ES2012948A6 - Procedimiento para la preparacion de sales de cefalosporina y composiciones inyectables - Google Patents

Procedimiento para la preparacion de sales de cefalosporina y composiciones inyectables

Info

Publication number
ES2012948A6
ES2012948A6 ES8900146A ES8900146A ES2012948A6 ES 2012948 A6 ES2012948 A6 ES 2012948A6 ES 8900146 A ES8900146 A ES 8900146A ES 8900146 A ES8900146 A ES 8900146A ES 2012948 A6 ES2012948 A6 ES 2012948A6
Authority
ES
Spain
Prior art keywords
salts
crystalline
zwitterion
admixture
crystals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8900146A
Other languages
English (en)
Inventor
Murray Arthur Kaplan
Thomas W Hudyma
Robert Alan Lipper
Kun Mao Shih
Susan D Boettger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22510643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2012948(A6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES2012948A6 publication Critical patent/ES2012948A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE SALES DE CEFALOSPORINA Y COMPOSICIONES INYECTABLES. LAS SALES CRISTALINAS DE ADICION DE LOS ACIDOS SULFURICO, DI-NITRICO, MONO-CLORHIDRICO, DI-CLORHPIDRICO Y DI- Y SESQUI-ORTO-FOSFORICO DEL 7- (2-AMINOTIAZOL-4-IL)- (Z)-METOXIIMINOACETAMIDO 3-(1-METIL-1-PIRROLIDINIO)METIL 3-CEFEM-4-CARBOXILATO SON ESTABLES INCLUSO A TEMPERATURAS ELEVADAS. LA SAL CRISTALINA DE ADICION DE ACIDO SULFURICO SE PREPARA FORMANDO UNA MEZCLA DE (A) POR LO MENOS UN EQUIVALENTE MOLAR DE ACIDO SULFURICO CON (B) UNA CANTIDAD DE ZWITTERION SUFICIENTE PARA QUE SU CONCENTRACION EN LA MEZCLA SUPERIOR A 25 MG/ML, HACIENDO CRISTALIZAR, SEPARANDO LOS CRITALES, LAVANDO Y SECANDO. LAS SALESCRITALINAS DE MONOHIDROCLORURO, DIHIDROCLORURO Y ORTOFOSFATO SE PREPARAN DISOLVIENDO EL ZWITTERION EN LA CANTIDAD APROPIADA DE ACIDO, HACIENDO CRISTALIZAR POR ADICION DE ACETONA Y ASILANDO LOS CRITALES.
ES8900146A 1988-01-19 1989-01-16 Procedimiento para la preparacion de sales de cefalosporina y composiciones inyectables Expired - Fee Related ES2012948A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/144,899 US4910301A (en) 1985-08-05 1988-01-19 Cefepime cephalosporin salts

Publications (1)

Publication Number Publication Date
ES2012948A6 true ES2012948A6 (es) 1990-04-16

Family

ID=22510643

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8900146A Expired - Fee Related ES2012948A6 (es) 1988-01-19 1989-01-16 Procedimiento para la preparacion de sales de cefalosporina y composiciones inyectables

Country Status (32)

Country Link
US (1) US4910301A (es)
JP (1) JPH0725768B2 (es)
KR (1) KR950003612B1 (es)
AT (1) AT399878B (es)
AU (1) AU615509B2 (es)
BE (1) BE1002749A5 (es)
CA (1) CA1298288C (es)
CY (1) CY1663A (es)
CZ (1) CZ281602B6 (es)
DD (2) DD284807A5 (es)
DE (1) DE3901359A1 (es)
DK (1) DK162054C (es)
EG (1) EG18749A (es)
ES (1) ES2012948A6 (es)
FI (1) FI86854C (es)
FR (1) FR2626003B1 (es)
GB (1) GB2213819B (es)
GR (1) GR1001218B (es)
HK (1) HK72292A (es)
HU (1) HU205940B (es)
IE (1) IE67447B1 (es)
IT (1) IT1229528B (es)
LU (1) LU87432A1 (es)
NL (1) NL192266C (es)
NZ (1) NZ227605A (es)
OA (1) OA09227A (es)
PT (1) PT89474B (es)
SE (1) SE505258C2 (es)
SG (1) SG75492G (es)
SK (1) SK281768B6 (es)
YU (1) YU221188A (es)
ZA (1) ZA89407B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
ES2061918T3 (es) * 1988-12-27 1994-12-16 Chugai Pharmaceutical Co Ltd Procedimiento para la purificacion de 1,2-bis (nicotinamido) propano.
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
DE3919259A1 (de) * 1989-06-13 1990-12-20 Hoechst Ag Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
IL103110A (en) * 1991-09-10 1997-04-15 Bristol Myers Squibb Co Anhydrous process for preparing cefepime dihydrochloride hydrate
US5698703A (en) * 1991-09-10 1997-12-16 Bristol-Myers Squibb Company Syn-isomer of thiazolyl intermediate and process for the preparation thereof
YU81692A (sh) * 1991-09-10 1995-03-27 Bristol-Myers Co. Postupak za proizvodnju cefalosporinskog antibiotika
US5594129A (en) * 1991-09-10 1997-01-14 Bristol-Myers Squibb Company Process for the preparation of a cephalosporin antibiotic
CA2099692C (en) * 1992-07-24 2003-09-30 Gary M. F. Lim Process for preparing cephalosporin intermediates
US5401842A (en) * 1992-09-08 1995-03-28 Bristol-Myers Squibb Company Injectable compositions of a cephalosporin dihydrate salt
US5391729A (en) * 1992-09-08 1995-02-21 Bristol-Myers Squibb Company Crystalline dihydrate of a cephalosporin salt
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
JPH0840907A (ja) 1994-08-03 1996-02-13 Meiji Seika Kaisha Ltd セファロスポリン注射剤
WO2005094800A2 (en) * 2004-03-31 2005-10-13 Lupin Ltd. A co-precipitated cefepime composition and process for preparation thereof
WO2006008749A1 (en) * 2004-07-16 2006-01-26 Hetero Drugs Limited Process for preparing pure cephalosporine intermediates
ITMI20051684A1 (it) * 2005-09-13 2007-03-14 Harvest Lodge Ltd Procedimento per la produzione del dicloridrato di amminoacidi
ITMI20060422A1 (it) * 2006-03-09 2007-09-10 Harvest Lodge Ltd Procedimento diretto per la produzione del dicloridrato di un amminoacido
US8151846B2 (en) * 2006-12-15 2012-04-10 Center Line Wheel Corporation Wheel having inner bead-lock
TWI400243B (zh) * 2009-07-20 2013-07-01 Intervet Int Bv 製造西喹諾（ｃｅｆｑｕｉｎｏｍｅ）粒子的方法
CN103304580B (zh) * 2013-06-09 2014-07-09 四川省惠达药业有限公司 一种盐酸头孢吡肟化合物、其制备方法及其药物组合物
WO2017096472A1 (en) * 2015-12-10 2017-06-15 Naeja-Rgm Pharmaceuticals Inc. Cephem compounds, their production and use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
FR2457295A1 (fr) * 1979-05-25 1980-12-19 Glaxo Group Ltd Composes intermediaires pour la preparation de cephalosporines
US4329453A (en) * 1979-10-02 1982-05-11 Glaxo Group Limited Cephalosporin antibiotic
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
US4537959A (en) * 1984-03-26 1985-08-27 Eli Lilly And Company Crystalline cephalosporin antibiotic salt
US4751295A (en) * 1984-04-09 1988-06-14 Bristol-Myers Company Cephalosporin derivatives
US4749694A (en) * 1984-04-26 1988-06-07 Merck & Co., Inc. Novel lysine esters used as absorption
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
US4791196A (en) * 1986-09-26 1988-12-13 Sankyo Company Limited Crystalline cephem carboxylic acid addition salt

Also Published As

Publication number Publication date
AU615509B2 (en) 1991-10-03
NL192266C (nl) 1997-04-03
DK162054C (da) 1992-02-10
DE3901359C2 (es) 1992-04-30
DK162054B (da) 1991-09-09
AU2862389A (en) 1989-07-20
SE505258C2 (sv) 1997-07-21
PT89474A (pt) 1990-02-08
NZ227605A (en) 1991-06-25
IE67447B1 (en) 1996-04-03
FR2626003A1 (fr) 1989-07-21
YU221188A (en) 1990-04-30
SK281768B6 (sk) 2001-07-10
FI890213A0 (fi) 1989-01-16
CZ281602B6 (cs) 1996-11-13
CA1298288C (en) 1992-03-31
DK20789A (da) 1989-07-20
GB8901073D0 (en) 1989-03-15
CZ24389A3 (en) 1996-08-14
FI86854C (fi) 1992-10-26
IT8947539A0 (it) 1988-01-17
LU87432A1 (fr) 1989-08-30
GR1001218B (el) 1993-06-21
ATA8589A (de) 1994-12-15
NL8900111A (nl) 1989-08-16
JPH0725768B2 (ja) 1995-03-22
US4910301A (en) 1990-03-20
HU205940B (en) 1992-07-28
PT89474B (pt) 1993-12-31
ZA89407B (en) 1989-09-27
SG75492G (en) 1992-10-02
DK20789D0 (da) 1989-01-18
DD283397A5 (de) 1990-10-10
SE8900173D0 (sv) 1989-01-18
BE1002749A5 (fr) 1991-05-28
GB2213819B (en) 1991-11-27
FI86854B (fi) 1992-07-15
IT1229528B (it) 1991-09-04
OA09227A (fr) 1992-06-30
GB2213819A (en) 1989-08-23
KR890011895A (ko) 1989-08-23
DD284807A5 (de) 1990-11-28
EG18749A (en) 1993-12-30
DE3901359A1 (de) 1989-10-05
SK24389A3 (en) 2000-12-11
HK72292A (en) 1992-10-02
NL192266B (nl) 1996-12-02
CY1663A (en) 1993-05-14
HUT50347A (en) 1990-01-29
FI890213L (fi) 1989-07-20
SE8900173L (en) 1989-01-18
AT399878B (de) 1995-08-25
FR2626003B1 (fr) 1992-10-16
IE890144L (en) 1989-07-19
JPH029885A (ja) 1990-01-12
KR950003612B1 (ko) 1995-04-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20090117