EP2910563A4 - Triterpenderivat und dessen verwendung gegen grippe - Google Patents

Triterpenderivat und dessen verwendung gegen grippe

Info

Publication number
EP2910563A4
EP2910563A4 EP13849730.0A EP13849730A EP2910563A4 EP 2910563 A4 EP2910563 A4 EP 2910563A4 EP 13849730 A EP13849730 A EP 13849730A EP 2910563 A4 EP2910563 A4 EP 2910563A4
Authority
EP
European Patent Office
Prior art keywords
antigrippal
triterpene derivative
triterpene
derivative
antigrippal use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13849730.0A
Other languages
English (en)
French (fr)
Other versions
EP2910563A8 (de
EP2910563A1 (de
EP2910563B1 (de
Inventor
Demin Zhou
Maorong Yu
Sulong Xiao
Fei Yu
Yiyun Peng
Yunyan Qiu
Lihe Zhang
Yitao Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Peking University
University of Macau
Original Assignee
Peking University
University of Macau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peking University, University of Macau filed Critical Peking University
Publication of EP2910563A1 publication Critical patent/EP2910563A1/de
Publication of EP2910563A8 publication Critical patent/EP2910563A8/de
Publication of EP2910563A4 publication Critical patent/EP2910563A4/de
Application granted granted Critical
Publication of EP2910563B1 publication Critical patent/EP2910563B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP13849730.0A 2012-10-22 2013-10-18 Triterpenderivat und dessen verwendung gegen grippe Not-in-force EP2910563B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201210402726.9A CN103768078B (zh) 2012-10-22 2012-10-22 三萜衍生物及其抗流感用途
PCT/CN2013/001266 WO2014063441A1 (zh) 2012-10-22 2013-10-18 三萜衍生物及其抗流感用途

Publications (4)

Publication Number Publication Date
EP2910563A1 EP2910563A1 (de) 2015-08-26
EP2910563A8 EP2910563A8 (de) 2015-10-28
EP2910563A4 true EP2910563A4 (de) 2016-05-25
EP2910563B1 EP2910563B1 (de) 2018-12-19

Family

ID=50543933

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13849730.0A Not-in-force EP2910563B1 (de) 2012-10-22 2013-10-18 Triterpenderivat und dessen verwendung gegen grippe

Country Status (5)

Country Link
US (1) US9920088B2 (de)
EP (1) EP2910563B1 (de)
JP (1) JP6441807B2 (de)
CN (1) CN103768078B (de)
WO (1) WO2014063441A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201610004PA (en) * 2014-05-30 2016-12-29 Sloan Kettering Inst Cancer Minimal saponin analogues, synthesis and use thereof
EP3389669B1 (de) * 2015-12-17 2023-03-15 Memorial Sloan-Kettering Cancer Center Triterpen-saponin-varianten, syntheseverfahren und verwendung davon
CN108640964B (zh) * 2018-06-21 2020-11-17 昆明理工大学 一种三萜-氨基酸衍生物、其制备方法和应用
CN109232706B (zh) * 2018-09-06 2021-05-14 昆明理工大学 一类三萜-寡糖偶联物及其应用
CN109134585B (zh) * 2018-09-06 2021-07-16 昆明理工大学 一类三萜与直链氨基衍生物的偶联物及其应用
CN111100102A (zh) * 2019-11-22 2020-05-05 吉尔生化（上海）有限公司 一种3，4，6-o-三乙酰基-d-葡萄糖烯的制备方法
JP2023533557A (ja) * 2020-07-07 2023-08-03 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ 五環性トリテルペノイドｃ－グリコシド、その製造方法及び使用
CN111961110B (zh) * 2020-09-17 2023-05-05 昆明理工大学 一种齐墩果酸c-3位糖偶联物其制备方法及抗流感病毒应用
CN115505020B (zh) * 2021-06-23 2023-09-12 沈阳药科大学 乌苏酸皂苷及其制备方法和用途
CN115611964B (zh) * 2021-07-15 2024-02-06 沈阳药科大学 具有炎症性肠病治疗作用的乌苏酸皂苷、其衍生物及制备方法和应用
CN115010782B (zh) * 2022-05-12 2024-01-30 陕西中医药大学 熊果酸n-糖苷衍生物及其制备方法和应用
CN115477681B (zh) * 2022-09-30 2024-07-05 苏州大学 一种五环三萜皂苷衍生物及制备方法与应用
CN116332767B (zh) * 2023-01-10 2025-11-18 中山大学 二倍半萜衍生物及其制备方法和抗新型冠状病毒应用
CN118994291B (zh) * 2024-07-09 2026-02-03 华南农业大学 一种c-3取代的齐墩果酸苄酰胺衍生物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1438237A (zh) * 2003-01-21 2003-08-27 吉林天药科技股份有限公司 刺囊酸的制备方法、药物制剂及医药新用途

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JPH05255373A (ja) * 1992-03-12 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス活性を有する新規グリチルレチン酸誘導体
JPH07188032A (ja) * 1993-12-28 1995-07-25 Minofuaagen Seiyaku Honpo:Goushi インフルエンザ治療薬
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
JPH09328426A (ja) * 1996-02-02 1997-12-22 Showa Shell Sekiyu Kk トリテルペン誘導体を有効成分とするヘルペスウイルスに起因するヘルペスウイルス感染症治療剤および感染症再発予防剤
JPH11193242A (ja) * 1997-12-26 1999-07-21 Itouen Ltd 抗インフルエンザウイルス剤
US6369109B1 (en) 1998-10-28 2002-04-09 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor
US6689767B2 (en) 2000-09-29 2004-02-10 Regents Of The University Of Minnesota Triterpenes having antibacterial activity
US7026305B2 (en) 2003-04-14 2006-04-11 Meharry Medical College Anti-HIV agents with dual sites of action
CN1295246C (zh) * 2003-11-07 2007-01-17 中国科学院上海有机化学研究所 葡萄糖醛酸苷齐墩果烷型双糖链三萜皂甙的化学合成
US8394776B2 (en) * 2007-01-16 2013-03-12 Chengdu Di'ao Jiuhong Pharmaceutical Factor Use of ursolic acid saponin,oleanolic acid saponin in preparation of increasing leucocytes and/or platelet medicine
KR101162710B1 (ko) * 2009-01-23 2012-07-05 (주) 비엔씨바이오팜 도라지 추출물 또는 도라지 사포닌 화합물을 함유하는 ｃ형 간염의 예방 또는 치료용 약학적 조성물
CN101941996B (zh) * 2009-05-18 2014-09-10 中国医学科学院药物研究所 一类熊果酸皂苷及其制法与抗高致病h5n1流感病毒的应用
KR101178947B1 (ko) * 2011-04-29 2012-09-03 한국생명공학연구원 올레아놀린산 아세테이트를 유효성분으로 포함하는 ｔｌｒ 및 ｉｌ-6 매개성 질환 예방 또는 치료용 약학적 조성물
CN102408466B (zh) * 2011-12-22 2014-05-14 江苏省中国科学院植物研究所 一种新盐角草皂苷及其制备方法和用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1438237A (zh) * 2003-01-21 2003-08-27 吉林天药科技股份有限公司 刺囊酸的制备方法、药物制剂及医药新用途

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HE Z ET AL: "New triterpenoid saponins from the roots of Platycodon grandiflorum", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 61, no. 8, 21 February 2005 (2005-02-21), pages 2211 - 2215, XP027860870, ISSN: 0040-4020, [retrieved on 20050221] *
HONGXIANG SUN ET AL: "Structure function relationship of the saponins from the roots offor hemolytic and adjuvant activity", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 11, no. 12, 25 August 2011 (2011-08-25), pages 2047 - 2056, XP028117470, ISSN: 1567-5769, [retrieved on 20110913], DOI: 10.1016/J.INTIMP.2011.08.018 *
See also references of WO2014063441A1 *
XIE YONG ET AL: "Platycodin d improves the immunogenicity of newcastle disease virus-based recombinant avian influenza vaccine in mice.", CHEMISTRY & BIODIVERSITY MAR 2010, vol. 7, no. 3, March 2010 (2010-03-01), pages 677 - 689, XP002756425, ISSN: 1612-1880 *

Also Published As

Publication number Publication date
CN103768078B (zh) 2019-02-05
WO2014063441A1 (zh) 2014-05-01
EP2910563A8 (de) 2015-10-28
CN103768078A (zh) 2014-05-07
EP2910563A1 (de) 2015-08-26
EP2910563B1 (de) 2018-12-19
US9920088B2 (en) 2018-03-20
US20150274766A1 (en) 2015-10-01
JP2015535222A (ja) 2015-12-10
JP6441807B2 (ja) 2018-12-19

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