EP1787528A1 - Verfahren zur Entaromatisierung von Molkeproteinen mittels Membranelektrodialyse - Google Patents

Verfahren zur Entaromatisierung von Molkeproteinen mittels Membranelektrodialyse Download PDF

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Publication number
EP1787528A1
EP1787528A1 EP06118694A EP06118694A EP1787528A1 EP 1787528 A1 EP1787528 A1 EP 1787528A1 EP 06118694 A EP06118694 A EP 06118694A EP 06118694 A EP06118694 A EP 06118694A EP 1787528 A1 EP1787528 A1 EP 1787528A1
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EP
European Patent Office
Prior art keywords
whey protein
whey
membrane
deflavored
ultrafiltration
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EP06118694A
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English (en)
French (fr)
Inventor
Peter H. Brown
Colin P. Crowley
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Intercontinental Great Brands LLC
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Kraft Foods Holdings Inc
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Publication of EP1787528A1 publication Critical patent/EP1787528A1/de
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/04—Animal proteins
    • A23J3/08—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/02—Making cheese curd
    • A23C19/05—Treating milk before coagulation; Separating whey from curd
    • A23C19/053—Enrichment of milk with whey, whey components, substances recovered from separated whey, isolated or concentrated proteins from milk
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C20/00—Cheese substitutes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A23C9/1425—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by ultrafiltration, microfiltration or diafiltration of whey, e.g. treatment of the UF permeate
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • A23J1/205—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey from whey, e.g. lactalbumine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • This invention relates generally to the processing of whey protein-containing materials for use in various food products. More particularly, the invention relates to a method of deflavoring whey protein materials using membrane electrodialysis for pH adjustment in order to make them acceptable in a wide range of foods.
  • whey proteins have become widely used in food products, in larger part, for the health benefits obtained from their use.
  • health benefits such as anti-hypertension activity, immune system enhancement, antimicrobial activity, intestinal health enhancement, and oral hygiene activity.
  • the taste of the whey protein materials is not objectionable (e.g., when the taste of whey is masked).
  • the flavors found in whey protein materials may prevent their ready acceptance by the consumer.
  • U.S. Patent 4,477,480 shows that starch can be treated with an alkali to remove objectionable flavor components.
  • U.S. Patent 4,761,186 ultrafiltration is used to purify starch. In both cases, flavor components are removed from the starch.
  • the '480 patent solubilizes the flavor components so that they can be washed out of the relatively insoluble starch.
  • the '186 patent uses ultrafiltration to remove the flavor components as permeate, while the insoluble starch remained in an aqueous slurry.
  • the present invention separates flavor components from soluble high molecular weight whey proteins.
  • Mead Johnson Company disclosed processes for solubilizing soy proteins by raising the pH of an aqueous solution of soy materials and recovering the proteins which are said to have a bland taste. The processes are principally directed to concentrating proteins rather than removing flavor compounds.
  • U.S. Patent 3,995,071 the pH was increased to 10.1 to 14 (preferably 11 to 12) to solubilize soy proteins, after which the pH was lowered to about 6 to 10 and the mixture subjected to ultrafiltration with a membrane having a molecular weight cutoff af 10,000 to 50,000 Daltons; the proteins were retained while discarding carbohydrates and minerals.
  • U.S. Patent 3,995,071 the pH was increased to 10.1 to 14 (preferably 11 to 12) to solubilize soy proteins, after which the pH was lowered to about 6 to 10 and the mixture subjected to ultrafiltration with a membrane having a molecular weight cutoff af 10,000 to 50,000 Daltons; the proteins were retained while discarding carbohydrates and minerals.
  • Patent 4,072,670 emphasis was placed on removing phytates and phytic acid by solubilizing proteins at a pH of 10.6 to 14 and a temperature of 10 to 50°C to render the phytates and phytic acid insoluble, then separating them, and finally acidifying the solution to a pH of about 4 to 5 to precipitate the soy proteins.
  • soy proteins were solubilized at a pH less than 10, preferably 7 to 9, and ultrafiltration was used to separate the proteins as retentate, while passing carbohydrates as permeate.
  • the present inventors have surprisingly discovered that related processes can be advantageously applied to whey protein materials to remove undesirable flavor components to obtain a deflavored whey protein material that can be incorporated into many different food products.
  • Electrodialysis apparatus is described in U.S. Patent Nos. 6,537,436 , 6,482,305 and 6,402,917 . None of these patents describe the use of electrodialysis treatment in the processing of whey protein materials.
  • the invention is a process for preparing an aqueous whey composition having a whey protein concentration of about 1 to about 50 percent, which is pH-adjusted using membrane electrodialysis to solubilize the whey protein content and to release the flavoring compounds. Then the composition is subjected to ultrafiltration, while maintaining pH control, using a membrane capable of retaining substantially all of the protein content of the whey protein material while removing flavoring components as permeate.
  • the present inventors have now surprisingly discovered that a method used for deflavoring soy protein materials and methods for adjusting pH using membrane electrodialysis can be combined and used for deflavoring whey protein materials.
  • the present process, as applied to whey proteins can be run under basic conditions as desired to produce deflavored whey protein material.
  • the deflavored whey protein materials prepared by the present methods are ideally suited for use in dairy and non-dairy beverages, smoothies, health drinks, confectionary type products, nutritional bars, cheeses, cheese analogs, dairy and non-dairy yogurts, meat and meat analog products, cereals, baked products, snacks, and the like.
  • the present invention provides methods for deflavoring whey proteins.
  • the present invention also allows the efficient removal of lactose, thereby allowing concentration of the whey proteins to high levels.
  • whey protein contains about 70 to about 80 percent (dry basis) lactose.
  • levels of lactose less than about 15 percent (dry basis) can be obtained in the deflavored whey protein.
  • extensive ultrafiltration/difiltration i.e., greater than 5 wash cycles and typically in the range of about 6 to 7 wash cycles
  • the level of lactose can be reduced to less than about 8 percent (dry basis).
  • the deflavored whey protein materials can be prepared containing greater than about 50 percent protein (on a dry basis), and preferably about 65 to about 95 percent protein; obtaining higher levels of protein (generally greater than about 85 percent) require extensive ultrafiltration/diafiltration.
  • whey protein in conventional food products at sufficiently high levels (generally sufficient to provide about 2.5 to about 30 g whey protein per single serving size (generally about 25 to about 100 g for solid food products and about 100 to about 300 ml for liquid food products) to provide health benefits of whey protein.
  • incorporation of whey proteins at such levels generally resulted in significant off-flavors and, therefore, only very limited acceptance by consumers.
  • the removal of lactose may allow the use of such food products by lactose-intolerant consumers; generally, in such cases, at least about 95 percent of the lactose should be removed.
  • the invention is a method of deflavoring whey protein materials which includes preparing an aqueous composition of the whey protein material containing flavoring compounds.
  • the pH of the aqueous composition is adjusted to a basic range of about 8.5 to about 12 with membrane electrodialysis or to an acidic range of about 2.4 to about 4 using membrane electrodialysis.
  • the pH adjustment is effective for solubilizing the protein content of the whey protein material and for releasing the flavor components.
  • the pH-adjusted composition is then passed adjacent to an ultrafiltration membrane having pores which provide a molecular weight cutoff up to 50,000 Daltons, while maintaining the pH in the same range as to which the aqueous composition was adjusted, thus retaining substantially all of the whey protein content, while passing through the pores the flavor producing compounds.
  • the pH of the deflavored protein solution is adjusted to the desired final pH by membrane electrodialysis.
  • the invention includes adjusting the pH to the range of about 8 to about 12 with membrane electrodialysis.
  • the pH may be maintained in this range with membrane electrodialysis and/or by using an alkali such as sodium, potassium or calcium hydroxides to maintain the solubility of the whey protein content and release the flavor compounds, making it possible to separate such compounds by ultrafiltration.
  • the pH in this basic mode of operation is also controlled within the range of about 8 to about 12 during the ultrafiltration process. Following removal of the off-flavors, the pH of the deflavored protein solution is adjusted to the desired final pH by membrane electrodialysis.
  • Native whey proteins are generally soluble over a wide range of pH values. Denaturing of such protein, as often occurs during processing (e.g., cheese manufacture, pasteurization, elevated temperature, ultrafiltration, and the like) results in decreased solubility (especially around the isoelectric point of about 5.2). Adjusting the final pH of the deflavored whey protein in essentially the same range as its ultimate use in a food product allows the maintenance of desired solubility.
  • Using a deflavored whey protein such that the final pH adjustment is neutral (pH 6.5-8.0) in a neutral or basic food product, and using a deflavored whey protein such that the final pH adjustment is acidic (below pH 6.5) but above the isoelectric point in an acidic food products avoids modifying the pH of the deflavored whey protein (and potentially passing it through its isoelectric point) and thereby provides maximum solubility in the food product.
  • the invention is a method for deflavoring whey protein materials in a continuous process wherein a pH-adjusted aqueous mixture of whey protein materials is passed adjacent an ultrafiltration membrane to separate the flavor components.
  • the pH is maintained at about 8.5 to about 12 for the basic mode of operation during the ultrafiltration with membrane electrodialysis and/or by the addition of the appropriate amount of an appropriate pH-altering material (i.e., a base).
  • the permeate containing flavor components, lactose, minerals, and water is passed adjacent a reverse osmosis membrane to dewater the permeate and the separated water can be recycled to join recycled retentate and fresh pH-adjusted whey materials. A portion of the retentate is continually removed and the deflavored whey protein materials recovered.
  • the invention is a method for deflavoring whey protein materials in a batch or semi-continuous process wherein a pH-adjusted aqueous mixture of whey protein materials is passed adjacent an ultrafiltration membrane, the permeate is separated for recovery of the flavor components, and the retentate may be recycled to join fresh pH-adjusted whey protein materials. Water is added periodically or continuously to replace the water lost to the permeate and to adjust the concentration of whey materials in the combined stream to a predetermined level.
  • Recycled retentate and/or added water may be subjected to membrane electrodialysis, and/or a pH-altering material (e.g., a base or an acid) can be added to the recycled retentate or added water to control the pH to the desired range during the ultrafiltration process.
  • a pH-altering material e.g., a base or an acid
  • the process is continued until essentially all of the flavoring compounds have been removed. If desired, the process can also be continued until sufficient levels of lactose removal have been obtained; such reduced lactose materials may be used in food products directed to lactose-intolerant individuals.
  • the pH of the deflavored protein solution is adjusted to the desired final pH by membrane electrodialysis.
  • the present invention provides a method for preparing deflavored whey protein material, said method comprising:
  • the ultrafiltration membrane used in the method of the invention will have a molecular weight cutoff up to 50,000 Daltons, preferably 1,000 to 50,000, most preferably about 5,000 to 10,000.
  • FIG. 1 is a block diagram of one embodiment of the invention.
  • FIG. 2 is one example of a membrane electrodialysis system for increasing pH.
  • FIG. 3 is another example of a membrane electrodialysis system for increasing pH.
  • FIG. 4 is one example of a membrane electrodialysis system for decreasing pH.
  • FIG. 5 is another example of a membrane electrodialysis system for decreasing pH.
  • Whey Protein Materials Whey proteins have high nutritive value for humans. In fact, the amino acid composition of such whey proteins is close to an ideal composition profile for human nutrition. Unfortunately, use of such whey proteins in food compositions have been limited due to undesirable odors and/or flavors as well as other organoleptic problems associated with whey proteins. Normal whey protein materials generally have significant lactose, milky, and animal flavors which can impact the flavor profiles of food products, especially otherwise bland food products. Off flavors in whey protein materials are generally attributed to lipid oxidation of unsaturated fatty acids during, or after, the cheese making process and/or to Maillard browning reactions.
  • Lipid oxidation can result in formation of volatile aldehydes, ketones, esters, and alcohols, which appear to contribute to a cardboard-like flavor.
  • whey protein materials contribute, or provide, off flavors described as cardboardy, musty, metallic, sour, cooked, astringent, and diacetyl; see, for example, Laye et al., Milchwissenschaft, 50, 268-272 (1995) ; Carunchia Whetstine et al., J. Dairy Sci., 86, 439-448 (2003) .
  • Deflavored whey protein as produced by the present invention can be used in a wide variety of food products, and at higher levels than has been possible before, thereby providing nutritionally superior food products.
  • Deflavored whey proteins can be prepared from, for example, whey obtained from conventional cheese making processes, whey protein isolate, whey protein concentrate, and the like.
  • Membrane electrodialysis is used to adjust the pH of whey protein materials.
  • the use of membrane electrodialysis provides a method for adjusting pH without the addition of acid or base. As such, salts and precipitates that may form with the addition of acids and bases and not formed and their removal is not required. Moreover, changes in organoleptic properties associated with addition of either acid or bases are avoided.
  • membrane electrodialysis may be conducted using a bipolar membrane and cationic membranes.
  • the membranes are disposed between a cathode and anode and subjected to an electrical field.
  • the membranes form separate compartments and materials flowing through those compartments may be collected separately.
  • An example of an electrodialysis apparatus containing ion-selective membranes is EUR6 (available from Eurodia Industrie, Wissous, France). Suitable membranes are available from Tokuyama (Japan).
  • a bipolar membrane includes a cationic membrane and an anionic membrane joined together. Of course, other apparatus and membranes could be used.
  • an aqueous mixture of whey protein material is contacted with the ion-selective membranes, Aqueous materials may be processed in a batch mode, semi-continuous mode, or continuous mode by flowing an aqueous solution over the ion-selective membranes.
  • an electrical potential is applied across the anode and cathode for a time effective for providing composition with the desired pH. Processing times in a batch mode and flow rates in a semi-continuous mode or continuous mode are a function of the number of ion-selective membranes and the electrical potential applied.
  • the resulting composition can be monitored and further processed until a desired pH is achieved.
  • Alternative membrane configurations are provided in the Figures. Other variations in membrane configuration are expected to achieve the same results.
  • the pH of the whey protein materials may be adjusted to a pH range of about 8.0 to about 12 by contacting the aqueous solution with at least one, preferably a plurality of bipolar membranes that includes anionic membranes on both sides of the bipolar membrane.
  • Materials from the compartments to the right of the bipolar membranes are collected for subsequent use.
  • Materials collected from the compartments to the left of the bipolar membranes may be recirculated back through the membranes or circulated to a second membrane electrodialysis as many times as are need to provide an aqueous solution having a pH of about 8.0 to about 12.
  • Materials from the compartments to the right of the bipolar membranes may be recirculated back through the membranes.
  • Materials from the compartments adjacent to the anode and cathode may be recirculated back through the membranes.
  • the pH of the deflavored whey protein materials may be adjusted to a neutral or acidic pH range by contacting the aqueous solution with at least one, preferably a plurality of bipolar membranes that includes cationic membranes on both sides of the bipolar membrane.
  • Materials from the compartments to the left of the bipolar membranes are collected for subsequent use.
  • Materials collected from the compartments to the right of the bipolar membranes may be recirculated back through the membranes or circulated to a second membrane electrodialysis as many times as are needed to provide an aqueous solution having the final desired pH.
  • Materials from the compartments to the left of the bipolar membranes may be recirculated back through the membranes.
  • Materials from the compartments adjacent to the anode and cathode may be recirculated back through the membranes.
  • the pH-adjusted aqueous solution is then treated to remove insoluble materials.
  • Any conventional technique e.g., filtration, decantation, centrifugation, and the like
  • the insoluble material is removed by centrifugation.
  • Commercial available continuous centrifugation units are ideally suited for this separation in a semi-batch or continuous type operation.
  • the pH-adjusted aqueous is subjected to the removal technique (e.g., centrifugation) at least twice in order facilitate or more completely removed of insoluble materials.
  • Ultrafiltration Membranes In the present invention, ultrafiltration is used to remove flavoring compounds from whey protein materials. Importantly, the pH of the whey protein material should be maintained in the range of about 8 to about 12 during the ultrafiltration process by circulating materials back through the membrane electrodialysis apparatus and/or by addition of acid or base. Ultrafiltration is intended to remove particles having a size between 10 to 1,000 Angstroms (0.001 to 0.1 ⁇ m), corresponding generally to particles having a molecular weight between 10,000 and 1,000,000, and which may also be affected by the shape of such high molecular weight particles. Whey proteins have molecular range between about 14,000 and 100,000 Daltons.
  • Whey Protein Faction MW (daltons) Percentage of Total Whey Proteins Beta-lactoglobulins 18,300 50 Alpha-lactoalbumin 14,000 12 Immunoglobulins 15,000 - 100,000 10 Bovine Serum Albumin 69,000 5 Proteose-peptones 4,100 - 41,000 23
  • a membrane may be chosen which is capable of passing all of the whey proteins or only a selected portion.
  • the whey proteins are retained by the ultrafiltration membrane under the selected operating conditions, while the lower molecular weight flavoring compounds pass through the membrane and are separated, thus improving the color and flavor of the retained whey proteins and associated solids.
  • a polymer ultrafiltration membrane may be defined as an anisotropic (nonuniform) layer.
  • One face is a skin containing pores which determine the size of molecules which can pass through the membrane.
  • Supporting the surface skin is a spongy structure which extends to the opposite face.
  • Such membranes are commonly made by coagulation of polymers in an aqueous bath.
  • Typical polymers which are used include polysulfones, cellulose esters, poly(vinylenefluoride), poly (dimethylphenylene oxide), poly (acrylonitrile), which can be cast into membranes.
  • the membranes are formed into hollow tubes which are assembled into bundles, through which the solution to be filtered is passed. Alternatively, flat membrane sheets and spiral designs may be used.
  • pressure is applied to facilitate movement of the lower molecular weight compounds through the membrane.
  • the membrane must be able to withstand the pressures used, making it important that the spongy supporting structure be uniform to avoid breaking the surface skin and bypassing the membrane.
  • the membrane of the invention will have a molecular weight cutoff up to about 50,000 Daltons, preferably about 1,000 to 50,000 Daltons, more preferably 5,000 to 30,000 Daltons.
  • the process of the invention includes the following steps:
  • the original whey protein material is an aqueous solution (e.g., whey from a cheese manufacturing process)
  • the material may be used as is, or additional water may be added or removed as desired to form the aqueous mixture.
  • whey materials e.g., whey protein isolate, whey protein concentrate, and the like
  • water will, of course, need to be added to form the aqueous mixture.
  • whey protein material may be treated to remove any water insoluble materials that may be present.
  • the water insoluble materials that may be present may be removed from the pH-adjusted aqueous composition using at least one centrifugation step or by using at least one clarification step.
  • the solubility of the whey proteins during ultrafiltration allows the flavoring compounds to remain in a form in which they can be removed; if the whey protein denature during ultrafiltration, the flavoring compounds may become bound or encapsulated by the whey proteins, thereby preventing or reducing the effectiveness of their removal.
  • the flavoring compounds which have relatively low molecular weight compared to the whey proteins are able to pass through the pores of the ultrafiltration membrane, while substantially all of the solubilized whey proteins are too large and are retained.
  • the pH should be maintained within the just described ranges (i.e., about 8.0 to about 12) during the ultrafiltration/diafiltration process to allow as much of the flavoring compounds as possible to be removed.
  • the third step may be carried out in a batch manner.
  • the pH-adjusted aqueous mixture would be circulated continuously adjacent to an ultrafiltration membrane. Since water, and the flavoring compounds pass through the membrane as permeate and are discarded, additional water will be added to maintain the desired concentration of whey protein materials, which will tend to change the pH of the aqueous mixture. This water may be augmented by dewatering the permeate and recycling the recovered water to the feed stream. The pH of the water may be pH adjusted using membrane eletrodialysis.
  • a pH-modifying material e.g., base or acid as appropriate
  • further neutralization of the filtered solution may be accomplished by withdrawing product and subjecting the solution to membrane electrodialysis and/or by adding an acid or base as required to reach the desired pH.
  • the aqueous mixture of whey proteins and other materials may be used directly in food products, or it may be concentrated or dried as required for the intended use. Preferably such neutralization does not cause the solution to pass through the isoelectric point of whey protein.
  • a process for deflavoring whey protein materials by ultrafiltration may be operated in various ways.
  • the pH during the ultrafiltration/diafiltration process is maintained in the desired range (i.e., about 8.0 to about 12, and preferably about 9.5 to about 10.5.
  • Several methods will be described, 1) continuous processing; 2) batch processing; and 3) semi-continuous processing. It is expected that commercial processes will adopt batch or semi-continuous operation, which should be better suited to production of food-grade whey protein products.
  • a continuous process is generally shown in FIG. 1.
  • an aqueous mixture of whey protein materials is pH adjusted with membrane electrodialysis to solubilize whey proteins and release flavor compounds and then passed adjacent an ultrafiltration membrane which permits the lower molecular weight flavoring materials to pass through its pores along with water (the permeate), leaving the higher molecular weight whey protein materials (the retentate) to be recirculated.
  • a portion of the retentate will be withdrawn as deflavored product, from which the whey protein materials can be recovered as needed for the ultimate end use. Water will be added to replace that lost in the permeate and to provide a constant concentration of whey protein materials in the feed stream supplied to the ultrafiltration membrane.
  • the permeate includes additional processing of the permeate to recover a portion of the water using a reverse osmosis membrane for recycling to join the retentate and fresh whey protein materials.
  • the advantage of such a step is in reducing the amount of fresh water which must be added to the process and removed in concentrating the permeate.
  • the pH of the whey protein materials can be kept within the desired range with membrane electrodialysis and/or by appropriate addition of a base or acid, as appropriate, to the recycled or fresh water added to the process or by membrane electrodialysis and/or direct addition of base as desired.
  • a batch of whey protein material in an aqueous mixture is placed in a vessel, pH adjusted with membrane electrodialysis, and fed to an ultrafiltration membrane.
  • the permeate is separated and the retentate is returned to the vessel.
  • the whey protein material is depleted in the lower molecular weight flavoring compounds and water and becomes more concentrated in the desirable whey proteins.
  • water is added to the retentate to dilute it and provide a carrier for the flavoring compounds which are passed through the membrane.
  • the water is added continuously at the rate it is being removed in the permeate.
  • a batch or semi-continuous process may also include the concentration of the permeate, with recycle of separated water in a similar manner as that shown in FIG. 1.
  • the pH during the ultrafiltration/diafiltration process is maintained in the desired range (i.e., about 8.0 to about 12, and preferably about 9.5 to about 10.5)
  • the pH may be adjusted with membrane electrodialysis or with addition of acid or base.
  • the ultrafiltration membrane will be operated with a pressure differential across the membrane which assists migration of the flavoring compounds, water and other materials which are capable of passing through the pores of the membrane, while not exceeding the physical strength of the membrane.
  • the trans-membrane pressure (in versus out) will be about 20 psi to about 60 psi. Of course, these pressures could be varied based on the membrane's specifications and other operational concerns.
  • the flow rate of the feed stream will provide sufficient residence time for significant permeate removal, but also will be high enough to provide turbulence so that the access of the feed stream to the membrane pores will not be hindered by solid deposits on the membrane walls.
  • the feed stream may be prefiltered prior to ultrafiltration to minimize fouling of the ultrafiltration membrane.
  • suitable operating parameters will be determined by experience with the materials being separated.
  • the present invention provides a method for preparing deflavored whey protein material, said method comprising: (a) providing an aqueous composition of a whey protein material containing soluble whey proteins, flavoring compounds, and insoluble materials; (b) solubilizing the whey proteins by adjusting the aqueous composition of (a) to a pH in the range of about 8.0 to about 12 and releasing the flavoring compounds; (c) removing the insoluble materials from the pH-adjusted aqueous composition of (b) to obtain a treated aqueous composition; (d) passing the treated aqueous composition of (c) adjacent an ultrafiltration membrane having a molecular weight cutoff up to about 50,000 Daltons, while maintaining the pH in the range of about 8.0 to about 12, under suitable ultrafiltration conditions wherein the flavor compounds pass through the membrane, thereby deflavoring the whey protein material and retaining substantially all of the solubilized whey proteins
  • the deflavored whey protein solution may be used directly or it may be converted to a solid form if desired. Any conventional technique for removing water can be used. Generally, spray or freeze drying techniques are preferred.
  • the deflavored whey protein materials prepared by the present methods are ideally suited for use in dairy and non-dairy beverages, smoothies, health drinks, cheeses, cheese analogs, dairy and non-dairy yogurts, meat and meat analog products, cereals, baked products, snacks, and the like.
  • such food products may contain up to about 40 percent deflavored whey proteins without significantly impacting organoleptic properties. More preferably, such food products contain about 10 to about 30 percent deflavored whey proteins.
  • whey protein in conventional food products at sufficiently high levels (generally sufficient to provide about 2.5 to about 30 g whey protein per single serving size (generally about 25 to about 100 g for solid food products and about 100 to about 300 ml for liquid food products)) to provide health benefits of whey protein.
  • whey protein Prior to this invention, incorporation whey proteins at such levels generally resulted in significant off-flavors and, therefore, only very limited acceptance by consumers.

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  • Separation Using Semi-Permeable Membranes (AREA)
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009113858A1 (en) * 2008-03-12 2009-09-17 N.V. Nutricia High protein liquid enteral nutritional composition
CN101270497B (zh) * 2008-05-16 2010-07-14 南京大学 一种料液的酸碱度的调节方法
US8409651B2 (en) 2007-12-05 2013-04-02 N. V. Nutricia High energy liquid enteral nutritional composition
EP2298090B1 (de) 2009-08-26 2016-01-13 Jeffrey M. Golini Pharmazeutische oder nutrazeutische Zusammensetzung
EP2488044B1 (de) 2009-10-16 2019-04-03 Dairy Australia Limited Allergiebehandlung mit einem säurebehandelten wässrigen molkeproteinextrakt
EP2592944B1 (de) 2010-07-18 2019-12-25 Glanbia Nutritionals (Ireland) Ltd. Getränke mit hohem proteingehalt und molkeproteinen

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094439B2 (en) * 2000-11-30 2006-08-22 Kraft Foods Holdings, Inc. Method of deflavoring whey protein
US8298604B2 (en) * 2003-02-19 2012-10-30 Franklin Foods, Inc. Yogurt-cheese compositions
US7998519B2 (en) 2003-02-19 2011-08-16 Franklin Foods, Inc. Yogurt-cheese products, and methods of making the same
US7763294B2 (en) * 2003-02-19 2010-07-27 Franklin Foods, Inc. Yogurt-cheese compositions
WO2005099876A1 (en) * 2004-04-16 2005-10-27 UNIVERSITé LAVAL Method for extracting lipids from biological solutions
US7897185B1 (en) * 2005-06-17 2011-03-01 Franklin Foods, Inc. Cream cheese products and methods of making the same
DK176760B1 (da) * 2007-10-03 2009-06-29 Arla Foods Amba Process for producing lactose-free milk
US9635870B2 (en) 2011-02-28 2017-05-02 Franklin Foods Holdings Inc. Direct-set cheese
US9462817B2 (en) 2011-02-28 2016-10-11 Franklin Foods Holdings Inc. Processes for making cheese products utilizing denatured acid whey proteins
WO2014189519A1 (en) * 2013-05-24 2014-11-27 General Mills, Inc. Yogurt whey and method
CA2913393A1 (en) 2013-05-24 2014-11-27 General Mills, Inc. Food products with yogurt whey
US9854818B2 (en) 2013-05-24 2018-01-02 General Mills, Inc. Yogurt whey and method
US20160199784A1 (en) * 2013-08-20 2016-07-14 Trish Choudhary Separating and Demineralizing Biomolecule Solutions by Electrodialysis
KR20160125990A (ko) 2014-02-28 2016-11-01 노람 엔지니어링 앤드 콘스트럭터스 엘티디. 부분적으로 가수분해된 셀룰로오스의 정제 과정
FR3028178A1 (fr) * 2014-11-06 2016-05-13 Even Sante Ind Composition nutritionnelle enterale a base de retentat et procede de fabrication
US20170223989A1 (en) * 2016-02-05 2017-08-10 Rembrandt Enterprises, Inc. Deflavored egg protein isolate, products made with protein isolates and methods of making same
WO2017194068A1 (en) * 2016-05-12 2017-11-16 Arla Foods Amba Whey preparation for improving brain development
US12022847B2 (en) 2017-06-26 2024-07-02 Michael Foods, Inc. Methods of egg yolk fractionation
US11937618B2 (en) 2017-11-22 2024-03-26 Michael Foods, Inc. Method for providing a proteinaceous composition without pH adjustment
JP7679166B2 (ja) * 2019-03-15 2025-05-19 雪印メグミルク株式会社 乳由来組成物及びその製造方法
CN110256487A (zh) * 2019-07-11 2019-09-20 刘秀丽 一种高纯度液体植酸的制备方法
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Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2631100A (en) * 1947-03-03 1953-03-10 Tno Palatable protein products from whey
US3905886A (en) * 1974-09-13 1975-09-16 Aqua Chem Inc Ultrafiltration and electrodialysis method and apparatus
US3995071A (en) 1975-06-23 1976-11-30 Mead Johnson & Company Aqueous purified soy protein and beverage
US4072670A (en) 1976-10-26 1978-02-07 Mead Johnson & Company Low phytate isoelectric precipitated soy protein isolate
US4091120A (en) 1976-11-15 1978-05-23 Mead Johnson & Company Liquid dietary product containing soy protein membrane isolate
US4420425A (en) 1982-08-02 1983-12-13 The Texas A&M University System Method for processing protein from nonbinding oilseed by ultrafiltration and solubilization
US4477480A (en) 1982-07-06 1984-10-16 General Foods Corporation Method of preparing a clean flavored cereal starch
US4761186A (en) 1986-08-18 1988-08-02 General Foods Corporation Method of purifying starches and products produced therefrom
US5658714A (en) 1991-02-28 1997-08-19 Abbott Laboratories Isolation of proteins by ultrafiltration
US6402917B1 (en) 1998-02-09 2002-06-11 Otv Societe Anonyme Electrodialysis apparatus
US6482305B1 (en) 1999-09-01 2002-11-19 Archer-Daniels-Midland Company Electrodialysis water splitting process
US6537436B2 (en) 2000-04-28 2003-03-25 Ernst Schmidt System for electrodialysis treatment of liquids
EP1498498A1 (de) * 2003-07-15 2005-01-19 Kraft Foods R & D, Inc. Molke-Pulver mit verbessertem Geschmack
EP1527690A1 (de) * 2003-10-29 2005-05-04 Kraft Foods Holdings, Inc. Verfahren zur Dearomatisierung von Molkeprotein

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL104346C (de) 1954-05-06
US3165415A (en) 1960-10-04 1965-01-12 American Mach & Foundry Modifying taste of fruit juice by dialysis
DE1692323A1 (de) 1966-03-16 1971-03-18 Ch Gervais S A Verfahren und Vorrichtung zum Herstellen von Kaeseteig
US4205090A (en) 1969-07-18 1980-05-27 Etablissement Public: Institut National de la Recherche Agronomique Preparation of cheese using ultrafiltration
US3615664A (en) 1969-12-05 1971-10-26 Foremost Mckesson Treatment of whey
DE2138277C2 (de) 1971-07-30 1982-09-16 Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring Verfahren zur Herstellung eines Molkeeiweißkonzentrates
DE2155696B2 (de) 1971-11-09 1974-02-28 Molkerei Josef Anton Meggle Milchindustrie, 8094 Reitmehring Verfahren zur Ultrafiltration von Molke
US3852491A (en) 1972-03-22 1974-12-03 Ralston Purina Co High protein ready-to-eat breakfast cereal
US3876805A (en) 1972-11-01 1975-04-08 Foremost Mckesson Dough conditioner product and process
US4125527A (en) * 1973-07-31 1978-11-14 Societe d'Assistance Technique S.A. pour Produits Nestle Process for the recovery of proteins
US3996702A (en) 1974-11-26 1976-12-14 Minnesota Mining And Manufacturing Company Coated abrasive product comprising fused zirconia grains and method for abrading iron
GB1547911A (en) 1976-01-19 1979-06-27 Novo Industri As Polypeptides
US4043896A (en) 1976-03-25 1977-08-23 Aqua-Chem, Inc. Ultrafiltration and electrodialysis apparatus
GB1580051A (en) 1976-06-11 1980-11-26 Unilever Ltd Proteinaceous foodstuff
US4088795A (en) 1976-11-19 1978-05-09 Mead Johnson & Company Low carbohydrate oilseed lipid-protein comestible
US4105803A (en) 1977-05-02 1978-08-08 Ohio Agricultural Research And Development Center Soybean-cheese whey food product
FR2391653A1 (fr) 1977-05-23 1978-12-22 Nestle Sa Soc Ass Tech Prod Procede de traitement du lactoserum
US4172828A (en) 1977-09-30 1979-10-30 Anderson, Clayton & Co. Method for processing soy protein and composition of matter
US4146455A (en) 1978-04-19 1979-03-27 Ionics Inc. Process for treating whey
SU689010A1 (ru) 1978-06-22 1987-09-30 Институт элементоорганических соединений АН СССР Способ очистки сухих молочно-белковых концентратов
US4211694A (en) 1978-07-07 1980-07-08 The Procter & Gamble Company Deflavoring vegetable seed materials
USRE32725E (en) 1978-12-26 1988-08-02 Central Soya Company, Inc. Water-soluble vegetable protein aggregates
US4253928A (en) 1979-10-04 1981-03-03 Shell Oil Company Process for sour water treatment
US4322275A (en) 1980-01-10 1982-03-30 Ionics Incorporated Fractionation of protein mixtures
US4351710A (en) 1980-01-10 1982-09-28 Ionics, Incorporated Fractionation of protein mixtures
US4432999A (en) 1981-09-10 1984-02-21 Bily Robert Raymond Whey-soybean product and process for making the product
US4478856A (en) 1982-05-06 1984-10-23 Novo Industri A/S Production of purified vegetable protein
US4497836A (en) 1982-08-06 1985-02-05 Dairy Technology Ltd. Modified whey product and process including ultrafiltration and demineralization
US4908224A (en) 1982-09-30 1990-03-13 Lois Yoder Process for debittering soybean grit
FR2534455B1 (fr) 1982-10-14 1985-08-23 Bridel Laiteries Procede de preparation des boissons aromatisees de longue conservation, a base de lactoserum acidifie
US4530788A (en) 1982-12-03 1985-07-23 Stauffer Chemical Company Oil seed proteins evidencing improved functionality
US4632903A (en) 1984-12-28 1986-12-30 Novo Laboratories, Inc. Enzyme modified soy protein for use as an egg white substitute
US4623550A (en) 1985-05-09 1986-11-18 Willard Miles J Method for preparing sheeted fried snack products from corn and other cereal flours
US4770891A (en) 1986-01-20 1988-09-13 Willard Miles J Method for preparing sheeted fried snack products
GB8604133D0 (en) 1986-02-19 1986-03-26 Unilever Plc Spreads
FI80574C (fi) 1987-11-06 1990-07-10 Valio Meijerien Elektrolytiskt foerfarande foer avsaltning av vassla eller naogon pao vassla baserad vaerska och foer producering av livsmedelsyra och -bas.
DE3876098D1 (de) 1988-04-20 1992-12-24 Applic Tech Nouvelles Verfahren zur abtrennung bestimmter proteine aus molke.
US4963253A (en) 1989-01-03 1990-10-16 Yen Richard C K Anti-clogging and dialysis device for filtration systems
DK0421309T4 (da) 1989-10-02 2003-04-22 Associated British Foods Plc Proteinhydrolysater
FR2657233B1 (fr) 1990-01-19 1993-07-16 Ingenierie Ste Vidaubanaise Procede de traitement du lait ecreme.
US5077062A (en) 1990-05-03 1991-12-31 Excelpro Inc. Hydrolyzed soy protein and process for preparing soy protein
NL9001650A (nl) 1990-07-19 1992-02-17 Ver Coop Melkind Werkwijze voor de bereiding van een melkeiwit-isolaat.
US5100679A (en) 1990-10-03 1992-03-31 Cargill B.V. Method of making a modified proteinaceous product and composition thereof
US6299929B1 (en) 1991-01-15 2001-10-09 Bariatrix Products International, Inc. Confectionery product made of protein and carbohydrate materials present in a relative weight ratio higher than 1
JPH04278057A (ja) 1991-03-04 1992-10-02 Calpis Food Ind Co Ltd:The 大豆ミネラル濃縮物およびその製造方法
US5160758A (en) 1991-05-31 1992-11-03 Protein Technologies International, Inc. Process for the production of a protein granule suitable for use as a meat extender
ES2097328T3 (es) 1991-05-31 1997-04-01 Danmark Protein As Metodo para la produccion de proteina de suero lacteo.
WO1993020713A1 (en) 1992-04-22 1993-10-28 Bopa Ireland Limited Products derived from whey and their use in foodstuffs
US5433969A (en) 1993-12-27 1995-07-18 Protein Technologies International, Inc. Process for the production of an improved protein granule suitable for use as a meat extender
SE502222C2 (sv) 1994-01-17 1995-09-18 Althin Medical Ab Sätt vid dialys
US5746920A (en) 1994-06-08 1998-05-05 Fraunhofer-Gesellschaft Zur Foerder Der Angewandten Forschung E.V. Process for purifying dairy wastewater
US5626899A (en) 1995-06-07 1997-05-06 Archer Daniels Midland Company Process for making vegetable-based meat extenders
US5858442A (en) 1995-06-07 1999-01-12 Archer Daniels Midland Company Process for making extenders for lower fat meat systems
US5936069A (en) 1995-12-06 1999-08-10 Iowa State University Research Foundation Process for producing improved soy protein concentrate from genetically-modified soybeans
DK0876106T3 (da) 1996-01-26 2004-08-16 Univ Massey Fremgangsmåde til adskillelse og genvinding af proteiner fra en proteinoplösning
DE69716852T2 (de) 1996-03-21 2003-09-11 Asahi Glass Co., Ltd. Methode und vorrichtung zur produktion von deionisiertem wasser
ES2152066T3 (es) 1996-03-28 2001-01-16 Fuji Oil Co Ltd Procedimiento para producir un hidrolizado de proteina de habas de soja y productos carnicos y bebidas que usan el mismo.
EP0797928B1 (de) 1996-03-28 1999-11-10 Fuji Oil Co., Ltd. Verfahren zur Herstellung eines Sojaproteinhydrolysats
JP3546592B2 (ja) 1996-05-24 2004-07-28 不二製油株式会社 フィチン酸の精製方法
JP3828665B2 (ja) 1997-09-02 2006-10-04 ホシザキ電機株式会社 小麦粉製食品用練り生地の調製方法
US6139901A (en) 1997-09-16 2000-10-31 New Zealand Milk Products (North Amerca) Inc. Membrane filtered milk proteins varying in composition and functional attributes
US6068865A (en) 1997-11-07 2000-05-30 Kraft Foods, Inc Chocolate yogurt and preparation
US6221423B1 (en) 1998-04-13 2001-04-24 Protein Technologies Int'l Inc. Short-chained peptide material
CA2281052A1 (en) 1998-08-31 2000-02-29 Kraft Foods, Inc. Stabilization of fermented dairy compositions using whey from nisin producing cultures
AU1322900A (en) 1998-10-29 2000-05-22 University Of Chicago, The Pressure assisted electrodialysis
JP4205227B2 (ja) 1999-01-11 2009-01-07 カルピス株式会社 ペプチド含有液の精製方法
AU3279999A (en) 1999-03-01 2000-09-21 New Zealand Dairy Board Membrane filtered milk proteins varying in composition and functional attributes
US6413569B1 (en) 1999-09-29 2002-07-02 Archer-Daniels-Midland Company Use of isolated soy protein for making fresh, unripened cheese analogs
US6399135B2 (en) 1999-09-29 2002-06-04 Archer-Daniels-Midland Company Use of soy isolated protein for making fresh cheese
AR026771A1 (es) 1999-12-08 2003-02-26 New Zealand Co Operartive Dair Metodo para obtener un producto con cantidad reducida de glucomacropeptidos, a partir de suero
JP4491698B2 (ja) 2000-02-29 2010-06-30 不二製油株式会社 大豆蛋白加水分解物の製造方法
US6726943B2 (en) 2000-04-12 2004-04-27 Mid-America Commercialization Corporation Nutritionally balanced snack food compositions
US6291009B1 (en) 2000-05-16 2001-09-18 Deborah W. Cohen Method of producing a soy-based dough and products made from the dough
US6630195B1 (en) 2000-11-21 2003-10-07 Cargill, Incorporated Process for producing oilseed protein products
US7108881B2 (en) 2000-11-30 2006-09-19 Kraft Foods Holdings, Inc. Method of preparation of high quality soy cultured products
US20040170743A1 (en) 2000-11-30 2004-09-02 Kraft Foods Holdings, Inc. Method of deflavoring soy-derived materials confectionary type products
US6787173B2 (en) 2000-11-30 2004-09-07 Kraft Foods Holdings, Inc. Method of deflavoring soy-derived materials
US7037547B2 (en) 2000-11-30 2006-05-02 Kraft Foods Holdings, Inc. Method of deflavoring soy-derived materials for use in beverages
US20040161512A1 (en) 2000-11-30 2004-08-19 Kraft Foods Holdings, Inc. Method of deflavoring soy-derived materials for use in dough-based and baked products
US7045163B2 (en) 2000-11-30 2006-05-16 Kraft Foods Holdings, Inc. Method of deflavoring soy-derived materials
US20040175474A1 (en) 2000-11-30 2004-09-09 Kraft Foods Holdings, Inc. Method of preparation of high quality soy-containing cheese products
US7175869B2 (en) * 2000-11-30 2007-02-13 Kraft Foods Holdings, Inc. Method of deflavoring soy-derived materials using electrodialysis
US6582746B2 (en) 2001-02-28 2003-06-24 Solae, Llp Meat product
DK1249176T3 (da) 2001-04-09 2006-03-27 Kraft Foods R & D Inc Fremgangsmåde til inkorporering af valleprotein i levnedsmidler
US20040253355A1 (en) 2001-08-23 2004-12-16 Ahmad Akashe Method of deflavoring soy-derived materials
ES2361004T3 (es) 2001-10-15 2011-06-13 Siemens Water Technologies Holding Corp. Aparato y método para purificación de fluidos.
US20050186311A1 (en) 2004-02-23 2005-08-25 Loh Jimbay P. Method for acidifying and preserving food compositions using electrodialyzed compositions

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2631100A (en) * 1947-03-03 1953-03-10 Tno Palatable protein products from whey
US3905886A (en) * 1974-09-13 1975-09-16 Aqua Chem Inc Ultrafiltration and electrodialysis method and apparatus
US3995071A (en) 1975-06-23 1976-11-30 Mead Johnson & Company Aqueous purified soy protein and beverage
US4072670A (en) 1976-10-26 1978-02-07 Mead Johnson & Company Low phytate isoelectric precipitated soy protein isolate
US4091120A (en) 1976-11-15 1978-05-23 Mead Johnson & Company Liquid dietary product containing soy protein membrane isolate
US4477480A (en) 1982-07-06 1984-10-16 General Foods Corporation Method of preparing a clean flavored cereal starch
US4420425A (en) 1982-08-02 1983-12-13 The Texas A&M University System Method for processing protein from nonbinding oilseed by ultrafiltration and solubilization
US4761186A (en) 1986-08-18 1988-08-02 General Foods Corporation Method of purifying starches and products produced therefrom
US5658714A (en) 1991-02-28 1997-08-19 Abbott Laboratories Isolation of proteins by ultrafiltration
US6402917B1 (en) 1998-02-09 2002-06-11 Otv Societe Anonyme Electrodialysis apparatus
US6482305B1 (en) 1999-09-01 2002-11-19 Archer-Daniels-Midland Company Electrodialysis water splitting process
US6537436B2 (en) 2000-04-28 2003-03-25 Ernst Schmidt System for electrodialysis treatment of liquids
EP1498498A1 (de) * 2003-07-15 2005-01-19 Kraft Foods R & D, Inc. Molke-Pulver mit verbessertem Geschmack
EP1527690A1 (de) * 2003-10-29 2005-05-04 Kraft Foods Holdings, Inc. Verfahren zur Dearomatisierung von Molkeprotein

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CARUNCHIA WHETSTINE, J. DAIRY SCI., vol. 86, 2003, pages 439 - 448
LAYE, MILCHWISSENSCHAFT, vol. 50, 1995, pages 268 - 272

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8409651B2 (en) 2007-12-05 2013-04-02 N. V. Nutricia High energy liquid enteral nutritional composition
US9345256B2 (en) 2007-12-05 2016-05-24 N.V. Nutricia High energy liquid enteral nutritional composition
US8999423B2 (en) 2007-12-05 2015-04-07 N. V. Nutricia High energy liquid enteral nutritional composition
CN102083329B (zh) * 2008-03-12 2014-12-10 荷兰纽迪希亚公司 高蛋白液体肠营养组合物
RU2489905C2 (ru) * 2008-03-12 2013-08-20 Н.В. Нютрисиа Жидкая энтеральная питательная композиция с высоким содержанием белка
US8815797B2 (en) 2008-03-12 2014-08-26 N.V. Nutricia High protein liquid enteral nutritional composition
WO2009113858A1 (en) * 2008-03-12 2009-09-17 N.V. Nutricia High protein liquid enteral nutritional composition
EP2835059A1 (de) 2008-03-12 2015-02-11 N.V. Nutricia Flüssige, enterale Nährstoffzusammensetzung mit hohem Proteingehalt
WO2009113845A1 (en) * 2008-03-12 2009-09-17 N.V. Nutricia High protein liquid enteral nutritional composition
US9420816B2 (en) 2008-03-12 2016-08-23 N.V. Nutricia High protein liquid enteral nutritional composition
CN101270497B (zh) * 2008-05-16 2010-07-14 南京大学 一种料液的酸碱度的调节方法
EP2298090B1 (de) 2009-08-26 2016-01-13 Jeffrey M. Golini Pharmazeutische oder nutrazeutische Zusammensetzung
EP2488044B1 (de) 2009-10-16 2019-04-03 Dairy Australia Limited Allergiebehandlung mit einem säurebehandelten wässrigen molkeproteinextrakt
EP2592944B1 (de) 2010-07-18 2019-12-25 Glanbia Nutritionals (Ireland) Ltd. Getränke mit hohem proteingehalt und molkeproteinen

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MXPA06009536A (es) 2007-11-06
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