ES2061695T3 - Acidos quinolinacarboxilicos sustituidos con heterociclos. - Google Patents

Acidos quinolinacarboxilicos sustituidos con heterociclos.

Info

Publication number
ES2061695T3
ES2061695T3 ES88311797T ES88311797T ES2061695T3 ES 2061695 T3 ES2061695 T3 ES 2061695T3 ES 88311797 T ES88311797 T ES 88311797T ES 88311797 T ES88311797 T ES 88311797T ES 2061695 T3 ES2061695 T3 ES 2061695T3
Authority
ES
Spain
Prior art keywords
quinolinacarboxilic
heterocicles
acids substituted
acids
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88311797T
Other languages
English (en)
Inventor
Katherine E Brighty
Iii John Adams Lowe
Paul Robert Mcguirk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2061695T3 publication Critical patent/ES2061695T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)

Abstract

LOS ACIDOS 1 - SUSTITUIDOS - 6 FLUOR - 7 - HETEROCICLICOS - 1,4 DIHIDROQUINO - 1 - (O DIHIDRONAFTIRIDIN) - 4 - ONA CARBOXILICOS RIENEN PROPIEDADES ANTIBACTERIANAS. EL GRUPO 7 - HETEROCICLICO ES UN GRUPO BICICLICO UNO DE CUYOS ANILLOS ES SATURADO Y EL OTRO INSATURADO.
ES88311797T 1987-12-18 1988-12-14 Acidos quinolinacarboxilicos sustituidos con heterociclos. Expired - Lifetime ES2061695T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/003412 WO1989005643A1 (en) 1987-12-18 1987-12-18 Heterocyclic-substituted quinoline-carboxylic acids

Publications (1)

Publication Number Publication Date
ES2061695T3 true ES2061695T3 (es) 1994-12-16

Family

ID=22202722

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88311797T Expired - Lifetime ES2061695T3 (es) 1987-12-18 1988-12-14 Acidos quinolinacarboxilicos sustituidos con heterociclos.

Country Status (18)

Country Link
US (1) US5037834A (es)
EP (1) EP0321191B1 (es)
JP (1) JPH0725757B2 (es)
KR (1) KR900008568B1 (es)
AT (1) ATE113599T1 (es)
AU (1) AU600188B2 (es)
DE (1) DE3852010T2 (es)
DK (1) DK699788A (es)
ES (1) ES2061695T3 (es)
FI (1) FI90239C (es)
IE (1) IE65732B1 (es)
IL (1) IL88664A (es)
MY (1) MY104072A (es)
NO (1) NO178149C (es)
NZ (1) NZ227357A (es)
PT (1) PT89222B (es)
WO (1) WO1989005643A1 (es)
ZA (1) ZA889395B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0251308B1 (de) * 1986-07-04 1990-11-22 Chemie Linz Gesellschaft m.b.H. 4-Chinolon-3-carbonsäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US5093515A (en) * 1987-08-14 1992-03-03 Asahi Glass Company Ltd. Fluorinated benzoyl compounds
EP0303291B1 (en) * 1987-08-14 1995-04-26 Asahi Glass Company Ltd. Fluorinated benzoyl compounds
US5214051A (en) * 1989-08-01 1993-05-25 Pfizer Inc. Thiazolyl and oxazolyl[5,4-c]piperidyl-substituted quinolone-carboxylic acid and related analogs thereof having antibacterial properties are disclosed
KR910009333B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
KR910009330B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
DE4342186A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten
DE19652239A1 (de) * 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6855385B2 (en) * 2000-05-31 2005-02-15 Ttm Advanced Circuits, Inc. PCB support plate for PCB via fill
US6951863B2 (en) * 2001-02-07 2005-10-04 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenly oxazolidinone antibacterials, and related compositions and methods
BR0314759A (pt) * 2002-09-26 2005-07-26 Pfizer Derivados de pirazol
CL2004000553A1 (es) * 2003-03-20 2005-02-04 Actelion Pharmaceuticals Ltd Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende.
GB0610804D0 (en) * 2006-05-31 2006-07-12 Portela & Ca Sa New crystal forms
KR20090047450A (ko) * 2006-08-04 2009-05-12 메르츠 파마 게엠베하 운트 코. 카가아 치환된 피라졸로피리미딘, 이의 제조 방법 및 의약품으로서의 이의 용도
EP2231648A1 (en) * 2007-12-05 2010-09-29 BIAL - Portela & Ca., S.A. New salts and crystal forms
CN105017151B (zh) * 2011-08-31 2019-04-02 大塚制药株式会社 喹诺酮化合物
TWI695000B (zh) * 2017-10-29 2020-06-01 中國醫藥大學 用於抑制ａｄａｍ９活性之化合物、其醫藥組合物及其用途
US20240132517A1 (en) * 2021-02-10 2024-04-25 Goharmony Therapeutics (Shenzhen) Co., Ltd. Macrocyclic compound, pharmaceutical composition, and use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
JPS59128383A (ja) * 1982-12-29 1984-07-24 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
JPS59204194A (ja) * 1983-05-09 1984-11-19 Hokuriku Seiyaku Co Ltd ７−ジアザビシクロアルカン置換−６，８−ジフオロ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸誘導体
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
US4636506A (en) * 1984-12-06 1987-01-13 Pfizer, Inc. 7-heterocyclic-1,4-dihydroquinolones
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
DE3519286A1 (de) * 1985-05-30 1986-12-04 Bayer Ag, 5090 Leverkusen 7-azolyl-1-cyclopropyl-1,4-dihydro-4-oxo-3- chinolincarbonsaeuren und -1,8-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
IN166416B (es) * 1985-09-18 1990-05-05 Pfizer

Also Published As

Publication number Publication date
FI90239C (fi) 1994-01-10
JPH0725757B2 (ja) 1995-03-22
AU600188B2 (en) 1990-08-02
KR890009925A (ko) 1989-08-04
FI893883A0 (fi) 1989-08-17
ZA889395B (en) 1990-08-29
DK699788A (da) 1989-08-11
NO893305D0 (no) 1989-08-17
NO893305L (no) 1989-10-17
FI893883A7 (fi) 1989-08-17
IL88664A0 (en) 1989-07-31
IL88664A (en) 1993-08-18
MY104072A (en) 1993-11-30
NO178149C (no) 1996-01-31
NZ227357A (en) 1991-04-26
KR900008568B1 (ko) 1990-11-24
JPH01211587A (ja) 1989-08-24
EP0321191A2 (en) 1989-06-21
ATE113599T1 (de) 1994-11-15
PT89222A (pt) 1989-12-29
IE883763L (en) 1989-06-18
AU2698788A (en) 1989-06-22
EP0321191B1 (en) 1994-11-02
IE65732B1 (en) 1995-11-15
DK699788D0 (da) 1988-12-16
DE3852010T2 (de) 1995-03-09
WO1989005643A1 (en) 1989-06-29
PT89222B (pt) 1994-11-30
EP0321191A3 (en) 1991-02-27
FI90239B (fi) 1993-09-30
NO178149B (no) 1995-10-23
DE3852010D1 (de) 1994-12-08
US5037834A (en) 1991-08-06

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