ES2087207T3 - Factor del crecimiento de fibroblasto quimerico. - Google Patents

Factor del crecimiento de fibroblasto quimerico.

Info

Publication number
ES2087207T3
ES2087207T3 ES91118725T ES91118725T ES2087207T3 ES 2087207 T3 ES2087207 T3 ES 2087207T3 ES 91118725 T ES91118725 T ES 91118725T ES 91118725 T ES91118725 T ES 91118725T ES 2087207 T3 ES2087207 T3 ES 2087207T3
Authority
ES
Spain
Prior art keywords
fibroblast growth
growth factor
fgf
chimeric
fgfs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91118725T
Other languages
English (en)
Inventor
Andrew P Seddon
Peter Bohlen
Yakov Gluzman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2087207T3 publication Critical patent/ES2087207T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS FACTORES DE CRECIMIENTO DEL FIBLOBLASTO QUIMERICO (FGF) EN LOS QUE LA ALAMINA EN EL ACIDO AMINO 3 Y LA SERINA 5 DEL FACTOR DE CRECIMIENTO DEL FIBLOBLASTO BASICO RECOMBINANTE HUMANO SE HAN REEMPLAZADO CON ACIDO GLUTAMICO. LA SECUENCIA N-TERMINAL DE LOS PRESENTES FGF''S QUIMERICOS IDENTIFICAN LA HOMOLOGIA CON LA DEL FACTOR DE CRECIMIENTO DEL FIBLOBLASTO ACIDICO HUMANO. LAS PROPIEDADES MITOGENICAS DEL FGF BASICO RECOMBINANTE HUMANO NATIVO SON TAMBIEN EXIBIDAS POR LOS PRESENTES FGF''S QUIMERICOS, Y ESTAN EXPRESADOS EFICIENTEMENTE EN "E. COLI" CON RENDIMIENTOS SIGNIFICANTEMENTE MAYORES QUE LOS APORTADOS HASTA AHORA. TAMBIEN SE DESCRIBEN NUEVAS VARIANTES DE ESTE NUEVO FACTOR DEL CRECIMIENTO DEL FIBLOBLASTO BASICO GLU ELEVADO 3,5, TALES COMO AQUELLAS EN LAS QUE LA CISTEINA 78 Y LA CISTEINA 96 ESTAN REEMPLAZADAS, POR EJ., CON SERINA U OTROS ACIDOS AMINOS, PARA PRODUCIR VERSIONES ESTABILIZADAS DEL FGF BASICO GLU ELEVADO 3,5 Y ELIMINAR LAS FORMAS MEZCLADAS DE DISULFURO.
ES91118725T 1990-11-23 1991-11-04 Factor del crecimiento de fibroblasto quimerico. Expired - Lifetime ES2087207T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61520290A 1990-11-23 1990-11-23

Publications (1)

Publication Number Publication Date
ES2087207T3 true ES2087207T3 (es) 1996-07-16

Family

ID=24464425

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91118725T Expired - Lifetime ES2087207T3 (es) 1990-11-23 1991-11-04 Factor del crecimiento de fibroblasto quimerico.

Country Status (16)

Country Link
US (3) US5310883A (es)
EP (1) EP0486862B1 (es)
JP (1) JP3205578B2 (es)
KR (1) KR100205078B1 (es)
AT (1) ATE138687T1 (es)
AU (1) AU646514B2 (es)
CA (1) CA2055963C (es)
DE (1) DE69119869T2 (es)
DK (1) DK0486862T3 (es)
ES (1) ES2087207T3 (es)
GR (1) GR3020237T3 (es)
IE (1) IE74956B1 (es)
IL (1) IL99984A (es)
NZ (1) NZ240622A (es)
PT (1) PT99565B (es)
ZA (1) ZA919260B (es)

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US7252929B2 (en) 1989-02-09 2007-08-07 United States Of America, As Represented By The Secretary, Dept Of Health & Human Services Methods for identifying alpha PDGFR agonists and antagonists
US5951972A (en) * 1990-05-04 1999-09-14 American Cyanamid Company Stabilization of somatotropins and other proteins by modification of cysteine residues
DE69119869T2 (de) * 1990-11-23 1996-12-12 American Cyanamid Co Chimeres Fibroblasten-Wachstumsfaktor
US5206354A (en) * 1990-11-23 1993-04-27 American Cyanamid Company Dna sequence encoding active fragment of fibroblast growth factor, hbf-2
KR100374310B1 (ko) * 1995-02-14 2003-05-22 주식회사 엘지생명과학 변형된인간염기성섬유아세포성장인자및이의생산방법
EP0880598A4 (en) * 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
DE69733815T2 (de) 1996-02-15 2006-06-08 Biosense Webster, Inc., Diamond Bar Sonde zur exkavation
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US6927287B1 (en) * 1996-06-03 2005-08-09 United States Surgical Corporation Nucleic acid encoding extracellular matrix protein or fragment thereof
US6443974B1 (en) 1996-07-28 2002-09-03 Biosense, Inc. Electromagnetic cardiac biostimulation
US20030144202A1 (en) * 1996-10-15 2003-07-31 Amgen Inc. Uses of keratinocyte growth factor-2
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
US20030129750A1 (en) * 1998-02-05 2003-07-10 Yitzhack Schwartz Homing of donor cells to a target zone in tissue using active therapeutics or substances
US20030113303A1 (en) * 1998-02-05 2003-06-19 Yitzhack Schwartz Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances
ES2255155T3 (es) 1998-02-05 2006-06-16 Biosense Webster, Inc. Dispositivo para la administracion intracardiaca de farmacos.
CA2329010A1 (en) * 1998-04-17 1999-10-28 Angiogenix Incorporated Therapeutic angiogenic factors and methods for their use
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US6313103B1 (en) 1998-05-13 2001-11-06 Carrington Laboratories, Inc. Pectic substance as a growth factor stabilizer
US5929051A (en) * 1998-05-13 1999-07-27 Carrington Laboratories, Inc. Aloe pectins
US8618052B2 (en) 1998-10-13 2013-12-31 Novartis Vaccines And Diagnostics, Inc. Method of treating coronary artery disease by administering FGF-5
US6440934B1 (en) 1998-10-13 2002-08-27 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US20020072489A1 (en) * 1998-10-13 2002-06-13 Whitehouse Martha J. Angiogenically effective unit dose of FGF-2 and method of use
JP2002527401A (ja) * 1998-10-13 2002-08-27 カイロン コーポレイション Ｆｇｆの脈管形成的に有効な単位用量および投与方法
US20030166550A1 (en) * 1999-08-27 2003-09-04 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
JP5704780B2 (ja) * 1999-08-13 2015-04-22 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 脈管形成因子の用量および心筋血流を改善するための投与方法
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
IL149562A0 (en) 2002-05-09 2002-11-10 Prochon Ltd Fgf variants and methods for use thereof
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
USD566506S1 (en) * 2006-07-20 2008-04-15 Robert Bosch Gmbh Power operated screwdriver
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
EP2310039B1 (en) * 2008-05-02 2014-07-16 University Of Western Ontario Fgf-9 and its use relating to blood vessels
US9169309B2 (en) * 2011-03-01 2015-10-27 Humanzyme Inc. Thermostable variants of fibroblast growth factors
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN105859892A (zh) * 2016-06-08 2016-08-17 浙江大学 一种类胶原蛋白-人碱性成纤维细胞生长因子融合蛋白及其制备方法

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US4296100A (en) * 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
US4378347A (en) * 1980-06-30 1983-03-29 Franco Wayne P Composition for treating the heart for myocardial infarction
US4588585A (en) * 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
US4785079A (en) * 1984-11-09 1988-11-15 The Salk Institute For Biological Studies Isolation of fibroblast growth factor
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US4902782A (en) * 1986-12-10 1990-02-20 The Salk Institute For Biological Studies Isolation of fibroblast growth factor
JP2879148B2 (ja) * 1987-07-07 1999-04-05 サイオス インコーポレイテッド 組換え繊維芽細胞成長因子
WO1989004832A1 (en) * 1987-11-24 1989-06-01 Amgen Inc. Analogs of fibroblast growth factor
US5130418A (en) * 1989-05-02 1992-07-14 California Biotechnology Inc. Method to stabilize basic fibroblast growth factor
DE69119869T2 (de) * 1990-11-23 1996-12-12 American Cyanamid Co Chimeres Fibroblasten-Wachstumsfaktor
CN1255194C (zh) * 1996-06-29 2006-05-10 D·穆勒 药物给药剂型

Also Published As

Publication number Publication date
KR920009848A (ko) 1992-06-25
PT99565A (pt) 1992-10-30
CA2055963C (en) 2002-11-12
AU646514B2 (en) 1994-02-24
KR100205078B1 (ko) 1999-06-15
IL99984A (en) 1998-12-06
DE69119869D1 (de) 1996-07-04
IL99984A0 (en) 1992-08-18
DE69119869T2 (de) 1996-12-12
US5371206A (en) 1994-12-06
JP3205578B2 (ja) 2001-09-04
CA2055963A1 (en) 1992-05-24
ZA919260B (en) 1992-08-26
EP0486862A1 (en) 1992-05-27
IE74956B1 (en) 1997-08-13
IE914068A1 (en) 1992-06-03
US5302702A (en) 1994-04-12
PT99565B (pt) 1999-04-30
AU8806291A (en) 1992-05-28
GR3020237T3 (en) 1996-09-30
US5310883A (en) 1994-05-10
EP0486862B1 (en) 1996-05-29
DK0486862T3 (da) 1996-06-24
JPH04330097A (ja) 1992-11-18
NZ240622A (en) 1994-08-26
ATE138687T1 (de) 1996-06-15

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