make the whole volume 5 ml (corresponding to one ampoule). Water is previously distilled and sterilized in an autoclave.

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• 1991
  • 1991-05-15 JP JP03110380A patent/JP3122671B2/ja not_active Expired - Fee Related
  • 1991-05-21 US US07/703,849 patent/US5248684A/en not_active Expired - Fee Related
  • 1991-05-23 ES ES91304674T patent/ES2075350T3/es not_active Expired - Lifetime
  • 1991-05-23 DK DK91304674.4T patent/DK0458636T3/da active
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• 1995
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