ES2070089B1 - Solucion de perfusion, conservacion y reperfusion de organos. - Google Patents

Solucion de perfusion, conservacion y reperfusion de organos.

Info

Publication number: ES2070089B1
Authority: ES; Spain
Prior art keywords: liter; mmoles; organs; solution; reduced
Prior art date: 1992-09-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

ES09301971A

Other languages

English (en)

Spanish (es)

Other versions

ES2070089A1 (es

Inventor

Philippe Menasche

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Pasteur SA

Original Assignee

Pasteur Merieux Serum et Vaccines SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-18

Filing date

1993-09-17

Publication date

1995-12-16

1993-09-17 Application filed by Pasteur Merieux Serum et Vaccines SA filed Critical Pasteur Merieux Serum et Vaccines SA

1995-05-16 Publication of ES2070089A1 publication Critical patent/ES2070089A1/es

1995-12-16 Application granted granted Critical

1995-12-16 Publication of ES2070089B1 publication Critical patent/ES2070089B1/es

2013-09-17 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

210000000056 organ Anatomy 0.000 title abstract 3
230000010412 perfusion Effects 0.000 title abstract 2
230000010410 reperfusion Effects 0.000 title abstract 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 3
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 abstract 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
XNPKNHHFCKSMRV-UHFFFAOYSA-N 4-(cyclohexylamino)butane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCCNC1CCCCC1 XNPKNHHFCKSMRV-UHFFFAOYSA-N 0.000 abstract 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
239000001110 calcium chloride Substances 0.000 abstract 1
229910001628 calcium chloride Inorganic materials 0.000 abstract 1
229930195712 glutamate Natural products 0.000 abstract 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
229940099584 lactobionate Drugs 0.000 abstract 1
JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 abstract 1
229910001629 magnesium chloride Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000001103 potassium chloride Substances 0.000 abstract 1
235000011164 potassium chloride Nutrition 0.000 abstract 1
238000001356 surgical procedure Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

ES09301971A 1992-09-18 1993-09-17 Solucion de perfusion, conservacion y reperfusion de organos. Expired - Fee Related ES2070089B1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US94607392A	1992-09-18	1992-09-18

Publications (2)

Publication Number	Publication Date
ES2070089A1 ES2070089A1 (es)	1995-05-16
ES2070089B1 true ES2070089B1 (es)	1995-12-16

Family

ID=25483919

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES09301971A Expired - Fee Related ES2070089B1 (es)	1992-09-18	1993-09-17	Solucion de perfusion, conservacion y reperfusion de organos.

Country Status (9)

Country	Link
AT (1)	AT407216B (de)
BE (1)	BE1007500A3 (de)
CA (1)	CA2106249C (de)
CH (1)	CH686870A5 (de)
DE (1)	DE4331711C2 (de)
ES (1)	ES2070089B1 (de)
FR (1)	FR2695827B1 (de)
GB (1)	GB2270614B (de)
IT (1)	IT1272638B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19527734A1 (de) *	1995-07-28	1997-01-30	Hubert Verhaag	Verfahren und Vorrichtung zur Konservierung von Geweben und Organen, insbesondere von Transplantationsgeweben und -organen
US5880098A (en) *	1996-04-12	1999-03-09	Pharmacia & Upjohn Aktiebolag	Therapeutic treatment
SE9601396D0 (sv) *	1996-04-12	1996-04-12	Dieter Haeussinger	New therapeutic treatment 2
DE19706111C2 (de) *	1997-02-17	1999-02-18	Fresenius Medical Care De Gmbh	Lösung zur Aufbewahrung von Organen
RU2140152C1 (ru) *	1997-03-13	1999-10-27	Иван Антонович Мазур	Консервирующий раствор "б-2" для трансплантатов
US5834178C1 (en) *	1997-07-09	2002-04-23	Univ Wayne State	Flush-storage solution for donor organs
CN1057192C (zh) *	1997-09-10	2000-10-11	上海长征医院	一种配制多器官保存液的方法
DE19834087C1 (de) *	1998-07-29	2000-03-30	Mirzaie Sedaposhteh Massoud	Wäßrige Konservierungslösung und Verfahren zur Aufbewahrung tierischen Gewebes
FR2785501B1 (fr) *	1998-11-10	2001-01-05	Centre Nat Rech Scient	Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
GB0028414D0 (en)	2000-11-22	2001-01-03	Univ Leeds	Flush preservation solution
US20060078872A1 (en) *	2004-10-12	2006-04-13	Atsushi Taguchi	Cell-preservation liquid
WO2007128866A2 (en) *	2006-05-09	2007-11-15	Novobion Oy	Novel chemical compositions
CA2910189A1 (en) *	2013-04-24	2014-10-30	Somahlution, Llc	Organ and tissue preservation solutions having increased oxygen-content, stability and shelf life
JP2016520580A (ja) *	2013-04-29	2016-07-14	ソマールション・エルエルシー	臓器及び組織の保存溶液の酸素含量、安定性、及び貯蔵寿命を増大させるための、ポリ（０−２−ヒドロキシエチル）デンプンを含有する製剤
CN105916374B (zh)	2013-11-22	2021-11-05	索玛解有限公司	用于增加器官和组织保存溶液的稳定性和储存寿命的溶液
CN115720893B (zh) *	2022-08-08	2024-02-23	四川大学华西医院	一种甲状旁腺体外保存液和保存方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4879283A (en) *	1985-10-03	1989-11-07	Wisconsin Alumni Research Foundation	Solution for the preservation of organs
US4798824A (en) *	1985-10-03	1989-01-17	Wisconsin Alumni Research Foundation	Perfusate for the preservation of organs
ES2007994A6 (es) *	1988-08-16	1989-07-01	Grino Boira Jose Maria	Medio liquido para perfusion y preservacion de organos.
US4920044A (en) *	1988-11-08	1990-04-24	The Cleveland Clinic Foundation	Intracellular flush solution for preserving organs
US4938961A (en) *	1989-04-28	1990-07-03	Geoffrey Collins	Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia
US5104787A (en) *	1990-03-05	1992-04-14	Lindstrom Richard L	Method for apparatus for a defined serumfree medical solution useful for corneal preservation
US5145771A (en) *	1990-04-12	1992-09-08	The University Of North Carolina At Chapel Hill	Rinse solution for organs and tissues
GB9021325D0 (en) *	1990-10-01	1990-11-14	Geistlich Soehne Ag	Chemical composition
CH683485A5 (fr) *	1990-11-20	1994-03-31	Pasteur Merieux Serums Vacc	Solutions de perfusion, de conservation et de reperfusion d'organes.

1993
- 1993-09-14 CH CH02760/93A patent/CH686870A5/fr not_active IP Right Cessation
- 1993-09-14 FR FR9310926A patent/FR2695827B1/fr not_active Expired - Lifetime
- 1993-09-14 BE BE9300965A patent/BE1007500A3/fr not_active IP Right Cessation
- 1993-09-15 CA CA002106249A patent/CA2106249C/fr not_active Expired - Lifetime
- 1993-09-16 IT ITMI931994A patent/IT1272638B/it active IP Right Grant
- 1993-09-17 ES ES09301971A patent/ES2070089B1/es not_active Expired - Fee Related
- 1993-09-17 GB GB9319264A patent/GB2270614B/en not_active Expired - Lifetime
- 1993-09-17 DE DE4331711A patent/DE4331711C2/de not_active Expired - Lifetime
- 1993-09-20 AT AT0189793A patent/AT407216B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ITMI931994A1 (it)	1995-03-16
ES2070089A1 (es)	1995-05-16
FR2695827A1 (fr)	1994-03-25
DE4331711A1 (de)	1994-03-24
ITMI931994A0 (it)	1993-09-16
GB2270614B (en)	1996-03-20
CA2106249A1 (fr)	1994-03-19
GB9319264D0 (en)	1993-11-03
GB2270614A (en)	1994-03-23
ATA189793A (de)	2000-06-15
IT1272638B (it)	1997-06-26
DE4331711C2 (de)	2001-05-03
BE1007500A3 (fr)	1995-07-18
CA2106249C (fr)	2009-04-14
CH686870A5 (fr)	1996-07-31
FR2695827B1 (fr)	1995-07-28
AT407216B (de)	2001-01-25

Legal Events

Date	Code	Title	Description
2014-11-20	FD2A	Announcement of lapse in spain	Effective date: 20141120

Publication	Publication Date	Title
ES2070089B1 (es)	1995-12-16	Solucion de perfusion, conservacion y reperfusion de organos.
FR2785501B1 (fr)	2001-01-05	Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
EP0634408A4 (de)	1995-03-08	Depsipeptide, herstellung und anwendung.
KR960703340A (ko)	1996-08-17	안정화된 약학적 펩티드 조성물
EP0943326A4 (de)	2000-12-20	Puderförmige zusammensetzung zur nasalen anwendung
KR900007427A (ko)	1990-06-01	안과용 수용액제 및 이를 보존하는 방법
CA2104196A1 (en)	1994-04-14	Methods of combating pneumocystis carinii pneumonia and compounds useful therefor
NO874908D0 (no)	1987-11-25	Antimikrobielle proteiner, preparater inneholdende disse og anvendelse derav.
ES8306996A1 (es)	1983-06-16	Procedimiento para preparar derivados de amidas.
FI820808L (fi)	1982-09-11	Stabiliserade insulinpreparat och foerfarande foer framstaellning av dessa
DK296389A (da)	1989-12-17	Farmaceutiske forbindelser
ES8504235A1 (es)	1984-08-16	Un procedimiento para la produccion de un concentrado de espuma antiincendios a base de un oligomero.
FI933814A0 (fi)	1993-09-01	Framstaellning av faktor-ix
LTIP508A (lt)	1994-08-25	Agrocheminės kompozicijos ir 3-hidroksi-5-metilizoksazolo taikymo būdai
CA2055827A1 (en)	1992-05-21	Solutions for the perfusion, preservation and reperfusion of organs
EP0621285A4 (de)	1995-05-24	Neuer megakaryocyten-verstärker.
ES2097423T3 (es)	1997-04-01	Analogos de vitamina d3.
IL108221A (en)	1997-09-30	Iron stabilized 3-isothiazolone solutions
IL101717A0 (en)	1992-12-30	Wf11243 substance,a method of preparation thereof,and fungicidal and protozoicidal pharmaceutical compositions containing the same
RU95117286A (ru)	1998-01-10	Ирригационный раствор для офтальмологических операций
BE903493A (fr)	1986-04-22	Penta-et hepta-peptides biologiquement actifs
RU98111171A (ru)	2000-09-20	Состав для обработки призабойной зоны пласта
ATE87477T1 (de)	1993-04-15	Chromoglycinsaeure-natriumsalz enthaltende aerosolzubereitungen.
PE16198A1 (es)	1998-04-11	Compuesto de ciclohexapeptidil bis-amina, composiciones que lo contienen y metodos de uso
UA6882C2 (uk)	1995-03-31	Стерилізуючий засіб