ES2018729A6 - Un metodo para preparar una variante de activador de plasmogeno de tejido. - Google Patents

Un metodo para preparar una variante de activador de plasmogeno de tejido.

Info

Publication number
ES2018729A6
ES2018729A6 ES8903004A ES8903004A ES2018729A6 ES 2018729 A6 ES2018729 A6 ES 2018729A6 ES 8903004 A ES8903004 A ES 8903004A ES 8903004 A ES8903004 A ES 8903004A ES 2018729 A6 ES2018729 A6 ES 2018729A6
Authority
ES
Spain
Prior art keywords
plasminogen activator
tissue plasminogen
variant
zymogenic
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8903004A
Other languages
English (en)
Inventor
Stephen Anderson
William F Bennett
David Botstein
Deborah L Higgins
Nicholas F Paoni
Mark Zoller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES2018729A6 publication Critical patent/ES2018729A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN METODO PARA PREPARAR UNA VARIANTE DE ACTIVADOR DE PLASMINOGENO DE TEJIDO. SE PREPARAN ZIMOGENOS Y VARIANTES DE ACTIVADOR DE PLASMINOGENO DE TEJIDO (T-PA) INCLUYENDO UNA VARIANTE ACTIVA FIBRINOLITICAMENTE DE T-PA QUE TIENE UNA ALTERACION HACE ZIMOGENICA A LA VARIANTE EN PRESENCIA DE FIBRINOGENO DEGRADADO POR PLASMINA, Y/O ESPECIFICA PARA FIBRINA (O PARA UN COAGULO DE PLASMA), EN COMPARACION CON EL CORRESPONDIENTE T-PA DE TIPO SILVESTRE. SE PUEDEN PREPARAR SECUENCIAS DE ADN QUE CODIFICAN LOS ZIMOGENOS Y LAS VARIANTES ASI COMO VECTORES DE EXPRESION QUE INCORPORAN LAS SECUENCIAS DE ADN, Y CELULAS HOSPEDANTES TRANSFORMADAS CON LOS VECTORES DE EXPRESION. LOS ZIMOGENOS Y LAS VARIANTES SE PUEDEN UTILIZAR EN UN PREPARADO FARMACEUTICO PARA TRATAR UNA ENFERMEDAD O CONDICION VASCULAR O PARA PREVENIR LA DEPOSICION DE FIBRINA O LA FORMACION O REFORMACION DE ADHERENCIAS EN MAMIFEROS.
ES8903004A 1988-09-02 1989-09-01 Un metodo para preparar una variante de activador de plasmogeno de tejido. Expired - Lifetime ES2018729A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24085688A 1988-09-02 1988-09-02
US07/384,608 US5108901A (en) 1988-09-02 1989-07-24 Tissue plasminogen activator having zymogenic or fibrin specific properties

Publications (1)

Publication Number Publication Date
ES2018729A6 true ES2018729A6 (es) 1991-05-01

Family

ID=26933781

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8903004A Expired - Lifetime ES2018729A6 (es) 1988-09-02 1989-09-01 Un metodo para preparar una variante de activador de plasmogeno de tejido.

Country Status (17)

Country Link
US (1) US5108901A (es)
EP (1) EP0457758B1 (es)
JP (1) JP2794028B2 (es)
KR (1) KR0148575B1 (es)
AT (1) ATE124452T1 (es)
AU (1) AU626323B2 (es)
CA (1) CA1341484C (es)
DE (1) DE68923298T2 (es)
DK (1) DK175958B1 (es)
ES (1) ES2018729A6 (es)
FI (1) FI109359B (es)
HU (1) HU213922B (es)
IE (1) IE67508B1 (es)
IL (1) IL91306A (es)
NO (1) NO310778B1 (es)
NZ (1) NZ230509A (es)
WO (1) WO1990002798A1 (es)

Families Citing this family (32)

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Publication number Priority date Publication date Assignee Title
US5736134A (en) * 1985-04-22 1998-04-07 Genentech, In.C Tissue plasminogen activator variants
US5756093A (en) * 1985-04-22 1998-05-26 Genentech, Inc. Tissue plasminogen activator variants
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5156969A (en) * 1988-09-02 1992-10-20 Genentech Inc. Tissue plasminogen activator variant with deletion of amino acids 466-470 having fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DK0462207T3 (da) * 1989-03-06 2001-06-18 Univ Texas t-Pa mutanter resistente mod deres respektive inhibitorer
US5866413A (en) * 1989-03-06 1999-02-02 Board Of Regents Of The University Of Texas System Pai-1 mutants
US5550042A (en) * 1989-03-06 1996-08-27 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
US5304482A (en) * 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
DE69333127T2 (de) * 1992-06-03 2004-05-06 Genentech, Inc., South San Francisco Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung
US5472692A (en) * 1993-07-02 1995-12-05 New England Deaconess Hospital Corporation Pro-urokinase mutants
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5759775A (en) 1994-10-27 1998-06-02 Genetech, Inc. Methods for detecting nucleic acids encoding AL--1 neurotrophic factor
ZA966663B (en) 1995-08-17 1998-02-06 Genentech Inc Traf Inhibitors.
US6610296B2 (en) 1995-10-26 2003-08-26 Genentech, Inc. Methods of enhancing cognitive function using an AL-1 neurotrophic factor immunoadhesin
AU735519B2 (en) * 1996-11-12 2001-07-12 Scripps Research Institute, The Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
US20040241645A1 (en) * 1997-01-31 2004-12-02 Genentech, Inc. O-fucosyltransferase
JP3394540B2 (ja) 1997-01-31 2003-04-07 ジェネンテク・インコーポレイテッド Ｏ−フコシルトランスフェラーゼ
WO1999009184A1 (de) * 1997-08-13 1999-02-25 Roche Diagnostics Gmbh Plasminogenaktivator mit verbesserter zymogenität und verminderter fibrinbindung
WO1999009185A1 (de) * 1997-08-13 1999-02-25 Roche Diagnostics Gmbh Plasminogenaktivator mit verbesserter zymogenität
KR100408844B1 (ko) * 2000-07-29 2003-12-06 한국산업기술평가원 동물세포 발현벡터
US20060104969A1 (en) * 2004-08-16 2006-05-18 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
US8969295B2 (en) * 2006-04-14 2015-03-03 Massachusetts Institute Of Technology Identifying and modulating molecular pathways that mediate nervous system plasticity
WO2008014054A2 (en) * 2006-07-27 2008-01-31 Centocor, Inc. Bmp-7 variant compositions, methods and uses
WO2015023830A1 (en) 2013-08-14 2015-02-19 Stc.Unm Treatment and prevention of stroke and other neurological disorders
EP3708226A1 (en) 2014-11-03 2020-09-16 Thrombolytic Science, LLC Methods and compositions for safe and effective thrombolysis
WO2018232305A1 (en) 2017-06-16 2018-12-20 Thrombolytic Science, Llc Methods and compositions for thrombolysis

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
EP0112122B1 (en) * 1982-12-14 1991-08-28 South African Inventions Development Corporation Plasminogen activator
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
AU596356B2 (en) * 1985-04-22 1990-05-03 Genentech Inc. Novel human tissue plasminogen activator mutants
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
DK623186A (da) * 1985-12-23 1987-08-26 Chiron Corp Polypeptid med vaevsplasminogen-aktivator-virkning
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
JP2527454B2 (ja) * 1986-01-31 1996-08-21 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド 新しい血栓溶解タンパク質
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
DK345087A (da) * 1986-07-11 1988-01-12 Novo Industri As Modificeret vaevsplasminogenaktivator
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
GB8705377D0 (en) * 1987-03-07 1987-04-08 Beecham Group Plc Compounds
EP0292009A1 (en) * 1987-05-22 1988-11-23 Zymogenetics, Inc. Fibrinolytic proteins
ATE118815T1 (de) * 1987-06-04 1995-03-15 Zymogenetics Inc Gewebs-plasminogen-aktivator-analoge mit modifizierten wachstumsfaktordomänen.
ATE110772T1 (de) * 1987-06-04 1994-09-15 Zymogenetics Inc Mutierter t-pa mit kringle-ersatz.
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
HUT51901A (en) * 1987-06-22 1990-06-28 Genetics Inst Process for production of new trombolitic ensimes
EP0394261A4 (en) * 1987-07-06 1991-09-11 Genetics Institute, Inc. Novel thrombolytic proteins
AU1893988A (en) * 1987-07-13 1989-01-19 Collaborative Research Inc. Nonglycosylated plasminogen activator and method of preparation
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner

Also Published As

Publication number Publication date
FI109359B (fi) 2002-07-15
DK36991A (da) 1991-05-02
NO310778B1 (no) 2001-08-27
CA1341484C (en) 2005-05-24
HK1007334A1 (en) 1999-04-09
NZ230509A (en) 1991-06-25
EP0457758A1 (en) 1991-11-27
DE68923298D1 (de) 1995-08-03
WO1990002798A1 (en) 1990-03-22
HU896005D0 (en) 1991-07-29
US5108901A (en) 1992-04-28
EP0457758B1 (en) 1995-06-28
NO910811D0 (no) 1991-02-28
JP2794028B2 (ja) 1998-09-03
DK175958B1 (da) 2005-08-29
DK36991D0 (da) 1991-03-01
IE892650L (en) 1990-03-02
HU213922B (en) 1997-11-28
KR0148575B1 (ko) 1998-10-15
KR900702019A (ko) 1990-12-05
DE68923298T2 (de) 1996-01-11
FI911049A0 (fi) 1991-03-01
JPH04500157A (ja) 1992-01-16
NO910811L (no) 1991-02-28
IL91306A (en) 1997-08-14
ATE124452T1 (de) 1995-07-15
HUT58812A (en) 1992-03-30
AU4194689A (en) 1990-04-02
IL91306A0 (en) 1990-03-19
AU626323B2 (en) 1992-07-30
IE67508B1 (en) 1996-04-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100623