ES2056908T3 - Analogos nonapeptidos y decapeptidos de la lhrh utiles como antagonistas de la lhrh. - Google Patents

Analogos nonapeptidos y decapeptidos de la lhrh utiles como antagonistas de la lhrh.

Info

Publication number
ES2056908T3
ES2056908T3 ES88300927T ES88300927T ES2056908T3 ES 2056908 T3 ES2056908 T3 ES 2056908T3 ES 88300927 T ES88300927 T ES 88300927T ES 88300927 T ES88300927 T ES 88300927T ES 2056908 T3 ES2056908 T3 ES 2056908T3
Authority
ES
Spain
Prior art keywords
lhrh
nonapeptide
useful
antagonists
decapeptide analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88300927T
Other languages
English (en)
Spanish (es)
Inventor
John J Nestor Jr
Brian H Vickery
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2056908T3 publication Critical patent/ES2056908T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES88300927T 1987-02-05 1988-02-04 Analogos nonapeptidos y decapeptidos de la lhrh utiles como antagonistas de la lhrh. Expired - Lifetime ES2056908T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/010,923 US4801577A (en) 1987-02-05 1987-02-05 Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists

Publications (1)

Publication Number Publication Date
ES2056908T3 true ES2056908T3 (es) 1994-10-16

Family

ID=21748050

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88300927T Expired - Lifetime ES2056908T3 (es) 1987-02-05 1988-02-04 Analogos nonapeptidos y decapeptidos de la lhrh utiles como antagonistas de la lhrh.

Country Status (22)

Country Link
US (2) US4801577A (fr)
EP (1) EP0277829B1 (fr)
JP (1) JPH0791314B2 (fr)
KR (1) KR930008095B1 (fr)
AT (1) ATE109159T1 (fr)
AU (1) AU614275B2 (fr)
BR (1) BR1100688A (fr)
CA (1) CA1339043C (fr)
DE (2) DE3850789T2 (fr)
DK (1) DK173544B1 (fr)
ES (1) ES2056908T3 (fr)
FI (2) FI92326C (fr)
HK (1) HK35997A (fr)
HU (3) HU215855B (fr)
IE (1) IE63707B1 (fr)
IL (1) IL85316A (fr)
LU (1) LU90657I2 (fr)
MX (1) MX9202737A (fr)
NL (1) NL300016I2 (fr)
NO (3) NO176440C (fr)
NZ (1) NZ223403A (fr)
ZA (1) ZA88795B (fr)

Families Citing this family (45)

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US5688519A (en) * 1987-04-06 1997-11-18 Leonard; Robert J. Flash-flow fused medicinal implants
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
HU203204B (en) * 1987-09-15 1991-06-28 Sandoz Ag Process for producing suppository containing calcitonin and taurocholic acid
DE3886880T2 (de) * 1987-10-15 1994-07-14 Syntex Inc Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden.
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5137669A (en) * 1988-03-02 1992-08-11 Endocon, Inc. Manufacture of partially fused peptide pellet
US5039660A (en) * 1988-03-02 1991-08-13 Endocon, Inc. Partially fused peptide pellet
WO1990010437A1 (fr) * 1989-03-09 1990-09-20 Endocon, Inc. Pellets de peptides partiellement fondus
US6156731A (en) * 1989-05-10 2000-12-05 G. D. Searle & Co. Polypeptide composition for oral administration
US5232707A (en) * 1989-07-10 1993-08-03 Syntex (U.S.A.) Inc. Solvent extraction process
US5169932A (en) * 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist
US5064939A (en) * 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
US5212288A (en) * 1990-02-20 1993-05-18 Syntex (U.S.A.) Inc. Temporary minimal protection synthesis of serine-containing polypeptides
ES2062628T3 (es) * 1990-08-04 1994-12-16 Hoechst Ag Antagonistas de gonadoliberina.
CN1036343C (zh) * 1990-11-10 1997-11-05 天津市计划生育研究所 新促黄体生成素释放激素拮抗类似物的制备方法
US5783562A (en) * 1990-11-10 1998-07-21 Asta Medica Aktiengesellschaft Luteinizing hormone releasing hormone analogs
IL101074A (en) * 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
DE69214818T2 (de) * 1991-04-25 1997-02-27 Romano S.-Cergue Deghenghi LHRH-Antagonisten
DE4117507A1 (de) * 1991-05-24 1992-11-26 Schering Ag Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
WO1993003752A1 (fr) * 1991-08-19 1993-03-04 The Arizona Board Of Regents On Behalf Of The University Of Arizona Decapeptide possedant une efficacite de stimulation de la dopamine
CA2103163C (fr) * 1991-08-26 1998-10-20 Mou-Ying Fu Lu Compositions et methodes pour l'administratiion sublinguale ou buccale d'agents therapeutiques
US5487898A (en) * 1991-08-26 1996-01-30 Abbott Laboratories Compositions and method for the sublingual or buccal administration therapeutic agents
US5480969A (en) * 1992-09-15 1996-01-02 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US5656727A (en) * 1992-09-15 1997-08-12 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
DE4305225A1 (de) * 1993-02-19 1994-08-25 Asta Medica Ag Neues Herstellverfahren für Cetrorelix Lyophilisat
US6828415B2 (en) 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
US5843901A (en) 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US6043218A (en) * 1996-10-22 2000-03-28 Medical University Of South Carolina Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides
US6566330B1 (en) 1996-10-22 2003-05-20 Medical University Of South Carolina Foundation Research Development Positively charged non-natural amino acids, methods of making and using thereof in peptides
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19712718C2 (de) * 1997-03-26 1999-09-23 Asta Medica Ag Immobilisierte und aktivitätsstabilisierte Komplexe von LHRH-Antagonisten und Verfahren zu deren Herstellung
ATE302018T1 (de) * 1997-06-20 2005-09-15 Akzo Nobel Nv Gonadotropin releasing hormon antagonist
US6217844B1 (en) 1998-04-27 2001-04-17 Praecis Pharmaceuticals, Inc. Methods for detecting lesions in dense breast tissue using LHRH antagonists
US6455499B1 (en) 1999-02-23 2002-09-24 Indiana University Foundation Methods for treating disorders associated with LHRH activity
US6598784B2 (en) * 2000-12-20 2003-07-29 Meadwestvaco Packaging Syatens, Llc Beverage carton with strap type carrying handle
WO2002056903A2 (fr) * 2001-01-17 2002-07-25 Praecis Pharmaceuticals Inc. Methodes pour traiter des etats lies aux hormones au moyen d'une combinaison d'antagonistes de la lhrh et de modulateurs selectifs des recepteurs des oestrogenes
GB0320806D0 (en) 2003-09-05 2003-10-08 Astrazeneca Ab Therapeutic treatment
AU2004313245B2 (en) 2003-12-30 2011-04-14 Durect Corporation Polymeric implants, preferably containing a mixture of PEG and PLG, for controlled release of active agents, preferably a GNRH
JP5361210B2 (ja) * 2008-02-22 2013-12-04 キヤノン株式会社 樹脂組成物および成形体
CN102584945A (zh) * 2012-02-09 2012-07-18 深圳翰宇药业股份有限公司 一种醋酸加尼瑞克的制备方法
CN104231055A (zh) 2013-06-18 2014-12-24 深圳翰宇药业股份有限公司 加尼瑞克前体以及由其制备醋酸加尼瑞克的方法
CN109443592A (zh) * 2018-09-19 2019-03-08 东华大学 一种温敏嵌段共聚物低临界溶解温度的测定方法
CN111943960B (zh) 2019-07-29 2022-02-15 广东东阳光药业有限公司 取代的嘧啶二酮类化合物及其用途
WO2023072284A1 (fr) 2021-11-01 2023-05-04 山东绿叶制药有限公司 Antagoniste de l'hormone de libération de la gonadotropine, son procédé de préparation et son utilisation

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215038A (en) * 1978-10-16 1980-07-29 The Salk Institute For Biological Studies Peptides which inhibit gonadal function
US4341767A (en) * 1980-10-06 1982-07-27 Syntex Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4419347A (en) * 1980-10-06 1983-12-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
FI832053L (fi) * 1982-06-10 1983-12-11 Syntex Inc Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande
US4481190A (en) * 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4667014A (en) * 1983-03-07 1987-05-19 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4581169A (en) * 1982-12-21 1986-04-08 Syntex (U.S.A.) Inc. Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
DE3467173D1 (en) * 1983-08-16 1987-12-10 Akzo Nv Lh- rh antagonists
ZA846154B (en) * 1983-08-16 1985-03-27 Akzo Nv Lh-rh antagonists
US4569927A (en) * 1984-02-23 1986-02-11 The Salk Institute For Biological Studies GnRH Antagonists IV
US4690916A (en) * 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
AU2012488A (en) * 1987-07-31 1989-02-02 Syntex (U.S.A.) Inc. Combination therapy with lhrh antagonist analogs and 19nor progestational steroids
US5300492A (en) * 1988-02-10 1994-04-05 Tap Pharmaceuticals LHRH analogs
DE4117507A1 (de) * 1991-05-24 1992-11-26 Schering Ag Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
US5480969A (en) * 1992-09-15 1996-01-02 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
CA2136079A1 (fr) * 1992-12-18 1994-07-07 Fortuna Haviv Antagonistes de lhrh presentant des residus aminoacyle modifies en position 5 et 6
US5502035A (en) * 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
US5516759A (en) * 1994-12-08 1996-05-14 Tap Holdings Inc. LHRH antagonists having lactam groups at the N-terminus
US5574011A (en) * 1995-04-04 1996-11-12 Tien; Henry C. Compositions and methods for the treatment of male-pattern baldness

Also Published As

Publication number Publication date
NL300016I1 (nl) 2000-11-01
AU1126588A (en) 1988-08-11
DE10075027I2 (de) 2004-07-01
FI880509A7 (fi) 1988-08-06
ATE109159T1 (de) 1994-08-15
ZA88795B (en) 1989-10-25
JPS63201199A (ja) 1988-08-19
NL300016I2 (nl) 2001-01-02
NZ223403A (en) 1990-10-26
KR890013060A (ko) 1989-09-21
NO922632D0 (no) 1992-07-03
US4801577A (en) 1989-01-31
DE3850789D1 (de) 1994-09-01
US5767082A (en) 1998-06-16
NO880494L (no) 1988-08-08
FI92211C (fi) 1994-10-10
EP0277829A3 (en) 1990-10-31
NO176440C (no) 1995-04-05
DE10075027I1 (de) 2000-11-30
HUT46340A (en) 1988-10-28
FI92326C (fi) 1994-10-25
IE880298L (en) 1988-08-05
CA1339043C (fr) 1997-04-01
HU215855B (hu) 2001-02-28
NO301014B1 (no) 1997-09-01
BR1100688A (pt) 2000-04-18
FI92211B (fi) 1994-06-30
MX9202737A (es) 1992-06-30
NO922632L (no) 1988-08-08
HUT63855A (en) 1993-10-28
HU210819A9 (en) 1995-08-28
FI930694A0 (fi) 1993-02-17
EP0277829A2 (fr) 1988-08-10
JPH0791314B2 (ja) 1995-10-04
NO880494D0 (no) 1988-02-04
FI880509A0 (fi) 1988-02-04
IL85316A (en) 1992-07-15
FI930694A7 (fi) 1993-02-17
AU614275B2 (en) 1991-08-29
FI92326B (fi) 1994-07-15
DK57288D0 (da) 1988-02-04
HK35997A (en) 1997-03-27
NO176440B (no) 1994-12-27
IL85316A0 (en) 1988-07-31
KR930008095B1 (ko) 1993-08-25
LU90657I2 (fr) 2001-01-15
DK173544B1 (da) 2001-02-19
EP0277829B1 (fr) 1994-07-27
DE3850789T2 (de) 1995-03-09
NO2001001I1 (no) 2001-02-05
IE63707B1 (en) 1995-05-31
DK57288A (da) 1988-08-06

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