ES2026251T3 - Procedimiento para la produccion de ibuprofeno. - Google Patents

Procedimiento para la produccion de ibuprofeno.

Info

Publication number
ES2026251T3
ES2026251T3 ES198888302410T ES88302410T ES2026251T3 ES 2026251 T3 ES2026251 T3 ES 2026251T3 ES 198888302410 T ES198888302410 T ES 198888302410T ES 88302410 T ES88302410 T ES 88302410T ES 2026251 T3 ES2026251 T3 ES 2026251T3
Authority
ES
Spain
Prior art keywords
paladium
ibpe
molar
ions
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888302410T
Other languages
English (en)
Inventor
Varadaraj Elango
Mark Alan Murphy
Brad Lee Smith
Kenneth G. Davenport
Graham N. Mott
Gary L. Moss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CNA Holdings LLC
Original Assignee
Hoechst Celanese Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Celanese Corp filed Critical Hoechst Celanese Corp
Application granted granted Critical
Publication of ES2026251T3 publication Critical patent/ES2026251T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/10—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide
    • C07C51/12—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide on an oxygen-containing group in organic compounds, e.g. alcohols
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
    • B01J2231/34—Other additions, e.g. Monsanto-type carbonylations, addition to 1,2-C=X or 1,2-C-X triplebonds, additions to 1,4-C=C-C=X or 1,4-C=-C-X triple bonds with X, e.g. O, S, NH/N
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN METODO PARA LA PREPARACION DE IBUPROFENO POR CARBONILACION DE 1-(4''-ISOBUTILFENIL) ETANOL (IBPE) CON MONOXIDO DE CARBONO EN UN MEDIO ACUOSO ACIDO, ES DECIR, CONTENIENDO AL MENOS 10% DE AGUA BASADO EN EL PESO DEL IBPE INICIALMENTE AÑADIDO, A UNA TEMPERATURA DE AL MENOS 10 GRADOS C Y UNA PRESION DE MONOXIDO DE CARBONO DE AL MENOS 500 PSIG, Y EN PRESENCIA DE (1) UN CATALIZADOR CONSISTENTE ESENCIALMENTE EN UN COMPUESTO DE PALADIO EN EL QUE EL PALADIO TIENE UNA VALENCIA DE 0 A 2 Y ESTA COMPLEJADO CON AL MENOS UN LIGANDO DE FOSFINA MONODENTADO MISCIBLE CON LA FASE ORGANICA DEL MEDIO DE REACCION, SIENDO LA RELACION MOLAR DE FOSFORO/PALADIO EN DICHO COMPUESTO DE PALADIO Y LIGANDO AL MENOS DE 2:1 CUANDO LA RELACION MOLAR PALADIO/IBPE ESTA POR DEBAJO DE 1:10000; (2) IONES HIDROGENOS DISOCIADOS DE UN ACIDO QUE ES SUSTANCIALMENTE COMPLETAMENTE IONIZABLE EN SOLUCION ACUOSA DISLUIDA TAL QUE LA RELACION MOLAR DE IONES HIDROGENO A IBPE A/ADIDO A LA ZONA DE REACCION ES AL MENOS 0,15 Y LA RELACION MOLAR DE IONES HIDROGENO A AGUA ES AL MEOS 0,026 Y (3) IONES HALURO DISOCIADOS TAL QUE LA RELACION MOLAR DE IONES HALURO A IBPE AÑADIDO ES AL MENOS 0,15
ES198888302410T 1987-03-20 1988-03-18 Procedimiento para la produccion de ibuprofeno. Expired - Lifetime ES2026251T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2851487A 1987-03-20 1987-03-20
US15814188A 1988-03-04 1988-03-04

Publications (1)

Publication Number Publication Date
ES2026251T3 true ES2026251T3 (es) 1992-04-16

Family

ID=26703780

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888302410T Expired - Lifetime ES2026251T3 (es) 1987-03-20 1988-03-18 Procedimiento para la produccion de ibuprofeno.

Country Status (22)

Country Link
EP (1) EP0284310B1 (es)
JP (1) JPH0686403B2 (es)
KR (1) KR960007822B1 (es)
CN (1) CN1029679C (es)
AU (1) AU620322B2 (es)
BR (1) BR8801238A (es)
CA (1) CA1329396C (es)
DE (1) DE3864713D1 (es)
DK (1) DK148488A (es)
ES (1) ES2026251T3 (es)
FI (1) FI90861C (es)
GR (1) GR3002693T3 (es)
HU (1) HU200983B (es)
IE (1) IE60502B1 (es)
IL (1) IL85736A (es)
MX (1) MX168833B (es)
NO (1) NO169890C (es)
NZ (1) NZ223950A (es)
PL (1) PL153826B1 (es)
PT (1) PT87014B (es)
SG (1) SG22892G (es)
YU (1) YU46539B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981995A (en) * 1987-03-20 1991-01-01 Varadaraj Elango Method for producing ibuprofen
CA1338673C (en) * 1988-04-15 1996-10-22 Graham N. Mott Catalyst recycle in the carbonylation of isobutylphenylethanol to ibuprofen
JP2782080B2 (ja) * 1989-03-06 1998-07-30 日本石油化学株式会社 α―（３―ベンゾイルフェニル）プロピオン酸誘導体の製造方法
HU209123B (en) * 1990-06-04 1994-03-28 Hoechst Celanese Corp Process for producing 2-(4'-isobutylphenyl)-propionic acid
US5166418A (en) * 1990-06-04 1992-11-24 Hoechst Celanese Corporation Method for producing ibuprofen
US5179229A (en) * 1992-04-24 1993-01-12 Hoechst Celanese Corporation Preparation of 2,2-diorgano-3-arylpropionic acids and esters thereof
US5315030A (en) * 1993-09-29 1994-05-24 Ethyl Corporation Catalytic carbonylation of ethers and thioethers
US5482596A (en) * 1994-01-27 1996-01-09 Albemarle Corporation Mixed ligand catalyst for preparing aryl-substituted aliphatic carboxylic esters
EP0701987A1 (de) 1994-09-16 1996-03-20 Cu Chemie Uetikon Ag Verfahren zur Herstellung von aromatischen Ketonen
US6268526B1 (en) 1998-12-16 2001-07-31 Albemarle Corporation Palladium catalyzed carbonylation process utilizing aromatic substituted alcohols and/or aromatic substituted alkyl halides
CN1309700C (zh) * 2005-05-27 2007-04-11 中国科学院上海有机化学研究所 一种制备2－芳基乳酸酯及萘普生、布洛芬的方法
CN102329194A (zh) * 2011-07-15 2012-01-25 浙江工业大学 一种布洛芬中间体对异丁基苯乙醇的制备方法
CN103254070B (zh) * 2013-02-03 2014-11-05 青岛科技大学 一种由1-(4-异丁基苯基)乙醇制备2-(4-异丁基苯基)丙酸酯的方法
JP7472133B2 (ja) * 2018-12-03 2024-04-22 ビーエーエスエフ ソシエタス・ヨーロピア 銅を含む触媒組成物の存在下で１－（４－イソブチルフェニル）エタノンの水素化により１－（４－イソブチルフェニル）エタノールを製造する方法
CN111689847B (zh) * 2020-06-12 2022-05-17 浙江新和成股份有限公司 芳基丙酸类化合物的制备方法
EP4423045A1 (en) * 2021-10-28 2024-09-04 Centre National de la Recherche Scientifique Process for preparing acyl derivatives
CN114195633A (zh) * 2021-12-24 2022-03-18 浙江新和成股份有限公司 一种布洛芬杂质f的合成方法
CN116392986B (zh) * 2023-06-09 2023-08-04 北京思达流体科技有限公司 1-(4-异丁基苯基)乙醇羰基化的连续化生产系统及操作方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6702884A (es) * 1966-03-22 1967-09-25
SE364254B (es) * 1967-04-05 1974-02-18 Monsanto Co
JPS5995238A (ja) * 1982-11-19 1984-06-01 Mitsubishi Petrochem Co Ltd フエニル酢酸誘導体の製造法
EP0124160B1 (en) * 1983-05-02 1986-09-17 Shell Internationale Researchmaatschappij B.V. A process for the preparation of carboxylic acids and/or esters

Also Published As

Publication number Publication date
PL153826B1 (en) 1991-06-28
EP0284310A1 (en) 1988-09-28
KR960007822B1 (ko) 1996-06-12
IE880800L (en) 1988-09-20
PT87014A (pt) 1988-04-01
IE60502B1 (en) 1994-07-27
KR890014436A (ko) 1989-10-23
IL85736A0 (en) 1988-08-31
MX168833B (es) 1993-06-10
CN1029679C (zh) 1995-09-06
FI90861C (fi) 1994-04-11
JPH0686403B2 (ja) 1994-11-02
GR3002693T3 (en) 1993-01-25
DE3864713D1 (de) 1991-10-17
IL85736A (en) 1992-07-15
FI881303A0 (fi) 1988-03-18
DK148488A (da) 1988-09-20
PT87014B (pt) 1992-07-31
AU620322B2 (en) 1992-02-20
NO881213D0 (no) 1988-03-18
NZ223950A (en) 1990-02-26
HUT46646A (en) 1988-11-28
HU200983B (en) 1991-04-29
NO169890C (no) 1992-08-19
EP0284310B1 (en) 1991-09-11
NO881213L (no) 1988-09-21
CA1329396C (en) 1994-05-10
CN88102150A (zh) 1988-11-23
FI90861B (fi) 1993-12-31
NO169890B (no) 1992-05-11
BR8801238A (pt) 1988-10-25
AU1328488A (en) 1988-09-22
PL271283A1 (en) 1988-12-08
YU55188A (en) 1989-12-31
FI881303A7 (fi) 1988-09-21
SG22892G (en) 1992-05-15
DK148488D0 (da) 1988-03-18
JPS63284143A (ja) 1988-11-21
YU46539B (sh) 1993-11-16

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