EP1281404A3 - Antikörper gegen den urokinaserezeptor ind ihre verwendung - Google Patents

Antikörper gegen den urokinaserezeptor ind ihre verwendung Download PDF

Info

Publication number
EP1281404A3
EP1281404A3 EP02013976A EP02013976A EP1281404A3 EP 1281404 A3 EP1281404 A3 EP 1281404A3 EP 02013976 A EP02013976 A EP 02013976A EP 02013976 A EP02013976 A EP 02013976A EP 1281404 A3 EP1281404 A3 EP 1281404A3
Authority
EP
European Patent Office
Prior art keywords
par
mammal
inhibiting
preventing
directed against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02013976A
Other languages
English (en)
French (fr)
Other versions
EP1281404A2 (de
Inventor
Nils BRÜNNER
Charles Pyke
Ebbe Roenne
Gunilla Hoeyer-Hansen
Keld Danoe
Vincent Ellis
Niels Behrendt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancerforskningsfonden af 1989 (fonden til fremme af eksperimentel cancerforskning)
Cancerforskningsfondet af 1989
Original Assignee
Cancerforskningsfonden af 1989 (fonden til fremme af eksperimentel cancerforskning)
Cancerforskningsfondet af 1989
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancerforskningsfonden af 1989 (fonden til fremme af eksperimentel cancerforskning), Cancerforskningsfondet af 1989 filed Critical Cancerforskningsfonden af 1989 (fonden til fremme af eksperimentel cancerforskning)
Publication of EP1281404A2 publication Critical patent/EP1281404A2/de
Publication of EP1281404A3 publication Critical patent/EP1281404A3/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972—Plasminogen activators
    • G01N2333/9723—Urokinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
EP02013976A 1990-10-18 1991-10-18 Antikörper gegen den urokinaserezeptor ind ihre verwendung Withdrawn EP1281404A3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPCTDK9000270 1990-10-18
WOPCT/DK90/00270 1990-10-18
EP91918632A EP0574391B1 (de) 1990-10-18 1991-10-18 Antikörper gegen den urokinaserezeptor und ihre verwendung

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP91918632.0 Division 1992-05-05

Publications (2)

Publication Number Publication Date
EP1281404A2 EP1281404A2 (de) 2003-02-05
EP1281404A3 true EP1281404A3 (de) 2004-04-07

Family

ID=8153643

Family Applications (2)

Application Number Title Priority Date Filing Date
EP02013976A Withdrawn EP1281404A3 (de) 1990-10-18 1991-10-18 Antikörper gegen den urokinaserezeptor ind ihre verwendung
EP91918632A Expired - Lifetime EP0574391B1 (de) 1990-10-18 1991-10-18 Antikörper gegen den urokinaserezeptor und ihre verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP91918632A Expired - Lifetime EP0574391B1 (de) 1990-10-18 1991-10-18 Antikörper gegen den urokinaserezeptor und ihre verwendung

Country Status (8)

Country Link
EP (2) EP1281404A3 (de)
JP (1) JPH07500486A (de)
AT (1) ATE219791T1 (de)
AU (1) AU661978B2 (de)
CA (1) CA2094276C (de)
DE (1) DE69133049T2 (de)
ES (1) ES2179036T3 (de)
WO (1) WO1992007083A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248715B1 (en) 1993-06-01 2001-06-19 Chiron Corporation Method of treating a urokinase-type plasminogen activator-mediated disorder
DE69432608T2 (de) 1993-06-01 2004-02-26 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Expression von inhibitoren vom plasminogenaktivator vom urokinasetyp
JP2852192B2 (ja) * 1994-07-08 1999-01-27 カンセアフォースクニングスフォンデン・アフ・１９８９（フォンデン・チル・フレメ・アフ・エクスペリメンテル・カンセアフォースクニング） ｕＰＡＲのドメイン２＋３のｕＰＡ結合部位および抗体
US6077508A (en) * 1998-03-23 2000-06-20 American Diagnostica Inc. Urokinase plasminogen activator receptor as a target for diagnosis of metastases
ES2274781T3 (es) * 1999-04-13 2007-06-01 Wilex Ag Empleo diagnostico y terapeutico de anticuerpos contra el receptor de la urocinasa.
US20030096733A1 (en) * 2001-07-10 2003-05-22 Omnio Ab Novel drug targets for arthritis
EP1413629A1 (de) * 2001-08-03 2004-04-28 ASAHI MEDICAL Co., Ltd. Verfahren zur bewertung der biokompatibilität
JP2004137151A (ja) * 2002-10-15 2004-05-13 Keio Gijuku 脳腫瘍の治療・診断薬
TW200813091A (en) * 2006-04-10 2008-03-16 Amgen Fremont Inc Targeted binding agents directed to uPAR and uses thereof
US20100075372A1 (en) * 2006-09-28 2010-03-25 Taka-Aki Sato Method for deparaffinization of paraffin-embedded specimen and method for analysis of paraffin-embedded specimen
PL2117571T3 (pl) 2006-12-08 2017-08-31 Monopar Therapeutics Inc. Epitop receptora aktywatora plazminogenu typu urokinazy
CA2757517A1 (en) * 2009-04-07 2010-10-21 Velin-Pharma A/S Method and device for treatment of conditions associated with inflammation or undesirable activation of the immune system
US10539487B2 (en) 2010-03-04 2020-01-21 Ventana Medical Systems, Inc. Systems and methods for monitoring tissue sample processing
US10126216B2 (en) 2011-02-17 2018-11-13 Ventana Medical Systems, Inc. Method for tissue sample fixation
WO2011109769A1 (en) 2010-03-04 2011-09-09 Ventana Medical Systems, Inc. Processing system for processing specimens using acoustic energy
MA41842A (fr) * 2015-03-31 2018-02-06 Oblique Therapeutics Ab Nouveaux procédés de sélection d'épitope
GB201617002D0 (en) 2016-10-06 2016-11-23 Oblique Therapeutics Ab Multi-protease method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0278696A2 (de) * 1987-02-06 1988-08-17 New England Medical Center Hospitals, Inc. Arg-Serpin-Hemmer von menschlichem Plasminogen-Aktivator, bezeichnet als PAI-2
WO1990012091A1 (en) * 1989-04-07 1990-10-18 Cancerforskningsfondet Af 1989 Urokinase-type plasminogen activator receptor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3902021A1 (de) * 1989-01-20 1990-07-26 Entec Verwendung von antipeptidergen mitteln, gegebenenfalls in kombination mit anti-androgenen mitteln zur behandlung des humanen prostatakarzinoms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0278696A2 (de) * 1987-02-06 1988-08-17 New England Medical Center Hospitals, Inc. Arg-Serpin-Hemmer von menschlichem Plasminogen-Aktivator, bezeichnet als PAI-2
WO1990012091A1 (en) * 1989-04-07 1990-10-18 Cancerforskningsfondet Af 1989 Urokinase-type plasminogen activator receptor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BEHRENDT, N. ET AL: "The human receptor for urokinase plasminogen activator", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 11, 15 April 1990 (1990-04-15), pages 6453 - 6460, XP009023713 *
BLASI, F. ET AL: "The urokinase receptor and regulation of cell surface plasminogen activation", CELL DIFFERENTIATION AND DEVELOPMENT, vol. 32, no. 3, 11 December 1990 (1990-12-11), pages 247 - 254, XP008025404 *
KIRCHHEIMER, J. C. ET AL: "Functional inhibition of endogenously produced urokinase decreases cell proliferation in a human melanoma cell line", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 86, July 1989 (1989-07-01), pages 5424 - 5428, XP001157209 *
MCNEILL H ET AL: "A HIGH-AFFINITY RECEPTOR FOR UROKINASE PLASMINOGEN ACTIVATOR ON HUMAN KERTINOCYTES CHARACTERIZATION AND POTENTIAL MODULATION DURING MIGRATION", CELL REGULATION, vol. 1, no. 11, 1990, pages 843 - 852, XP009023712, ISSN: 1044-2030 *
OSSOWSKI, L. ET AL: "In vivo invasion of modified chorioallantoic membrane by tumor cells: the role of cell surface-bound urokinase", THE JOURNAL OF CELL BIOLOGY, vol. 107, no. 6, December 1988 (1988-12-01), pages 2437 - 2445, XP009023728 *
ROLDAN A L ET AL: "CLONING AND EXPRESSION OF THE RECEPTOR FOR HUMAN UROKINASE PLASMINOGEN ACTIVATOR A CENTRAL MOLECULE IN CELL SURFACE PLASMIN DEPENDENT PROTEOLYSIS", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 9, no. 2, 1990, pages 467 - 474, XP000086848, ISSN: 0261-4189 *
WEN-CHANG LIN ET AL: "Bacterial LacZ gene is a highly sensitive marker to detect micrometastasis formation during tumor progression", CNECER RESEARCH, vol. 50, 1 May 1990 (1990-05-01), pages 2808 - 2817, XP001157208 *

Also Published As

Publication number Publication date
DE69133049D1 (de) 2002-08-01
CA2094276A1 (en) 1992-04-19
EP0574391B1 (de) 2002-06-26
DE69133049T2 (de) 2003-01-02
AU8757291A (en) 1992-05-20
WO1992007083A1 (en) 1992-04-30
CA2094276C (en) 2005-08-23
ATE219791T1 (de) 2002-07-15
EP0574391A1 (de) 1993-12-22
JPH07500486A (ja) 1995-01-19
AU661978B2 (en) 1995-08-17
EP1281404A2 (de) 2003-02-05
ES2179036T3 (es) 2003-01-16

Similar Documents

Publication Publication Date Title
EP1281404A3 (de) Antikörper gegen den urokinaserezeptor ind ihre verwendung
DE69033653D1 (de) Plasminogen-aktivator-rezeptor vom urokinasetyp
EP0193561A4 (de) Monoklonale antikörper gegen metallchelate.
NO922238D0 (no) Aktiverbare, fibrinolytiske og antitrombotiske proteiner
EP0376176A3 (de) Bispezifischer monoklonaler Antikörper, seine Herstellung und Verwendung
DK0573545T3 (da) Monoklonale antistoffer mod receptor-inducerede bindingssteder
EP0395918A3 (de) Plasminogen-Aktivatorkomplex von reiner Pro-Urokinase, kovalent gebunden durch eine Disulfidbrücke an menschlichem Serumalbumin
ATE239784T1 (de) Monoklonale antikörper gegen isozyme der thymidinkinase
Bajpai et al. Urokinase binding sites on human foreskin cells. Evidence for occupancy with endogenous urokinase
GB1533205A (en) Plasmin fractions and complexes thereof
FI891956A7 (fi) Kudosplasminogeeniaktivaattorin (t-PA) vastaisia monoklonaalisia vasta-aineita, jotka pidentävät sen funktionaalista puoliintumisaikaa
DE3684050D1 (de) Antikoerper nuetzlich als fuehrungsagenzien und konjugate die sie enthalten.
NO173901C (no) Fremgangsmaate, monoklonalt antistoff og sett for maaling av vevplasminogenaktivator-aktivitet
CA2075937A1 (en) Anti-human plasmin-.alpha.2- plasmin inhibitor complex antibodies, hybridomas, and immunological determination method
US20030215447A1 (en) Inhibitory monoclonal antibody against blood clotting factor VII-activating protease
AU7896891A (en) Trypsin inhibitor (alpha, at) peptide, immunoassay, monoclonal antibody and hybridoma
Tapiovaara et al. Enhanced activation of prourokinase by human RC2A leukemia cells
EP0437547A4 (en) Monoclonal antibodies against receptor-induced binding sites
DK329789D0 (da) Monoklonalt antistof
CA2145005A1 (en) Monoclonal antibodies specific for tcf-ii
FR2415565A1 (fr) Perfectionnement a un wagon
DK176986D0 (da) Monoklonalt anti-urokinase-antistof og produktion og anvendelse deraf
Zacharias et al. Characterization of human tissue-type plasminogen activator with monoclonal antibodies: mapping of epitopes and binding sites for fibrin and lysine
EP0486325A3 (en) Process for selective removal of salivary alpha-amylase and assay for pancreatic alpha-amylase
Thirapakpoomanunt et al. An ELISA for optimization of horse antivenom digestion by pepsin

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AC Divisional application: reference to earlier application

Ref document number: 0574391

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17P Request for examination filed

Effective date: 20040429

17Q First examination report despatched

Effective date: 20040608

AKX Designation fees paid

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20050606