ES2082201T3 - Uso de il-4 para mejorar la respuesta inmune a las pruebas de antigenos infecciosos. - Google Patents

Uso de il-4 para mejorar la respuesta inmune a las pruebas de antigenos infecciosos.

Info

Publication number
ES2082201T3
ES2082201T3 ES91906129T ES91906129T ES2082201T3 ES 2082201 T3 ES2082201 T3 ES 2082201T3 ES 91906129 T ES91906129 T ES 91906129T ES 91906129 T ES91906129 T ES 91906129T ES 2082201 T3 ES2082201 T3 ES 2082201T3
Authority
ES
Spain
Prior art keywords
agents
immune response
response
infectious
improve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91906129T
Other languages
English (en)
Inventor
Jerome Schwartz
Claude H Nash
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2082201T3 publication Critical patent/ES2082201T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2026—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE PRESENTA EL USO DE IL-4 PARA LA FABRICACION DE UN MEDICAMENTO PARA INDUCIR UNA RESPUESTA INMUNE EFECTIVA A AGENTES INFECCIOSO CRONICOS ENDEMICOS EN UN MAMIFERO EXPUESTO A TALES AGENTES Y UNA COMPOSICION FARMACEUTICA PARA INDUCIR UNA RESPUESTA INMUNE EFECTIVA A LOS AGENTES INFECCIOSOS CRONICOS ENDEMICOS EN MAMIFEROS EXPUESTOS A TALES AGENTES, DICHAS COMPOSICIONES COMPRENDEN IL-4, PREFERIBLEMENTE IL-4 HUMANO RECOMBINANTE DEL "E. COLI" COMO INGREDIENTE ACTIVO, ASI MISMO SE PRESENTAN METODOS PARA INDUCIR UNA RESPUESTA INMUNE EFECTIVA A AGENTES INFECCIOSOS CRONICOS ENDEMICOS EN MAMIFEROS EXPUESTOS A TALES AGENTES MEDIANTE LA ADMINISTRACION A DICHOS MAMIFEROS DE UNA CANTIDAD EFECTIVA DE IL-4, PREFERIBLEMENTE IL-4 HUMANO RECOMBINANTE DERIVADO DEL "E. COLI".
ES91906129T 1990-03-21 1991-03-19 Uso de il-4 para mejorar la respuesta inmune a las pruebas de antigenos infecciosos. Expired - Lifetime ES2082201T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49683290A 1990-03-21 1990-03-21

Publications (1)

Publication Number Publication Date
ES2082201T3 true ES2082201T3 (es) 1996-03-16

Family

ID=23974340

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91906129T Expired - Lifetime ES2082201T3 (es) 1990-03-21 1991-03-19 Uso de il-4 para mejorar la respuesta inmune a las pruebas de antigenos infecciosos.

Country Status (19)

Country Link
EP (1) EP0521916B1 (es)
JP (1) JPH05505799A (es)
CN (1) CN1055116A (es)
AT (1) ATE133074T1 (es)
AU (1) AU656889B2 (es)
CA (1) CA2078676A1 (es)
DE (1) DE69116552T2 (es)
DK (1) DK0521916T3 (es)
ES (1) ES2082201T3 (es)
FI (1) FI924215L (es)
GR (1) GR3019018T3 (es)
HU (1) HUT63062A (es)
IE (1) IE72204B1 (es)
IL (1) IL97600A0 (es)
MY (1) MY108672A (es)
OA (1) OA09672A (es)
PT (1) PT97082B (es)
WO (1) WO1991014450A1 (es)
ZA (1) ZA912037B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100191223B1 (ko) * 1989-07-28 1999-06-15 둘락 노먼 씨. 인터루킨-4의 정제방법 및 이를 함유하는 약제학적 조성물
US5827670A (en) * 1990-08-02 1998-10-27 Fred Hutchinson Cancer Research Center Methods of isolating and detecting bone marrow stromal cells with VCAM-1-specific antibodies
US7449186B1 (en) 1990-08-02 2008-11-11 Fred Hutchinson Cancer Research Center Methods of blocking the interaction between stromal cells and hemopoietic cells with anti-VCAM-1 antibodies
DK0563254T3 (da) * 1990-12-19 1996-02-12 Schering Corp Anvendelse af IL-4 til forstærkning af immunrespons på immunogener i vacciner
JPH0747545B2 (ja) * 1991-01-10 1995-05-24 シェリング・コーポレーション 創傷治癒及び修復の修復段階を促進し、かつ感染した創傷及び糖尿病哺乳類の創傷の治癒を促進するためのｉｌ−４の用途
GB9124347D0 (en) * 1991-11-15 1992-01-08 Isis Innovation Treatment of macrophages
CA2142862C (en) * 1992-08-19 2000-05-30 Jerome Schwartz Method for inhibiting hiv replication using il-4

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83761B (pt) * 1985-11-19 1989-06-30 Schering Biotech Corp Metodo para a producao de interleuquina-4 de mamifero
ES2059453T3 (es) * 1987-08-03 1994-11-16 Tasuku Honjo Un procedimiento para la produccion de interleuquina 4 humana.
JPH0236129A (ja) * 1988-07-22 1990-02-06 Ajinomoto Co Inc ワクチン効果増強剤
JPH0611706B2 (ja) * 1989-01-20 1994-02-16 ザ ユニバーシティ オブ メルボルン フィブリン溶解

Also Published As

Publication number Publication date
DE69116552T2 (de) 1996-05-30
WO1991014450A1 (en) 1991-10-03
EP0521916A1 (en) 1993-01-13
CA2078676A1 (en) 1991-09-22
AU7469091A (en) 1991-10-21
IE72204B1 (en) 1997-04-09
OA09672A (en) 1993-05-15
FI924215A0 (fi) 1992-09-21
FI924215A7 (fi) 1992-09-21
IE910921A1 (en) 1991-09-25
CN1055116A (zh) 1991-10-09
GR3019018T3 (en) 1996-05-31
AU656889B2 (en) 1995-02-23
FI924215L (fi) 1992-09-21
DK0521916T3 (da) 1996-03-04
DE69116552D1 (de) 1996-02-29
PT97082A (pt) 1991-11-29
JPH05505799A (ja) 1993-08-26
PT97082B (pt) 1998-07-31
ZA912037B (en) 1992-03-25
EP0521916B1 (en) 1996-01-17
HUT63062A (en) 1993-07-28
MY108672A (en) 1996-10-31
ATE133074T1 (de) 1996-02-15
IL97600A0 (en) 1992-06-21

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