ES2075378T3 - Procedimiento para la preparacion del factor viii humano y de analogos del factor viii. - Google Patents

Procedimiento para la preparacion del factor viii humano y de analogos del factor viii.

Info

Publication number
ES2075378T3
ES2075378T3 ES91400267T ES91400267T ES2075378T3 ES 2075378 T3 ES2075378 T3 ES 2075378T3 ES 91400267 T ES91400267 T ES 91400267T ES 91400267 T ES91400267 T ES 91400267T ES 2075378 T3 ES2075378 T3 ES 2075378T3
Authority
ES
Spain
Prior art keywords
factor viii
procedure
analogue
preparation
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91400267T
Other languages
English (en)
Inventor
Gerard Mignot
Nicolas Bihoreau
Philippe Adamowicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TM Innovation
Original Assignee
TM Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TM Innovation filed Critical TM Innovation
Application granted granted Critical
Publication of ES2075378T3 publication Critical patent/ES2075378T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO DE PREPARACION DEL FACTOR VIII O DE UN ANALOGO DEL FACTOR VIII POR CULTIVO SOBRE UN MEDIO DE CULTIVO DE CELULAS QUE PRODUCEN DICHO FACTOR VIII O UN ANALOGO DEL FACTOR VIII Y SEPARACION DEL FACTOR VIII O DE SU ANALOGO, CARACTERIZADO PORQUE EL MEDIO DE CULTIVO CONTIENE AL MENOS UN DERIVADO DE UN POLIMERO POLICATONICO Y LO POLIANIONICO. SE REFIERE IGUALMENTE AL FACTOR VIII O ANALOGO DEL FACTOR VIII Y AL COMPLEJO DEL FACTOR VIII O ANALOGO DEL FACTOR VIII CON UN DERIVADO DE UN POLIMERO POLICATONICO Y LO POLIANIONICO OBTENIDOS POR EL EMPLEO DE ESTE PROCESO.
ES91400267T 1990-02-05 1991-02-05 Procedimiento para la preparacion del factor viii humano y de analogos del factor viii. Expired - Lifetime ES2075378T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR909001302A FR2657884B1 (fr) 1990-02-05 1990-02-05 Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.

Publications (1)

Publication Number Publication Date
ES2075378T3 true ES2075378T3 (es) 1995-10-01

Family

ID=9393391

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91400267T Expired - Lifetime ES2075378T3 (es) 1990-02-05 1991-02-05 Procedimiento para la preparacion del factor viii humano y de analogos del factor viii.

Country Status (10)

Country Link
US (2) US5422250A (es)
EP (1) EP0441695B1 (es)
JP (1) JPH06113879A (es)
AT (1) ATE123069T1 (es)
CA (1) CA2035691A1 (es)
DE (1) DE69109886T2 (es)
DK (1) DK0441695T3 (es)
ES (1) ES2075378T3 (es)
FR (1) FR2657884B1 (es)
GR (1) GR3017201T3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2657884B1 (fr) * 1990-02-05 1994-09-02 Tm Innovation Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
CA2149212A1 (en) * 1992-11-17 1994-05-26 Mirella Ezban Rasmussen Improved recombinant production of proteins having factor viii:c activity
JP3428687B2 (ja) * 1993-06-30 2003-07-22 財団法人化学及血清療法研究所 組織因子凝固系インヒビターの調製法
SE9303601D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Improved cell cultivation method and medium
EP2243827B2 (en) * 1996-08-30 2017-11-22 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
JP2002526455A (ja) 1998-09-21 2002-08-20 ジェネティックス インスティテュート インク． 治療用たんぱく質に対する免疫応答を下方変調する方法
EP2042196B1 (en) 2001-10-10 2016-07-13 ratiopharm GmbH Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF)
US20030181416A1 (en) * 2002-01-10 2003-09-25 Comper Wayne D. Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
EP1877545A2 (en) * 2005-04-20 2008-01-16 Wyeth Mammalian expression systems
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
KR101389376B1 (ko) * 2007-02-23 2014-04-29 에스케이케미칼주식회사 제 ８ 인자 및 그의 유도체의 제조 및 정제 방법
KR101808751B1 (ko) 2009-11-13 2017-12-13 그리폴스 테라퓨틱스 인코포레이티드 폰 빌레브란트 인자(ｖＷＦ)-함유 제제, 및 그와 관련된 방법, 키트 및 용도
AU2012324020A1 (en) 2011-12-30 2013-07-18 Grifols, S.A. Method for purifying Factor VIII
JP2014138614A (ja) * 2014-04-09 2014-07-31 Sk Chemicals Co Ltd 第ｖｉｉｉ因子とその誘導体の製造及び精製方法
US10119117B2 (en) 2016-01-28 2018-11-06 Nanogen Pharmaceutical Biotechnology Co., Ltd Universal, glycosylation enhancer, completely chemically defined medium formulation
JP6351679B2 (ja) * 2016-09-30 2018-07-04 エスケー ケミカルズ カンパニー リミテッド 第ｖｉｉｉ因子とその誘導体の製造及び精製方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803115A (en) * 1972-05-17 1974-04-09 Baxter Laboratories Inc Stabilization of ahf using heparin
US4443546A (en) * 1980-07-07 1984-04-17 The Beth Israel Hospital Association Process and composition for propagating mammalian cells
US4359463A (en) * 1980-11-26 1982-11-16 Rock Gail A Stabilization of Factor VIII activity in whole blood or blood plasma
US4397841A (en) * 1982-06-28 1983-08-09 Monsanto Company Production of blood coagulation factor VIII:C
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
US5132223A (en) * 1983-11-10 1992-07-21 Thomas Jefferson University Process and medium for cloning and long-term serial cultivation of adult human endothelial cells
ZA852099B (en) 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4670394A (en) * 1984-11-16 1987-06-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Isolation and culture of adrenal medullary endothelial cells producing blood clotting factor VIII:C
GB8505882D0 (en) * 1985-03-07 1985-04-11 Central Blood Lab Authority Purification of blood coagulation factor viii
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
JP2525022B2 (ja) 1986-01-03 1996-08-14 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド ▲ＶＩＩＩ▼：ｃ因子型タンパク質の改良生産方法
FI98829C (fi) 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
DK155388C (da) 1986-07-08 1989-10-23 Palle Pedersen Laas
EP0254076B1 (en) * 1986-07-11 1991-05-08 Miles Inc. Improved recombinant protein production
IL83192A (en) 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
US4980456A (en) * 1987-04-06 1990-12-25 Scripps Clinic And Research Foundation Recombinant factor VIIIC derived fragments
IE69026B1 (en) * 1987-06-12 1996-08-07 Immuno Ag Novel proteins with factor VIII activity process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
EP0690126B1 (en) 1987-06-12 2001-11-28 Baxter Aktiengesellschaft Novel proteins with factor VIII activitiy: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
FR2619314B1 (fr) 1987-08-11 1990-06-15 Transgene Sa Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
FR2657884B1 (fr) * 1990-02-05 1994-09-02 Tm Innovation Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.

Also Published As

Publication number Publication date
JPH06113879A (ja) 1994-04-26
FR2657884B1 (fr) 1994-09-02
DE69109886D1 (de) 1995-06-29
DE69109886T2 (de) 1996-02-29
US5422250A (en) 1995-06-06
US5707832A (en) 1998-01-13
EP0441695A1 (fr) 1991-08-14
EP0441695B1 (fr) 1995-05-24
DK0441695T3 (da) 1995-10-16
GR3017201T3 (en) 1995-11-30
ATE123069T1 (de) 1995-06-15
CA2035691A1 (fr) 1991-08-06
FR2657884A1 (fr) 1991-08-09

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Effective date: 19930512

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