ES2017277A6 - Un procedimiento para la preparacion de nuevos agentes iodados no ionicos de contraste. - Google Patents
Un procedimiento para la preparacion de nuevos agentes iodados no ionicos de contraste.Info
- Publication number
- ES2017277A6 ES2017277A6 ES8903184A ES8903184A ES2017277A6 ES 2017277 A6 ES2017277 A6 ES 2017277A6 ES 8903184 A ES8903184 A ES 8903184A ES 8903184 A ES8903184 A ES 8903184A ES 2017277 A6 ES2017277 A6 ES 2017277A6
- Authority
- ES
- Spain
- Prior art keywords
- ionic
- formula
- iodated
- preparation
- contrast media
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002872 contrast media Substances 0.000 title abstract 2
- 229940039231 contrast media Drugs 0.000 title abstract 2
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- FOLYKNXDLNPWGC-UHFFFAOYSA-N 1-chloro-3-methoxypropan-2-ol Chemical compound COCC(O)CCl FOLYKNXDLNPWGC-UHFFFAOYSA-N 0.000 abstract 1
- -1 2-hydroxyethyl halide Chemical class 0.000 abstract 1
- JJKWHOSQTYYFAE-UHFFFAOYSA-N 2-methoxyacetyl chloride Chemical compound COCC(Cl)=O JJKWHOSQTYYFAE-UHFFFAOYSA-N 0.000 abstract 1
- KQIGMPWTAHJUMN-UHFFFAOYSA-N 3-aminopropane-1,2-diol Chemical compound NCC(O)CO KQIGMPWTAHJUMN-UHFFFAOYSA-N 0.000 abstract 1
- FBJVWRITWDYUAC-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarbonyl chloride Chemical compound NC1=C(I)C(C(Cl)=O)=C(I)C(C(Cl)=O)=C1I FBJVWRITWDYUAC-UHFFFAOYSA-N 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000003690 nonionic contrast media Substances 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS AGENTES IODADOS NO IONICOS DE CONTRASTE. UN PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS AGENTES IODADOS NO IONICOS DE CONTRATES, DE FOMULA (1), DONDE R ES -CHSI2CHSI2OH O -CHSI2CH(OH)-CHSI2-OCHSI3. EL PROCEDIMIENTO COMPRENDE LA REACCION DEL CLORURO DEL ACIDO 2,4,6-TRIIODO-5-AMINO-ISOFTALICO CON EL CLORURO DE METOXIACETILO PARA DAR UN DICLORURO DE FORMULA (3) QUE SE TRATA CON 3-AMINO-1,2-PROPANODIOL Y TRIETILAMINA PARA DAR UNA DIAMIDA DE FORMULA (4) QUE PUEDE REACCIONAR CON UN HALURO DE 2-HIDROXIETILO O ALTERNATIVAMENTE CON 3-CLORO-1-METOXI-2-PROPANOL PARA DAR LOS COMPUESTOS DE FORMULA (1). LOS COMPUESTOS DE FORMULA (1) SON COMPUESTOS IODADOS NO IONICOS UTILES EN EL DIAGNOSTICO RADIOLOGICO.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8903184A ES2017277A6 (es) | 1989-09-20 | 1989-09-20 | Un procedimiento para la preparacion de nuevos agentes iodados no ionicos de contraste. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8903184A ES2017277A6 (es) | 1989-09-20 | 1989-09-20 | Un procedimiento para la preparacion de nuevos agentes iodados no ionicos de contraste. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2017277A6 true ES2017277A6 (es) | 1991-01-16 |
Family
ID=8263971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8903184A Expired - Lifetime ES2017277A6 (es) | 1989-09-20 | 1989-09-20 | Un procedimiento para la preparacion de nuevos agentes iodados no ionicos de contraste. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2017277A6 (es) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4109169A1 (de) * | 1991-03-20 | 1992-09-24 | Koehler Chemie Dr Franz | Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung |
| ES2073370A1 (es) * | 1992-10-27 | 1995-08-01 | Zambon Spa | Procedimiento para la preparacion del compuesto bis-(1,3-dihidroxi-propilamida) del acido l-5-(2-acetoxi-propionilamino)-2,4,6-triyodo-isoftalico. |
| ES2136011A1 (es) * | 1996-03-29 | 1999-11-01 | Bracco Int Bv | Procedimiento para la preparacion de un intermedio util en la sintesis de medios de contraste yodados. |
| EP4001261A1 (en) | 2020-11-23 | 2022-05-25 | Justesa Imagen S.A.U | Procedure for obtaining high purity iohexol |
-
1989
- 1989-09-20 ES ES8903184A patent/ES2017277A6/es not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4109169A1 (de) * | 1991-03-20 | 1992-09-24 | Koehler Chemie Dr Franz | Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung |
| ES2073370A1 (es) * | 1992-10-27 | 1995-08-01 | Zambon Spa | Procedimiento para la preparacion del compuesto bis-(1,3-dihidroxi-propilamida) del acido l-5-(2-acetoxi-propionilamino)-2,4,6-triyodo-isoftalico. |
| ES2136011A1 (es) * | 1996-03-29 | 1999-11-01 | Bracco Int Bv | Procedimiento para la preparacion de un intermedio util en la sintesis de medios de contraste yodados. |
| EP4001261A1 (en) | 2020-11-23 | 2022-05-25 | Justesa Imagen S.A.U | Procedure for obtaining high purity iohexol |
| WO2022106715A1 (en) | 2020-11-23 | 2022-05-27 | Justesa Imagen S.A.U. | Procedure for obtaining high purity iohexol |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2009-09-20 |