EP0904782A4 - Heilung von wirbelsäulenverletzungen - Google Patents

Heilung von wirbelsäulenverletzungen

Info

Publication number
EP0904782A4
EP0904782A4 EP97907430A EP97907430A EP0904782A4 EP 0904782 A4 EP0904782 A4 EP 0904782A4 EP 97907430 A EP97907430 A EP 97907430A EP 97907430 A EP97907430 A EP 97907430A EP 0904782 A4 EP0904782 A4 EP 0904782A4
Authority
EP
European Patent Office
Prior art keywords
spinal injury
spine
remedy
trauma
event
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97907430A
Other languages
English (en)
French (fr)
Other versions
EP0904782A1 (de
Inventor
Toshizo Ishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of EP0904782A1 publication Critical patent/EP0904782A1/de
Publication of EP0904782A4 publication Critical patent/EP0904782A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
EP97907430A 1996-03-22 1997-03-24 Heilung von wirbelsäulenverletzungen Withdrawn EP0904782A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP65998/96 1996-03-22
JP6599896 1996-03-22
PCT/JP1997/000954 WO1997035577A1 (en) 1996-03-22 1997-03-24 Remedy for spinal injury

Publications (2)

Publication Number Publication Date
EP0904782A1 EP0904782A1 (de) 1999-03-31
EP0904782A4 true EP0904782A4 (de) 2003-07-30

Family

ID=13303194

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97907430A Withdrawn EP0904782A4 (de) 1996-03-22 1997-03-24 Heilung von wirbelsäulenverletzungen

Country Status (5)

Country Link
US (1) US6090823A (de)
EP (1) EP0904782A4 (de)
JP (1) JPH09315972A (de)
AU (1) AU1944297A (de)
WO (1) WO1997035577A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174548B1 (en) * 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US7582680B1 (en) * 1998-11-12 2009-09-01 Purdue Research Foundation Methods and compositions for treating mammalian spinal cord injuries
WO2001068094A1 (en) * 2000-03-17 2001-09-20 Toshio Tanaka Heme oxygenase-1 inducers or induction enhancers
EP1389121B1 (de) 2001-04-24 2012-02-22 Purdue Research Foundation Verfahren und zusammensetzungen zur behandlung von nervengewebeverletzungen in säugetieren
US20050255098A1 (en) * 2004-05-11 2005-11-17 Rosen Steven D Methods of treating traumatic spinal cord injury
US20090076085A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched nicraven

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029602A1 (de) * 1979-11-22 1981-06-03 Chugai Seiyaku Kabushiki Kaisha 1,2-Bis-(nicotinoylamino)-propan, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zusammensetzung
EP0376185A2 (de) * 1988-12-27 1990-07-04 Chugai Seiyaku Kabushiki Kaisha Reinigungsverfahren für 1,2-Bis(nicotinamido)propan

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5581861A (en) * 1978-12-15 1980-06-20 Chugai Pharmaceut Co Ltd Nicotinamide derivative
FR2644789B1 (fr) * 1989-03-22 1995-02-03 Roussel Uclaf Nouveaux steroides 19-nor, 3-ceto comportant une chaine en 17 aminosubstituee, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
JPH0381222A (ja) * 1989-08-22 1991-04-05 Yoshitomi Pharmaceut Ind Ltd 制癌剤
JPH03279328A (ja) * 1990-03-29 1991-12-10 Chugai Pharmaceut Co Ltd 虚血性心疾患治療剤
JPH04178336A (ja) * 1990-10-01 1992-06-25 Akzo Nv 脊髄外傷治療用セロトニン拮抗薬
AU644500B2 (en) * 1990-12-20 1993-12-09 Merrell Dow Pharmaceuticals Inc. 3-aryl-5-alkylthio-4h-1,2,4-triazoles for treatment of hyperreflexia due to spinal trauma
JP3170364B2 (ja) * 1992-11-05 2001-05-28 中外製薬株式会社 放射線障害防護剤
CA2085785C (en) * 1992-12-18 2005-03-15 Robert R. Hansebout The use of 4-aminopyridine in the treatment of a neurological condition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029602A1 (de) * 1979-11-22 1981-06-03 Chugai Seiyaku Kabushiki Kaisha 1,2-Bis-(nicotinoylamino)-propan, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zusammensetzung
EP0376185A2 (de) * 1988-12-27 1990-07-04 Chugai Seiyaku Kabushiki Kaisha Reinigungsverfahren für 1,2-Bis(nicotinamido)propan

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ASANO, TAKAO ET AL: "Effects of a hydroxyl radical scavenger on delayed ischemic neurological deficits following aneurysmal subarachnoid hemorrhage: Results of a multicenter, placebo-controlled double-blind trial", JOURNAL OF NEUROSURGERY (1996), 84(5), 792-803, XP008016895 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; IGARASHI, SHIN-ICHI ET AL: "A perinatal and postnatal study of AVS in rats", XP002241848, retrieved from STN Database accession no. 122:153912 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; ASANO T ET AL: "The pathomechanism underlying ischemic brain edema: the role of Na+, K+-ATPase of the brain microvessels.", XP002241928, retrieved from STN Database accession no. 86119041 *
NO SHINKEI GEKA. NEUROLOGICAL SURGERY, (1985 NOV) 13 (11) 1147-59. *
See also references of WO9735577A1 *
YAKURI TO CHIRYO (1995), 23(SUPPL. 1), 191-202 *

Also Published As

Publication number Publication date
AU1944297A (en) 1997-10-17
JPH09315972A (ja) 1997-12-09
EP0904782A1 (de) 1999-03-31
WO1997035577A1 (en) 1997-10-02
US6090823A (en) 2000-07-18

Similar Documents

Publication Publication Date Title
BR9404203A (pt) Compostos, processo para a preparação dos mesmos, medicamento, uso dos ditos compostos e processo de tratamento ou prevenção de distúrbios nervosos centrais
IL126589A (en) 2,3-disubstituted-4-(3h)-quinazolinones, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating or preventing cerebral deficits
CA2123909A1 (en) New combination of formoterol and budesonide
ATE196989T1 (de) Inhalationszusammensetzungmit lactosegranulate
EP1941898A3 (de) Behandlung neuromuskulärer Erkrankungen und Zustände mit verschiedenem Botulin-Serotyp
GR3032207T3 (en) 2-Bromomelatonin in the therapy of sleep disorders
SE9701956D0 (sv) New composition of matter
NO20053105D0 (no) Oral, analgesisk doseringsform med forlenget frigivelse for administrering ±n gang pr. dag.
EP0699072A4 (de) Eisenbindende polymere zur oralen verabreichung
EP0904782A4 (de) Heilung von wirbelsäulenverletzungen
DK0846173T3 (da) Anvendelse af et anti-interleukin-9-antistof til fremstilling af et lægemiddel til behandling af astma
Gouvier et al. Cognitive retraining with brain-damaged patients.
ZA9610457B (en) Use of 1(4-(aryl(or heteroaryl)-1-piperazinyl)-1H-azole derivatives for the preparation of a medicament for use in the treatment of compulsive obsessive disorders sleeps apnoea syndrome sexual dysfunctions emesis and travel sickness in mammals including man
BG103687A (en) Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative processes and conditions related to the central nervous system
CA2217513A1 (en) Pharmaceutical agents for the treatment of alzheimer's disease
Solkoff The holocaust: survivors and their children.
IL116828A (en) Use of 3, 4-diphenyl chromans for the preparation of pharmaceutical compositions for the treatment or prophylaxis of cerebral degenerative disorders
WO2002005801A3 (en) Compositions containing diacyltartaric salts of (e)-metanicotine
EP0744176A3 (de) Arzneimittel zur Hemmung von Knochenschwund
EP1101493A3 (de) Neue Verwendung von Budesonide und Formoterol
RU97109793A (ru) Способ моделирования позвоночно-спинномозговой травмы шейного отдела
Tardiff Violence by psychiatric patients.
ZA859695B (en) 2-(arylalkyloxymethyl)morpholine,preparation thereof and their application as drugs which are useful in the treatment of disorders of the central nervous system
IL101441A0 (en) Pharmaceutical compositions for the treatment and/or prevention of degenerative disorders in the retina
Bennett Post-traumatic epilepsy: Its nature and implications for head injury recovery.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19981021

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20030618

17Q First examination report despatched

Effective date: 20040330

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 25/28 B

Ipc: 7C 07D 213/38 B

Ipc: 7A 61K 31/44 A

RTI1 Title (correction)

Free format text: REMEDY FOR SPINAL INJURY COMPRISING N, N' PROPYLENE DINICOTINAMIDE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20051011