ES2018967A6 - Procedimiento de preparacion del acido 2-(2-(4-n(4-clorofenil)fenilmeti-piperazinil etoxin-acetico y de su dihidrocloruro. - Google Patents

Procedimiento de preparacion del acido 2-(2-(4-n(4-clorofenil)fenilmeti-piperazinil etoxin-acetico y de su dihidrocloruro.

Info

Publication number
ES2018967A6
ES2018967A6 ES8903974A ES8903974A ES2018967A6 ES 2018967 A6 ES2018967 A6 ES 2018967A6 ES 8903974 A ES8903974 A ES 8903974A ES 8903974 A ES8903974 A ES 8903974A ES 2018967 A6 ES2018967 A6 ES 2018967A6
Authority
ES
Spain
Prior art keywords
piperazine
preparation
ethoxyacetic acid
alkaline metal
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8903974A
Other languages
English (en)
Spanish (es)
Inventor
Guy Bodson
Eric Cossement
Jean Gobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Publication of ES2018967A6 publication Critical patent/ES2018967A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES8903974A 1988-11-23 1989-11-22 Procedimiento de preparacion del acido 2-(2-(4-n(4-clorofenil)fenilmeti-piperazinil etoxin-acetico y de su dihidrocloruro. Expired - Lifetime ES2018967A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827390A GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (1)

Publication Number Publication Date
ES2018967A6 true ES2018967A6 (es) 1991-05-16

Family

ID=10647346

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8903974A Expired - Lifetime ES2018967A6 (es) 1988-11-23 1989-11-22 Procedimiento de preparacion del acido 2-(2-(4-n(4-clorofenil)fenilmeti-piperazinil etoxin-acetico y de su dihidrocloruro.

Country Status (17)

Country Link
KR (1) KR970009727B1 (fr)
AT (1) AT398970B (fr)
CA (1) CA1320732C (fr)
CY (1) CY1696A (fr)
DK (1) DK174289B1 (fr)
ES (1) ES2018967A6 (fr)
FI (1) FI91861C (fr)
GB (2) GB8827390D0 (fr)
GR (1) GR1000576B (fr)
HK (1) HK45493A (fr)
HU (1) HU208002B (fr)
NO (1) NO172287C (fr)
PH (1) PH26334A (fr)
PL (1) PL161374B1 (fr)
PT (1) PT92363B (fr)
RU (1) RU1838306C (fr)
SG (1) SG12793G (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2128556T3 (es) * 1992-09-24 1999-05-16 Sepracor Inc Tratamiento transdermico de la urticaria usando (+)-cetirizina opticamente pura.
JPH08501561A (ja) * 1992-09-24 1996-02-20 セプラコア，インコーポレイテッド （−）セチリジンを用いたアレルギー疾患の治療のための組成物
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
CA2180993A1 (fr) * 1996-07-11 1998-01-12 Yong Tao Methodes pour la preparation de cetirizine
EP0919550A1 (fr) 1997-11-26 1999-06-02 Ucb, S.A. Formes pseudopolymorphiques de l'acide 2-2-4-bis(4-fluorophényl)méthyl -1-pipérazinyl-éthoxy acétique dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
DK176706B1 (da) * 1999-03-04 2009-03-30 Sandoz As Fremgangsmåde til fremstilling af 2-{2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy}-eddikesyre-forbindelser eller salte deraf
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
WO2003104211A2 (fr) * 2002-06-05 2003-12-18 Dr. Reddy's Laboratories Limited Dichlorhydrate cristallin d'acide acetique [2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl] ethoxy]
EP1590323A2 (fr) 2003-01-23 2005-11-02 Ucb Farchim, S.A. Nouveaux derives de piperazine et leur utilisation comme intermediaires de synthese
WO2004103982A1 (fr) * 2003-05-21 2004-12-02 Wockhardt Limited Monochlorhydrate d'acide 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetique utile comme compose anti-allergenique et son procede de production
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817231A (en) * 1956-01-27 1959-07-29 Henri Morren New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof
US3090725A (en) * 1960-02-29 1963-05-21 Burroughs Wellcome Co Phosphorylated quaternary ammonium compounds of improved oral absorption
FI75816C (fi) * 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.

Also Published As

Publication number Publication date
GB2225320A (en) 1990-05-30
CA1320732C (fr) 1993-07-27
PT92363A (pt) 1990-05-31
FI895563A0 (fi) 1989-11-22
PT92363B (pt) 1995-07-18
HU896130D0 (en) 1990-02-28
CY1696A (en) 1994-01-14
GR890100771A (en) 1990-12-31
HK45493A (en) 1993-05-21
NO894650D0 (no) 1989-11-22
GB8827390D0 (en) 1988-12-29
FI91861B (fi) 1994-05-13
ATA266489A (de) 1994-07-15
AT398970B (de) 1995-02-27
DK586589D0 (da) 1989-11-22
RU1838306C (ru) 1993-08-30
PH26334A (en) 1992-04-29
GR1000576B (el) 1992-08-26
PL161374B1 (pl) 1993-06-30
FI91861C (fi) 1994-08-25
NO172287B (no) 1993-03-22
GB8926242D0 (en) 1990-01-10
KR900007824A (ko) 1990-06-02
GB2225320B (en) 1992-09-02
SG12793G (en) 1993-04-16
HUT53626A (en) 1990-11-28
HU208002B (en) 1993-07-28
DK174289B1 (da) 2002-11-18
KR970009727B1 (ko) 1997-06-17
NO894650L (no) 1990-05-25
NO172287C (no) 1993-06-30
DK586589A (da) 1990-05-24

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2009-11-22

FD1A Patent lapsed

Effective date: 20100803