ES2070488T3 - Procedimiento para la deteccion de enfermedades malignas. - Google Patents

Procedimiento para la deteccion de enfermedades malignas.

Info

Publication number
ES2070488T3
ES2070488T3 ES91902191T ES91902191T ES2070488T3 ES 2070488 T3 ES2070488 T3 ES 2070488T3 ES 91902191 T ES91902191 T ES 91902191T ES 91902191 T ES91902191 T ES 91902191T ES 2070488 T3 ES2070488 T3 ES 2070488T3
Authority
ES
Spain
Prior art keywords
sub
malignant diseases
receptors
procedure
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91902191T
Other languages
English (en)
Other versions
ES2070488T5 (es
Inventor
Heinz Bodenmuller
Andreas Dessauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6396458&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2070488(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES2070488T3 publication Critical patent/ES2070488T3/es
Application granted granted Critical
Publication of ES2070488T5 publication Critical patent/ES2070488T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

PARA DETECTAR ENFERMEDADES MALIGNAS SE INCUBA UNA MUESTRA DE UN LIQUIDO DEL CUERPO CON DOS RECEPTORES, R SUB 1 Y R SUB 2, POR LO MENOS Y SE PRODUCE UNA VARIACION EN LA SEÑAL ENLAZANDO POR LO MENOS LOS RECEPTORES R SUB 1 Y R SUB 2 A UNA SUSTANCIA QUE VA A SER DETECTADA EN LA SOLUCION DE MUESTRA. UNO DE LOS DOS RECEPTORES CONTIENE UN ANTICUERPO MONOCLONAL QUE ENLAZA LA SECUENCIA AMINOACIDA (291 A 335) DE CITOCESATINA (19) Y EL OTRO RECEPTOR CONTIENE UN ANTICUERPO MONOCLONAL QUE ENLAZA LA SECUENCIA AMINOACIDA (346 A 367) DE CITOCERATINA (19) Y DETERMINA LA VARIACION DE LA SEÑAL DEBIDA AL ENLACE.
ES91902191T 1989-12-27 1990-12-27 Procedimiento para la diagnosis de enfermedades tumorales. Expired - Lifetime ES2070488T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3942999A DE3942999C2 (de) 1989-12-27 1989-12-27 Verfahren zum Nachweis von malignen Erkrankungen

Publications (2)

Publication Number Publication Date
ES2070488T3 true ES2070488T3 (es) 1995-06-01
ES2070488T5 ES2070488T5 (es) 2002-07-01

Family

ID=6396458

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91902191T Expired - Lifetime ES2070488T5 (es) 1989-12-27 1990-12-27 Procedimiento para la diagnosis de enfermedades tumorales.

Country Status (9)

Country Link
US (1) US5288614A (es)
EP (1) EP0460190B2 (es)
JP (1) JPH082919B2 (es)
AT (1) ATE120550T1 (es)
CA (1) CA2046888A1 (es)
DE (2) DE3942999C2 (es)
DK (1) DK0460190T3 (es)
ES (1) ES2070488T5 (es)
WO (1) WO1991010139A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4208422A1 (de) * 1992-03-16 1993-09-30 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Mikrometastasen ekto- oder entodermaler Tumoren
US5547928A (en) * 1993-12-17 1996-08-20 Matritech, Inc. Methods and compositions for the detection of colon cancers
US6207380B1 (en) 1997-09-15 2001-03-27 Abbott Laboratories Reagents and methods useful for detecting diseases of the urinary tract
DE19855819C2 (de) * 1998-12-03 2001-02-15 Roche Diagnostics Gmbh Stabilisierung von Cytokeratin enthaltenden Kalibratoren
US8980568B2 (en) * 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
WO2005043166A1 (ja) * 2003-10-30 2005-05-12 Sysmex Corporation 子宮腺癌の診断薬及び腺癌細胞の検出方法
EP3147665A1 (en) * 2005-12-22 2017-03-29 Abbott Molecular Inc. Methods and marker combinations for screening for predisposition to lung cancer
CA2657621A1 (en) * 2006-07-14 2008-01-17 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
EP2064552B1 (en) * 2006-09-07 2011-08-31 Universitätsklinikum Hamburg-Eppendorf Method for the detection of cancerous epithelial cells using released cytokeratins as markers for said cells
CN103476428B (zh) * 2010-09-09 2016-10-26 北京同为时代生物技术有限公司 用于诊断上皮源性癌症的血液标志物及其单克隆抗体
SG11201408651TA (en) 2012-06-27 2015-01-29 Berg Llc Use of markers in the diagnosis and treatment of prostate cancer
CN106061998B (zh) * 2014-02-05 2020-12-11 弗吉瑞必欧诊断股份公司 用于检测恶性赘生性疾病的组合物和方法
KR102657306B1 (ko) 2014-12-08 2024-04-12 버그 엘엘씨 전립선암의 진단 및 치료에서 필라민을 포함하는 마커의 용도
JP6637290B2 (ja) * 2015-11-05 2020-01-29 武 永安 Ｃｋ１９に特異的なモノクローナル抗体およびこれを産生するハイブリドーマ、癌の検出キット、癌の検出方法および癌の転移の判定方法
US10301057B2 (en) 2016-07-11 2019-05-28 Calibre Closures Llc Dispensing container with internal squeeze limiting member
CN113061184B (zh) * 2021-04-25 2022-07-01 福州迈新生物技术开发有限公司 抗ck7蛋白单克隆抗体及其细胞株、制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE125626T1 (de) * 1984-01-06 1995-08-15 Univ California Cytokeratin-tumormarkierer und test zu deren nachweis.
US4727021A (en) * 1984-06-01 1988-02-23 Sloan-Kettering Institute For Cancer Research Human monoclonal antibodies to cytokeratin
DE3815932A1 (de) * 1988-01-26 1989-08-03 Progen Biotechnik Gmbh Verfahren zur identifizierung des ursprungs einer zellgewebsprobe
DE3640412A1 (de) * 1986-11-26 1988-06-09 Boehringer Mannheim Gmbh Verfahren zur bestimmung einer spezifisch bindefaehigen substanz

Also Published As

Publication number Publication date
US5288614A (en) 1994-02-22
DE3942999A1 (de) 1991-07-04
WO1991010139A1 (de) 1991-07-11
JPH082919B2 (ja) 1996-01-17
ATE120550T1 (de) 1995-04-15
DE59008810D1 (de) 1995-05-04
JPH04504063A (ja) 1992-07-23
EP0460190A1 (de) 1991-12-11
EP0460190B2 (de) 2001-11-28
CA2046888A1 (en) 1991-06-28
EP0460190B1 (de) 1995-03-29
ES2070488T5 (es) 2002-07-01
DE3942999C2 (de) 1997-12-18
DK0460190T3 (da) 1995-08-28

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