ES2085651T3 - Inhibidores no peptidicos de integrina que presentan especificidad para el receptor gpiibiiia. - Google Patents

Inhibidores no peptidicos de integrina que presentan especificidad para el receptor gpiibiiia.

Info

Publication number
ES2085651T3
ES2085651T3 ES92922468T ES92922468T ES2085651T3 ES 2085651 T3 ES2085651 T3 ES 2085651T3 ES 92922468 T ES92922468 T ES 92922468T ES 92922468 T ES92922468 T ES 92922468T ES 2085651 T3 ES2085651 T3 ES 2085651T3
Authority
ES
Spain
Prior art keywords
inhibitors
integrine
peptidic
gpiibiiia receptor
gpiibiiia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92922468T
Other languages
English (en)
Inventor
Brent Blackburn
Peter Barker
Thomas Gadek
Robert Mcdowell
Lawrence Mcgee
Todd Somers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2085651T3 publication Critical patent/ES2085651T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTA UN DERIVADO DE LA BENZODIAZEPINODIONA QUE ACTUA COMO INHIBIDOR DE LA CONGREGACION DE PLAQUETAS. ESTE INHIBIDOR INHIBE POTENTEMENTE LA UNION DEL FIBRINOGENO AL RECEPTOR DEL GPIIBIIIA Y SE SUMINISTRA EN COMPOSICIONES TERAPEUTICAS PARA EL TRATAMIENTO DE ENFERMEDADES PARA LOS CUALES ESTA INDICADO EL BLOQUEO DE LA AGREGACION DE PLAQUETAS. ESTOS INHIBIDORES DIFERENTES DEL PEPTIDIL SE SUMINISTRAN EN COMBINACION CON TROMBOLITICOS Y ANTICOAGULANTES.
ES92922468T 1991-10-18 1992-10-15 Inhibidores no peptidicos de integrina que presentan especificidad para el receptor gpiibiiia. Expired - Lifetime ES2085651T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78147791A 1991-10-18 1991-10-18
US07/866,931 US5250679A (en) 1991-10-18 1992-04-10 Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor

Publications (1)

Publication Number Publication Date
ES2085651T3 true ES2085651T3 (es) 1996-06-01

Family

ID=27119863

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92922468T Expired - Lifetime ES2085651T3 (es) 1991-10-18 1992-10-15 Inhibidores no peptidicos de integrina que presentan especificidad para el receptor gpiibiiia.

Country Status (15)

Country Link
US (2) US5250679A (es)
EP (1) EP0610334B1 (es)
JP (2) JP3789468B2 (es)
AT (1) ATE133412T1 (es)
AU (1) AU673501B2 (es)
CA (1) CA2119745C (es)
DE (1) DE69207916T2 (es)
DK (1) DK0610334T3 (es)
ES (1) ES2085651T3 (es)
FI (1) FI941222A7 (es)
GE (1) GEP20032957B (es)
GR (1) GR3019517T3 (es)
MD (1) MD960330A (es)
NO (1) NO307417B1 (es)
WO (1) WO1993008174A1 (es)

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FI941222A0 (fi) 1994-03-15
MD960330A (ro) 1998-05-31
GR3019517T3 (en) 1996-07-31
WO1993008174A1 (en) 1993-04-29
CA2119745C (en) 2007-02-20
AU2797692A (en) 1993-05-21
FI941222L (fi) 1994-06-02
GEP20032957B (en) 2003-04-25
NO307417B1 (no) 2000-04-03
US5250679A (en) 1993-10-05
JPH07500341A (ja) 1995-01-12
EP0610334B1 (en) 1996-01-24
DE69207916D1 (de) 1996-03-07
NO941378D0 (no) 1994-04-15
ATE133412T1 (de) 1996-02-15
FI941222A7 (fi) 1994-06-02
AU673501B2 (en) 1996-11-14
CA2119745A1 (en) 1993-04-29
NO941378L (no) 1994-06-20
JP3789468B2 (ja) 2006-06-21
US5403836A (en) 1995-04-04
EP0610334A1 (en) 1994-08-17
JP2003300962A (ja) 2003-10-21
DK0610334T3 (da) 1996-06-03
DE69207916T2 (de) 1996-10-17

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