ES2051867T3 - Procedimiento de preparacion de un compuesto heterociclico. - Google Patents

Procedimiento de preparacion de un compuesto heterociclico.

Info

Publication number
ES2051867T3
ES2051867T3 ES88311802T ES88311802T ES2051867T3 ES 2051867 T3 ES2051867 T3 ES 2051867T3 ES 88311802 T ES88311802 T ES 88311802T ES 88311802 T ES88311802 T ES 88311802T ES 2051867 T3 ES2051867 T3 ES 2051867T3
Authority
ES
Spain
Prior art keywords
hetero
procedure
preparation
ilo
cycle compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88311802T
Other languages
English (en)
Inventor
Terence James Ward
Janet Christine White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878730193A external-priority patent/GB8730193D0/en
Priority claimed from GB888819728A external-priority patent/GB8819728D0/en
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Application granted granted Critical
Publication of ES2051867T3 publication Critical patent/ES2051867T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

DERIVADOS DE ARIL O AROIL UREAS Y ACIDO CARBAMICO DE FORMULA A - X NHCW - Y - B Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE A ES UN RADICAL AROMATICO ESPECIFICADO INCLUYENDO FENILO OPCIONALMENTE SUSTITUIDO, X ES O O S; Y ES NH O S; B ES UN ANILLO AZACICLICO SATURADO ESPECIFICADO, P.E. TROPANO - 3 - ILO P QUINUCLIDINA - 3 ILO, POSEEN ACTIVIDAD ANTAGONISTA DE 5 - HT3 Y SON, P.E. UTILES EN EL TRATAMIENTO DE LA MIGRAÑA, ENESIS, ANSIEDAD, ALTERACIONES GASTROINTESTINALES Y COMO PSICOTICOS.
ES88311802T 1987-12-24 1988-12-14 Procedimiento de preparacion de un compuesto heterociclico. Expired - Lifetime ES2051867T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878730193A GB8730193D0 (en) 1987-12-24 1987-12-24 Heterocyclic compounds
GB888819728A GB8819728D0 (en) 1988-08-19 1988-08-19 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ES2051867T3 true ES2051867T3 (es) 1994-07-01

Family

ID=26293248

Family Applications (2)

Application Number Title Priority Date Filing Date
ES88311802T Expired - Lifetime ES2051867T3 (es) 1987-12-24 1988-12-14 Procedimiento de preparacion de un compuesto heterociclico.
ES89202801T Expired - Lifetime ES2053959T3 (es) 1987-12-24 1988-12-14 Compuestos heterociclicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES89202801T Expired - Lifetime ES2053959T3 (es) 1987-12-24 1988-12-14 Compuestos heterociclicos.

Country Status (18)

Country Link
US (2) US4983600A (es)
EP (2) EP0323077B1 (es)
JP (1) JP2588265B2 (es)
KR (1) KR970009588B1 (es)
AT (2) ATE67200T1 (es)
AU (1) AU611976B2 (es)
CA (1) CA1334095C (es)
DE (2) DE3864807D1 (es)
DK (2) DK710488A (es)
ES (2) ES2051867T3 (es)
FI (1) FI95031C (es)
GB (1) GB2213816B (es)
GR (1) GR3002701T3 (es)
HU (1) HU204267B (es)
IE (2) IE62231B1 (es)
IL (1) IL88644A (es)
PH (1) PH27437A (es)
PT (1) PT89286B (es)

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Also Published As

Publication number Publication date
US5106843A (en) 1992-04-21
IE881029L (en) 1989-06-24
PH27437A (en) 1993-07-02
CA1334095C (en) 1995-01-24
ES2053959T3 (es) 1994-08-01
GR3002701T3 (en) 1993-01-25
GB2213816B (en) 1991-05-08
AU2670288A (en) 1989-06-29
ATE67200T1 (de) 1991-09-15
EP0361629A3 (en) 1990-06-13
EP0361629A2 (en) 1990-04-04
DE3864807D1 (de) 1991-10-17
IE883661L (en) 1989-05-24
IL88644A0 (en) 1989-07-31
EP0323077A1 (en) 1989-07-05
EP0323077B1 (en) 1991-09-11
PT89286B (pt) 1994-11-30
KR890009923A (ko) 1989-08-04
EP0361629B1 (en) 1994-06-15
IE63474B1 (en) 1995-04-19
KR970009588B1 (ko) 1997-06-14
AU611976B2 (en) 1991-06-27
JPH01203365A (ja) 1989-08-16
DE3850255T2 (de) 1994-09-22
DK710488A (da) 1989-06-25
JP2588265B2 (ja) 1997-03-05
DK82793D0 (da) 1993-07-08
GB8829164D0 (en) 1989-01-25
IL88644A (en) 1993-05-13
DK710488D0 (da) 1988-12-20
FI885917A7 (fi) 1989-06-25
US4983600A (en) 1991-01-08
DK82793A (da) 1993-07-08
PT89286A (pt) 1989-12-29
FI95031C (fi) 1995-12-11
HUT53101A (en) 1990-09-28
ATE107304T1 (de) 1994-07-15
GB2213816A (en) 1989-08-23
IE62231B1 (en) 1995-01-11
FI95031B (fi) 1995-08-31
DE3850255D1 (de) 1994-07-21
HU204267B (en) 1991-12-30

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