ES2056263T3 - Procedimiento para la preparacion de l-lisina por fermentacion. - Google Patents

Procedimiento para la preparacion de l-lisina por fermentacion.

Info

Publication number
ES2056263T3
ES2056263T3 ES90102685T ES90102685T ES2056263T3 ES 2056263 T3 ES2056263 T3 ES 2056263T3 ES 90102685 T ES90102685 T ES 90102685T ES 90102685 T ES90102685 T ES 90102685T ES 2056263 T3 ES2056263 T3 ES 2056263T3
Authority
ES
Spain
Prior art keywords
lysine
preparation
brevibacterium
microorganism
fermentation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90102685T
Other languages
English (en)
Inventor
Bernd Dr Bachmann
Georg Dr Thierbach
Jorn Kalinowski
Alfred Prof Dr Puhler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Application granted granted Critical
Publication of ES2056263T3 publication Critical patent/ES2056263T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE L-LISINA SEGUN EL CUAL DNA RECOMBINANTE, PRODUCIDO POR UN FRAGMENTO DE DNA QUE PRESENTA UNA SECUENCIA PARA LA CODIFICACION GENETICA QUE CONDUCE A LA PRODUCCION DE PROTEINAS, LAS CUALES MANIFIESTAN UNA ACTIVIDAD DE ASPARTIL-(BETA)-SEMIALDEHIDO-DESHIDROGENASA (ASD), O DE DEREGULACION DE LA ASPARTO-QUINASA (LYSC), Y QUE PROCEDE DE UN MICROORGANISMO DE LA ESPECIE CORYNEBACTERIUM O BREVIBACTERIUM, Y QUE SE COMPONE DE VECTOR DNA, SE INJERTA EN UN MICROORGANISMO DE LAS ESPECIES ANTES CITADAS. EL MUTANTE ASI OBTENIDO SE CULTIVA EN UN MEDIO ADECUADO, SEPARANDOSE DE ESTE MEDIO LA L-LISINA PRODUCIDA.
ES90102685T 1989-03-14 1990-02-12 Procedimiento para la preparacion de l-lisina por fermentacion. Expired - Lifetime ES2056263T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3908201A DE3908201A1 (de) 1989-03-14 1989-03-14 Verfahren zur fermentativen herstellung von l-lysin

Publications (1)

Publication Number Publication Date
ES2056263T3 true ES2056263T3 (es) 1994-10-01

Family

ID=6376268

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90102685T Expired - Lifetime ES2056263T3 (es) 1989-03-14 1990-02-12 Procedimiento para la preparacion de l-lisina por fermentacion.

Country Status (6)

Country Link
EP (1) EP0387527B1 (es)
JP (1) JP3000087B2 (es)
AT (1) ATE107699T1 (es)
DE (2) DE3908201A1 (es)
ES (1) ES2056263T3 (es)
SK (1) SK122890A3 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3943117A1 (de) * 1989-12-27 1991-07-04 Forschungszentrum Juelich Gmbh Verfahren zur fermentativen herstellung von aminosaeure, insbesondere l-lysin, dafuer geeignete mikroorganismen und rekombinante dna
JPH07108228B2 (ja) * 1990-10-15 1995-11-22 味の素株式会社 温度感受性プラスミド
JP3473042B2 (ja) * 1992-04-28 2003-12-02 味の素株式会社 変異型アスパルトキナーゼ遺伝子
JP3783065B2 (ja) * 1994-03-04 2006-06-07 味の素株式会社 Ｌ−リジンの製造法
DK0841395T3 (da) * 1995-06-07 2012-01-09 Ajinomoto Kk Fremgangsmåde til at fremstille L-lysin
JP4075087B2 (ja) 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
DE19924364A1 (de) 1999-05-27 2000-11-30 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
JP4623825B2 (ja) * 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
US6927046B1 (en) 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
EP1307476A1 (en) * 2000-08-02 2003-05-07 Degussa AG Nucleotide sequences which code for the mete gene
AU2001287631A1 (en) * 2000-08-02 2002-02-13 Degussa A.G. Nucleotide sequences which code for the metf gene
EP1307475A1 (en) * 2000-08-02 2003-05-07 Degussa AG Nucleotide sequences which code for the meth gene
US6958228B2 (en) 2000-08-02 2005-10-25 Degussa Ag Nucleotide sequence which code for the metH gene
US6942996B2 (en) 2000-08-02 2005-09-13 Degussa Ag Isolated polynucleotide from Corynebacterium encoding a homocysteine methyltransferase
US6812016B2 (en) 2000-09-02 2004-11-02 Degussa Ag Nucleotide sequences which code for the metY gene
DE10109690A1 (de) * 2000-09-02 2002-03-14 Degussa Neue für das metY-Gen kodierende Nukleotidsequenzen
DE10044681A1 (de) * 2000-09-09 2002-03-21 Degussa Neue für das lldD2-Gen kodierende Nukleotidsequenzen
WO2002020573A2 (en) * 2000-09-09 2002-03-14 Degussa Ag Nucleotide sequences which code for the gpmb gene
WO2002022670A1 (en) * 2000-09-12 2002-03-21 Degussa Ag Nucleotide sequences coding for the ftsx gene
AU2001285878A1 (en) * 2000-09-12 2002-03-26 Degussa A.G. Nucleotide sequences which code for the roda gene
DE10046625A1 (de) * 2000-09-20 2002-04-11 Degussa Neue für das ndkA-Gen kodierende Nukleotidsequenzen
DE10047864A1 (de) * 2000-09-27 2002-04-11 Degussa Neue für das truB-Gen kodierende Nukleotidsequenzen
US7026158B2 (en) * 2000-09-27 2006-04-11 Degussa Ag Nucleotide sequences which code for the mikE17 gene
AU2002218223A1 (en) * 2000-10-28 2002-05-06 Degussa A.G. Nucleotide sequences encoding the hemd and hemb genes
AR032570A1 (es) 2001-02-08 2003-11-12 Archer Daniels Midland Co Construcciones de polinucleotidicas para aumentar la produccion de lisina
DE10155505A1 (de) 2001-11-13 2003-05-22 Basf Ag Gene die für Glucose-6-Phosphat-Dehydrogenase Proteine codieren
DE10210527A1 (de) 2002-03-09 2003-09-18 Degussa Allele des aceA-Gens aus coryneformen Bakterien
ATE525457T1 (de) 2004-12-06 2011-10-15 Sage Biosciences Inc Verfahren zur züchtung von bakterien zur abgabe von bioaktiven verbindungen an das intestinum von wiederkäuern
DE102014208199A1 (de) 2014-04-30 2015-11-05 Evonik Degussa Gmbh Verfahren zur Produktion von L-Aminosäuren unter Verwendung eines alkaliphilen Bakteriums
EP2940143B1 (de) 2014-04-30 2020-02-05 Evonik Operations GmbH Verfahren zur Produktion von L-Aminosäuren unter Verwendung eines alkaliphilen Bakteriums
EP2940039A1 (de) 2014-04-30 2015-11-04 Evonik Degussa GmbH Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
WO2022191357A1 (ko) * 2021-03-09 2022-09-15 대상 주식회사 L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법
US20250340893A1 (en) 2022-05-18 2025-11-06 Evonik Operations Gmbh Biotechnological production of desferrioxamines and analogs thereof
CN119212692A (zh) 2022-05-18 2024-12-27 赢创运营有限公司 比苏卡林、去铁胺及其类似物的单体的生物技术生产
CN119212691A (zh) 2022-05-18 2024-12-27 赢创运营有限公司 比苏卡林、去铁胺及其类似物的生物技术生产

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58126789A (ja) * 1981-12-29 1983-07-28 Kyowa Hakko Kogyo Co Ltd レースレオニンの製造法
JPH0655149B2 (ja) * 1985-03-12 1994-07-27 協和醗酵工業株式会社 Ｌ―リジンの製造法
JPH06102028B2 (ja) * 1985-10-04 1994-12-14 協和醗酵工業株式会社 アミノ酸の製造法

Also Published As

Publication number Publication date
ATE107699T1 (de) 1994-07-15
SK279719B6 (sk) 1999-02-11
DE59006167D1 (de) 1994-07-28
JPH03219885A (ja) 1991-09-27
DE3908201A1 (de) 1990-09-27
EP0387527B1 (de) 1994-06-22
EP0387527A1 (de) 1990-09-19
SK122890A3 (en) 1999-02-11
JP3000087B2 (ja) 2000-01-17

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