EP1126833A4 - Derivate von oxadiazolen, thiadiazolen und triazolen sowie kombinatorische bibliotheken davon - Google Patents

Derivate von oxadiazolen, thiadiazolen und triazolen sowie kombinatorische bibliotheken davon

Info

Publication number
EP1126833A4
EP1126833A4 EP99971314A EP99971314A EP1126833A4 EP 1126833 A4 EP1126833 A4 EP 1126833A4 EP 99971314 A EP99971314 A EP 99971314A EP 99971314 A EP99971314 A EP 99971314A EP 1126833 A4 EP1126833 A4 EP 1126833A4
Authority
EP
European Patent Office
Prior art keywords
thiadiazole
oxadiazole
combinatorial libraries
triazole derivatives
triazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99971314A
Other languages
English (en)
French (fr)
Other versions
EP1126833A2 (de
Inventor
R Normand Hebert
Amy L Hannah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trega Biosciences Inc
Original Assignee
Trega Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trega Biosciences Inc filed Critical Trega Biosciences Inc
Publication of EP1126833A2 publication Critical patent/EP1126833A2/de
Publication of EP1126833A4 publication Critical patent/EP1126833A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Structural Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP99971314A 1998-10-29 1999-10-28 Derivate von oxadiazolen, thiadiazolen und triazolen sowie kombinatorische bibliotheken davon Withdrawn EP1126833A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US183222 1994-01-14
US18322298A 1998-10-29 1998-10-29
PCT/US1999/025331 WO2000025768A1 (en) 1998-10-29 1999-10-28 Oxadiazole, thiadiazole and triazole derivatives and combinatorial libraries thereof

Publications (2)

Publication Number Publication Date
EP1126833A2 EP1126833A2 (de) 2001-08-29
EP1126833A4 true EP1126833A4 (de) 2004-09-08

Family

ID=22671958

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99971314A Withdrawn EP1126833A4 (de) 1998-10-29 1999-10-28 Derivate von oxadiazolen, thiadiazolen und triazolen sowie kombinatorische bibliotheken davon

Country Status (3)

Country Link
EP (1) EP1126833A4 (de)
AU (1) AU1455500A (de)
WO (1) WO2000025768A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5891600A (en) * 1999-07-01 2001-01-22 Chemrx Advanced Technologies, Inc. Process for synthesizing oxadiazoles
AU2001233044A1 (en) * 2000-01-28 2001-08-07 Akkadix Corporation Methods for killing nematodes and nematode eggs using bis-amino-1,2,4-thiadiazoles
US6683191B2 (en) * 2000-06-05 2004-01-27 Ortho-Mcneil Pharmaceuticals, Inc. Method for synthesis of substituted azole libraries
AU2001264872A1 (en) * 2000-06-05 2001-12-17 Ortho-Mcneil Pharmaceutical, Inc. Method for synthesis of substituted azole libraries
US6482829B2 (en) 2000-06-08 2002-11-19 Hoffmann-La Roche Inc. Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
EP4101846B1 (de) 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazolbenzoesäureverbindungen und deren verwendung zur nonsense-unterdrückung und behandlung von krankheiten
EP2316827B1 (de) 2003-07-30 2016-01-27 Xenon Pharmaceuticals Inc. Piperazin derivate und deren anwendung als therapeutische wirkstoffe
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
US7605171B2 (en) 2003-12-17 2009-10-20 Merck & Co., Inc. (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US7767677B2 (en) 2004-09-20 2010-08-03 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP1804799B1 (de) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren
US7951805B2 (en) 2004-09-20 2011-05-31 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
EP1799667B1 (de) 2004-09-20 2013-03-20 Xenon Pharmaceuticals Inc. Heterozyklische derivate und ihre verwendung als therapeutische wirkstoffe
EP2316458A1 (de) 2004-09-20 2011-05-04 Xenon Pharmaceuticals Inc. Pyridazin-Derivate zur Verhinderung menschlicher Stearoyl-coa-desaturas
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
EP2029138A1 (de) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazolderivate als humane stearoyl-coa desaturasehemmer
EP2387995A1 (de) 2006-03-30 2011-11-23 PTC Therapeutics, Inc. Verfahren zur Produktion von funktionellem Protein aus DNA mit Nonsense-Mutation und Behandlung von damit assoziierten Erkrankungen
WO2008013622A2 (en) * 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
BRPI0719122A2 (pt) 2006-08-24 2013-12-10 Novartis Ag Compostos orgânicos
RU2009127095A (ru) 2006-12-15 2011-01-20 Эбботт Лэборетриз (Us) Новые оксадиазольные соединения
US8969342B2 (en) 2009-03-20 2015-03-03 Brandeis University Compounds and methods for treating mammalian gastrointestinal microbial infections
EP2560488B1 (de) 2010-04-23 2015-10-28 Cytokinetics, Inc. Bestimmte aminopyrimidine und aminotriazine, zusammensetzungen daraus und verfahren zu ihrer verwendung
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
WO2014028931A2 (en) 2012-08-17 2014-02-20 Brandeis University Compounds and methods for treating mammalian gastrointestinal microbial infections
WO2015134711A1 (en) 2014-03-06 2015-09-11 Ptc Therapeutics, Inc. Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
TW201729807A (zh) 2015-10-30 2017-09-01 Ｐｔｃ治療公司 用於治療癲癇的方法
CN112010828B (zh) * 2020-09-27 2023-01-31 中国医科大学 Cdk7小分子抑制剂的化合物及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019330A1 (en) * 1993-02-18 1994-09-01 Warner-Lambert Company Heterocyclic-substituted alkyl amide acat inhibitors
WO1996022997A1 (en) * 1995-01-27 1996-08-01 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1997014671A1 (en) * 1995-10-18 1997-04-24 Merck & Co., Inc. Cyclopentyl tachykinin receptor antagonists
WO1997016433A1 (en) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Protease inhibitors
WO1998037068A1 (en) * 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8801289D0 (en) * 1988-01-21 1988-02-17 Shell Int Research Oxadiazole compounds their preparation & their use as pesticides
US5242890A (en) * 1988-07-07 1993-09-07 Korea Research Institute Of Chemical Technology 1,2,4-oxadiazole derivative, useful as selective herbicide

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019330A1 (en) * 1993-02-18 1994-09-01 Warner-Lambert Company Heterocyclic-substituted alkyl amide acat inhibitors
WO1996022997A1 (en) * 1995-01-27 1996-08-01 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1997014671A1 (en) * 1995-10-18 1997-04-24 Merck & Co., Inc. Cyclopentyl tachykinin receptor antagonists
WO1997016433A1 (en) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Protease inhibitors
WO1998037068A1 (en) * 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO0025768A1 *
SUSANNA BORG: "synthesis of 1,2,4-oxadiazole-", JOURNAL OF ORGANIC CHEMISTRY., vol. 60, no. 10, 1995, USAMERICAN CHEMICAL SOCIETY. EASTON., pages 3112 - 20, XP002288337 *

Also Published As

Publication number Publication date
WO2000025768A1 (en) 2000-05-11
AU1455500A (en) 2000-05-22
EP1126833A2 (de) 2001-08-29
WO2000025768A8 (en) 2000-08-24

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Legal Events

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Inventor name: HANNAH, AMY, L.

Inventor name: HEBERT, R., NORMAND

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 43/00 B

Ipc: 7C 07D 271/10 B

Ipc: 7C 07D 271/06 B

Ipc: 7A 61K 31/10 B

Ipc: 7A 61K 31/075 A

A4 Supplementary search report drawn up and despatched

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: HANNAH, AMY, L.

Inventor name: HEBERT, R., NORMAND