ES2073162T3 - Metodo para incrementar la relacion alfa/beta en una reaccion de condensacion de aspartama. - Google Patents

Metodo para incrementar la relacion alfa/beta en una reaccion de condensacion de aspartama.

Info

Publication number
ES2073162T3
ES2073162T3 ES91906462T ES91906462T ES2073162T3 ES 2073162 T3 ES2073162 T3 ES 2073162T3 ES 91906462 T ES91906462 T ES 91906462T ES 91906462 T ES91906462 T ES 91906462T ES 2073162 T3 ES2073162 T3 ES 2073162T3
Authority
ES
Spain
Prior art keywords
alpha
aspartama
increasing
condensation reaction
coupling step
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91906462T
Other languages
English (en)
Inventor
Yefim Gelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nutrasweet Co
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Application granted granted Critical
Publication of ES2073162T3 publication Critical patent/ES2073162T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Arrangement And Mounting Of Devices That Control Transmission Of Motive Force (AREA)
  • Mechanical Operated Clutches (AREA)
  • Seasonings (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

SE PRESENTA UN PASO DE ACOPLAMIENTO MEJORADO DE UN PROCESO DE FABRICACION DE ALFA-APM. LOS SOLVENTES DEL PASO DE ACOPLAMIENTO SE AJUSTAN DE UNA O DOS MANERAS PARA MEJORAR EL PORCENTAJE ISOMERICO DE ALFA A BETA DEL PRODUCTO DEL PASO DE ACOPLAMIENTO, L-ASPARTIL-L-FENILALANINA PROTEGIDA ALFA, BETA O ALQUILESTER INFERIOR DEL MISMO. EL SOLVENTE PUEDE CONTENER, POR UN LADO, UNA CONCENTRACION AUMENTADA DE UN ACIDO CARBOXILICO COMO POR EJEMPLO UN ACIDO ACETICO SOLO. POR OTRO LADO, SE UTILIZAN UNO O MAS SOLVENTES ADICIONALES JUNTO CON UN ACIDO CARBOXILICO COMO POR EJEMPLO ACIDO ACETICO EN CONCENTRACIONES TRADICIONALMENTE CONOCIDAS.
ES91906462T 1990-03-12 1991-03-06 Metodo para incrementar la relacion alfa/beta en una reaccion de condensacion de aspartama. Expired - Lifetime ES2073162T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49252490A 1990-03-12 1990-03-12

Publications (1)

Publication Number Publication Date
ES2073162T3 true ES2073162T3 (es) 1995-08-01

Family

ID=23956610

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91906462T Expired - Lifetime ES2073162T3 (es) 1990-03-12 1991-03-06 Metodo para incrementar la relacion alfa/beta en una reaccion de condensacion de aspartama.

Country Status (21)

Country Link
EP (1) EP0471833B1 (es)
CN (1) CN1052490C (es)
AT (1) ATE123782T1 (es)
AU (1) AU650647B2 (es)
BG (1) BG61687B1 (es)
CA (1) CA2058932C (es)
CZ (1) CZ281204B6 (es)
DE (1) DE69110374T2 (es)
DK (1) DK0471833T3 (es)
ES (1) ES2073162T3 (es)
HR (1) HRP921061A2 (es)
HU (1) HU212897B (es)
IE (1) IE68315B1 (es)
NO (1) NO920158L (es)
PT (1) PT97021B (es)
RO (1) RO111571B1 (es)
SK (1) SK279939B6 (es)
TW (1) TW207991B (es)
WO (1) WO1991013860A1 (es)
YU (1) YU44291A (es)
ZA (1) ZA911810B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104628819B (zh) * 2014-10-23 2019-05-21 常茂生物化学工程股份有限公司 一种偶合反应生成阿斯巴甜的工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
FR2516077A1 (fr) * 1981-11-06 1983-05-13 Human Pharm Sa Laboratoires Procede de preparation de l'ester-methylique de l'a-aspartyl phenylalanine
IT8419324A0 (it) * 1984-01-26 1984-01-26 Pierrel Spa Procedimento per la sintesi di derivati n-acilici dell'aspartame.
JPH07636B2 (ja) * 1984-12-17 1995-01-11 三井東圧化学株式会社 Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
JPH085912B2 (ja) * 1986-09-04 1996-01-24 味の素株式会社 Ｎ−ホルミルアスパルチル−フエニルアラニンまたはそのメチルエステルの製造方法
US4946988A (en) * 1988-07-14 1990-08-07 The Nutrasweet Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride

Also Published As

Publication number Publication date
ATE123782T1 (de) 1995-06-15
RO111571B1 (ro) 1996-11-29
IE68315B1 (en) 1996-06-12
NO920158D0 (no) 1992-01-13
HU913775D0 (en) 1992-04-28
DK0471833T3 (da) 1995-09-25
CA2058932A1 (en) 1991-09-13
DE69110374T2 (de) 1995-11-02
CN1052490C (zh) 2000-05-17
TW207991B (es) 1993-06-21
CS9100639A2 (en) 1991-12-17
DE69110374D1 (de) 1995-07-20
CA2058932C (en) 1998-08-25
WO1991013860A1 (en) 1991-09-19
HRP921061A2 (en) 1996-02-29
CN1055539A (zh) 1991-10-23
NO920158L (no) 1992-01-13
HUT61268A (en) 1992-12-28
PT97021A (pt) 1991-10-31
EP0471833A1 (en) 1992-02-26
EP0471833A4 (en) 1993-06-16
ZA911810B (en) 1992-01-29
SK279939B6 (sk) 1999-06-11
IE910826A1 (en) 1991-09-25
AU650647B2 (en) 1994-06-30
YU44291A (sh) 1994-05-10
EP0471833B1 (en) 1995-06-14
AU7545291A (en) 1991-10-10
HU212897B (en) 1996-12-30
PT97021B (pt) 1998-07-31
CZ281204B6 (cs) 1996-07-17
BG61687B1 (bg) 1998-03-31
BG95616A (bg) 1993-12-24

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