ES8300700A1 - Un procedimiento para la preparacion de un derivado del indol. - Google Patents

Un procedimiento para la preparacion de un derivado del indol.

Info

Publication number
ES8300700A1
ES8300700A1 ES504695A ES504695A ES8300700A1 ES 8300700 A1 ES8300700 A1 ES 8300700A1 ES 504695 A ES504695 A ES 504695A ES 504695 A ES504695 A ES 504695A ES 8300700 A1 ES8300700 A1 ES 8300700A1
Authority
ES
Spain
Prior art keywords
alkyl
represents hydrogen
aralkyl
cycloalkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504695A
Other languages
English (en)
Other versions
ES504695A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8300700A1 publication Critical patent/ES8300700A1/es
Publication of ES504695A0 publication Critical patent/ES504695A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN DERIVADO DE INDOL, ASI COMO DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE SUS SOLVATOS O BIO-PRECURSORES, DE FORMULA (I), EN LA QUE R , R E, R , R Y R PUEDEN SER HIDROGENO O ALQUILO C <003> ; R Y R PUEDEN SER VARIOS RADICALES Y ALQ ES UNA CADENA ALQUILENO C <003> . CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) O UNA SAL O DERIVADO PROTEGIDO DEL MISMO, CON UN ACIDO SULFONICO DE FORMULA R SO H,O UN AGENTE SULFONILANTE CORRESPONDIENTE, FORMULAS EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA ENTRE -70<025>C Y 100<025>C. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA MIGRAÑA.
ES504695A 1980-08-12 1981-08-11 Un procedimiento para la preparacion de un derivado del indol. Granted ES504695A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026288 1980-08-12

Publications (2)

Publication Number Publication Date
ES8300700A1 true ES8300700A1 (es) 1982-11-01
ES504695A0 ES504695A0 (es) 1982-11-01

Family

ID=10515412

Family Applications (2)

Application Number Title Priority Date Filing Date
ES504695A Granted ES504695A0 (es) 1980-08-12 1981-08-11 Un procedimiento para la preparacion de un derivado del indol.
ES513935A Expired ES8404327A1 (es) 1980-08-12 1982-07-13 Un procedimiento para la preparacion de un derivado del indol.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES513935A Expired ES8404327A1 (es) 1980-08-12 1982-07-13 Un procedimiento para la preparacion de un derivado del indol.

Country Status (28)

Country Link
US (2) US4672067A (es)
JP (1) JPS5759864A (es)
AR (1) AR231533A1 (es)
AT (1) AT381304B (es)
AU (1) AU548270B2 (es)
BE (1) BE889930A (es)
CA (2) CA1169077A (es)
CH (1) CH651550A5 (es)
DE (1) DE3131748A1 (es)
DK (1) DK157680C (es)
ES (2) ES504695A0 (es)
FI (1) FI812475A7 (es)
FR (1) FR2488605A1 (es)
GB (1) GB2081717B (es)
GR (1) GR74536B (es)
IE (1) IE51492B1 (es)
IL (1) IL63541A (es)
IT (1) IT1171451B (es)
LU (1) LU83546A1 (es)
MY (1) MY8600577A (es)
NL (1) NL8103768A (es)
NO (1) NO812722L (es)
NZ (1) NZ197997A (es)
PH (1) PH17428A (es)
PT (1) PT73503B (es)
SE (1) SE454881B (es)
ZA (1) ZA815539B (es)
ZW (1) ZW19381A1 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8332434D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Production of chemical compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
US4833153A (en) * 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
DE3613623A1 (de) * 1986-04-23 1987-10-29 Bayer Ag N-dihydroindolylethyl-sulfonamide
GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
KR100215627B1 (ko) * 1990-06-07 1999-08-16 레슬리 제인 에드워즈 치료용 헤테로사이클 화합물
GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
CA2091562C (en) * 1990-10-15 2001-03-27 John Eugene Macor Indole derivatives useful in psychotherapeutics
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
GB9103770D0 (en) * 1991-02-22 1991-04-10 Glaxo Group Ltd Chemical compounds
ES2033577B1 (es) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 Procedimiento para la obtencion de la 2-carboxi-3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida y sus esteres alquilicos inferiores.
ES2033578B1 (es) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 Procedimiento para la obtencion de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida.
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
CA2169179C (en) * 1993-08-31 2000-02-29 John E. Macor 5-arylindole derivatives
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
AU7261196A (en) * 1995-10-10 1997-04-30 Eli Lilly And Company N-{2-substituted-3-(2-aminoethyl)-1h-indol-5-yl}-amides: new 5-ht1f agonists
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
US7026364B2 (en) * 2001-04-13 2006-04-11 Organo Corporation Ion exchanger
JP5833804B2 (ja) * 2005-04-13 2015-12-16 ニューラクソン，インコーポレーテッド Ｎｏｓ阻害活性を有する置換インドール化合物
WO2017004501A1 (en) 2015-07-02 2017-01-05 Civitas Therapeutics, Inc. Triptan powders for pulmonary delivery

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870162A (en) * 1954-04-28 1959-01-20 Upjohn Co Production of certain tryptamines and compounds produced in the process
BE632051A (fr) * 1963-05-08 1963-11-18 Sandoz Sa Nouveaux dérivés de l'indole et leur préparation.
CH442303A (de) * 1964-06-26 1967-08-31 Sandoz Ag Verfahren zur Herstellung von neuen Indol-Derivaten
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
US4180509A (en) * 1977-07-01 1979-12-25 Merrell Toraude Et Compagnie α-Ethynyl tryptophanes
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
MY8600577A (en) 1986-12-31
NZ197997A (en) 1985-08-16
ZW19381A1 (en) 1983-03-09
CA1169429A (en) 1984-06-19
DK357181A (da) 1982-02-13
AT381304B (de) 1986-09-25
BE889930A (fr) 1982-02-11
IE811831L (en) 1982-02-12
IT8149086A0 (it) 1981-08-11
DE3131748C2 (es) 1992-04-23
US4636521A (en) 1987-01-13
GB2081717B (en) 1983-09-28
SE8104782L (sv) 1982-02-13
PT73503A (en) 1981-09-01
JPH0148895B2 (es) 1989-10-20
IL63541A (en) 1985-08-30
ZA815539B (en) 1983-03-30
FR2488605A1 (fr) 1982-02-19
ES513935A0 (es) 1984-04-16
DK157680C (da) 1990-07-09
FR2488605B1 (es) 1984-11-16
CH651550A5 (fr) 1985-09-30
PT73503B (en) 1983-09-14
GR74536B (es) 1984-06-29
DK157680B (da) 1990-02-05
CA1169077A (en) 1984-06-12
ATA352881A (de) 1986-02-15
IT1171451B (it) 1987-06-10
PH17428A (en) 1984-08-20
NO812722L (no) 1982-02-15
ES504695A0 (es) 1982-11-01
FI812475L (fi) 1982-02-13
US4672067A (en) 1987-06-09
IT8149086A1 (it) 1983-02-11
AU548270B2 (en) 1985-12-05
LU83546A1 (fr) 1983-06-08
NL8103768A (nl) 1982-03-01
JPS5759864A (en) 1982-04-10
SE454881B (sv) 1988-06-06
FI812475A7 (fi) 1982-02-13
GB2081717A (en) 1982-02-24
IE51492B1 (en) 1987-01-07
DE3131748A1 (de) 1982-04-01
AU7399681A (en) 1982-02-18
AR231533A1 (es) 1984-12-28
ES8404327A1 (es) 1984-04-16

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