ES2003549A6 - Un procedimiento para la preparacion de derivados de cefalosporina. - Google Patents

Un procedimiento para la preparacion de derivados de cefalosporina.

Info

Publication number
ES2003549A6
ES2003549A6 ES8603195A ES8603195A ES2003549A6 ES 2003549 A6 ES2003549 A6 ES 2003549A6 ES 8603195 A ES8603195 A ES 8603195A ES 8603195 A ES8603195 A ES 8603195A ES 2003549 A6 ES2003549 A6 ES 2003549A6
Authority
ES
Spain
Prior art keywords
same
cephalosporin derivatives
new cephalosporin
new
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8603195A
Other languages
English (en)
Inventor
Seiji Shibahara
Tsuneo Okonogi
Yasushi Murai
Takashi Yoshida
Ken Nishihata
Shinichi Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Publication of ES2003549A6 publication Critical patent/ES2003549A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

DICHO PROCEDIMIENTO COMPRENDE LAS SIGUIENTES ETAPAS: (A) CONDENSAR (IV) (DONDE TR ES TRIFENILMETILO, A ES UN GRUPO PROTECTOR, X ES HALOGENO Y R ES EL DEFINIDO ANTERIORMENTE) CON (XI) PARA DAR (XII); (B) HACER REACCIONAR (XII) CON (XIII) PARA DAR (XIV) Y SEPARAR LOS GRUPOS PROTECTORES PARA PRODUCIR LOS DERIVADOS DE CEFALOSPORINA DE FORMULA (I) (DONDE R ES ALQUILO, N ES 0 O 1, N1 ES 0-3 Y N2 ES 0-3). LOS COMPUESTOS (I) SON UTILES PORQUE PRESENTAN UNA ACTIVIDAD BACTERICIDA ELEVADA CON UN ESPECTRO ANTIBACTERIANO AMPLIO AL TIEMPO QUE CARECEN DE TOXICIDAD.
ES8603195A 1985-11-27 1986-11-26 Un procedimiento para la preparacion de derivados de cefalosporina. Expired ES2003549A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60267984A JPH064645B2 (ja) 1985-11-27 1985-11-27 新規セフアロスポリン誘導体およびそれを含む抗菌剤

Publications (1)

Publication Number Publication Date
ES2003549A6 true ES2003549A6 (es) 1988-11-01

Family

ID=17452295

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8603195A Expired ES2003549A6 (es) 1985-11-27 1986-11-26 Un procedimiento para la preparacion de derivados de cefalosporina.

Country Status (10)

Country Link
US (1) US4898858A (es)
EP (1) EP0227953B1 (es)
JP (1) JPH064645B2 (es)
KR (1) KR900003563B1 (es)
CN (1) CN1024012C (es)
AT (1) ATE85339T1 (es)
CA (1) CA1281712C (es)
DE (1) DE3687703T2 (es)
ES (1) ES2003549A6 (es)
IE (1) IE62019B1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63154622A (ja) * 1986-12-18 1988-06-27 Meiji Seika Kaisha Ltd セフアロスポリン誘導体を有効成分とする哺乳動物用抗菌剤
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2005787A1 (en) * 1988-12-29 1990-06-29 Masao Wada Cephalosporin compounds
JPH0320265A (ja) * 1989-02-10 1991-01-29 Meiji Seika Kaisha Ltd アミノチアゾール酢酸誘導体並びにその製造法
JPH11124384A (ja) * 1997-10-17 1999-05-11 Otsuka Chem Co Ltd ３−セフェム化合物の製造法
KR100453713B1 (ko) * 2002-02-28 2004-10-20 주식회사 엘지생명과학 신규 세팔로스포린 화합물 및 그의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR229882A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para preparar antibioticos de cefalosporina
BE880068A (fr) * 1978-11-17 1980-05-16 Glaxo Group Ltd Nouvelles cephalosporines et leur preparation
FR2516515A1 (fr) * 1981-11-16 1983-05-20 Sanofi Sa Nouveaux derives de pyridinium thiomethyl cephalosporines, procede pour leur preparation et compositions pharmaceutiques les contenant
KR920004820B1 (ko) * 1984-02-23 1992-06-18 메이지제과 주식회사 새로운 세팔로스포린 유도체의 제조방법
JPS63154622A (ja) * 1986-12-18 1988-06-27 Meiji Seika Kaisha Ltd セフアロスポリン誘導体を有効成分とする哺乳動物用抗菌剤

Also Published As

Publication number Publication date
DE3687703T2 (de) 1993-08-05
JPS62126189A (ja) 1987-06-08
IE62019B1 (en) 1994-12-14
EP0227953B1 (en) 1993-02-03
JPH064645B2 (ja) 1994-01-19
CN86107949A (zh) 1987-08-05
CA1281712C (en) 1991-03-19
KR870004992A (ko) 1987-06-04
EP0227953A3 (en) 1989-01-25
EP0227953A2 (en) 1987-07-08
DE3687703D1 (de) 1993-03-18
KR900003563B1 (ko) 1990-05-21
CN1024012C (zh) 1994-03-16
US4898858A (en) 1990-02-06
IE863114L (en) 1987-05-27
ATE85339T1 (de) 1993-02-15

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-11-26