ES2057045T3 - Procedimiento para la determinacion de osteocalcina en plasma o suero humano. - Google Patents
Procedimiento para la determinacion de osteocalcina en plasma o suero humano.Info
- Publication number
- ES2057045T3 ES2057045T3 ES89118250T ES89118250T ES2057045T3 ES 2057045 T3 ES2057045 T3 ES 2057045T3 ES 89118250 T ES89118250 T ES 89118250T ES 89118250 T ES89118250 T ES 89118250T ES 2057045 T3 ES2057045 T3 ES 2057045T3
- Authority
- ES
- Spain
- Prior art keywords
- plasma
- osteocalcin
- tracer
- human serum
- determination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000002966 serum Anatomy 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000000700 radioactive tracer Substances 0.000 abstract 5
- 108010038807 Oligopeptides Proteins 0.000 abstract 4
- 102000015636 Oligopeptides Human genes 0.000 abstract 4
- 102000004067 Osteocalcin Human genes 0.000 abstract 4
- 108090000573 Osteocalcin Proteins 0.000 abstract 4
- 229940124143 Endopeptidase inhibitor Drugs 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 229940097396 Aminopeptidase inhibitor Drugs 0.000 abstract 1
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 abstract 1
- 108010052590 amastatin Proteins 0.000 abstract 1
- QFAADIRHLBXJJS-ZAZJUGBXSA-N amastatin Chemical compound CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC(O)=O QFAADIRHLBXJJS-ZAZJUGBXSA-N 0.000 abstract 1
- 239000013060 biological fluid Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 108010052968 leupeptin Proteins 0.000 abstract 1
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/963—Methods of stopping an enzyme reaction or stabilizing the test materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
PARA LA DETERMINACION DE OSCTEOCALCINA EN EL SUERO HUMANO O PLASMA SE CONOCE UN PROCEDIMIENTO EN EL QUE SE INCUBA UNA PRUEBA DEL FLUIDO BIOLOGICO QUE CONTIENE LA OSTEOCALCINA A DETERMINAR JUNTO CON UNA CANTIDAD CONOCIDA DE UN TRAZADOR DE OLIGOPEPTIDOS CON UN ANTICUERPO ADECUADO QUE CONECTA TANTO LA OSTEOCALCINA COMO EL TRAZADOR. ESTE PROCEDIMIENTO HA DEMOSTRADO SER ERRONEO, DADO QUE LAS CONDICIONES DE INCUBACION INFLUYEN LOS VALORES MEDIDOS Y FRECUENTEMENTE SE OBTUVIERON VALORES DE OSTEOCALCINA MUY ELEVADOS. EL CONOCIMIENTO DE QUE LOS ERRORES OBSERVADOS SON DEBIDOS A UNA DESINTEGRACION PROTEOLITICA DEL TRAZADOR DE OLIGOPEPTIDOS MEDIANTE SUSTANCIAS CONTENIDAS EN EL SUERO O EN EL PLASMA, CONDUJO A LA IDEA DE AÑADIR A LA PRUEBA DEL SUERO HUMANO O PLASMA ANTES O JUNTO CON LA INTRODUCCION DEL TRAZADOR DE OLIGOPEPTIDOS UNA O VARIAS SUSTANCIAS INHIBIDORAS DE LA EMNDOPEPTIDASA CON UNA SUSTANCIA INHIBIDORA DE LA AMINOPEPTIDASA, O BIEN, AL UTILIZAR UN TRAZADOR DE OLIGOPEPTIDOS N-TERMINAL PROTEGIDO,SOLAMENTE UNA SUSTANCIA INHIBIDORA DE LA ENDOPEPTIDASA. SON PREFERIBLES COMO SUSTANCIAS INHIBIDORAS LA AMASTATINA Y LA LEUPEPTINA. DETERMINACION DE LA OSTEOCALCINA CON VISTAS AL DIAGNOSTICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3833936A DE3833936C1 (es) | 1988-10-05 | 1988-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2057045T3 true ES2057045T3 (es) | 1994-10-16 |
Family
ID=6364464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89118250T Expired - Lifetime ES2057045T3 (es) | 1988-10-05 | 1989-10-02 | Procedimiento para la determinacion de osteocalcina en plasma o suero humano. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5168041A (es) |
| EP (1) | EP0362773B1 (es) |
| JP (1) | JPH02147954A (es) |
| AT (1) | ATE110854T1 (es) |
| DE (2) | DE3833936C1 (es) |
| ES (1) | ES2057045T3 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05232109A (ja) * | 1990-10-04 | 1993-09-07 | Teijin Ltd | ヒト・オステオカルシンプロ蛋白の測定方法 |
| US5541116A (en) * | 1991-09-30 | 1996-07-30 | B.R.A.H.M.S. Diagnostica Gmbh | Method for the stabilization of endogenous, physiologically active peptides |
| US6632613B1 (en) * | 1993-06-02 | 2003-10-14 | University Of Utah Research Foundation | Compositions and kits for fluorescence polarization assay of large molecules |
| DE4340597C2 (de) * | 1993-11-29 | 1995-11-30 | Brahms Diagnostica Gmbh | Verfahren zur Verhinderung des Abbaus von Osteocalcin in humanem Serum oder Plasma f}r seine nachfolgende Bestimmung sowie Instrumente und Probengef{ße zur Durchf}hrung dieses Verfahrens |
| WO1995015981A1 (en) * | 1993-12-09 | 1995-06-15 | University Of Utah Research Foundation | Compositions and kits for fluorescence polarization assay of large molecules |
| US20040259167A1 (en) * | 1997-08-15 | 2004-12-23 | Jukka Hellman | Isolated osteocalcin fragments |
| DE19903336C2 (de) * | 1999-01-28 | 2000-12-14 | Brahms Diagnostica Gmbh | Gebrauchsfertige Kalibratoren für die Bestimmung von Procalcitonin |
| CH695985A5 (de) * | 2002-01-21 | 2006-11-15 | Straumann Holding Ag | Oberflächenmodifizierte Implantate. |
| DE10231574A1 (de) * | 2002-07-11 | 2004-01-29 | Sartorius Ag | Membran, Vorrichtung und Verfahren zum Entfernen von Proteasen aus Flüssigkeiten |
| WO2008089226A2 (en) * | 2007-01-16 | 2008-07-24 | Mayo Foundation For Medical Education And Research | Assessing mammals for vascular diseases |
| JP4947725B2 (ja) * | 2008-03-28 | 2012-06-06 | ヤマサ醤油株式会社 | ジアセチルポリアミンの分解防止法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4082612A (en) * | 1976-09-24 | 1978-04-04 | Michael Reese Research Foundation | Plasminogen activator complex |
| US4410506A (en) * | 1981-03-24 | 1983-10-18 | The Regents Of The University Of California | Immunoassay for vitamin K-dependent bone protein |
| US4438208A (en) * | 1982-05-27 | 1984-03-20 | The Regents Of The University Of California | Region-specific determinants for vitamin K dependent bone protein |
| US4505853A (en) * | 1983-11-18 | 1985-03-19 | Ortho Pharmaceutical Corporation | Enzyme-resistant immunomodulatory peptides |
| US4981952A (en) * | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
-
1988
- 1988-10-05 DE DE3833936A patent/DE3833936C1/de not_active Expired
-
1989
- 1989-10-02 AT AT89118250T patent/ATE110854T1/de not_active IP Right Cessation
- 1989-10-02 DE DE58908270T patent/DE58908270D1/de not_active Expired - Fee Related
- 1989-10-02 EP EP89118250A patent/EP0362773B1/de not_active Expired - Lifetime
- 1989-10-02 ES ES89118250T patent/ES2057045T3/es not_active Expired - Lifetime
- 1989-10-03 JP JP1258638A patent/JPH02147954A/ja active Pending
- 1989-10-03 US US07/416,728 patent/US5168041A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5168041A (en) | 1992-12-01 |
| DE3833936C1 (es) | 1989-09-21 |
| JPH02147954A (ja) | 1990-06-06 |
| DE58908270D1 (de) | 1994-10-06 |
| EP0362773A3 (de) | 1991-09-11 |
| ATE110854T1 (de) | 1994-09-15 |
| EP0362773A2 (de) | 1990-04-11 |
| EP0362773B1 (de) | 1994-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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