EP2185931A4 - Verwendung von secretor-, lewis- und sialyl-antigen-konzentrationen als krankheitsvorhersage-indikatoren - Google Patents

Verwendung von secretor-, lewis- und sialyl-antigen-konzentrationen als krankheitsvorhersage-indikatoren

Info

Publication number
EP2185931A4
EP2185931A4 EP08799226A EP08799226A EP2185931A4 EP 2185931 A4 EP2185931 A4 EP 2185931A4 EP 08799226 A EP08799226 A EP 08799226A EP 08799226 A EP08799226 A EP 08799226A EP 2185931 A4 EP2185931 A4 EP 2185931A4
Authority
EP
European Patent Office
Prior art keywords
lewis
sialyle
secretary
predictors
clinical samples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08799226A
Other languages
English (en)
French (fr)
Other versions
EP2185931B1 (de
EP2185931A1 (de
Inventor
Ardythe L Morrow
Guillermo M Ruiz-Palacios
David S Newburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto Nacional de Ciencias Medicas Y Nutricion
Cincinnati Childrens Hospital Medical Center
General Hospital Corp
Original Assignee
Instituto Nacional de Ciencias Medicas Y Nutricion
Cincinnati Childrens Hospital Medical Center
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40429358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2185931(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Instituto Nacional de Ciencias Medicas Y Nutricion, Cincinnati Childrens Hospital Medical Center, General Hospital Corp filed Critical Instituto Nacional de Ciencias Medicas Y Nutricion
Priority to EP20130169236 priority Critical patent/EP2631650B1/de
Publication of EP2185931A1 publication Critical patent/EP2185931A1/de
Publication of EP2185931A4 publication Critical patent/EP2185931A4/de
Application granted granted Critical
Publication of EP2185931B1 publication Critical patent/EP2185931B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/067—Pancreatitis or colitis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
EP08799226.9A 2007-09-07 2008-09-05 Verwendung von secretor-, lewis- und sialyl-antigen-konzentrationen als krankheitsvorhersage-indikatoren Not-in-force EP2185931B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20130169236 EP2631650B1 (de) 2007-09-07 2008-09-05 Zusammensetzung mit alpha-1,2 Fukosyl Glykanen für die Behandlung von Magen-Darmerkrankungen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97090207P 2007-09-07 2007-09-07
PCT/US2008/075385 WO2009033011A1 (en) 2007-09-07 2008-09-05 Use of secretor, lewis and sialyl antigen levels as predictors for disease

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP20130169236 Division EP2631650B1 (de) 2007-09-07 2008-09-05 Zusammensetzung mit alpha-1,2 Fukosyl Glykanen für die Behandlung von Magen-Darmerkrankungen
EP13169236.0 Division-Into 2013-05-24

Publications (3)

Publication Number Publication Date
EP2185931A1 EP2185931A1 (de) 2010-05-19
EP2185931A4 true EP2185931A4 (de) 2011-01-19
EP2185931B1 EP2185931B1 (de) 2013-07-10

Family

ID=40429358

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20130169236 Revoked EP2631650B1 (de) 2007-09-07 2008-09-05 Zusammensetzung mit alpha-1,2 Fukosyl Glykanen für die Behandlung von Magen-Darmerkrankungen
EP08799226.9A Not-in-force EP2185931B1 (de) 2007-09-07 2008-09-05 Verwendung von secretor-, lewis- und sialyl-antigen-konzentrationen als krankheitsvorhersage-indikatoren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20130169236 Revoked EP2631650B1 (de) 2007-09-07 2008-09-05 Zusammensetzung mit alpha-1,2 Fukosyl Glykanen für die Behandlung von Magen-Darmerkrankungen

Country Status (7)

Country Link
US (4) US7871785B2 (de)
EP (2) EP2631650B1 (de)
JP (2) JP5766947B2 (de)
CN (1) CN101855554B (de)
CA (1) CA2698374C (de)
MX (1) MX2010002562A (de)
WO (1) WO2009033011A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5766947B2 (ja) 2007-09-07 2015-08-19 チルドレンズ ホスピタル メディカル センター 臨床サンプルにおける分泌性のルイス抗原およびシアル化抗原のレベルの疾患リスクの予測指標としての使用
EP2451462B1 (de) 2009-07-06 2017-09-06 Children's Hospital Medical Center Entzündungshemmung mit milch-oligosacchariden
WO2011053832A1 (en) * 2009-10-29 2011-05-05 The Trustees Of Columbia University In The City Of New York Use of urinary ngal to diagnose sepsis in very low birth weight infants
FI20096400A0 (fi) * 2009-12-28 2009-12-28 Suomen Punainen Risti Veripalv Veriryhmästatuksen käyttö I
US20120315250A1 (en) * 2009-12-28 2012-12-13 Suomen Punainen Risti Veripalvelu Probiotic bifidobacterial composition in accordance with secretor blood group status
FI20096402A0 (fi) * 2009-12-28 2009-12-28 Suomen Punainen Risti Veripalv Veriryhmästatuksen käyttö II
WO2011136637A1 (en) 2010-04-27 2011-11-03 N.V. Nutricia Use of human milk oligosaccharides in infant nutrition
CN106509916A (zh) 2010-04-27 2017-03-22 N·V·努特里奇亚 人乳寡糖在婴儿营养物中的用途
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
ES2667066T3 (es) 2010-05-24 2018-05-09 The Trustees Of Columbia University In The City Of New York Proteínas NGAL mutantes y usos de las mismas
WO2012013861A2 (en) * 2010-07-26 2012-02-02 Suomen Punainen Risti Veripalvelu Use of blood group status iii
FI20105824A0 (fi) * 2010-07-26 2010-07-26 Suomen Punainen Risti Veripalv Veriryhmästatuksen käyttö IV
US20120020941A1 (en) * 2010-07-26 2012-01-26 Suomen Punainen Risti Veripalvelu Use of blood group status iii
US20130004968A1 (en) * 2010-09-22 2013-01-03 Robert Webber Sepsis blood biomarker system
SG191798A1 (en) * 2010-12-31 2013-08-30 Abbott Lab Synbiotic combination of probiotic and human milk oligosaccharides to promote growth of beneficial microbiota
ES2708924T3 (es) 2010-12-31 2019-04-12 Abbott Lab Procedimientos de uso de oligosacáridos de la leche humana para mejorar la salud respiratoria de las vías respiratorias
BR112013015951A2 (en) 2010-12-31 2018-07-10 Abbott Laboratories nutritional compositions comprising human milk oligosaccharides and nucleotides and uses thereof to treat and / or prevent enteric viral infection.
MY180910A (en) 2010-12-31 2020-12-11 Abbott Lab Methods for reducing the incidence of oxidative stress using human milk oligosaccharides, vitamin c and anti-inflammatory agents
WO2012092157A2 (en) 2010-12-31 2012-07-05 Abbott Laboratories Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof
US11337990B2 (en) * 2010-12-31 2022-05-24 Abbott Laboratories Human milk oligosaccharides to promote growth of beneficial bacteria
MY197622A (en) 2010-12-31 2023-06-28 Abbott Lab Methods for decreasing the incidence of necrotizing enterocolitis in infants, toddlers, or children using human milk oligosaccharides
EP3338784B1 (de) 2010-12-31 2020-07-22 Abbott Laboratories Oligosaccharide aus muttermilch zur modulierung von entzündungen
GB201102693D0 (en) * 2011-02-16 2011-03-30 Genetic Analysis As Method for identifying neonates at risk for necrotizing enterocolitis
JP6129821B2 (ja) 2011-05-13 2017-05-17 グリコシン リミテッド ライアビリティー カンパニー プレバイオティクスとしての、精製された２’−フコシルラクトース、３−フコシルラクトース、およびラクトジフコテトラオースの使用
WO2012174129A1 (en) * 2011-06-14 2012-12-20 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers for necrotizing enterocolitis and sepsis
SG2014013478A (en) 2011-08-29 2014-05-29 Abbott Lab Human milk oligosaccharides for preventing injury and/or promoting healing of the gastrointestinal tract
WO2013185134A2 (en) 2012-06-08 2013-12-12 The Board Of Trustees Of The Leland Stanford Junior University Blood biomarkers for necrotizing enterocolitis
EP2687845A1 (de) * 2012-07-20 2014-01-22 Nestec S.A. Fucose als Biomarker für Darmimmunität
EP2925337B1 (de) 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutante ngal-proteine und verwendungen davon
US10626460B2 (en) 2013-02-21 2020-04-21 Children's Hospital Medical Center Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease
WO2014152985A1 (en) * 2013-03-14 2014-09-25 Children's Hospital Medical Center Biomarkers of preterm necrotizing enterocolitis
KR102313341B1 (ko) * 2013-08-26 2021-10-18 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 시알릴-루이스 ａ에 대한 사람 항체 코드화 핵산
CN106661548B (zh) 2014-05-28 2020-12-11 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
WO2016176484A1 (en) 2015-04-28 2016-11-03 Children's Hospital Medical Center Use of oligosaccharide compositions to enhance weight gain
CN107567588A (zh) 2015-05-19 2018-01-09 雀巢产品技术援助有限公司 用于鉴定母乳缺失岩藻糖基转移酶‑2相关聚糖以及喂食一定剂量所述聚糖的成套试剂盒
US20180103675A1 (en) 2016-10-14 2018-04-19 Mead Johnson Nutrition Company Personalized pediatric nutrition products comprising human milk oligosaccharides
KR102729404B1 (ko) 2016-11-04 2024-11-14 칠드런즈 호스피탈 메디칼 센터 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
EP3548515B1 (de) 2016-12-01 2026-01-21 Regeneron Pharmaceuticals, Inc. Radioaktiv markierte anti-pd-l1-antikörper für immuno-pet-bildgebung
JP7068305B2 (ja) 2016-12-05 2022-05-16 チルドレンズ ホスピタル メディカル センター 結腸オルガノイドならびにその作製方法および使用方法
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
EP3694603B1 (de) 2017-10-10 2026-04-08 Children's Hospital Medical Center Ösophagusgewebe- und/oder organoidzusammensetzungen und verfahren zu ihrer herstellung
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
AU2019339410A1 (en) 2018-09-12 2021-04-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
WO2020243633A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
WO2020243613A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056754A1 (en) * 1998-04-30 1999-11-11 Abbott Laboratories COMPOSITIONS CONTAINING AN α1,2-FUCOSE LINKAGE AND USES THEREOF

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1246902A (en) * 1969-03-27 1971-09-22 Boots Pure Drug Co Ltd Improvements in therapeutic agents
DK455088D0 (da) 1988-08-12 1988-08-12 Symbicom Ab Syntetiske receptoranaloger
CA2108786A1 (en) 1991-04-19 1992-10-20 John L. Magnani Compositions and methods for endothelial binding
EP0601417A3 (de) 1992-12-11 1998-07-01 Hoechst Aktiengesellschaft Physiologisch verträglicher und physiologisch abbaubarer, Kohlenhydratrezeptorblocker auf Polymerbasis, ein Verfahren zu seiner Herstellung und seine Verwendung
JPH08509467A (ja) * 1993-02-26 1996-10-08 ノルマーク，ヤーン・スタツフアン 細菌接着のインヒビターとしてのオリゴ糖グリコシドの使用
US5484773A (en) 1994-02-14 1996-01-16 Alberta Research Council Treatment of antibiotic associated diarrhea
ATE209862T1 (de) 1994-02-16 2001-12-15 Pharming Intellectual Pty Bv Isolierung von lactoferrin aus milch
US6204431B1 (en) 1994-03-09 2001-03-20 Abbott Laboratories Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
MX198456B (es) 1994-03-09 2000-09-05 Abbott Lab Animales trangenicos que producen oligosacaridos y glucoconjugados.
US5750176A (en) 1994-03-09 1998-05-12 Abbott Laboratories Transgenic non-human mammal milk comprising 2'-fucosyl-lactose
US5576300A (en) 1994-09-16 1996-11-19 Abbott Laboratories Method for inhibition of human rotavirus infection
US6841543B1 (en) 1996-01-31 2005-01-11 President And Fellows Of Harvard College Methods of inhibiting production of T helper type 2 cytokines in human immune cells
CA2237849C (en) 1996-09-17 2009-06-16 Kyowa Hakko Kogyo Co., Ltd. Processes for producing sugar nucleotides and complex carbohydrates
US6132710A (en) * 1997-03-17 2000-10-17 Probiotix, Inc. Preventing/treating neonatal NEC by administering lactobacillus salivarius and lactobacillus plantarum or a combination thereof
US6045854A (en) 1997-03-31 2000-04-04 Abbott Laboraties Nutritional formulations containing oligosaccharides
US7244601B2 (en) 1997-12-15 2007-07-17 National Research Council Of Canada Fusion proteins for use in enzymatic synthesis of oligosaccharides
US6126961A (en) 1998-04-13 2000-10-03 Kross; Robert D. Composition and method for reducing the colonization of animal intestines by salmonella and other bacterial pathogens
AT408446B (de) * 1999-02-18 2001-11-26 Altmann Friedrich Dr Fucosyltransferase-gen
US6291435B1 (en) 1999-03-04 2001-09-18 The Governs Of The University Of Alberta Treatment of diarrhea caused by enteropathogenic Escherichia coli
FI109811B (fi) 2000-09-26 2002-10-15 Medicel Oy Menetelmä GDP-L-fukoosin valmistamiseksi ja menetelmässä käytettäviä välineitä
DE60143858D1 (de) 2000-11-28 2011-02-24 Premacure Ab Reduzierung DES RISIKOS FÜR KOMPLIKATIONEN BEI FRÜHGEBURTEN
JP2002218996A (ja) * 2001-01-23 2002-08-06 Nobuyuki Hamashima 分泌型遺伝子、ルイス遺伝子、インターロイキン１ｂおよびミエロパーオキシダーゼ遺伝子の遺伝子多型解析によるヘリコバクターピロリ菌に対する感受性の予測方法
DK1531832T3 (da) 2002-06-28 2009-07-27 Glykos Finland Oy Terapeutiske sammensætninger til anvendelse ved profylakse eller behandling af diarré
FI20021989A0 (fi) 2002-11-06 2002-11-06 Halina Miller-Podraza Korkean affiniteetin Helicobacter pylori-reseptorit ja niiden käyttö
DK1675481T3 (da) 2003-10-24 2009-01-19 Nutricia Nv Synbiotisk præparat til börn
EP1689348B1 (de) * 2003-12-05 2013-05-15 Children's Hospital Medical Center Oligosaccharid-Zusammensetzungen und ihre Verwendung bei der Behandlung von Infektionen
EP1597978A1 (de) 2004-05-17 2005-11-23 Nutricia N.V. Synergie von GOS und polyfruktose
MX2007001469A (es) * 2004-08-06 2007-03-26 Genentech Inc Ensayos y metodos que utilizan biomarcadores.
PL1774037T3 (pl) * 2004-08-06 2011-09-30 Genentech Inc Oznaczenia i sposoby wykorzystujące biomarkery
AU2006217160B2 (en) 2005-02-28 2011-09-15 N.V. Nutricia Nutritional composition with probiotics
EP1981526A4 (de) 2006-01-09 2011-03-02 Childrens Hosp Medical Center Adiponectin zur behandlung verschiedener erkrankungen
BRPI0707620A2 (pt) * 2006-02-10 2011-05-10 Nestec Sa mistura de oligossacarÍdeo
KR20080106455A (ko) * 2006-03-31 2008-12-05 웰스태트 테러퓨틱스 코포레이션 대사장애의 조합치료
JP5766947B2 (ja) 2007-09-07 2015-08-19 チルドレンズ ホスピタル メディカル センター 臨床サンプルにおける分泌性のルイス抗原およびシアル化抗原のレベルの疾患リスクの予測指標としての使用
EP2072052A1 (de) 2007-12-17 2009-06-24 Nestec S.A. Verhinderung opportunistischer Infektionen bei Personen mit schwachem Immunsystem
EP2451462B1 (de) 2009-07-06 2017-09-06 Children's Hospital Medical Center Entzündungshemmung mit milch-oligosacchariden
JP6129821B2 (ja) 2011-05-13 2017-05-17 グリコシン リミテッド ライアビリティー カンパニー プレバイオティクスとしての、精製された２’−フコシルラクトース、３−フコシルラクトース、およびラクトジフコテトラオースの使用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056754A1 (en) * 1998-04-30 1999-11-11 Abbott Laboratories COMPOSITIONS CONTAINING AN α1,2-FUCOSE LINKAGE AND USES THEREOF

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BROWN STEVEN J ET AL: "Altered immune system glycosylation causes colitis in alpha1,2-fucosyltransferase transgenic mice.", INFLAMMATORY BOWEL DISEASES SEP 2004 LNKD- PUBMED:15472514, vol. 10, no. 5, September 2004 (2004-09-01), pages 546 - 556, XP002611515, ISSN: 1078-0998 *
COOPER H S ET AL: "Immunohistologic study of ulcerative colitis with monoclonal antibodies against tumor-associated and/or differentiation antigens", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 95, no. 3, 1 September 1988 (1988-09-01), pages 686 - 693, XP009141403, ISSN: 0016-5085 *
D'ADAMO P J ET AL: "Metabolic and immunologic consequences of ABH secretor and Lewis subtype status", ALTERNATIVE MEDICINE REVIEW, THORNE RESEARCH INC., SANDPOINT, US, vol. 6, no. 4, 1 August 2001 (2001-08-01), pages 390 - 410, XP009141407, ISSN: 1089-5159 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 2005, MADJD ZAHRA ET AL: "High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas.", XP002611512, Database accession no. NLM16168124 *
KIM Y S ET AL: "Expression of LeY and extended LeY blood group-related antigens in human malignant, premalignant, and nonmalignant colonic tissues.", CANCER RESEARCH NOV 1986 LNKD- PUBMED:2428490, vol. 46, no. 11, November 1986 (1986-11-01), pages 5985 - 5992, XP002611514, ISSN: 0008-5472 *
KOBAYASHI K ET AL: "Lewis blood group-related antigen expression in normal gastric epithelium, intestinal metaplasia, gastric adenoma, and gastric carcinoma", AMERICAN JOURNAL OF GASTROENTEROLOGY, ELSEVIER SCIENCE INC, US, vol. 88, no. 6, 1 June 1993 (1993-06-01), pages 919 - 924, XP009141406, ISSN: 0002-9270 *
LEIPER KEITH ET AL: "Altered expression of fucosyl-transferases in inflammatory bowel disease", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 120, no. 5, suppl. 1, 1 April 2001 (2001-04-01), pages A.525, XP009141050, ISSN: 0016-5085, DOI: 10.1016/S0016-5085(08)82608-X *
See also references of WO2009033011A1 *
TSUBOI KAORI ET AL: "Alpha1,2fucosylation is a superior predictor of postoperative prognosis for colorectal cancer compared with blood group A, B, or sialyl Lewis X antigen generated within colorectal tumor tissues.", ANNALS OF SURGICAL ONCOLOGY JUN 2007 LNKD- PUBMED:17375356, vol. 14, no. 6, June 2007 (2007-06-01), pages 1880 - 1889, XP002611513, ISSN: 1068-9265 *

Also Published As

Publication number Publication date
EP2185931B1 (de) 2013-07-10
US20110177035A1 (en) 2011-07-21
EP2631650B1 (de) 2015-04-22
US20090191551A1 (en) 2009-07-30
CA2698374C (en) 2018-04-03
US20150079055A1 (en) 2015-03-19
US9132143B2 (en) 2015-09-15
JP5766947B2 (ja) 2015-08-19
CA2698374A1 (en) 2009-03-12
US7871785B2 (en) 2011-01-18
US20140140970A1 (en) 2014-05-22
CN101855554A (zh) 2010-10-06
WO2009033011A1 (en) 2009-03-12
EP2185931A1 (de) 2010-05-19
JP2014129363A (ja) 2014-07-10
MX2010002562A (es) 2011-04-11
US9132142B2 (en) 2015-09-15
EP2631650A1 (de) 2013-08-28
US8574850B2 (en) 2013-11-05
JP2010538301A (ja) 2010-12-09
CN101855554B (zh) 2014-05-14

Similar Documents

Publication Publication Date Title
EP2185931A4 (de) Verwendung von secretor-, lewis- und sialyl-antigen-konzentrationen als krankheitsvorhersage-indikatoren
MX2010006484A (es) Composiciones y metodos para detectar anticuerpos de infidelidad de transcripcion (tiab).
Harbo et al. The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis
EP1881008A4 (de) Verfahren zur in-vitro-diagnose von alzheimer-krankheit mit einem monoklonalen antikörper
SG156625A1 (en) Method for measuring resistance or sensitivity to docetaxel
ZA200605239B (en) Fiber optic device for sensing analytes
ES2572372T3 (es) Método de diagnóstico de enfermedades neurodegenerativas basado en la medición de los niveles o de la actividad de SIRT1
BRPI0615657A2 (pt) seqüência de nucleotìdeos que codificam proteìnas inseticidas
MX342791B (es) Ensayo elisa para la detección de vegf.
WO2005108989A3 (en) Assay for antibodies
WO2008122670A3 (en) Human diabetes susceptibility tnfrsf10b gene
WO2006127861A3 (en) Diagnosis of diseases and conditions by analysis of histopathologically processed biological samples using liquid tissue preparations
SI3171174T1 (en) Lactoferrin for use in the diagnosis or prognosis of Alzheimer's disease
Kronenberg et al. Increased collagen turnover impairs tendon microstructure and stability in integrin α2β1-deficient mice
BR112014018204A8 (pt) Método de diagnóstico de distúrbio de células beta pancreáticas em um indivíduo
WO2005098433A3 (en) Diagnostic assays for alzheimer’s disease
NZ564923A (en) Polynucleotide marker genes and their expression, for diagnosis of endotoxemia
WO2007006911A8 (fr) Procede pour le diagnostic du cancer du sein
WO2010035259A3 (en) Compositions comprising soluble cd84 or anti-cd84 antibodies and methods for diagnosing and treating b-cll
WO2010033951A3 (en) Methods for identification and prediction of multiple sclerosis disease and therapy response
FR2930036B1 (fr) Procede de diagnostic d'une hypertension arterielle pulmonaire.
WO2008090177A3 (en) Diagnosis of prostate cancer
DE602004027534D1 (de) Diagnostische verfahren für therapeutische verbindungen sowie verfahren zur überwachung der azathioprin-therapie
ES2570609T3 (es) Método para someter a ensayo la aminoacilasa 1 para el diagnóstico in vitro del cáncer colorrectal
IL175692A0 (en) Method for diagnosing diseases based on levels of anti-glycan antibodies

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20100322

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA MK RS

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/80 20060101ALI20101201BHEP

Ipc: G01N 33/68 20060101ALI20101201BHEP

Ipc: G01N 33/53 20060101AFI20090325BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20101221

17Q First examination report despatched

Effective date: 20120524

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

Ref country code: AT

Ref legal event code: REF

Ref document number: 621243

Country of ref document: AT

Kind code of ref document: T

Effective date: 20130715

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602008025947

Country of ref document: DE

Effective date: 20130912

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 621243

Country of ref document: AT

Kind code of ref document: T

Effective date: 20130710

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20130710

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131111

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131110

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130828

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131010

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131021

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131011

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

26N No opposition filed

Effective date: 20140411

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602008025947

Country of ref document: DE

Effective date: 20140411

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130930

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130930

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130905

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130710

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20080905

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130905

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 9

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 10

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20220927

Year of fee payment: 15

Ref country code: DE

Payment date: 20220928

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20220926

Year of fee payment: 15

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230516

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602008025947

Country of ref document: DE

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20230905

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230905

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230905

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230930

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20240403