ES2001696A6 - Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida - Google Patents

Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida

Info

Publication number
ES2001696A6
ES2001696A6 ES8602069A ES8602069A ES2001696A6 ES 2001696 A6 ES2001696 A6 ES 2001696A6 ES 8602069 A ES8602069 A ES 8602069A ES 8602069 A ES8602069 A ES 8602069A ES 2001696 A6 ES2001696 A6 ES 2001696A6
Authority
ES
Spain
Prior art keywords
pyrrolidin
oxo
hydroxy
acetic acid
alkyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602069A
Other languages
English (en)
Inventor
Thomas Meul
Garrity John Mc
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH412685A external-priority patent/CH664957A5/de
Priority claimed from CH202386A external-priority patent/CH666481A5/de
Application filed by Lonza AG filed Critical Lonza AG
Publication of ES2001696A6 publication Critical patent/ES2001696A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA PREPARAR 4-HIDROXI-2-OXO-PIRROLIDIN-1-ILACETAMIDA EN EL QUE SE HACEN REACCIONAR ESTERES ALQUILICOS DE ACIDO 4-ALCOXI-3-PIRROLIN-2-ON-1-IL-ACETICO DE FORMULA DONDE R1 Y R2 SON ALQUILO, CON TRICLOROMETILSILANO EN PRESENCIA DE UN YODURO ALCALINO O EN UN MEDIO ANHIDRO ACIDO, PARA DAR EL ESTER ALQUILICO DE ACIDO 2,4-DIOXO-PIRROLIDIN-1-IL-ACETICO, SE AISLA EVENTUALMENTE ESTE ESTER Y A CONTINUACION SE HIDROGENA CON BOROHIDRURO SODICO PARA DAR UN ESTER ALQUILICO DE ACIDO 4-HIDROXI-2-OXO-PIRROLIDIN-1-IL-ACETICO, EL CUAL SE TRANSFORMA MEDIANTE AMIDACION CON AMONIACO EN EL PRODUCTO FINAL DESEADO. ESTE PRODUCTO FINAL SE CARACTERIZA POR SU ACCION CEREBRAL.
ES8602069A 1985-09-24 1986-09-22 Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida Expired ES2001696A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH412685A CH664957A5 (de) 1985-09-24 1985-09-24 Verfahren zur herstellung von 4-hydroxy-2-oxo-pyrrolidin-1-yl-acetamid.
CH202386A CH666481A5 (de) 1986-05-20 1986-05-20 Verfahren zur herstellung von 4-hydroxy-2-oxo-pyrrolidin-1-yl-acetamid.

Publications (1)

Publication Number Publication Date
ES2001696A6 true ES2001696A6 (es) 1988-06-01

Family

ID=25689290

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602069A Expired ES2001696A6 (es) 1985-09-24 1986-09-22 Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida

Country Status (7)

Country Link
US (1) US4824966A (es)
EP (1) EP0216325A3 (es)
DK (1) DK453586A (es)
ES (1) ES2001696A6 (es)
HU (1) HUT43039A (es)
IL (1) IL80071A0 (es)
NO (1) NO863769L (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK356288A (da) * 1987-07-30 1989-01-31 Lonza Ag Fremgangsmaade til fremstilling af n-((4-hydroxy-pyrrolidin-2-on-1-yl)-acetyl)-glycinamid
ATE124396T1 (de) * 1988-09-06 1995-07-15 Lonza Ag Verfahren zur herstellung von 5- alkyltetramsäuren.
CH680293A5 (es) * 1990-06-26 1992-07-31 Lonza Ag
CN105820102A (zh) * 2016-05-10 2016-08-03 武汉工程大学 奥拉西坦的合成工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2784191A (en) * 1957-03-05 Process for the production of lactams
US2535010A (en) * 1948-10-02 1950-12-19 Rohm & Haas Transetherification of beta-ethersubstituted esters
DE850007C (de) * 1950-12-22 1952-09-22 Basf Ag Verfahren zur Herstellung von N-Aryl-ª‡-pyrrolidonen
US3299095A (en) * 1964-04-16 1967-01-17 Merck & Co Inc 1-benzyl tetramic acid derivatives
JPS4941521A (es) * 1972-06-02 1974-04-18
NZ181727A (en) * 1975-08-13 1978-03-06 Isf Spa Pyrroline-2-one derivatives and pharmaceutical compositions
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
JPS5812272B2 (ja) * 1981-04-28 1983-03-07 電気化学工業株式会社 ４−ヒドロキシ−２−ピロリドンの製造法
FI83510C (fi) * 1985-02-22 1991-07-25 Ciba Geigy Ag Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara bi-2h- pyrroli(di)ndioner.

Also Published As

Publication number Publication date
IL80071A0 (en) 1986-12-31
EP0216325A3 (de) 1987-08-26
DK453586D0 (da) 1986-09-23
US4824966A (en) 1989-04-25
DK453586A (da) 1987-03-25
NO863769D0 (no) 1986-09-22
EP0216325A2 (de) 1987-04-01
NO863769L (no) 1987-03-25
HUT43039A (en) 1987-09-28

Similar Documents

Publication Publication Date Title
ES8202546A1 (es) Metodo de producir derivados de tiazolidina
ES8800272A1 (es) Un procedimiento para la preparacion de polipeptidos.
MX9801205A (es) Compuestos de sales de aminoacidos y procesos para la produccion de los mismos.
ES480721A1 (es) Un procedimiento para aislar pseudomonato de litio.
IE34807B1 (en) Substituted naphthylalkylamines
ES2001696A6 (es) Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida
ES8609195A1 (es) Un nuevo procedimiento para la preparacion de derivados del acido cicloalquilidenmetilfenilacetico.
EP0857158A4 (en) METHOD FOR PRODUCING CALCIUM BORATE
DE3263882D1 (en) 11-deoxoglycyrrhetinic acid hydrogen maleate, process for its production, and its use as a medicine
ES8101592A1 (es) Un procedimiento para la preparacion del acido 7-oxo-1-aza- biciclo (3.2.0)hept-2-en-2-carboxilico
IL77329A (en) Manufacture of aminothiazole-acetic acid derivatives
JPS57171972A (en) Manufacture of quinoline-4-ones
EP0191286A3 (en) Sebosuppressive cosmetic compositions containing alkoxy or alkylbenzyloxybenzoic acids or salts thereof
ES8101041A1 (es) Procedimiento para la obtencion de esteres de acido estiril-ciclopropancarboxilico sustituidos, de efecto insecticida y acaricida
IL74269A0 (en) 2-alkoxyaminosulfonylbenzene-sulfonylureas,their production and their use as herbicides
ES484321A1 (es) Un procedimiento para la preparacion de un compuesto de 3- carbamoiloximetil-cefalosporina
ES8507123A1 (es) Procedimiento para la preparacion de un derivado de 4-alquil-2-hidroxi-3-metil-2-fenil-morfolina
ES8404326A1 (es) Un procedimiento para preparar el nuevo compuesto ester guayacilico del acido 1-metil-5-p-toluilpirrol-2-acetico.
ES8705860A1 (es) Procedimiento de preparacion de derivados de 3-hidroxi-3-fenilpiperidina
ES8603819A1 (es) Procedimiento para la fabricacion de derivados de pirrolidi-na
EP0521571A3 (en) Procedure for the preparation of bicyclo (3.2.0) hept-2-en-7-ones
ES471356A1 (es) Procedimiento de obtencion de r,s-2,3,5,6-tetrahidro-6-fenil-imidazo (2,1-b)-tiazole (tetramisole)
JO1214B1 (en) A way to prepare Lacta derivatives
PT81014A (en) Process for preparing the crystalline sodium salt of d-6-<alpha-<(2-oxo-3-furfurylideneamine-imidazolidin-1-yl)-carbonylamino>-2-thienyl-acetamido> -penicillanic acid useful as medicament
ES445072A1 (es) Procedimiento para la obtencion de fluoruro de acido 2-clo- rometil-fenilcarbamidico.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301