ES2003774A6 - Procedimiento para preparar nuevas 8 alfa-acilamino-ergolinas - Google Patents

Procedimiento para preparar nuevas 8 alfa-acilamino-ergolinas

Info

Publication number: ES2003774A6
Authority: ES; Spain
Prior art keywords: compound; alkyl; formula; alpha; react
Prior art date: 1986-01-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES8700163A

Other languages

English (en)

Spanish (es)

Inventor

Rene Ziegler

Peter Nuemann

Walter Haefliger

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-24

Filing date

1987-01-22

Publication date

1988-11-16

1987-01-22 Application filed by Sandoz AG filed Critical Sandoz AG

1988-11-16 Publication of ES2003774A6 publication Critical patent/ES2003774A6/es

Status Expired legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 abstract 7
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
-1 COOR5 Chemical group 0.000 abstract 1
101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
WRJWRGBVPUUDLA-UHFFFAOYSA-N chlorosulfonyl isocyanate Chemical compound ClS(=O)(=O)N=C=O WRJWRGBVPUUDLA-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
239000003176 neuroleptic agent Substances 0.000 abstract 1
230000000701 neuroleptic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ES8700163A 1986-01-24 1987-01-22 Procedimiento para preparar nuevas 8 alfa-acilamino-ergolinas Expired ES2003774A6 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3602058		1986-01-24

Publications (1)

Publication Number	Publication Date
ES2003774A6 true ES2003774A6 (es)	1988-11-16

Family

ID=6292510

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES8700163A Expired ES2003774A6 (es)	1986-01-24	1987-01-22	Procedimiento para preparar nuevas 8 alfa-acilamino-ergolinas

Country Status (18)

Country	Link
JP (1)	JPS62190184A (fr)
KR (1)	KR870007175A (fr)
AU (1)	AU6791487A (fr)
BE (1)	BE1000039A4 (fr)
DK (1)	DK35787A (fr)
ES (1)	ES2003774A6 (fr)
FI (1)	FI870293A7 (fr)
FR (1)	FR2595699A1 (fr)
GB (1)	GB2185743A (fr)
GR (1)	GR870093B (fr)
HU (1)	HUT45248A (fr)
IL (1)	IL81355A0 (fr)
IT (1)	IT1216783B (fr)
LU (1)	LU86743A1 (fr)
NL (1)	NL8700046A (fr)
PT (1)	PT84184A (fr)
SE (1)	SE8700250L (fr)
ZA (1)	ZA87520B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8714767D0 (en) *	1987-06-24	1987-07-29	Erba Farmitalia	Egoline derivatives
DE3587860D1 (de) *	1984-04-09	1994-07-28	Schering Ag	2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
DK338789A (da) *	1988-07-15	1990-01-16	Schering Ag	2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
DE3915950A1 (de) *	1989-05-12	1990-11-15	Schering Ag	8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
KR20140042868A (ko) *	2011-06-23	2014-04-07	맵 파마슈티컬스, 인코포레이티드	신규한 플루오로에르골린 유사체
SG10201509139QA (en) *	2011-12-19	2015-12-30	Map Pharmaceuticals Inc	Novel iso-ergoline derivatives
MX2017009405A (es)	2015-01-20	2018-01-18	Xoc Pharmaceuticals Inc	Compuestos de tipo ergolina y usos de estos.
EP3247357A4 (fr) *	2015-01-20	2018-07-11	Xoc Pharmaceuticals, Inc	Composés d'isoergoline et leurs utilisations
WO2018223065A1 (fr)	2017-06-01	2018-12-06	Xoc Pharmaceuticals, Inc.	Dérivés d'ergoline destinés à être utilisés en médecine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1517973A (en) *	1974-07-19	1978-07-19	Sandoz Ltd	6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
CH615929A5 (en) *	1975-06-02	1980-02-29	Sandoz Ag	Process for the preparation of novel ergoline compounds
HU197569B (en) *	1984-01-12	1989-04-28	Sandoz Ag	Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds

1987
- 1987-01-12 NL NL8700046A patent/NL8700046A/nl not_active Application Discontinuation
- 1987-01-12 HU HU8792A patent/HUT45248A/hu unknown
- 1987-01-21 GB GB08701274A patent/GB2185743A/en not_active Withdrawn
- 1987-01-22 SE SE8700250A patent/SE8700250L/xx not_active Application Discontinuation
- 1987-01-22 DK DK035787A patent/DK35787A/da not_active Application Discontinuation
- 1987-01-22 ES ES8700163A patent/ES2003774A6/es not_active Expired
- 1987-01-22 IL IL81355A patent/IL81355A0/xx unknown
- 1987-01-22 IT IT8747551A patent/IT1216783B/it active
- 1987-01-22 PT PT84184A patent/PT84184A/pt unknown
- 1987-01-22 KR KR870000556A patent/KR870007175A/ko not_active Ceased
- 1987-01-22 LU LU86743A patent/LU86743A1/fr unknown
- 1987-01-22 FR FR8700834A patent/FR2595699A1/fr active Pending
- 1987-01-22 GR GR870093A patent/GR870093B/el unknown
- 1987-01-22 AU AU67914/87A patent/AU6791487A/en not_active Abandoned
- 1987-01-23 ZA ZA87520A patent/ZA87520B/xx unknown
- 1987-01-23 BE BE8700046A patent/BE1000039A4/fr not_active IP Right Cessation
- 1987-01-23 JP JP62015028A patent/JPS62190184A/ja active Pending
- 1987-01-23 FI FI870293A patent/FI870293A7/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI870293A7 (fi)	1987-07-25
LU86743A1 (fr)	1987-09-03
AU6791487A (en)	1987-07-30
FI870293A0 (fi)	1987-01-23
HUT45248A (en)	1988-06-28
DK35787A (da)	1987-07-25
GR870093B (en)	1987-05-25
SE8700250L (sv)	1987-07-25
FR2595699A1 (fr)	1987-09-18
KR870007175A (ko)	1987-08-17
BE1000039A4 (fr)	1987-12-15
SE8700250D0 (sv)	1987-01-22
IT1216783B (it)	1990-03-14
PT84184A (pt)	1987-02-01
NL8700046A (nl)	1987-08-17
DK35787D0 (da)	1987-01-22
IT8747551A0 (it)	1987-01-22
JPS62190184A (ja)	1987-08-20
IL81355A0 (en)	1987-08-31
GB8701274D0 (en)	1987-02-25
GB2185743A (en)	1987-07-29
ZA87520B (en)	1988-09-28

Publication	Publication Date	Title
ES8706130A1 (es)	1987-06-01	Procedimiento para la preparacion de 3-ariluracilos
ES8705353A1 (es)	1987-05-16	Procedimiento de producir derivados dihidro- y tetradhidroquinolinicos
ES2003774A6 (es)	1988-11-16	Procedimiento para preparar nuevas 8 alfa-acilamino-ergolinas
ES2033675T3 (es)	1993-04-01	Un procedimiento para preparar un compuesto de n-benzoil urea.
ES8707250A1 (es)	1987-07-16	Procedimiento para preparar acidos fosfonicos y derivados de los mismos
FI872636A0 (fi)	1987-06-12	Substituerade 4-bensyl -piperazinylfoereningar.
CO4410185A1 (es)	1997-01-09	Nueva benzamidina, su preparacion y su empleo como medica- mento
ATE40947T1 (de)	1989-03-15	Verwendung von cystein-derivaten oder deren salzen, zur steigerung der insulinsekretion der langerhans'schen inseln der bauchspeicheldruese.
MY101618A (en)	1991-12-17	Intermediates for the production of epipodophyloxin and related compounds and processes for the preparation and use thereof
ES8704153A1 (es)	1987-03-16	Un procedimiento para preparar derivados de pirimidina
ES2040222T3 (es)	1993-10-16	Procedimiento para preparar ciertas 2-benzoil-2,3,5-ciclohexanotrionas.
IT1202321B (it)	1989-02-02	Nucleotidi ciclici fluorescenti biologicamente attivi
ES2043738T3 (es)	1994-01-01	Procedimiento para la reduccion de cetonas.
HU9400587D0 (en)	1994-05-30	Herbicidal sulphonyl ureas, process and intermediates for producing the same
ES8706152A1 (es)	1987-06-01	Procedimiento para preparar un nuevo derivado de octahidroindol (2,3-a) quinolizina
HK64691A (en)	1991-08-23	Anticonvulsant agents
ES8504794A1 (es)	1985-05-01	Un procedimiento para la preparacion de una quinazolina
IT1215251B (it)	1990-01-31	Farmaceutiche che li contengono. composti ad attivita'antiaggregante piastrinica, procedimento per la loro preparazione e composizioni
IT1122376B (it)	1986-04-23	Prodotti diuretici
ES2017459B3 (es)	1991-02-16	Procedimiento de obtencion de alfa-halogeno-alquil arilcetonas opticamente activas.
PH18629A (en)	1985-08-23	Substituted 2,3-alkylene bis (oxy) benzoic acid derivatives
ES548497A0 (es)	1986-03-16	Procedimiento para preparar compuestos de 3-amino-2,3-dihi- dro-1-benzoxepina
FR2226163A2 (en)	1974-11-15	2-Amino-5-methyl-4-phenyl-1-pyrrolines - with antidepressant and antiarrhythmic activity
SE8801166D0 (sv)	1988-03-29	Substituted 1,3-dioxolane and 1,3-dioxane derivatives, processes for the production and their use
JPS5737594B2 (fr)	1982-08-10