ES2058301T3 - Derivados de piridina o piridazina como agentes cardioprotectores y para el tratamiento de enfermedades isquemicas, y procedimiento para su preparacion. - Google Patents

Derivados de piridina o piridazina como agentes cardioprotectores y para el tratamiento de enfermedades isquemicas, y procedimiento para su preparacion.

Info

Publication number
ES2058301T3
ES2058301T3 ES88309155T ES88309155T ES2058301T3 ES 2058301 T3 ES2058301 T3 ES 2058301T3 ES 88309155 T ES88309155 T ES 88309155T ES 88309155 T ES88309155 T ES 88309155T ES 2058301 T3 ES2058301 T3 ES 2058301T3
Authority
ES
Spain
Prior art keywords
short chain
alkyl
preparation
cardioprotecting
piridazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88309155T
Other languages
English (en)
Inventor
Takao - Suimeidai -Chom Takaya
Hisashi - Hamaguchini Takasugi
Kimio - - Sumiyoshiyamat Esumi
Atsushi - Shinkofudai -Ch Kuno
Hiroyoshi Sakai
Kazuhiro Maeda
Yoshie Sakamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/184,195 external-priority patent/US4857527A/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority claimed from HU885132A external-priority patent/HUT51614A/hu
Application granted granted Critical
Publication of ES2058301T3 publication Critical patent/ES2058301T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

COMPOSICION FARMACEUTICA COMO AGENTE CARDIOPROTECTOR O COMO AGENTE TERAPEUTICO PARA CARDIOPATIA ISQUEMICA, QUE COMPRENDE UN COMPUESTO DE FORMULA(I), EN LA QUE R1 ES UN ALQUILO DE CADENA CORTA SUSTITUIDO CON UN GRUPO HETEROCICLICO; CARBAMOILO SUSTITUIDO CON ALQUIL - HETEROCICLICO O CON ALQUILAMINOALQUILO DE CADENA CORTA; CARBONILHETEROCICLICO QUE CONTIENE NITROGENO, OPCIONALMENTE SUSTITUIDO CON ALQUILO DE CADENA CORTA; O UREIDO SUSTITUIDO CON ALQUILAMINOALQUILO DE CADENA CORTA; R2 ES FENILO SUSTITUIDO CON NITRO; Y X ES = N - O = CR3 - (SIENDO R3 ALQUILO DE CADENA CORTA); O R2 ES ALQUILO DE CADENA CORTA Y X ES = CR3 (SIENDO R3 FENILO SUSTITUIDO CON NITRO); O SAL COMO INGREDIENTE ACTIVO, EN ASOCIACION CON UN VEHICULO O EXCIPIENTE FARMACEUTICAMENTE ACEPTABLE, Y UN PROCESO PARA LA PREPARACION DE ALGUNOS DE DICHOS COMPUESTOS O SUS SALES.
ES88309155T 1987-10-05 1988-10-03 Derivados de piridina o piridazina como agentes cardioprotectores y para el tratamiento de enfermedades isquemicas, y procedimiento para su preparacion. Expired - Lifetime ES2058301T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25177187 1987-10-05
US07/184,195 US4857527A (en) 1985-12-12 1988-04-21 Morpholine containing pyridine compounds, compositions and use
HU885132A HUT51614A (en) 1985-12-12 1988-10-04 Process for producing cardio-protective and suitable for treating ischemic illnesses pharmaceutical compositions containing nitriferous heterocyclic compounds as active agent as well as for producing the active agents

Publications (1)

Publication Number Publication Date
ES2058301T3 true ES2058301T3 (es) 1994-11-01

Family

ID=27270050

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88309155T Expired - Lifetime ES2058301T3 (es) 1987-10-05 1988-10-03 Derivados de piridina o piridazina como agentes cardioprotectores y para el tratamiento de enfermedades isquemicas, y procedimiento para su preparacion.

Country Status (10)

Country Link
EP (1) EP0311322B1 (es)
JP (1) JPH01207234A (es)
CN (1) CN1041589A (es)
AU (1) AU621067B2 (es)
CA (1) CA1317296C (es)
DE (1) DE3882476T2 (es)
DK (1) DK554988A (es)
ES (1) ES2058301T3 (es)
FI (1) FI884418L (es)
NO (1) NO884399L (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8905526D0 (en) * 1989-03-10 1989-04-19 Fujisawa Pharmaceutical Co N-containing heterocyclic compounds,processes for the preparation thereof and composition comprising the same
GB2266841A (en) * 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
US6384057B1 (en) 1997-12-11 2002-05-07 American Home Products Corporation 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis
US6503917B1 (en) 1998-12-10 2003-01-07 Wyeth, Five Giralda Farms 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof
EP2295060B1 (en) * 2001-12-06 2018-10-31 Fibrogen, Inc. Treatment or prevention of ischemic or hypoxic conditions
CN102552263A (zh) * 2001-12-06 2012-07-11 法布罗根股份有限公司 提高内源性红细胞生成素(epo)的方法
CN101664552B (zh) * 2001-12-06 2013-04-10 法布罗根股份有限公司 低氧诱导因子(HIF)α的稳定化

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8530602D0 (en) * 1985-12-12 1986-01-22 Fujisawa Pharmaceutical Co Heterocyclic compounds

Also Published As

Publication number Publication date
DK554988D0 (da) 1988-10-04
JPH01207234A (ja) 1989-08-21
AU2333888A (en) 1989-06-01
FI884418A7 (fi) 1989-04-06
EP0311322B1 (en) 1993-07-21
DE3882476T2 (de) 1993-11-11
DE3882476D1 (de) 1993-08-26
NO884399L (no) 1989-04-06
EP0311322A3 (en) 1990-11-22
NO884399D0 (no) 1988-10-04
FI884418L (fi) 1989-04-06
AU621067B2 (en) 1992-03-05
DK554988A (da) 1989-04-06
CA1317296C (en) 1993-05-04
CN1041589A (zh) 1990-04-25
FI884418A0 (fi) 1988-09-27
EP0311322A2 (en) 1989-04-12

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