ES2060107T5 - Nuevo procedimiento de preparacion de microparticulas lipidicas. - Google Patents

Nuevo procedimiento de preparacion de microparticulas lipidicas.

Info

Publication number
ES2060107T5
ES2060107T5 ES90402509T ES90402509T ES2060107T5 ES 2060107 T5 ES2060107 T5 ES 2060107T5 ES 90402509 T ES90402509 T ES 90402509T ES 90402509 T ES90402509 T ES 90402509T ES 2060107 T5 ES2060107 T5 ES 2060107T5
Authority
ES
Spain
Prior art keywords
phospholipid
microparticles
substance
preparation
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90402509T
Other languages
English (en)
Other versions
ES2060107T3 (es
Inventor
Brigitte Leclef
Patrick Cerfontaine
Jean-Marie Nicolas
Henri Wantier
Andre Trouet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9385466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2060107(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ES2060107T3 publication Critical patent/ES2060107T3/es
Publication of ES2060107T5 publication Critical patent/ES2060107T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

EL PRESENTE INVENTO TIENE POR OBJETO UN PROCESO DE PREPARACION DE MICROPARTICULAS LIPIDAS, DE ASPECTO MICROCRISTALINO DE UNA SUSTANCIA INSOLUBLE EN EL AGUA QUE PRESENTA UNA AFINIDAD POR LOS FOSFOLIPIDOS, Y AL MENOS UN FOSFOLIPIDO, MICROPARTICULAS ESTABLES EN SUSPENSION EN UNA SOLUCION ACUOSA, CARACTERIZADO EN QUE: A) SE DISUELVE DICHA SUSTANCIA Y EL O LOS FOSFOLIPIDOS EN UN DISOLVENTE ORGANICO COMUN DE DICHA SUSTANCIA Y DEL O DE LOS FOSFOLIPIDOS, B) SE MEZCLA LA SOLUCION DE DICHA SUSTANCIA Y DEL O DE LOS FOSFOLIPIDOS EN UNA SOLUCION ACUOSA EN UNA CANTIDAD TAL QUE UNA INSOLUBILIZACION BAJO FORMA DE PRECIPITADO SE PRODUCE, C) SE ELIMINA PARA RECUPERAR UNA SOLUCION ACUOSA CONTENIENDO LAS MICROPARTICULAS BAJO FORMA DE MICROSUSPENSIONES.
ES90402509T 1989-09-14 1990-09-12 Nuevo procedimiento de preparacion de microparticulas lipidicas. Expired - Lifetime ES2060107T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8912038A FR2651680B1 (fr) 1989-09-14 1989-09-14 Nouveau procede de preparation de microparticules lipidiques.

Publications (2)

Publication Number Publication Date
ES2060107T3 ES2060107T3 (es) 1994-11-16
ES2060107T5 true ES2060107T5 (es) 1996-06-16

Family

ID=9385466

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90402509T Expired - Lifetime ES2060107T5 (es) 1989-09-14 1990-09-12 Nuevo procedimiento de preparacion de microparticulas lipidicas.

Country Status (11)

Country Link
US (1) US5100591A (es)
EP (1) EP0418153B2 (es)
JP (1) JP2831455B2 (es)
AT (1) ATE93385T1 (es)
CA (1) CA2025298C (es)
DE (1) DE69002905T2 (es)
DK (1) DK0418153T4 (es)
ES (1) ES2060107T5 (es)
FR (1) FR2651680B1 (es)
GR (1) GR3020068T3 (es)
MX (1) MX9203803A (es)

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JPH0753661B2 (ja) * 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
DE3515335C2 (de) * 1985-04-27 1995-01-26 Bayer Ag Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung
US4766046A (en) * 1985-09-27 1988-08-23 Liposome Technology, Inc. Stabilized liposome/amphotericin composition and method
CA1338736C (fr) * 1986-12-05 1996-11-26 Roger Baurain Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
US4839111A (en) * 1987-02-02 1989-06-13 The University Of Tennessee Research Corporation Preparation of solid core liposomes
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
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US4994213A (en) * 1988-05-17 1991-02-19 Liposome Technology, Inc. Method of preparing lipid structures

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FR2651680B1 (fr) 1991-12-27
FR2651680A1 (fr) 1991-03-15
MX9203803A (es) 1992-08-01
EP0418153A1 (fr) 1991-03-20
ES2060107T3 (es) 1994-11-16
ATE93385T1 (de) 1993-09-15
GR3020068T3 (en) 1996-08-31
EP0418153B2 (fr) 1996-03-27
EP0418153B1 (fr) 1993-08-25
JP2831455B2 (ja) 1998-12-02
DK0418153T4 (da) 1996-08-12
CA2025298A1 (fr) 1991-03-15
JPH03169808A (ja) 1991-07-23
US5100591A (en) 1992-03-31
DE69002905D1 (de) 1993-09-30
DE69002905T2 (de) 1993-12-23
CA2025298C (fr) 2005-05-10

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