ES2061422T1 - Metodos para detectar la degradacion de colageno in vivo. - Google Patents

Metodos para detectar la degradacion de colageno in vivo.

Info

Publication number
ES2061422T1
ES2061422T1 ES91900109T ES91900109T ES2061422T1 ES 2061422 T1 ES2061422 T1 ES 2061422T1 ES 91900109 T ES91900109 T ES 91900109T ES 91900109 T ES91900109 T ES 91900109T ES 2061422 T1 ES2061422 T1 ES 2061422T1
Authority
ES
Spain
Prior art keywords
vivo
methods
collagen degradation
detect collagen
detect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES91900109T
Other languages
English (en)
Other versions
ES2061422T3 (es
Inventor
David R Eyre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Washington Research Foundation
Original Assignee
Washington Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27034100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2061422(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/444,881 external-priority patent/US5140103A/en
Application filed by Washington Research Foundation filed Critical Washington Research Foundation
Publication of ES2061422T1 publication Critical patent/ES2061422T1/es
Application granted granted Critical
Publication of ES2061422T3 publication Critical patent/ES2061422T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

METODOS DE DETERMINACION DE LA DEGRADACION DEL COLAGENO IN VIVO, MEDIANTE LA CUANTIFICACION DE UN PEPTIDO EN UN CUERPO LIQUIDO, SIENDO EL PEPTIDO UN TELOPEPTIDO DE COLAGENO DEL TIPO II C-TERMINAL QUE CONTIENE UNA LIGADURA TRANSVERSAL DE PIRIDINOLINA DE HIDROXILISILO O UN TELEPEPTIDO DE COLAGENO DE TIPO III QUE CONTIENE UNA LIGADURA TRANSVERSAL DE PIRIDINOLINA DE HIDROXILISILO. ALGUNOS METODOS ADECUADOS PARA LA CUANTIFICACION INCLUYEN ENSAYOS INMUNOMETRICOS, ENSAYOS FLUOROMETRICOS Y VALORACIONES ELECTROQUIMICAS. SE DESCRIBEN LAS ESTRUCTURAS DE PEPTIDOS ESPECIFICOS CON LIGADURAS TRANSVERSALES Y EFECTOS PARA CUANTIFICAR ESTOS PEPTIDOS EN UN CUERPO LIQUIDO.
ES91900109T 1989-12-01 1990-11-30 Metodos para detectar la resorcion osea in vivo. Expired - Lifetime ES2061422T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/444,881 US5140103A (en) 1987-11-06 1989-12-01 Peptide fragments containing HP and LP cross-links
US07/614,719 US5300434A (en) 1987-11-06 1990-11-21 Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide

Publications (2)

Publication Number Publication Date
ES2061422T1 true ES2061422T1 (es) 1994-12-16
ES2061422T3 ES2061422T3 (es) 1996-03-16

Family

ID=27034100

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95201176T Expired - Lifetime ES2133656T3 (es) 1989-12-01 1990-11-30 Metodos para detectar in vivo la degradacion de colageno.
ES91900109T Expired - Lifetime ES2061422T3 (es) 1989-12-01 1990-11-30 Metodos para detectar la resorcion osea in vivo.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES95201176T Expired - Lifetime ES2133656T3 (es) 1989-12-01 1990-11-30 Metodos para detectar in vivo la degradacion de colageno.

Country Status (13)

Country Link
US (5) US5300434A (es)
EP (6) EP1560026A1 (es)
JP (6) JP2782017B2 (es)
AT (3) ATE179521T1 (es)
AU (1) AU645049B2 (es)
DE (4) DE502928T1 (es)
DK (3) DK0682256T3 (es)
ES (2) ES2133656T3 (es)
GR (3) GR940300047T1 (es)
IE (1) IE65280B1 (es)
NO (1) NO309483B1 (es)
RU (1) RU2139541C1 (es)
WO (1) WO1991008478A2 (es)

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US6153732A (en) * 1987-11-06 2000-11-28 Washington Research Foundation Kit for detecting analyte indicative of type II collagen resorption in vivo
US4973666A (en) * 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US5320970A (en) * 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
US5300434A (en) * 1987-11-06 1994-04-05 Washington Research Foundation Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
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Also Published As

Publication number Publication date
RU2139541C1 (ru) 1999-10-10
JP2782017B2 (ja) 1998-07-30
DE69033082D1 (de) 1999-06-02
US5677198A (en) 1997-10-14
EP1632502A1 (en) 2006-03-08
IE904344A1 (en) 1991-06-05
JPH05502223A (ja) 1993-04-22
JP2002139492A (ja) 2002-05-17
EP0682256A1 (en) 1995-11-15
JPH10260183A (ja) 1998-09-29
NO922149L (no) 1992-07-29
DE69034170D1 (de) 2004-11-18
JP2999416B2 (ja) 2000-01-17
DE69025199D1 (de) 1996-03-14
WO1991008478A2 (en) 1991-06-13
EP0502928A1 (en) 1992-09-16
EP0502928B1 (en) 1996-01-31
EP0682257A1 (en) 1995-11-15
EP1560026A1 (en) 2005-08-03
DK0502928T3 (da) 1996-02-19
NO922149D0 (no) 1992-05-29
GR940300047T1 (en) 1994-07-29
DK0682256T3 (da) 2005-02-14
GR3018852T3 (en) 1996-05-31
ES2061422T3 (es) 1996-03-16
EP0890840A3 (en) 2000-05-17
JP2000050865A (ja) 2000-02-22
ATE133790T1 (de) 1996-02-15
GR3030646T3 (en) 1999-10-29
DE69033082T2 (de) 1999-09-30
JP3299941B2 (ja) 2002-07-08
AU645049B2 (en) 1994-01-06
AU6889891A (en) 1991-06-26
EP0890840A2 (en) 1999-01-13
ATE279730T1 (de) 2004-10-15
NO309483B1 (no) 2001-02-05
JPH09113510A (ja) 1997-05-02
EP0682256B1 (en) 2004-10-13
JP2999444B2 (ja) 2000-01-17
DK0682257T3 (da) 1999-11-08
DE502928T1 (de) 1994-08-18
US5576189A (en) 1996-11-19
US5473052A (en) 1995-12-05
ATE179521T1 (de) 1999-05-15
DE69034170T2 (de) 2006-03-02
US5300434A (en) 1994-04-05
EP0682257B1 (en) 1999-04-28
DE69025199T2 (de) 1996-05-30
ES2133656T3 (es) 1999-09-16
WO1991008478A3 (en) 1991-11-28
JP2000055915A (ja) 2000-02-25
US5656439A (en) 1997-08-12
IE65280B1 (en) 1995-10-18

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