ES2003774A6 - Procedimiento para preparar nuevas 8 alfa-acilamino-ergolinas - Google Patents

Procedimiento para preparar nuevas 8 alfa-acilamino-ergolinas

Info

Publication number: ES2003774A6
Authority: ES; Spain
Prior art keywords: compound; alkyl; formula; alpha; react
Prior art date: 1986-01-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES8700163A

Other languages

English (en)

Spanish (es)

Inventor

Rene Ziegler

Peter Nuemann

Walter Haefliger

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-24

Filing date

1987-01-22

Publication date

1988-11-16

1987-01-22 Application filed by Sandoz AG filed Critical Sandoz AG

1988-11-16 Publication of ES2003774A6 publication Critical patent/ES2003774A6/es

Status Expired legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 abstract 7
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
-1 COOR5 Chemical group 0.000 abstract 1
101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
WRJWRGBVPUUDLA-UHFFFAOYSA-N chlorosulfonyl isocyanate Chemical compound ClS(=O)(=O)N=C=O WRJWRGBVPUUDLA-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
239000003176 neuroleptic agent Substances 0.000 abstract 1
230000000701 neuroleptic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ES8700163A 1986-01-24 1987-01-22 Procedimiento para preparar nuevas 8 alfa-acilamino-ergolinas Expired ES2003774A6 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3602058		1986-01-24

Publications (1)

Publication Number	Publication Date
ES2003774A6 true ES2003774A6 (es)	1988-11-16

Family

ID=6292510

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES8700163A Expired ES2003774A6 (es)	1986-01-24	1987-01-22	Procedimiento para preparar nuevas 8 alfa-acilamino-ergolinas

Country Status (18)

Country	Link
JP (1)	JPS62190184A (fr)
KR (1)	KR870007175A (fr)
AU (1)	AU6791487A (fr)
BE (1)	BE1000039A4 (fr)
DK (1)	DK35787A (fr)
ES (1)	ES2003774A6 (fr)
FI (1)	FI870293A7 (fr)
FR (1)	FR2595699A1 (fr)
GB (1)	GB2185743A (fr)
GR (1)	GR870093B (fr)
HU (1)	HUT45248A (fr)
IL (1)	IL81355A0 (fr)
IT (1)	IT1216783B (fr)
LU (1)	LU86743A1 (fr)
NL (1)	NL8700046A (fr)
PT (1)	PT84184A (fr)
SE (1)	SE8700250L (fr)
ZA (1)	ZA87520B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8714767D0 (en) *	1987-06-24	1987-07-29	Erba Farmitalia	Egoline derivatives
EP0160842B1 (fr) *	1984-04-09	1994-06-22	Schering Aktiengesellschaft	Dérivés d'ergoline substitués sur la position 2, procédés pour leur préparation et leur utilisation comme médicaments
DK338789A (da) *	1988-07-15	1990-01-16	Schering Ag	2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
DE3915950A1 (de) *	1989-05-12	1990-11-15	Schering Ag	8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
WO2012177962A1 (fr) *	2011-06-23	2012-12-27	Map Pharmaceuticals, Inc.	Nouveaux analogues de fluoro-ergoline
EP2793580A4 (fr) *	2011-12-19	2015-05-20	Map Pharmaceuticals Inc	Nouveaux dérivés d'iso-ergoline
CN107405346A (zh) *	2015-01-20	2017-11-28	Xoc制药股份有限公司	异麦角灵化合物及其用途
CN113149982A (zh)	2015-01-20	2021-07-23	Xoc制药股份有限公司	麦角灵化合物及其用途
CA3064274A1 (fr)	2017-06-01	2018-12-06	Xoc Pharmaceuticals, Inc.	Derives d'ergoline destines a etre utilises en medecine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1517971A (en) *	1974-07-19	1978-07-19	Sandoz Ltd	8alpha-substituted ergoline i derivatives
CH615929A5 (en) *	1975-06-02	1980-02-29	Sandoz Ag	Process for the preparation of novel ergoline compounds
HU197569B (en) *	1984-01-12	1989-04-28	Sandoz Ag	Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds

1987
- 1987-01-12 HU HU8792A patent/HUT45248A/hu unknown
- 1987-01-12 NL NL8700046A patent/NL8700046A/nl not_active Application Discontinuation
- 1987-01-21 GB GB08701274A patent/GB2185743A/en not_active Withdrawn
- 1987-01-22 AU AU67914/87A patent/AU6791487A/en not_active Abandoned
- 1987-01-22 DK DK035787A patent/DK35787A/da not_active Application Discontinuation
- 1987-01-22 IL IL81355A patent/IL81355A0/xx unknown
- 1987-01-22 KR KR870000556A patent/KR870007175A/ko not_active Ceased
- 1987-01-22 ES ES8700163A patent/ES2003774A6/es not_active Expired
- 1987-01-22 PT PT84184A patent/PT84184A/pt unknown
- 1987-01-22 GR GR870093A patent/GR870093B/el unknown
- 1987-01-22 FR FR8700834A patent/FR2595699A1/fr active Pending
- 1987-01-22 IT IT8747551A patent/IT1216783B/it active
- 1987-01-22 SE SE8700250A patent/SE8700250L/xx not_active Application Discontinuation
- 1987-01-22 LU LU86743A patent/LU86743A1/fr unknown
- 1987-01-23 JP JP62015028A patent/JPS62190184A/ja active Pending
- 1987-01-23 ZA ZA87520A patent/ZA87520B/xx unknown
- 1987-01-23 BE BE8700046A patent/BE1000039A4/fr not_active IP Right Cessation
- 1987-01-23 FI FI870293A patent/FI870293A7/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK35787A (da)	1987-07-25
KR870007175A (ko)	1987-08-17
GB8701274D0 (en)	1987-02-25
AU6791487A (en)	1987-07-30
SE8700250L (sv)	1987-07-25
DK35787D0 (da)	1987-01-22
HUT45248A (en)	1988-06-28
FI870293A0 (fi)	1987-01-23
PT84184A (pt)	1987-02-01
SE8700250D0 (sv)	1987-01-22
IL81355A0 (en)	1987-08-31
JPS62190184A (ja)	1987-08-20
FI870293A7 (fi)	1987-07-25
FR2595699A1 (fr)	1987-09-18
BE1000039A4 (fr)	1987-12-15
ZA87520B (en)	1988-09-28
GR870093B (en)	1987-05-25
NL8700046A (nl)	1987-08-17
LU86743A1 (fr)	1987-09-03
IT8747551A0 (it)	1987-01-22
GB2185743A (en)	1987-07-29
IT1216783B (it)	1990-03-14

Publication	Publication Date	Title
ES8706130A1 (es)	1987-06-01	Procedimiento para la preparacion de 3-ariluracilos
ES2003774A6 (es)	1988-11-16	Procedimiento para preparar nuevas 8 alfa-acilamino-ergolinas
ES2033675T3 (es)	1993-04-01	Un procedimiento para preparar un compuesto de n-benzoil urea.
MY106638A (en)	1995-07-31	Calcium independent camp phosphodiesterase inhibitor antidepressant
NO892381D0 (no)	1989-06-09	1-indolylalkyl-4-(substituert-pyridinyl)piperaziner.
ES8707250A1 (es)	1987-07-16	Procedimiento para preparar acidos fosfonicos y derivados de los mismos
FI872636A0 (fi)	1987-06-12	Substituerade 4-bensyl -piperazinylfoereningar.
CO4410185A1 (es)	1997-01-09	Nueva benzamidina, su preparacion y su empleo como medica- mento
MY101618A (en)	1991-12-17	Intermediates for the production of epipodophyloxin and related compounds and processes for the preparation and use thereof
ES8704153A1 (es)	1987-03-16	Un procedimiento para preparar derivados de pirimidina
ES8506655A1 (es)	1985-08-01	Procedimiento para la obtencion de un derivado de fenilsulfonilguanidina
ES8506647A1 (es)	1985-07-16	Procedimiento para la obtencion de derivados de fenilsulfonilguanidina sustituidos de efecto herbicida
ES2040222T3 (es)	1993-10-16	Procedimiento para preparar ciertas 2-benzoil-2,3,5-ciclohexanotrionas.
ES2043738T3 (es)	1994-01-01	Procedimiento para la reduccion de cetonas.
HU9400587D0 (en)	1994-05-30	Herbicidal sulphonyl ureas, process and intermediates for producing the same
ATE47135T1 (de)	1989-10-15	Antikonvulsive mittel.
DK7286D0 (da)	1986-01-08	Octahydroindoliziner
ATE38829T1 (de)	1988-12-15	Phenylbenzoylharnstoffe.
ES8504794A1 (es)	1985-05-01	Un procedimiento para la preparacion de una quinazolina
IT1215251B (it)	1990-01-31	Farmaceutiche che li contengono. composti ad attivita'antiaggregante piastrinica, procedimento per la loro preparazione e composizioni
IT1122376B (it)	1986-04-23	Prodotti diuretici
PH18629A (en)	1985-08-23	Substituted 2,3-alkylene bis (oxy) benzoic acid derivatives
ES548497A0 (es)	1986-03-16	Procedimiento para preparar compuestos de 3-amino-2,3-dihi- dro-1-benzoxepina
JO1412B1 (en)	1986-11-30	Replaced 4 benzyl piperazineil compounds
ES468582A1 (es)	1979-09-16	Procedimiento para producir compuestos terapeuticos cefalos-porinicos