EP1662003A3 - Vecteur de paramyxovirus pour le transfert de gènes au système cardiovasculaire - Google Patents

Vecteur de paramyxovirus pour le transfert de gènes au système cardiovasculaire Download PDF

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Publication number
EP1662003A3
EP1662003A3 EP06002264A EP06002264A EP1662003A3 EP 1662003 A3 EP1662003 A3 EP 1662003A3 EP 06002264 A EP06002264 A EP 06002264A EP 06002264 A EP06002264 A EP 06002264A EP 1662003 A3 EP1662003 A3 EP 1662003A3
Authority
EP
European Patent Office
Prior art keywords
cardiovascular system
vector
gene transfer
paramyxovirus vector
paramyxovirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP06002264A
Other languages
German (de)
English (en)
Other versions
EP1662003A2 (fr
Inventor
Uta c/o Imperial School of Medicine Griesenbach
Stefano c/o Imperial School of Medicine Ferrari
Duncan M. c/o Imperial School of Medicine Geddes
Eric WFW c/o Imperial School of Medicine Alton
Mamoru Hasegawa
Xiogang Hou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dnavec Research Inc
Original Assignee
Dnavec Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnavec Research Inc filed Critical Dnavec Research Inc
Publication of EP1662003A2 publication Critical patent/EP1662003A2/fr
Publication of EP1662003A3 publication Critical patent/EP1662003A3/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18841—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP06002264A 2000-11-08 2001-11-08 Vecteur de paramyxovirus pour le transfert de gènes au système cardiovasculaire Ceased EP1662003A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000339942A JP2002142770A (ja) 2000-11-08 2000-11-08 循環系への遺伝子送達用パラミクソウイルスベクター
EP01981031A EP1334174B1 (fr) 2000-11-08 2001-11-08 Vecteur de paramyxovirus destine au transfert de genes dans le systeme cardiovasculaire

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP01981031A Division EP1334174B1 (fr) 2000-11-08 2001-11-08 Vecteur de paramyxovirus destine au transfert de genes dans le systeme cardiovasculaire

Publications (2)

Publication Number Publication Date
EP1662003A2 EP1662003A2 (fr) 2006-05-31
EP1662003A3 true EP1662003A3 (fr) 2006-06-14

Family

ID=18814933

Family Applications (2)

Application Number Title Priority Date Filing Date
EP01981031A Expired - Lifetime EP1334174B1 (fr) 2000-11-08 2001-11-08 Vecteur de paramyxovirus destine au transfert de genes dans le systeme cardiovasculaire
EP06002264A Ceased EP1662003A3 (fr) 2000-11-08 2001-11-08 Vecteur de paramyxovirus pour le transfert de gènes au système cardiovasculaire

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP01981031A Expired - Lifetime EP1334174B1 (fr) 2000-11-08 2001-11-08 Vecteur de paramyxovirus destine au transfert de genes dans le systeme cardiovasculaire

Country Status (12)

Country Link
US (1) US20040101965A1 (fr)
EP (2) EP1334174B1 (fr)
JP (1) JP2002142770A (fr)
KR (1) KR100852078B1 (fr)
CN (1) CN1555417B (fr)
AT (1) ATE323149T1 (fr)
AU (1) AU2002212733A1 (fr)
CA (1) CA2428073C (fr)
DE (1) DE60118771T2 (fr)
DK (1) DK1334174T3 (fr)
ES (1) ES2260301T3 (fr)
WO (1) WO2002038726A2 (fr)

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CA2376106A1 (fr) 1999-09-06 2001-03-15 Dnavec Research Inc. Paramoxyvirus possedant une sequence d'initiation de transcription modifiee
US7314614B1 (en) 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
KR100854917B1 (ko) 2000-03-30 2008-08-27 가부시키가이샤 디나벡크 겐큐쇼 센다이바이러스 벡터를 사용한 ａｉｄｓ 바이러스 백신
AU2001262684A1 (en) * 2000-06-01 2001-12-11 Dnavec Research Inc. Pseudo-type retrovirus vector containing membrane protein having hemagglutinin activity
AU2001266337A1 (en) * 2000-06-27 2002-01-08 Dnavec Research Inc. Virus vector for transferring gene into renal cells
CN1526014A (zh) * 2000-10-06 2004-09-01 ��ʽ���������о��� 用于将外源基因导入骨骼肌的副粘病毒载体
ES2305138T3 (es) 2000-11-27 2008-11-01 Dnavec Research Inc. Vector de paramixovirus que codifica factor 2 de crecimiento de fibroblastos (fgf2) y uso del mismo.
EP1504766A4 (fr) * 2002-04-30 2006-11-02 Dnavec Research Inc Composition support de medicament ou de gene avec activite d'hemagglutinine
US20060128019A1 (en) * 2002-09-04 2006-06-15 Masanori Kobayashi Process for producing virus vector containing membrane protein having sialic acid-binding in envelope with the use of gram-positive bacterium origin nueraminidase
WO2004038029A1 (fr) * 2002-10-24 2004-05-06 Dnavec Research Inc. Procede permettant de transferer des genes dans des lymphocytes t
JPWO2005001082A1 (ja) * 2003-06-30 2006-08-10 株式会社ディナベック研究所 高変異領域が改変された遺伝子を搭載するマイナス鎖ｒｎａウイルスベクター
JPWO2005067981A1 (ja) * 2004-01-13 2007-12-27 株式会社ディナベック研究所 免疫刺激性サイトカインをコードするマイナス鎖ｒｎａウイルスベクターを用いる腫瘍の遺伝子治療
KR20070004637A (ko) * 2004-01-22 2007-01-09 가부시키가이샤 디나벡크 겐큐쇼 바이러스 벡터의 제조방법
CN1957084A (zh) * 2004-03-23 2007-05-02 株式会社载体研究所 与组织的维持和/或修复相关联的骨髓相关细胞
EP1891215B1 (fr) * 2005-04-20 2009-10-28 Dnavec Corporation Vaccins geniques sans danger administrables par voie intranasale pour le traitement de la maladie d'alzheimer
JP4969444B2 (ja) * 2005-06-14 2012-07-04 ディナベック株式会社 抗体の作製方法
DK1950307T3 (en) 2005-10-28 2016-02-15 Id Pharma Co Ltd Luftvejsepitelstamcelle for gene transfer using a lentiviral vector, which is pseudo typified by RNA virus spike protein
EP1983048A4 (fr) * 2006-01-17 2009-04-22 Dnavec Corp Nouveau système d'expression de protéines
CN105209054A (zh) 2013-04-18 2015-12-30 阿尔莫生物科技股份有限公司 使用白细胞介素-10治疗疾病和病症的方法
JP2016528879A (ja) 2013-06-17 2016-09-23 アルモ・バイオサイエンシーズ・インコーポレイテッド タンパク質の同一性および安定性を評価する方法
HK1226308A1 (zh) 2013-08-30 2017-09-29 Armo Biosciences, Inc. 使用白细胞介素-10治疗疾病和病症的方法
US11413332B2 (en) 2013-11-11 2022-08-16 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
US10293043B2 (en) * 2014-06-02 2019-05-21 Armo Biosciences, Inc. Methods of lowering serum cholesterol
JP6675394B2 (ja) 2014-10-22 2020-04-01 アルモ・バイオサイエンシーズ・インコーポレイテッド 疾患及び障害の治療のためにインターロイキン−１０を使用する方法
US10618970B2 (en) 2015-02-03 2020-04-14 Armo Biosciences, Inc. Method of treating cancer with IL-10 and antibodies that induce ADCC
JP7053453B2 (ja) 2015-08-25 2022-04-12 アルモ・バイオサイエンシーズ・インコーポレイテッド 疾患及び障害を治療するためのインターロイキン１０の使用方法

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ES2305138T3 (es) * 2000-11-27 2008-11-01 Dnavec Research Inc. Vector de paramixovirus que codifica factor 2 de crecimiento de fibroblastos (fgf2) y uso del mismo.
WO2004038029A1 (fr) * 2002-10-24 2004-05-06 Dnavec Research Inc. Procede permettant de transferer des genes dans des lymphocytes t
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Also Published As

Publication number Publication date
DE60118771D1 (de) 2006-05-24
ATE323149T1 (de) 2006-04-15
KR100852078B1 (ko) 2008-08-13
CA2428073C (fr) 2012-01-10
WO2002038726A2 (fr) 2002-05-16
CA2428073A1 (fr) 2002-05-16
HK1070100A1 (zh) 2005-06-10
DK1334174T3 (da) 2006-06-26
DE60118771T2 (de) 2007-04-12
CN1555417A (zh) 2004-12-15
AU2002212733A1 (en) 2002-05-21
EP1662003A2 (fr) 2006-05-31
CN1555417B (zh) 2010-04-28
ES2260301T3 (es) 2006-11-01
EP1334174A2 (fr) 2003-08-13
EP1334174B1 (fr) 2006-04-12
KR20030074617A (ko) 2003-09-19
JP2002142770A (ja) 2002-05-21
WO2002038726A3 (fr) 2003-03-20
US20040101965A1 (en) 2004-05-27

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