ES2062688T3 - Derivados tioalquiltio cefalosporina. - Google Patents

Derivados tioalquiltio cefalosporina.

Info

Publication number
ES2062688T3
ES2062688T3 ES91306442T ES91306442T ES2062688T3 ES 2062688 T3 ES2062688 T3 ES 2062688T3 ES 91306442 T ES91306442 T ES 91306442T ES 91306442 T ES91306442 T ES 91306442T ES 2062688 T3 ES2062688 T3 ES 2062688T3
Authority
ES
Spain
Prior art keywords
sub
thioalkyltio
acil
cephalosporin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91306442T
Other languages
English (en)
Inventor
Tadatoshi Kubota
Masaharu Kume
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2062688T3 publication Critical patent/ES2062688T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

ES UN NUEVO COMPUESTO ANTIBIOTICO DE CEFALOSPORIN TIOALKILTIO DE FORMULA I: DONDE EL ACIL ES ACIL C SUB 1 ET ES GRUPO HETEROAROMATICO MONOCLINICO OPCIONALMENTE SUSTITUIDO CONTENIENDO UNO O MAS ATOMOS HETERO; R ELEVADO 1 ES UN ENLACE UNICO O ALQUILENO C SUB 1 ILENO LINEAL O RAMIFICADO C SUB 1 AZUFRE O UN GRUPO SULFOXIDO; E Y ES UN ATOMO DE HIDROGENO O UN GRUPO METOXI, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS ANTERIORES O UN AMINO-CARBOXI ELLOS; UNA FORMULA CONTENIENDO LO MISMO Y UN METODO PARA TRATAR LAS INFECCIONES BACTERIANAS.
ES91306442T 1990-07-19 1991-07-16 Derivados tioalquiltio cefalosporina. Expired - Lifetime ES2062688T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP19188990 1990-07-19
JP28977290 1990-10-25
JP31957890 1990-11-21
JP14735791 1991-06-19

Publications (1)

Publication Number Publication Date
ES2062688T3 true ES2062688T3 (es) 1994-12-16

Family

ID=27472779

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91306442T Expired - Lifetime ES2062688T3 (es) 1990-07-19 1991-07-16 Derivados tioalquiltio cefalosporina.

Country Status (22)

Country Link
US (2) US5214037A (es)
EP (2) EP0467647B1 (es)
JP (1) JP2618119B2 (es)
KR (1) KR100203726B1 (es)
CN (1) CN1034504C (es)
AT (2) ATE181066T1 (es)
AU (1) AU634074B2 (es)
CA (2) CA2047347C (es)
DE (2) DE69103490T2 (es)
DK (2) DK0594263T3 (es)
ES (1) ES2062688T3 (es)
FI (1) FI110322B (es)
HU (2) HUT60274A (es)
IE (1) IE65926B1 (es)
IL (1) IL98745A (es)
MX (1) MX9100227A (es)
NO (1) NO178544C (es)
NZ (1) NZ238838A (es)
PH (1) PH31091A (es)
PL (3) PL167091B1 (es)
PT (1) PT98362B (es)
RU (2) RU2071963C1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100576A (en) * 1991-01-18 1995-11-27 Eli Lilley And Company Cephalosporin antibiotics
ES2115725T3 (es) * 1992-07-31 1998-07-01 Shionogi & Co Hidrocloruro de triazoliltiometiltiocefalosporina, su hidrato cristalino y la preparacion de este.
JP3238209B2 (ja) * 1992-09-30 2001-12-10 塩野義製薬株式会社 チオメチルチオカルバセファロスポリン誘導体
KR100377559B1 (ko) * 1998-08-31 2003-03-26 주식회사 엘지생명과학 경구투여 가능한 세팔로스포린계 화합물 및 이의 제조방법
CA2287663C (en) * 1998-11-02 2008-04-08 Isao Kurimoto Process for producing 2-alkylidene-4-bromoacetoacetic acid ester
ATE250044T1 (de) 1998-11-12 2003-10-15 Sumitomo Chemical Co Herstellung von derivaten von 2-aminothiazol hydrobromid z-isomeren
IT1317735B1 (it) * 2000-01-26 2003-07-15 Nicox Sa Sali di agenti antimicrobici.
US20030166922A1 (en) * 2000-06-28 2003-09-04 Yang-Rae Cho Novel cephalosporin compounds and process for preparing the same
ZA200302127B (en) * 2000-09-21 2007-07-25 Trine Pharmaceuticals Inc Prodrugs of a 7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotic
KR20020085178A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20020085181A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20030076759A (ko) * 2002-03-21 2003-09-29 주식회사 엘지생명과학 신규 세팔로스포린 화합물 및 그의 제조 방법
JP2007523864A (ja) * 2003-07-10 2007-08-23 シェーリング　コーポレイション ３−ケトアルカン酸エステルから２−（アルコキシアルキリデン）−３−ケトアルカン酸エステルを調製および精製するためのプロセス
RU2286158C2 (ru) * 2004-04-23 2006-10-27 Институт биологии Уфимского научного центра Российской Академии Наук (ИБ УНЦ РАН) Дезинфицирующий состав - стабилизированный раствор однохлористого йода (варианты)
RU2277908C1 (ru) * 2005-11-25 2006-06-20 Закрытое акционерное общество "БиоАргоФарм" Водорастворимое средство, обладающее противовирусной активностью, на основе соединения серебра с цистином и способ его получения
CN103193731B (zh) * 2012-01-09 2015-04-22 华东理工大学 一种制备顺式-2-(2-叔丁氧甲酰胺基噻唑-4-基)-2-戊烯酸的方法
CN106831639B (zh) * 2016-12-31 2019-03-19 山东金城柯瑞化学有限公司 头孢卡品侧链酸的制备方法
IL271394B2 (en) * 2017-12-22 2023-12-01 Illumina Inc Catalytically active substances
CN108440442A (zh) * 2018-05-08 2018-08-24 湖北凌晟药业有限公司 一种bapa的合成方法
EP4366295A3 (en) 2018-10-04 2024-08-07 Samsung Electronics Co., Ltd. Method and system for recording a super slow motion video in a portable electronic device
CN111395694A (zh) * 2020-04-09 2020-07-10 安徽扬子地板股份有限公司 一种基于石墨烯的防霉导热地板

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1595995A1 (de) * 1966-04-23 1970-02-12 Merck Ag E Fungizides Mittel
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
GB8314803D0 (en) * 1983-05-27 1983-07-06 Hoechst Uk Ltd 7-oxo-4-thia-1 azabicyclo 3.2.0 heptene derivatives
US4812562A (en) * 1985-07-25 1989-03-14 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4921953A (en) * 1988-02-18 1990-05-01 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives

Also Published As

Publication number Publication date
KR920002609A (ko) 1992-02-28
JP2618119B2 (ja) 1997-06-11
DE69131325D1 (de) 1999-07-15
AU8110291A (en) 1992-01-23
NZ238838A (en) 1992-08-26
PL167091B1 (pl) 1995-07-31
EP0467647A3 (en) 1992-08-12
ATE110081T1 (de) 1994-09-15
CA2047347C (en) 2002-03-19
DE69103490D1 (de) 1994-09-22
DK0467647T3 (da) 1994-12-05
JPH0559066A (ja) 1993-03-09
CN1058595A (zh) 1992-02-12
EP0467647A2 (en) 1992-01-22
PL167119B1 (pl) 1995-07-31
EP0467647B1 (en) 1994-08-17
PL291129A1 (en) 1992-04-06
RU2060993C1 (ru) 1996-05-27
PL167099B1 (en) 1995-07-31
FI110322B (fi) 2002-12-31
ATE181066T1 (de) 1999-06-15
MX9100227A (es) 1993-01-01
FI913458A0 (fi) 1991-07-18
HUT60274A (en) 1992-08-28
US5352792A (en) 1994-10-04
NO178544C (no) 1996-04-17
KR100203726B1 (ko) 1999-06-15
DE69131325T2 (de) 1999-12-02
IE912321A1 (en) 1992-01-29
DE69103490T2 (de) 1994-12-15
NO912821L (no) 1992-01-20
CA2359026A1 (en) 1992-01-20
EP0594263A1 (en) 1994-04-27
AU634074B2 (en) 1993-02-11
RU2071963C1 (ru) 1997-01-20
IL98745A (en) 1997-03-18
PT98362A (pt) 1992-05-29
PT98362B (pt) 1999-01-29
FI913458L (fi) 1992-01-20
IL98745A0 (en) 1992-07-15
IE65926B1 (en) 1995-11-29
NO912821D0 (no) 1991-07-18
CN1034504C (zh) 1997-04-09
NO178544B (no) 1996-01-08
US5214037A (en) 1993-05-25
EP0594263B1 (en) 1999-06-09
PH31091A (en) 1998-02-05
CA2047347A1 (en) 1992-01-20
HU222727B1 (hu) 2003-09-29
DK0594263T3 (da) 1999-11-15
HU912409D0 (en) 1991-12-30

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