EP1126833A4 - Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives - Google Patents

Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives

Info

Publication number
EP1126833A4
EP1126833A4 EP99971314A EP99971314A EP1126833A4 EP 1126833 A4 EP1126833 A4 EP 1126833A4 EP 99971314 A EP99971314 A EP 99971314A EP 99971314 A EP99971314 A EP 99971314A EP 1126833 A4 EP1126833 A4 EP 1126833A4
Authority
EP
European Patent Office
Prior art keywords
thiadiazole
oxadiazole
combinatorial libraries
triazole derivatives
triazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99971314A
Other languages
German (de)
English (en)
Other versions
EP1126833A2 (fr
Inventor
R Normand Hebert
Amy L Hannah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trega Biosciences Inc
Original Assignee
Trega Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trega Biosciences Inc filed Critical Trega Biosciences Inc
Publication of EP1126833A2 publication Critical patent/EP1126833A2/fr
Publication of EP1126833A4 publication Critical patent/EP1126833A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Structural Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP99971314A 1998-10-29 1999-10-28 Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives Withdrawn EP1126833A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US183222 1994-01-14
US18322298A 1998-10-29 1998-10-29
PCT/US1999/025331 WO2000025768A1 (fr) 1998-10-29 1999-10-28 Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives

Publications (2)

Publication Number Publication Date
EP1126833A2 EP1126833A2 (fr) 2001-08-29
EP1126833A4 true EP1126833A4 (fr) 2004-09-08

Family

ID=22671958

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99971314A Withdrawn EP1126833A4 (fr) 1998-10-29 1999-10-28 Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives

Country Status (3)

Country Link
EP (1) EP1126833A4 (fr)
AU (1) AU1455500A (fr)
WO (1) WO2000025768A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5891600A (en) * 1999-07-01 2001-01-22 Chemrx Advanced Technologies, Inc. Process for synthesizing oxadiazoles
WO2001054503A1 (fr) * 2000-01-28 2001-08-02 Akkadix Corporation Procedes de destruction des nematodes et des oeufs de nematodes a l'aide de derives 4-phenoxy-6-aminopyrimidine
US6683191B2 (en) 2000-06-05 2004-01-27 Ortho-Mcneil Pharmaceuticals, Inc. Method for synthesis of substituted azole libraries
AU2001264872A1 (en) * 2000-06-05 2001-12-17 Ortho-Mcneil Pharmaceutical, Inc. Method for synthesis of substituted azole libraries
US6482829B2 (en) * 2000-06-08 2002-11-19 Hoffmann-La Roche Inc. Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
HUE047569T2 (hu) 2003-04-11 2020-04-28 Ptc Therapeutics Inc 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása
PL1648874T3 (pl) 2003-07-30 2012-04-30 Xenon Pharmaceuticals Inc Pochodne piperazyny i ich zastosowanie jako środków leczniczych
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
EP1697333A4 (fr) 2003-12-17 2009-07-08 Merck & Co Inc Carboxylates propanoiques 3,4-disusbstitues utilises en tant qu'agonistes du recepteur s1p (edg)
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
BRPI0515500A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados piridazina para inibição de estearoil-coa-desaturase
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
AU2005286647A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
BRPI0515482A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seus usos como agentes terapêuticos
CN101084211A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为治疗剂的用途
MX2007003332A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
CA2618646A1 (fr) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Derives aminothiazole utilises en tant qu'inhibiteurs de la stearoyle-coa desaturase humaine
RU2462246C2 (ru) 2006-03-30 2012-09-27 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы получения функционального белка из днк, имеющей нонсенс-мутацию, и лечения нарушений, ассоциированных с ней
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
WO2008013622A2 (fr) * 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Amides azocycliques fongicides
MX2009002019A (es) 2006-08-24 2009-03-09 Novartis Ag Derivados de 2-(pirazin-2-il)-tiazol y 2-(1h-pirazol-3-il)-tiazol asi como compuestos relacionados como inhibidores de la estearoil-coa-desaturasa (scd) para el tratamiento de trastornos metabolicos, cardiovasculares, y otros.
EP2109364A4 (fr) 2006-12-15 2010-04-14 Abbott Lab Composés d'oxadiazole innovants
US8969342B2 (en) 2009-03-20 2015-03-03 Brandeis University Compounds and methods for treating mammalian gastrointestinal microbial infections
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
WO2014028931A2 (fr) 2012-08-17 2014-02-20 Brandeis University Composés et procédés de traitement d'infections microbiennes gastro-intestinales de mammifère
KR102497273B1 (ko) 2014-03-06 2023-02-07 피티씨 테라퓨틱스, 인크. 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염
JP2018531975A (ja) 2015-10-30 2018-11-01 ピーティーシー セラピューティクス，インコーポレーテッド てんかんの治療方法
CN112010828B (zh) * 2020-09-27 2023-01-31 中国医科大学 Cdk7小分子抑制剂的化合物及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019330A1 (fr) * 1993-02-18 1994-09-01 Warner-Lambert Company AMIDES ALKYLE SUBSTITUES HETEROCYCLIQUES EXERÇANT UNE ACTIVITE INHIBITRICE DE L'ACYLE-CoA: CHOLESTEROL ACYLTRANSFERASE
WO1996022997A1 (fr) * 1995-01-27 1996-08-01 Novo Nordisk A/S Composes ayant des proprietes de liberation de l'hormone de croissance
WO1997014671A1 (fr) * 1995-10-18 1997-04-24 Merck & Co., Inc. Antagonistes des recepteurs de la cyclopentyle-tachykinine
WO1997016433A1 (fr) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Inhibiteurs de proteases
WO1998037068A1 (fr) * 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Derives d'acide benzoïque et composes apparentes utilises comme agents antiarythmiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8801289D0 (en) * 1988-01-21 1988-02-17 Shell Int Research Oxadiazole compounds their preparation & their use as pesticides
US5242890A (en) * 1988-07-07 1993-09-07 Korea Research Institute Of Chemical Technology 1,2,4-oxadiazole derivative, useful as selective herbicide

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019330A1 (fr) * 1993-02-18 1994-09-01 Warner-Lambert Company AMIDES ALKYLE SUBSTITUES HETEROCYCLIQUES EXERÇANT UNE ACTIVITE INHIBITRICE DE L'ACYLE-CoA: CHOLESTEROL ACYLTRANSFERASE
WO1996022997A1 (fr) * 1995-01-27 1996-08-01 Novo Nordisk A/S Composes ayant des proprietes de liberation de l'hormone de croissance
WO1997014671A1 (fr) * 1995-10-18 1997-04-24 Merck & Co., Inc. Antagonistes des recepteurs de la cyclopentyle-tachykinine
WO1997016433A1 (fr) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Inhibiteurs de proteases
WO1998037068A1 (fr) * 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Derives d'acide benzoïque et composes apparentes utilises comme agents antiarythmiques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO0025768A1 *
SUSANNA BORG: "synthesis of 1,2,4-oxadiazole-", JOURNAL OF ORGANIC CHEMISTRY., vol. 60, no. 10, 1995, USAMERICAN CHEMICAL SOCIETY. EASTON., pages 3112 - 20, XP002288337 *

Also Published As

Publication number Publication date
EP1126833A2 (fr) 2001-08-29
WO2000025768A8 (fr) 2000-08-24
AU1455500A (en) 2000-05-22
WO2000025768A1 (fr) 2000-05-11

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Inventor name: HANNAH, AMY, L.

Inventor name: HEBERT, R., NORMAND

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 43/00 B

Ipc: 7C 07D 271/10 B

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Inventor name: HEBERT, R., NORMAND