EP0674518A1 - Verwendung von lamotrigin zur behandlung von traumatischen neurologischen schädungen - Google Patents

Verwendung von lamotrigin zur behandlung von traumatischen neurologischen schädungen

Info

Publication number
EP0674518A1
EP0674518A1 EP94902802A EP94902802A EP0674518A1 EP 0674518 A1 EP0674518 A1 EP 0674518A1 EP 94902802 A EP94902802 A EP 94902802A EP 94902802 A EP94902802 A EP 94902802A EP 0674518 A1 EP0674518 A1 EP 0674518A1
Authority
EP
European Patent Office
Prior art keywords
treatment
lamotrigine
neurological lesions
spinal
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94902802A
Other languages
English (en)
French (fr)
Inventor
Adam Doble
Erik Louvel
Jérémy Pratt
Jean-Marie Stutzmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of EP0674518A1 publication Critical patent/EP0674518A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Definitions

  • the present invention relates to a new therapeutic application of lamotrigine or the pharmaceutically acceptable salts of this compound.
  • Lamotrigine and the pharmaceutically acceptable salts of this compound are described as anticonvulsants and antiepileptics in particular in patent EP 247892.
  • this compound can also be used in the treatment of neurological lesions linked to traumas and, in particular, to spinal, cranial or cranio-spinal traumas.
  • lamotrigine decreases the neurological deficit of the animals (paraplegia) linked to the lesion of the spinal cord as well as the histopathological lesions (necrosis of the cord). This reduction is generally equal to or greater than 5%.
  • a) preparation of the animal the rabbits are injected intramuscularly with 5 mg of valium® and 1/16 mg of atropine. 30 minutes later, an isotonic saline infusion is set up and the rabbits are anesthetized by injection 40 mg / kg slow intravenous injection of Nesdonal®. We then put in place a cardioscope because the animal may present, especially during re-injections of Nesdonal®, lasting apnea with bradycardia.
  • PES somesthesic evoked potentials
  • the trauma is carried out by inflating the balloon of a Fogarty French 3 probe placed in the spinal canal in the extradural position. For this, we perform a low lumbar laminectomy. The opening of the yellow ligament allows the passage of the probe up to the level of the first lumbar vertebra and the operating wound is closed. A new PES is recorded to ensure that there is no functional lesion during the passage of the probe. The lesion is then carried out by inflating the balloon with variable amounts of air (0.2; 0.4 and 0.55 ml of air) then the probe is removed. A new PES is performed just after the trauma and is compared (amplitudes and latencies) to the reference PES.
  • the product is injected intraperitoneally once a day for 5 days, at doses between 1 and 8 mg / kg.
  • a spinal cord block is taken comprising the injured level which is placed in 10% formalin. A week later, the cord is extracted from the block (this fixation period seems necessary to avoid post-mortem injury). A hemorrhagic area visible to the naked eye shows the level of trauma. Staged histological sections specify the extent of the lesions.
  • lamotrigine makes it possible to decrease the neurological deficit linked to the lesion of the spinal cord, to protect the sensitive neurological pathways and to decrease the necrotic hemorrhagic zone within the gray substance of the spinal cord. These decreases are generally equal to or greater than 5%.
  • lamotrigine improves the neurological score of animals that have suffered a head trauma and reduces necrotic lesions. This reduction is generally equal to or greater than 5%.
  • salts As pharmaceutically acceptable salts, mention may in particular be made of addition salts with mineral acids such as hydrochloride, sulfate, nitrate, phosphate or organic salts such as acetate, propionate, succinate, oxalate, benzoate, fumarate. maleate, methanesulfonate, isethionate, theophillin-acetate, salicylate, phenolphthalinate, methylene-bis- ⁇ -oxynaphtoate or substitution derivatives of these derivatives.
  • mineral acids such as hydrochloride, sulfate, nitrate, phosphate or organic salts such as acetate, propionate, succinate, oxalate, benzoate, fumarate. maleate, methanesulfonate, isethionate, theophillin-acetate, salicylate, phenolphthalinate, methylene-bis- ⁇ -oxynaphtoate or substitution derivatives of these derivatives.
  • the medicaments consist of at least lamotrigine in free form or in the form of an addition salt with a pharmaceutically acceptable acid, in the pure state or in the form of a composition in which it is associated with any other pharmaceutical product. compatible, possibly inert or physiologically active.
  • the medicaments according to the invention can be used orally or parenterally.
  • compositions for oral administration tablets, pills, powders (gelatin capsules, cachets) or granules can be used.
  • the active principle according to the invention is mixed with one or more inert diluents, such as starch, cellulose, sucrose, lactose or silica, under a stream of argon.
  • these compositions can also include substances other than thinners, for example one or more lubricants such as magnesium stearate or talc, a colorant, a coating (dragees) or a varnish.
  • compositions for oral administration there can be used pharmaceutically acceptable solutions, suspensions, emulsions, syrups and elixirs containing diluents .
  • inert such as water, ethanol, glycerol, vegetable oils or paraffin oil.
  • These compositions can include substances other than diluents, for example wetting, sweetening, thickening, flavoring or stabilizing products.
  • the sterile compositions for parenteral administration can preferably be aqueous or non-aqueous solutions, suspensions or emulsions.
  • solvent or vehicle water, propylene glycol, polyethylene glycol, vegetable oils, in particular olive oil, injectable organic esters, for example ethyl oleate or other organic solvents can be used. suitable.
  • These compositions can also contain adjuvants, in particular wetting agents, isotonizers, emulsifiers, dispersants and stabilizers. Sterilization can be done in several ways, for example by aseptic filtration, by incorporating sterilizing agents into the composition, by irradiation or by heating. They can also be prepared in the form of sterile solid compositions which can be dissolved at the time of use in sterile water or any other sterile injectable medium.
  • the doses depend on the desired effect, on the duration of the treatment and on the route of administration used; they are generally between 50 and 800 mg per day by the oral route for an adult with unit doses ranging from 25 to 200 mg of active substance and between 25 and 600 mg per day by the intravenous route for an adult with unit doses ranging from 12.5 to 200 mg of active substance.
  • the doctor will determine the appropriate dosage based on age, weight and all other factors specific to the subject to be treated.
  • Example A illustrate medicaments according to the invention:
  • Tablets containing 50 mg of active product having the following composition are prepared according to the usual technique:
  • capsules containing 50 mg of active product having the following composition are prepared:
  • a solution for injection containing 10 mg of active product having the following composition is prepared:
  • the invention also relates to the process for the preparation of medicaments useful in the treatment of neurological lesions linked to traumas and, in particular, to spinal, cranial or craniospinal traumas, consisting in mixing the lamotrigine or the pharmaceutically acceptable salts of this compound. with one or more compatible and pharmaceutically acceptable diluents and / or adjuvants.
  • the invention also relates to a method of treatment of a mammal and, in particular, of a man presenting with neurological lesions linked to traumas and, in particular, to spinal, cranial or craniospinal traumas, comprising the administration of an effective amount of lamotrigine or the pharmaceutically acceptable salts of this compound.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Data Exchanges In Wide-Area Networks (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
EP94902802A 1992-12-16 1993-12-10 Verwendung von lamotrigin zur behandlung von traumatischen neurologischen schädungen Withdrawn EP0674518A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9215148 1992-12-16
FR9215148A FR2699077B1 (fr) 1992-12-16 1992-12-16 Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
PCT/FR1993/001227 WO1994013296A1 (fr) 1992-12-16 1993-12-10 Application de la lamotrigine dans le traitement de lesions neurologiques liees a des traumatismes

Publications (1)

Publication Number Publication Date
EP0674518A1 true EP0674518A1 (de) 1995-10-04

Family

ID=9436652

Family Applications (3)

Application Number Title Priority Date Filing Date
EP94902019A Expired - Lifetime EP0674512B1 (de) 1992-12-16 1993-12-10 Verwendung von riluzole zur behandlung von traumatischen neurologischen-schädigungen
EP94902802A Withdrawn EP0674518A1 (de) 1992-12-16 1993-12-10 Verwendung von lamotrigin zur behandlung von traumatischen neurologischen schädungen
EP94902018A Ceased EP0674520A1 (de) 1992-12-16 1993-12-10 Verwendung von carbamazepin und oxcarbazepin zur behandlung von traumatischen neurologischen schädungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP94902019A Expired - Lifetime EP0674512B1 (de) 1992-12-16 1993-12-10 Verwendung von riluzole zur behandlung von traumatischen neurologischen-schädigungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP94902018A Ceased EP0674520A1 (de) 1992-12-16 1993-12-10 Verwendung von carbamazepin und oxcarbazepin zur behandlung von traumatischen neurologischen schädungen

Country Status (23)

Country Link
US (1) US5830907A (de)
EP (3) EP0674512B1 (de)
JP (3) JP3712239B2 (de)
KR (3) KR100298808B1 (de)
AT (1) ATE164067T1 (de)
AU (3) AU678795B2 (de)
CA (3) CA2151601A1 (de)
CZ (3) CZ154695A3 (de)
DE (1) DE69317578T2 (de)
DK (1) DK0674512T3 (de)
ES (1) ES2113635T3 (de)
FR (1) FR2699077B1 (de)
GR (1) GR3026403T3 (de)
HU (3) HUT71839A (de)
IL (3) IL108051A (de)
MX (3) MX9307883A (de)
NO (3) NO952228L (de)
PL (3) PL309348A1 (de)
RU (1) RU2142800C1 (de)
SK (3) SK279759B6 (de)
UA (1) UA41906C2 (de)
WO (3) WO1994013298A1 (de)
ZA (3) ZA939401B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12605388B2 (en) 2024-09-25 2026-04-21 Azurity Pharmaceuticals Ireland Limited Lamotrigine salts, co-crystals, and compositions

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2700117B1 (fr) * 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens.
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
FR2733684B1 (fr) 1995-05-03 1997-05-30 Cird Galderma Utilisation de retinoides dans une composition cosmetique ou pour la fabrication d'une composition pharmaceutique
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
US20020022056A1 (en) 1997-02-14 2002-02-21 Burkhard Schlutermann Oxacarbazepine film-coated tablets
CO4920215A1 (es) * 1997-02-14 2000-05-29 Novartis Ag Tabletas de oxacarbazepina recubiertas de una pelicula y metodo para la produccion de estas formulaciones
DK1032575T3 (da) 1997-09-05 2003-10-20 Glaxo Group Ltd 2,3-diaryl-pyrazol(1,5-b)pyridazinderivater, deres fremstilling og anvendelse som cyclooxygenase 2 (COX-2) inhibitor
GB9808015D0 (en) * 1998-04-15 1998-06-17 United Medical And Dental Scho Protection of the nervous system from the effects of inflammatory disease
US6150423A (en) * 1998-10-15 2000-11-21 Phoenix Scientific, Inc. Propofol-based anesthetic and method of making same
FR2787028B1 (fr) 1998-12-15 2002-10-18 Aventis Pharma Sa Utilisation du riluzole dans le traitement des traumatismes acoustiques
JP2002543131A (ja) * 1999-04-29 2002-12-17 センター ナショナル デ ラ レシェルシェ サイエンティフィック（シーエヌアールエス） 大動脈クロスクランピングが原因の虚血性脊髄損傷の防止方法
GB9925962D0 (en) * 1999-11-02 1999-12-29 Novartis Ag Organic compounds
GB9930058D0 (en) * 1999-12-20 2000-02-09 Novartis Ag Organic compounds
RU2240113C1 (ru) * 2003-01-23 2004-11-20 Государственное образовательное учреждение высшего профессионального образования Московская медицинская академия им. И.М.Сеченова Способ экстренной медикаментозной помощи при острой травме спинного мозга
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
EP1924326B1 (de) 2005-08-25 2016-10-12 Steven Michael Weiss Reduzierung von myokard-schaden und inzidenz von arrhythmien durch verlust, verringerung oder unterbrechung des koronaren blutflusses
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
WO2014037832A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of epilepsy and neurological diseases
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WO2019108594A1 (en) * 2017-11-28 2019-06-06 University Of Houston System Liquid formulations of riluzole for oral and intravenous use
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WO2025216887A1 (en) 2024-04-11 2025-10-16 Dow Global Technologies Llc High internal phase emulsion

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK153787C (da) * 1979-06-01 1989-01-16 Wellcome Found Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved
FR2492258A1 (fr) * 1980-10-17 1982-04-23 Pharmindustrie Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
US4431641A (en) * 1980-10-17 1984-02-14 Ciba-Geigy Corporation Pharmaceutical compositions having antiepileptic and antineuralgic action
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
US4826860A (en) * 1987-03-16 1989-05-02 Warner-Lambert Company Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
US4918090A (en) * 1988-01-25 1990-04-17 Warner-Lambert Company Substituted 2-aminbenzothiazoles and derivatives useful as cerebrovascular agents
US5240948A (en) * 1989-12-13 1993-08-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. 3-(3-alkylthiopropyl)benzothiazoline derivatives, their preparation and the medicament containing them
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
WO1992014697A1 (en) * 1991-02-08 1992-09-03 Cambridge Neuroscience, Inc. Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers
FR2688138B1 (fr) * 1992-03-06 1995-05-05 Rhone Poulenc Rorer Sa Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9413296A1 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12605388B2 (en) 2024-09-25 2026-04-21 Azurity Pharmaceuticals Ireland Limited Lamotrigine salts, co-crystals, and compositions

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WO1994013296A1 (fr) 1994-06-23
EP0674520A1 (de) 1995-10-04
FR2699077A1 (fr) 1994-06-17
JPH08504428A (ja) 1996-05-14
NO952228D0 (no) 1995-06-06
FR2699077B1 (fr) 1995-01-13
SK78595A3 (en) 1996-05-08
HU217133B (hu) 1999-11-29
HU9501751D0 (en) 1995-08-28
CA2151604C (fr) 2005-09-20
EP0674512A1 (de) 1995-10-04
HUT71839A (en) 1996-02-28
DE69317578D1 (de) 1998-04-23
WO1994013288A1 (fr) 1994-06-23
UA41906C2 (uk) 2001-10-15
ZA939400B (en) 1994-08-19
WO1994013298A1 (fr) 1994-06-23
HUT71812A (en) 1996-02-28
NO952229D0 (no) 1995-06-06
PL309347A1 (en) 1995-10-02
ZA939401B (en) 1994-08-19
JP3712239B2 (ja) 2005-11-02
SK279759B6 (sk) 1999-03-12
NO307027B1 (no) 2000-01-31
ZA939399B (en) 1994-08-22
KR950703965A (ko) 1995-11-17
NO952228L (no) 1995-06-06
CA2151603A1 (fr) 1994-06-23
DK0674512T3 (da) 1998-05-25
EP0674512B1 (de) 1998-03-18
ATE164067T1 (de) 1998-04-15
CZ154795A3 (en) 1995-11-15
US5830907A (en) 1998-11-03
CA2151601A1 (fr) 1994-06-23
CZ154695A3 (en) 1995-11-15
KR950703954A (ko) 1995-11-17
AU5653994A (en) 1994-07-04
CA2151604A1 (fr) 1994-06-23
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PL309348A1 (en) 1995-10-02
PL309346A1 (en) 1995-10-02
DE69317578T2 (de) 1998-07-23
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NO952229L (no) 1995-06-06
ES2113635T3 (es) 1998-05-01
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RU2142800C1 (ru) 1999-12-20
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KR950703968A (ko) 1995-11-17
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KR100298808B1 (ko) 2001-11-22
MX9307882A (es) 1994-06-30

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