EP2471942A4 - Procédé pour la production d un acide l-aminé - Google Patents

Procédé pour la production d un acide l-aminé

Info

Publication number
EP2471942A4
EP2471942A4 EP10811606.2A EP10811606A EP2471942A4 EP 2471942 A4 EP2471942 A4 EP 2471942A4 EP 10811606 A EP10811606 A EP 10811606A EP 2471942 A4 EP2471942 A4 EP 2471942A4
Authority
EP
European Patent Office
Prior art keywords
production
amino acid
amino
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10811606.2A
Other languages
German (de)
English (en)
Other versions
EP2471942B1 (fr
EP2471942A1 (fr
Inventor
Hidetaka Doi
Yoshihiro Usuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of EP2471942A1 publication Critical patent/EP2471942A1/fr
Publication of EP2471942A4 publication Critical patent/EP2471942A4/fr
Application granted granted Critical
Publication of EP2471942B1 publication Critical patent/EP2471942B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/08Lysine; Diaminopimelic acid; Threonine; Valine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1096Transferases (2.) transferring nitrogenous groups (2.6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/12Methionine; Cysteine; Cystine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/22Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227Tryptophan
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01109Arginine N-succinyltransferase (2.3.1.109)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y206/00Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01Transaminases (2.6.1)
    • C12Y206/01081Succinylornithine transaminase (2.6.1.81)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y305/00Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01096Succinylglutamate desuccinylase (3.5.1.96)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y305/00Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03023N-Succinylarginine dihydrolase (3.5.3.23)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
EP10811606.2A 2009-08-28 2010-07-01 Procédé pour la production d' un acide l-aminé Not-in-force EP2471942B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009197575A JP2012223092A (ja) 2009-08-28 2009-08-28 L−アミノ酸の製造法
PCT/JP2010/061268 WO2011024555A1 (fr) 2009-08-28 2010-07-01 Procédé pour la production d’un acide l-aminé

Publications (3)

Publication Number Publication Date
EP2471942A1 EP2471942A1 (fr) 2012-07-04
EP2471942A4 true EP2471942A4 (fr) 2013-05-15
EP2471942B1 EP2471942B1 (fr) 2014-12-24

Family

ID=43627666

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10811606.2A Not-in-force EP2471942B1 (fr) 2009-08-28 2010-07-01 Procédé pour la production d' un acide l-aminé

Country Status (5)

Country Link
US (1) US8932834B2 (fr)
EP (1) EP2471942B1 (fr)
JP (1) JP2012223092A (fr)
BR (1) BR112012004482B1 (fr)
WO (1) WO2011024555A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009093703A1 (fr) 2008-01-23 2009-07-30 Ajinomoto Co., Inc. Procédé de fabrication de l-aminoacide
JP2012223092A (ja) 2009-08-28 2012-11-15 Ajinomoto Co Inc L−アミノ酸の製造法
RU2482188C2 (ru) * 2010-07-21 2013-05-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ РОДА Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ОПЕРОН astCADBE
JP2014036576A (ja) 2010-12-10 2014-02-27 Ajinomoto Co Inc L−アミノ酸の製造法
CN102719469A (zh) * 2012-07-09 2012-10-10 黑龙江省科学院微生物研究所 产色氨酸基因工程菌株的构建方法
KR101608734B1 (ko) * 2014-03-21 2016-04-04 씨제이제일제당 주식회사 L-아미노산을 생산하는 미생물 및 이를 이용하여 l-아미노산을 생산하는 방법
JP2017131111A (ja) 2014-06-03 2017-08-03 味の素株式会社 L−アミノ酸の製造法
CN110494559B (zh) 2017-03-28 2023-10-31 味之素株式会社 不分化地维持用培养基添加剂
CN110964683B (zh) * 2019-12-02 2021-08-13 天津科技大学 生产l-精氨酸的基因工程菌及其构建方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2050816A1 (fr) * 2006-07-25 2009-04-22 Kyowa Hakko Bio Co., Ltd. Procédé de production d'un acide aminé

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786039A (en) 1969-04-30 1974-01-15 Ajinomoto Kk Method of producing alpha-l-aspartyl-l-phenylalanine lower alkyl esters
JPS51113841A (en) 1975-03-28 1976-10-07 Ajinomoto Co Inc Process for preparing lower alkyl esters of n-formyl-alpha -l-aspartyl-l-phenylalanine
JPS561890A (en) 1979-06-15 1981-01-10 Ajinomoto Co Inc Preparation of l-phenylalanine by fermentation
JPS5618596A (en) 1979-07-23 1981-02-21 Ajinomoto Co Inc Production of l-lysine through fermentation process
US4371614A (en) 1980-08-22 1983-02-01 Ajinomoto Co., Inc. E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan
DE3565475D1 (en) 1984-04-07 1988-11-17 Bayer Ag Process and apparatus for the production of granules
JPH06102024B2 (ja) 1986-04-16 1994-12-14 味の素株式会社 新規プロモーター及び該プロモーターを用いた遺伝子発現方法
FR2603581B1 (fr) 1986-04-28 1993-08-13 Ajinomoto Kk Procede pour isoler et purifier des aminoacides par chromatographie
US4777051A (en) 1986-06-20 1988-10-11 Ajinomoto Co., Inc. Process for the production of a composition for animal feed
JP2537260B2 (ja) 1988-02-23 1996-09-25 東陶機器株式会社 和風便器の施工方法
US5705371A (en) 1990-06-12 1998-01-06 Ajinomoto Co., Inc. Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine
US5175107A (en) 1988-10-25 1992-12-29 Ajinomoto Co., Inc. Bacterial strain of escherichia coli bkiim b-3996 as the producer of l-threonine
NO904636L (no) 1989-03-14 1990-10-25 Crown Cork Ag Skrukappe av kunststoffmateriale.
JPH07108228B2 (ja) 1990-10-15 1995-11-22 味の素株式会社 温度感受性プラスミド
DE69124939T2 (de) 1990-11-30 1997-10-02 Ajinomoto Kk Rekombinante DNS-Sequenzen kodierend für Enzyme frei von Feedback Inhibition, Plasmide diese Sequenzen enthaltend, transformierte Mikroorganismen nützlich für Produktion von aromatischen Aminosäuren, und deren Verfahren zur Herstellung durch Fermentation
JP3006926B2 (ja) 1991-09-04 2000-02-07 協和醗酵工業株式会社 発酵法によるl−スレオニンの製造法
DE4130868C2 (de) 1991-09-17 1994-10-13 Degussa Tierfuttermittelsupplement auf der Basis einer Aminosäure und Verfahren zu dessen Herstellung
JP3151073B2 (ja) 1992-02-25 2001-04-03 協和醗酵工業株式会社 発酵法によるアミノ酸の製造法
DE4232468A1 (de) 1992-09-28 1994-03-31 Consortium Elektrochem Ind Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung
EP0593792B2 (fr) 1992-10-14 2004-01-07 Ajinomoto Co., Inc. Nouvelle micro-bactérie capable de produire de la L-thréonine et procédé de production de la L-thréonine
CZ285453B6 (cs) 1992-11-10 1999-08-11 Ajinomoto Co.,Inc. DNA, která obsahuje gen kódující aspartokinézu III, mikroorganizmus Escherichia coli a způsob výroby L-threoninu fermentací
US5354672A (en) 1992-11-24 1994-10-11 Ian Fotheringham Materials and methods for hypersecretion of amino acids
US5776736A (en) 1992-12-21 1998-07-07 Purdue Research Foundation Deblocking the common pathway of aromatic amino acid synthesis
PL181380B1 (pl) 1993-08-24 2001-07-31 Ajinomoto Kk zmutowana karboksylaze, zrekombinowany DNA, mikroorganizm zawierajacy DNA kodujacy zmutowana karboksylaze, sposób wytwarzania aminokwasu, sposób selekcji E. coli, oraz sposób wytwarzania zmutowanej karboksylazy PL PL PL PL PL PL
SK283058B6 (sk) 1993-10-28 2003-02-04 Ajinomoto Co., Inc. Spôsob produkcie cieľovej látky použitím mikroorganizmov
JPH07155184A (ja) 1993-12-08 1995-06-20 Ajinomoto Co Inc 発酵法によるl−リジンの製造法
WO1995034672A1 (fr) 1994-06-14 1995-12-21 Ajinomoto Co., Inc. GENE A DESHYDROGENASE α-CETOGLUTARIQUE
KR100420743B1 (ko) 1994-12-09 2004-05-24 아지노모토 가부시키가이샤 신규한리신데카복실라제유전자및l-리신의제조방법
JP4032441B2 (ja) 1995-08-30 2008-01-16 味の素株式会社 L−アミノ酸の製造方法
GB2304718B (en) 1995-09-05 2000-01-19 Degussa The production of tryptophan by the bacterium escherichia coli
JP3861341B2 (ja) 1995-10-13 2006-12-20 味の素株式会社 発酵液の膜除菌方法
JPH09173792A (ja) 1995-10-23 1997-07-08 Ajinomoto Co Inc 発酵液の処理方法
DE19621930C1 (de) 1996-05-31 1997-12-11 Degussa Verfahren zur Herstellung eines Tierfuttermittel-Zusatzes auf Fermentationsbrühe-Basis
US5939307A (en) 1996-07-30 1999-08-17 The Archer-Daniels-Midland Company Strains of Escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production
JP4088982B2 (ja) 1996-10-15 2008-05-21 味の素株式会社 発酵法によるl−アミノ酸の製造法
RU2231552C2 (ru) 1997-10-04 2004-06-27 Форшунгсцентрум Юлих Гмбх Способ микробиологического получения аминокислот семейства аспартатов и/или глутаматов и используемые в способе средства
SK7702000A3 (en) 1998-09-25 2000-10-09 Ajinomoto Kk Process for preparing coryneform bacteria having an improved amino acid- or nucleic acid-productivity
RU2144564C1 (ru) 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
JP4110641B2 (ja) 1998-11-17 2008-07-02 味の素株式会社 発酵法によるl−メチオニンの製造法
EP1010755B1 (fr) 1998-12-18 2010-10-06 Ajinomoto Co., Inc. Procédé de production d'acide L-glutamique par fermentation
RU2148642C1 (ru) 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты
RU2175351C2 (ru) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
JP2000262288A (ja) 1999-03-16 2000-09-26 Ajinomoto Co Inc コリネ型細菌の温度感受性プラスミド
US6238714B1 (en) 1999-05-05 2001-05-29 Degussa-Huls Ag Feedstuff additive which contains D-pantothenic acid and/or its salts and a process for the preparation thereof
RU2207376C2 (ru) 1999-10-14 2003-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислоты методом ферментации, штамм бактерии escherichia coli - продуцент l-аминокислоты (варианты)
ES2313878T3 (es) 2000-01-21 2009-03-16 Ajinomoto Co., Inc. Procedimiento para la produccion de l-lisina.
RU2212447C2 (ru) 2000-04-26 2003-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты)
JP4380029B2 (ja) 2000-07-05 2009-12-09 味の素株式会社 微生物を利用した物質の製造法
JP4362959B2 (ja) 2000-08-24 2009-11-11 味の素株式会社 塩基性アミノ酸の製造方法
US7220571B2 (en) 2000-09-28 2007-05-22 Archer-Daniels-Midland Company Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation
JP2002209596A (ja) 2001-01-19 2002-07-30 Ajinomoto Co Inc L−アミノ酸の製造法
MXPA04004874A (es) 2001-11-23 2004-09-03 Ajinomoto Kk Procedimiento para producir l-aminoacido utilizando escherichia.
RU2229513C2 (ru) 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты)
JP2003250544A (ja) 2002-03-04 2003-09-09 National Institute Of Technology & Evaluation タンパク質の性質を改変する方法
KR100459758B1 (ko) 2002-05-15 2004-12-03 씨제이 주식회사 이소루이신 조절이 해제된 트레오닌 오페론 염기서열 및그를 포함하는 형질전환 세포를 이용한 l-트레오닌의생산방법
US6911332B2 (en) 2002-06-12 2005-06-28 Ajinomoto Co., Inc. Isolated polynucleotides encoding d-arabino-3-hexulose-6-phosphate synthases from Methylophilus methylotrophus
US7026149B2 (en) 2003-02-28 2006-04-11 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in the stress response to environmental changes in Methylophilus methylotrophus
US7060475B2 (en) 2003-02-28 2006-06-13 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in intermediates metabolism of central metabolic pathway in methylophilus methylotrophus
US7029893B2 (en) 2003-02-28 2006-04-18 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in amino acid biosynthesis in methylophilus methylotrophus
RU2268300C2 (ru) 2003-04-07 2006-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA
US7468262B2 (en) 2003-05-16 2008-12-23 Ajinomoto Co., Inc. Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum
US7335496B2 (en) 2003-06-05 2008-02-26 Ajinomoto Co., Inc. Method for producing target substance
DE10331366A1 (de) 2003-07-11 2005-01-27 Degussa Ag Verfahren zur Granulation eines Tierfuttermittel-Zusatzes
WO2005010175A1 (fr) 2003-07-29 2005-02-03 Ajinomoto Co., Inc. Procede de production de l-lysine ou de l-threonine au moyen de bacteries escherichia a activite enzyme malique attenuee
JP4380305B2 (ja) 2003-11-21 2009-12-09 味の素株式会社 発酵法によるl−アミノ酸の製造法
BRPI0506369B1 (pt) 2004-01-30 2020-11-03 Ajinomoto Co., Inc microorganismo transgênico, e, método para produzir um l-aminoácido
KR100576342B1 (ko) 2004-02-05 2006-05-03 씨제이 주식회사 galR 유전자가 불활성화된 L-쓰레오닌 생성 미생물,그를 제조하는 방법 및 상기 미생물을 이용한L-쓰레오닌의 제조방법
WO2005103275A1 (fr) 2004-04-26 2005-11-03 Ajinomoto Co., Ltd. Procédé de fabrication de l-tryptophane selon le procédé de fermentation
US7482140B2 (en) 2004-06-15 2009-01-27 Ajinomoto Co., Inc. L-tyrosine-producing bacterium and a method for producing L-tyrosine
EP1838726A1 (fr) 2005-01-18 2007-10-03 Ajinomoto Co., Inc. Micro-organismes produisant un acide amine l et procede permettant de produire un acide amine l
DE102005018835A1 (de) 2005-04-22 2006-11-02 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung verbesserter Stämme der Familie Enterobacteriaceae
DE102005019040A1 (de) 2005-04-23 2006-10-26 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung verbesserter Stämme der Familie Enterobacteriaceae
JP2007117082A (ja) 2005-09-27 2007-05-17 Ajinomoto Co Inc L−アミノ酸生産菌及びl−アミノ酸の製造法
DK2314710T3 (en) * 2006-01-04 2016-06-13 Metabolic Explorer Sa A process for the production of methionine by culturing a microorganism modified to enhance the production of cysteine
JP2009118740A (ja) 2006-03-03 2009-06-04 Ajinomoto Co Inc L−アミノ酸の製造法
CN103215319A (zh) 2006-07-19 2013-07-24 味之素株式会社 使用肠杆菌科细菌产生l-氨基酸的方法
WO2008072761A2 (fr) 2006-12-11 2008-06-19 Ajinomoto Co., Inc. Procédé de production d'acide l-aminé
WO2008078646A1 (fr) 2006-12-22 2008-07-03 Ajinomoto Co., Inc. Procédé de séparation de cristaux d'acide aminé ou d'acide nucléique
RU2006145712A (ru) 2006-12-22 2008-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Способ получения l-аминокислот методом ферментации с использованием бактерий, обладающих повышенной способностью к утилизации глицерина
BRPI0703692B1 (pt) 2006-12-25 2016-12-27 Ajinomoto Kk método para se obter os cristais de um hidrocloreto de aminoácido básico compreendendo gerar um aminoácido básico usando células microbianas por fermentação em um caldo de fermentação ou por um método enzimático em uma solução de reação de enzima usando as células como catalisadores
JP2010110217A (ja) 2007-02-22 2010-05-20 Ajinomoto Co Inc L−アミノ酸生産菌及びl−アミノ酸の製造法
DE102007051024A1 (de) 2007-03-05 2008-09-11 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
JP2010130899A (ja) 2007-03-14 2010-06-17 Ajinomoto Co Inc L−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法
WO2008133131A1 (fr) 2007-04-16 2008-11-06 Ajinomoto Co., Inc. Procédé de fabrication d'un acide organique
CN101688176B (zh) 2007-04-17 2013-11-06 味之素株式会社 具有羧基的酸性物质的生产方法
BRPI0814090A2 (pt) 2007-07-19 2014-10-14 Ajinomoto Kk Método para produzir um l-aminoácido.
JP2010226956A (ja) 2007-07-23 2010-10-14 Ajinomoto Co Inc L−リジンの製造法
JP2010263790A (ja) 2007-09-04 2010-11-25 Ajinomoto Co Inc アミノ酸生産微生物及びアミノ酸の製造法
WO2009031565A1 (fr) 2007-09-04 2009-03-12 Ajinomoto Co., Inc. Microorganisme produisant des acides aminés et procédé de production des acides aminés
JP2010226957A (ja) 2007-10-17 2010-10-14 Ajinomoto Co Inc L−アミノ酸の製造法
WO2009093703A1 (fr) 2008-01-23 2009-07-30 Ajinomoto Co., Inc. Procédé de fabrication de l-aminoacide
JP5175600B2 (ja) 2008-04-09 2013-04-03 株式会社日立ハイテクノロジーズ 検査装置
JP2011167071A (ja) 2008-05-22 2011-09-01 Ajinomoto Co Inc L−アミノ酸の製造法
JP5488467B2 (ja) 2008-09-05 2014-05-14 味の素株式会社 L−アミノ酸生産菌及びl−アミノ酸の製造法
JP2012223092A (ja) 2009-08-28 2012-11-15 Ajinomoto Co Inc L−アミノ酸の製造法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2050816A1 (fr) * 2006-07-25 2009-04-22 Kyowa Hakko Bio Co., Ltd. Procédé de production d'un acide aminé

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2011024555A1 *
SHIRAI HIROKI ET AL: "Prediction of the structure and function of AstA and AstB, the first two enzymes of the arginine succinyltransferase pathway of arginine catabolism.", FEBS LETTERS 18 DEC 2003, vol. 555, no. 3, 18 December 2003 (2003-12-18), pages 505 - 510, XP002693324, ISSN: 0014-5793 *

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EP2471942B1 (fr) 2014-12-24
US8932834B2 (en) 2015-01-13
JP2012223092A (ja) 2012-11-15
EP2471942A1 (fr) 2012-07-04
BR112012004482B1 (pt) 2020-05-19
BR112012004482A2 (pt) 2015-09-08
US20120219995A1 (en) 2012-08-30

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