ES2061785T3 - Benzopiranos 2,2-disustituidos de utilidad como antagonistas de leucotrieno-d4. - Google Patents

Benzopiranos 2,2-disustituidos de utilidad como antagonistas de leucotrieno-d4.

Info

Publication number
ES2061785T3
ES2061785T3 ES89108925T ES89108925T ES2061785T3 ES 2061785 T3 ES2061785 T3 ES 2061785T3 ES 89108925 T ES89108925 T ES 89108925T ES 89108925 T ES89108925 T ES 89108925T ES 2061785 T3 ES2061785 T3 ES 2061785T3
Authority
ES
Spain
Prior art keywords
hydrogen
chem
straight
carbon atoms
branched chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89108925T
Other languages
English (en)
Inventor
Francis J Koszyk
James Ronald Deason
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2061785T3 publication Critical patent/ES2061785T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pretreatment Of Seeds And Plants (AREA)

Abstract

ESTA SE REFIERE A COMPUESTOS DE BENZOPIRANO 2,2 - DISUSTITUIDOS QUE POSEEN ACTIVIDAD ANTAGONISTA DE LEUCOTRIENO - D4, (LTD4). EN ESPECIAL SE REFIERE A ANTAGONISTAS DE LTD4 DE LA FORMULA(I) O UNA SAL DE ESTO, DONDE X1 Y X2 PUEDEN SER LOS MISMOS O DIFERENTES Y SON MIEMBROS DEL GRUPO QUE COMPRENDE H, - CL, - BR - CF3, NH2, NO2 O ALQUILO DE CADENA RECTA O RAMIFICADA DE 1 A 3 C, SIENDO M UN ENTERO DE 1 A 9, N ES DE 1 A 5, Y V = C = O, - CH(OH) - O CH2 -, W ES H O ALQUILO DE 1 A 6 C DE CADENA RECTA O RAMIFICADA, Y ES H O - COCH3, Z ES - CHO, - COOR2, - COR3, Y R2, R3, R4, R5, R6, R7 Y R8 TIENEN EL SIGNIFICADO DADO EN LA ESPECIFICACION.
ES89108925T 1988-05-20 1989-05-18 Benzopiranos 2,2-disustituidos de utilidad como antagonistas de leucotrieno-d4. Expired - Lifetime ES2061785T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/196,996 US4950684A (en) 1988-05-20 1988-05-20 2,2-di-substituted benzopyran leukotriene-D4 antagonists

Publications (1)

Publication Number Publication Date
ES2061785T3 true ES2061785T3 (es) 1994-12-16

Family

ID=22727590

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89108925T Expired - Lifetime ES2061785T3 (es) 1988-05-20 1989-05-18 Benzopiranos 2,2-disustituidos de utilidad como antagonistas de leucotrieno-d4.

Country Status (6)

Country Link
US (1) US4950684A (es)
EP (1) EP0342664B1 (es)
JP (1) JPH0217182A (es)
AT (1) ATE98642T1 (es)
DE (1) DE68911371T2 (es)
ES (1) ES2061785T3 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
US5686465A (en) * 1988-10-31 1997-11-11 Endorecherche Inc. Sex steroid activity inhibitors
FR2673629B1 (fr) * 1991-03-08 1993-05-07 Adir Nouveaux derives du benzopyrane leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US6060503A (en) * 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
US5457124A (en) * 1993-12-07 1995-10-10 Hoffmann-La Roche Inc. Carboxylic acid Leukotriene B4 antagonists
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
CA2583084C (en) * 2003-09-19 2010-12-07 Galileo Pharmaceuticals, Inc. 7,8-bicycloalkyl-chroman derivatives
WO2006065686A2 (en) 2004-12-13 2006-06-22 Galileo Pharmaceuticals, Inc. Spiro derivatives as lipoxygenase inhibitors
CA2600004A1 (en) 2005-02-25 2006-09-08 Eli Lilly And Company Spiro-heterocyclic chromans, thiochromans and dihydroquinolines
US8093253B2 (en) * 2008-03-06 2012-01-10 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3952013A (en) * 1969-02-12 1976-04-20 Fisons Limited 1-Thiachromone-2-carboxylic acids and derivatives
GB1384530A (en) * 1971-07-29 1975-02-19 Fisons Ltd Chromone derivatives
US4006245A (en) * 1971-07-29 1977-02-01 Fisons Limited Chemical compounds
US4133889A (en) * 1971-07-29 1979-01-09 Fisons, Ltd. 2(5-Tetrazolyl)chromones
US3953604A (en) * 1972-01-14 1976-04-27 Miles Laboratories, Inc. 1-(2-Substituted-chromonyloxy)-2-hydroxy-3-(substituted phenoxy)propanes
US4156726A (en) * 1974-12-07 1979-05-29 Fisons Limited 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds
GB1493998A (en) * 1975-06-03 1977-12-07 Beecham Group Ltd Propanolamine derivatives
US4238495A (en) * 1976-01-30 1980-12-09 Miles Laboratories, Inc. 1-(4-Cyano-phenoxy)-2-hydroxy-3-[2-(5-1H-tetrazolyl)-chromon-5-yloxy]-propane and salts thereof
GB1583691A (en) * 1977-01-26 1981-01-28 Fisons Ltd Benzopyrans
US4158663A (en) * 1977-07-15 1979-06-19 Warner-Lambert Company Process for the production of 2-substituted chromones
ATE14579T1 (de) * 1979-03-20 1985-08-15 Fisons Plc Pharmazeutische heterocyclische verbindungen, verfahren zu ihrer herstellung und sie enthaltende zusammensetzungen.
HU184359B (en) * 1980-12-16 1984-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing substituted acyl-carbamides
DE3275295D1 (en) * 1981-11-12 1987-03-05 Fisons Plc Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them
ZA844519B (en) * 1983-06-24 1985-02-27 Hoffmann La Roche Dihydrobenzopyran derivatives
US4665203A (en) * 1983-08-08 1987-05-12 G. D. Searle & Co. Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors
AU548450B2 (en) * 1983-08-08 1985-12-12 G.D. Searle & Co. Substituted dihydrobenzopyrans
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
US4546194A (en) * 1984-05-29 1985-10-08 G. D. Searle & Co. Substituted chromanon-2-yl alkanols and derivatives thereof
CA1261835A (en) * 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides

Also Published As

Publication number Publication date
JPH0217182A (ja) 1990-01-22
DE68911371D1 (de) 1994-01-27
ATE98642T1 (de) 1994-01-15
EP0342664B1 (en) 1993-12-15
EP0342664A3 (en) 1990-01-10
US4950684A (en) 1990-08-21
DE68911371T2 (de) 1994-05-19
EP0342664A2 (en) 1989-11-23

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