SE8700250L - 8alfa-acylaminoergoliner, deras framstellning och farmaceutiska kompositioner innehallande dem - Google Patents

8alfa-acylaminoergoliner, deras framstellning och farmaceutiska kompositioner innehallande dem

Info

Publication number: SE8700250L
Authority: SE; Sweden
Prior art keywords: alkyl; phenyl; 8alfa; acylaminoergolines; preparation
Prior art date: 1986-01-24

Application number

SE8700250A

Other languages

English (en)

Swedish (sv)

Other versions

SE8700250D0 (sv

Inventor

R Ziegler

P Neumann

W Haefliger

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-24

Filing date

1987-01-22

Publication date

1987-07-25

1987-01-22 Application filed by Sandoz Ag filed Critical Sandoz Ag

1987-01-22 Publication of SE8700250D0 publication Critical patent/SE8700250D0/xx

1987-07-25 Publication of SE8700250L publication Critical patent/SE8700250L/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
-1 R2 is CN Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
101100439664 Arabidopsis thaliana CHR8 gene Proteins 0.000 abstract 1
101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 1
101100533874 Hypocrea jecorina (strain QM6a) sor5 gene Proteins 0.000 abstract 1
102000003946 Prolactin Human genes 0.000 abstract 1
108010057464 Prolactin Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
239000003176 neuroleptic agent Substances 0.000 abstract 1
230000000701 neuroleptic effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229940097325 prolactin Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SE8700250A 1986-01-24 1987-01-22 8alfa-acylaminoergoliner, deras framstellning och farmaceutiska kompositioner innehallande dem SE8700250L (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3602058		1986-01-24

Publications (2)

Publication Number	Publication Date
SE8700250D0 SE8700250D0 (sv)	1987-01-22
SE8700250L true SE8700250L (sv)	1987-07-25

Family

ID=6292510

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8700250A SE8700250L (sv)	1986-01-24	1987-01-22	8alfa-acylaminoergoliner, deras framstellning och farmaceutiska kompositioner innehallande dem

Country Status (18)

Country	Link
JP (1)	JPS62190184A (fr)
KR (1)	KR870007175A (fr)
AU (1)	AU6791487A (fr)
BE (1)	BE1000039A4 (fr)
DK (1)	DK35787A (fr)
ES (1)	ES2003774A6 (fr)
FI (1)	FI870293A7 (fr)
FR (1)	FR2595699A1 (fr)
GB (1)	GB2185743A (fr)
GR (1)	GR870093B (fr)
HU (1)	HUT45248A (fr)
IL (1)	IL81355A0 (fr)
IT (1)	IT1216783B (fr)
LU (1)	LU86743A1 (fr)
NL (1)	NL8700046A (fr)
PT (1)	PT84184A (fr)
SE (1)	SE8700250L (fr)
ZA (1)	ZA87520B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8714767D0 (en) *	1987-06-24	1987-07-29	Erba Farmitalia	Egoline derivatives
DE3587860D1 (de) *	1984-04-09	1994-07-28	Schering Ag	2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
DK338789A (da) *	1988-07-15	1990-01-16	Schering Ag	2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
DE3915950A1 (de) *	1989-05-12	1990-11-15	Schering Ag	8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
KR20140042868A (ko) *	2011-06-23	2014-04-07	맵 파마슈티컬스, 인코포레이티드	신규한 플루오로에르골린 유사체
SG10201509139QA (en) *	2011-12-19	2015-12-30	Map Pharmaceuticals Inc	Novel iso-ergoline derivatives
MX2017009405A (es)	2015-01-20	2018-01-18	Xoc Pharmaceuticals Inc	Compuestos de tipo ergolina y usos de estos.
EP3247357A4 (fr) *	2015-01-20	2018-07-11	Xoc Pharmaceuticals, Inc	Composés d'isoergoline et leurs utilisations
WO2018223065A1 (fr)	2017-06-01	2018-12-06	Xoc Pharmaceuticals, Inc.	Dérivés d'ergoline destinés à être utilisés en médecine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1517973A (en) *	1974-07-19	1978-07-19	Sandoz Ltd	6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
CH615929A5 (en) *	1975-06-02	1980-02-29	Sandoz Ag	Process for the preparation of novel ergoline compounds
HU197569B (en) *	1984-01-12	1989-04-28	Sandoz Ag	Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds

1987
- 1987-01-12 NL NL8700046A patent/NL8700046A/nl not_active Application Discontinuation
- 1987-01-12 HU HU8792A patent/HUT45248A/hu unknown
- 1987-01-21 GB GB08701274A patent/GB2185743A/en not_active Withdrawn
- 1987-01-22 SE SE8700250A patent/SE8700250L/xx not_active Application Discontinuation
- 1987-01-22 DK DK035787A patent/DK35787A/da not_active Application Discontinuation
- 1987-01-22 ES ES8700163A patent/ES2003774A6/es not_active Expired
- 1987-01-22 IL IL81355A patent/IL81355A0/xx unknown
- 1987-01-22 IT IT8747551A patent/IT1216783B/it active
- 1987-01-22 PT PT84184A patent/PT84184A/pt unknown
- 1987-01-22 KR KR870000556A patent/KR870007175A/ko not_active Ceased
- 1987-01-22 LU LU86743A patent/LU86743A1/fr unknown
- 1987-01-22 FR FR8700834A patent/FR2595699A1/fr active Pending
- 1987-01-22 GR GR870093A patent/GR870093B/el unknown
- 1987-01-22 AU AU67914/87A patent/AU6791487A/en not_active Abandoned
- 1987-01-23 ZA ZA87520A patent/ZA87520B/xx unknown
- 1987-01-23 BE BE8700046A patent/BE1000039A4/fr not_active IP Right Cessation
- 1987-01-23 JP JP62015028A patent/JPS62190184A/ja active Pending
- 1987-01-23 FI FI870293A patent/FI870293A7/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI870293A7 (fi)	1987-07-25
LU86743A1 (fr)	1987-09-03
AU6791487A (en)	1987-07-30
FI870293A0 (fi)	1987-01-23
HUT45248A (en)	1988-06-28
DK35787A (da)	1987-07-25
GR870093B (en)	1987-05-25
FR2595699A1 (fr)	1987-09-18
KR870007175A (ko)	1987-08-17
BE1000039A4 (fr)	1987-12-15
SE8700250D0 (sv)	1987-01-22
IT1216783B (it)	1990-03-14
PT84184A (pt)	1987-02-01
ES2003774A6 (es)	1988-11-16
NL8700046A (nl)	1987-08-17
DK35787D0 (da)	1987-01-22
IT8747551A0 (it)	1987-01-22
JPS62190184A (ja)	1987-08-20
IL81355A0 (en)	1987-08-31
GB8701274D0 (en)	1987-02-25
GB2185743A (en)	1987-07-29
ZA87520B (en)	1988-09-28

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Legal Events

Date

Code

Title

Description

1995-02-28

NAV

Patent application has lapsed

Ref document number: 8700250-7

Effective date: 19900623