GR1000576B - Μεθοδος παρασκευης του 2-(2-(4-((4-χλωροφενυλ)φενυλμεθυλ)-1-πιπεραζινυλ)εθοξυ)οξικου οξεος και του διυδροχλωρικου αλατιου του. - Google Patents
Μεθοδος παρασκευης του 2-(2-(4-((4-χλωροφενυλ)φενυλμεθυλ)-1-πιπεραζινυλ)εθοξυ)οξικου οξεος και του διυδροχλωρικου αλατιου του.Info
- Publication number
- GR1000576B GR1000576B GR890100771A GR890100771A GR1000576B GR 1000576 B GR1000576 B GR 1000576B GR 890100771 A GR890100771 A GR 890100771A GR 890100771 A GR890100771 A GR 890100771A GR 1000576 B GR1000576 B GR 1000576B
- Authority
- GR
- Greece
- Prior art keywords
- piperazinyl
- chlorophenyl
- ethoxy
- preparing
- acetic acid
- Prior art date
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 title 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888827390A GB8827390D0 (en) | 1988-11-23 | 1988-11-23 | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GR890100771A GR890100771A (en) | 1990-12-31 |
| GR1000576B true GR1000576B (el) | 1992-08-26 |
Family
ID=10647346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR890100771A GR1000576B (el) | 1988-11-23 | 1989-11-20 | Μεθοδος παρασκευης του 2-(2-(4-((4-χλωροφενυλ)φενυλμεθυλ)-1-πιπεραζινυλ)εθοξυ)οξικου οξεος και του διυδροχλωρικου αλατιου του. |
Country Status (17)
| Country | Link |
|---|---|
| KR (1) | KR970009727B1 (fr) |
| AT (1) | AT398970B (fr) |
| CA (1) | CA1320732C (fr) |
| CY (1) | CY1696A (fr) |
| DK (1) | DK174289B1 (fr) |
| ES (1) | ES2018967A6 (fr) |
| FI (1) | FI91861C (fr) |
| GB (2) | GB8827390D0 (fr) |
| GR (1) | GR1000576B (fr) |
| HK (1) | HK45493A (fr) |
| HU (1) | HU208002B (fr) |
| NO (1) | NO172287C (fr) |
| PH (1) | PH26334A (fr) |
| PL (1) | PL161374B1 (fr) |
| PT (1) | PT92363B (fr) |
| RU (1) | RU1838306C (fr) |
| SG (1) | SG12793G (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2122042T3 (es) * | 1992-09-24 | 1998-12-16 | Sepracor Inc | Tratamiento de rinitis alergica y asma que emplea (-)cetirizina. |
| ES2128556T3 (es) * | 1992-09-24 | 1999-05-16 | Sepracor Inc | Tratamiento transdermico de la urticaria usando (+)-cetirizina opticamente pura. |
| BE1010094A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues. |
| BE1010095A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels. |
| CA2180993A1 (fr) * | 1996-07-11 | 1998-01-12 | Yong Tao | Methodes pour la preparation de cetirizine |
| EP0919550A1 (fr) * | 1997-11-26 | 1999-06-02 | Ucb, S.A. | Formes pseudopolymorphiques de l'acide 2-2-4-bis(4-fluorophényl)méthyl -1-pipérazinyl-éthoxy acétique dihydrochloride |
| IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
| DK176706B1 (da) * | 1999-03-04 | 2009-03-30 | Sandoz As | Fremgangsmåde til fremstilling af 2-{2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy}-eddikesyre-forbindelser eller salte deraf |
| US6265579B1 (en) * | 1999-10-29 | 2001-07-24 | Salsbury Chemicals, Inc. | Process for preparing piperazine-substituted aliphatic carboxylates |
| US7199241B1 (en) | 2001-05-29 | 2007-04-03 | Ucb, S.A. | Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
| US6977301B1 (en) | 2001-05-29 | 2005-12-20 | Ucb, S.A. | Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
| WO2003104212A1 (fr) * | 2002-06-05 | 2003-12-18 | Dr.Reddy's Laboratories Ltd. | Nouvelle forme amorphe de l'acide [2-[4-[(4-chlorophenyl)-phenyl methyl]-1- piperazinyl] ethoxy] acetique dihydrochloride (cetirizine dihydrochloride) |
| US7381821B2 (en) | 2003-01-23 | 2008-06-03 | Ucb, S.A. | Piperazine derivatives and their use as synthesis intermediates |
| AU2003228011A1 (en) * | 2003-05-21 | 2004-12-13 | Wockhardt Limited | 2-(2-(4-((4-chlorophenyl) phenylmethyl)-1-piperazinyl)ethoxy)acetic acid monohydrochloride as anti-allergenic compound and process for its production |
| WO2010046908A2 (fr) | 2008-09-17 | 2010-04-29 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Nouveau procédé aqueux pour la synthèse de diphénylméthylpipérazines substituées |
| KR101418404B1 (ko) | 2012-01-06 | 2014-07-10 | 한미약품 주식회사 | 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제 |
| KR102226833B1 (ko) | 2013-06-28 | 2021-03-12 | 한미약품 주식회사 | 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB817231A (en) * | 1956-01-27 | 1959-07-29 | Henri Morren | New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof |
| US3090725A (en) * | 1960-02-29 | 1963-05-21 | Burroughs Wellcome Co | Phosphorylated quaternary ammonium compounds of improved oral absorption |
| FI75816C (fi) * | 1981-02-06 | 1988-08-08 | Ucb Sa | Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid. |
-
1988
- 1988-11-23 GB GB888827390A patent/GB8827390D0/en active Pending
-
1989
- 1989-09-29 CA CA000614708A patent/CA1320732C/fr not_active Expired - Fee Related
- 1989-11-20 GR GR890100771A patent/GR1000576B/el not_active IP Right Cessation
- 1989-11-21 PT PT92363A patent/PT92363B/pt not_active IP Right Cessation
- 1989-11-21 GB GB8926242A patent/GB2225320B/en not_active Expired - Lifetime
- 1989-11-22 PL PL1989282411A patent/PL161374B1/pl unknown
- 1989-11-22 NO NO894650A patent/NO172287C/no not_active IP Right Cessation
- 1989-11-22 FI FI895563A patent/FI91861C/fi not_active IP Right Cessation
- 1989-11-22 DK DK198905865A patent/DK174289B1/da not_active IP Right Cessation
- 1989-11-22 ES ES8903974A patent/ES2018967A6/es not_active Expired - Lifetime
- 1989-11-22 AT AT0266489A patent/AT398970B/de not_active IP Right Cessation
- 1989-11-22 RU SU894742406A patent/RU1838306C/ru active
- 1989-11-22 HU HU896130A patent/HU208002B/hu not_active IP Right Cessation
- 1989-11-23 PH PH39569A patent/PH26334A/en unknown
- 1989-11-23 KR KR1019890017039A patent/KR970009727B1/ko not_active Expired - Fee Related
-
1993
- 1993-02-06 SG SG127/93A patent/SG12793G/en unknown
- 1993-05-13 HK HK454/93A patent/HK45493A/xx not_active IP Right Cessation
-
1994
- 1994-01-14 CY CY160694A patent/CY1696A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU1838306C (ru) | 1993-08-30 |
| NO172287B (no) | 1993-03-22 |
| PT92363A (pt) | 1990-05-31 |
| NO894650D0 (no) | 1989-11-22 |
| PH26334A (en) | 1992-04-29 |
| SG12793G (en) | 1993-04-16 |
| PL161374B1 (pl) | 1993-06-30 |
| AT398970B (de) | 1995-02-27 |
| NO172287C (no) | 1993-06-30 |
| KR970009727B1 (ko) | 1997-06-17 |
| CA1320732C (fr) | 1993-07-27 |
| FI91861C (fi) | 1994-08-25 |
| DK586589D0 (da) | 1989-11-22 |
| PT92363B (pt) | 1995-07-18 |
| DK586589A (da) | 1990-05-24 |
| HUT53626A (en) | 1990-11-28 |
| HU208002B (en) | 1993-07-28 |
| FI895563A0 (fi) | 1989-11-22 |
| CY1696A (en) | 1994-01-14 |
| GR890100771A (en) | 1990-12-31 |
| HU896130D0 (en) | 1990-02-28 |
| GB2225320B (en) | 1992-09-02 |
| NO894650L (no) | 1990-05-25 |
| DK174289B1 (da) | 2002-11-18 |
| GB2225320A (en) | 1990-05-30 |
| KR900007824A (ko) | 1990-06-02 |
| FI91861B (fi) | 1994-05-13 |
| ATA266489A (de) | 1994-07-15 |
| ES2018967A6 (es) | 1991-05-16 |
| HK45493A (en) | 1993-05-21 |
| GB8827390D0 (en) | 1988-12-29 |
| GB8926242D0 (en) | 1990-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |