PT99565A - Processo para a preparacao de factores de crescimento de fibroblastos quimerico s - Google Patents

Processo para a preparacao de factores de crescimento de fibroblastos quimerico s

Info

Publication number: PT99565A
Authority: PT; Portugal
Prior art keywords: fibroblast growth; growth factor; fgf; chimeric; growth factors
Prior art date: 1990-11-23

Application number

PT99565A

Other languages

English (en)

Other versions

PT99565B (pt

Inventor

Yakov Gluzman

Peter Bohlen

Andrew P Seddon

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-23

Filing date

1991-11-21

Publication date

1992-10-30

1991-11-21 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1992-10-30 Publication of PT99565A publication Critical patent/PT99565A/pt

1999-04-30 Publication of PT99565B publication Critical patent/PT99565B/pt

Links

239000003102 growth factor Substances 0.000 title 1
108050007372 Fibroblast Growth Factor Proteins 0.000 abstract 4
102000018233 Fibroblast Growth Factor Human genes 0.000 abstract 4
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 3
102000003974 Fibroblast growth factor 2 Human genes 0.000 abstract 2
108090000379 Fibroblast growth factor 2 Proteins 0.000 abstract 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 2
235000001014 amino acid Nutrition 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
235000018417 cysteine Nutrition 0.000 abstract 2
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 1
241000588724 Escherichia coli Species 0.000 abstract 1
101000846416 Homo sapiens Fibroblast growth factor 1 Proteins 0.000 abstract 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
235000004279 alanine Nutrition 0.000 abstract 1
235000013922 glutamic acid Nutrition 0.000 abstract 1
239000004220 glutamic acid Substances 0.000 abstract 1
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
230000002297 mitogenic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT99565A 1990-11-23 1991-11-21 Processo para a preparacao de factores de crescimento de fibroblastos quimerico s PT99565B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US61520290A	1990-11-23	1990-11-23

Publications (2)

Publication Number	Publication Date
PT99565A true PT99565A (pt)	1992-10-30
PT99565B PT99565B (pt)	1999-04-30

Family

ID=24464425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99565A PT99565B (pt)	1990-11-23	1991-11-21	Processo para a preparacao de factores de crescimento de fibroblastos quimerico s

Country Status (16)

Country	Link
US (3)	US5310883A (pt)
EP (1)	EP0486862B1 (pt)
JP (1)	JP3205578B2 (pt)
KR (1)	KR100205078B1 (pt)
AT (1)	ATE138687T1 (pt)
AU (1)	AU646514B2 (pt)
CA (1)	CA2055963C (pt)
DE (1)	DE69119869T2 (pt)
DK (1)	DK0486862T3 (pt)
ES (1)	ES2087207T3 (pt)
GR (1)	GR3020237T3 (pt)
IE (1)	IE74956B1 (pt)
IL (1)	IL99984A (pt)
NZ (1)	NZ240622A (pt)
PT (1)	PT99565B (pt)
ZA (1)	ZA919260B (pt)

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US7252929B2 (en)	1989-02-09	2007-08-07	United States Of America, As Represented By The Secretary, Dept Of Health & Human Services	Methods for identifying alpha PDGFR agonists and antagonists
US5951972A (en) *	1990-05-04	1999-09-14	American Cyanamid Company	Stabilization of somatotropins and other proteins by modification of cysteine residues
ATE138687T1 (de) *	1990-11-23	1996-06-15	American Cyanamid Co	Chimeres fibroblasten-wachstumsfaktor
US5206354A (en) *	1990-11-23	1993-04-27	American Cyanamid Company	Dna sequence encoding active fragment of fibroblast growth factor, hbf-2
KR100374310B1 (ko) *	1995-02-14	2003-05-22	주식회사 엘지생명과학	변형된인간염기성섬유아세포성장인자및이의생산방법
EP0880598A4 (en) *	1996-01-23	2005-02-23	Affymetrix Inc	RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
DE69733815T2 (de)	1996-02-15	2006-06-08	Biosense Webster, Inc., Diamond Bar	Sonde zur exkavation
US6927287B1 (en) *	1996-06-03	2005-08-09	United States Surgical Corporation	Nucleic acid encoding extracellular matrix protein or fragment thereof
US6492508B1 (en) *	1996-06-03	2002-12-10	United States Surgical Corp. A Division Of Tyco Healthcare Group	Nucleic acids encoding extracellular matrix proteins
US6443974B1 (en) *	1996-07-28	2002-09-03	Biosense, Inc.	Electromagnetic cardiac biostimulation
US6743422B1 (en)	1996-10-15	2004-06-01	Amgen, Inc.	Keratinocyte growth factor-2 products
US20030144202A1 (en) *	1996-10-15	2003-07-31	Amgen Inc.	Uses of keratinocyte growth factor-2
US6274712B1 (en)	1997-12-23	2001-08-14	3-Dimensional Pharmaceuticals, Inc.	Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
ES2255155T3 (es)	1998-02-05	2006-06-16	Biosense Webster, Inc.	Dispositivo para la administracion intracardiaca de farmacos.
US20030129750A1 (en) *	1998-02-05	2003-07-10	Yitzhack Schwartz	Homing of donor cells to a target zone in tissue using active therapeutics or substances
US20030113303A1 (en) *	1998-02-05	2003-06-19	Yitzhack Schwartz	Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances
JP2002512200A (ja) *	1998-04-17	2002-04-23	アンジオジェニックス，インコーポレイテッド	治療的な脈管形成因子およびその使用方法
US6313103B1 (en)	1998-05-13	2001-11-06	Carrington Laboratories, Inc.	Pectic substance as a growth factor stabilizer
US7022683B1 (en)	1998-05-13	2006-04-04	Carrington Laboratories, Inc.	Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US5929051A (en) *	1998-05-13	1999-07-27	Carrington Laboratories, Inc.	Aloe pectins
AU6411199A (en) *	1998-10-13	2000-05-01	Chiron Corporation	Angiogenically effective unit dose of fgf and method of administering
US20030166550A1 (en) *	1999-08-27	2003-09-04	Chiron Corporation	Angiogenically effective unit dose of FGF-2 and method of use
US20020072489A1 (en) *	1998-10-13	2002-06-13	Whitehouse Martha J.	Angiogenically effective unit dose of FGF-2 and method of use
US8618052B2 (en)	1998-10-13	2013-12-31	Novartis Vaccines And Diagnostics, Inc.	Method of treating coronary artery disease by administering FGF-5
US6440934B1 (en)	1998-10-13	2002-08-27	Chiron Corporation	Angiogenically effective unit dose of FGF-2 and method of use
AU6634400A (en) *	1999-08-13	2001-03-13	Chiron Corporation	Dose of an angiogenic factor and method of administering to improve myocardial blood flow
US7494669B2 (en)	2001-02-28	2009-02-24	Carrington Laboratories, Inc.	Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
IL149562A0 (en)	2002-05-09	2002-11-10	Prochon Ltd	Fgf variants and methods for use thereof
US7067123B2 (en)	2003-04-29	2006-06-27	Musculoskeletal Transplant Foundation	Glue for cartilage repair
US7901457B2 (en)	2003-05-16	2011-03-08	Musculoskeletal Transplant Foundation	Cartilage allograft plug
US7837740B2 (en)	2007-01-24	2010-11-23	Musculoskeletal Transplant Foundation	Two piece cancellous construct for cartilage repair
US20090319045A1 (en)	2004-10-12	2009-12-24	Truncale Katherine G	Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US7815926B2 (en)	2005-07-11	2010-10-19	Musculoskeletal Transplant Foundation	Implant for articular cartilage repair
CA2623106C (en)	2005-09-19	2013-12-24	Histogenics Corporation	Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
USD566506S1 (en) *	2006-07-20	2008-04-15	Robert Bosch Gmbh	Power operated screwdriver
US8435551B2 (en)	2007-03-06	2013-05-07	Musculoskeletal Transplant Foundation	Cancellous construct with support ring for repair of osteochondral defects
US8685107B2 (en)	2007-07-03	2014-04-01	Histogenics Corporation	Double-structured tissue implant and a method for preparation and use thereof
US20090054984A1 (en)	2007-08-20	2009-02-26	Histogenics Corporation	Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
CN102076352B (zh) *	2008-05-02	2016-06-15	西安大略大学	与血管有关的fgf-9和它的用途
US9169309B2 (en) *	2011-03-01	2015-10-27	Humanzyme Inc.	Thermostable variants of fibroblast growth factors
US10077420B2 (en)	2014-12-02	2018-09-18	Histogenics Corporation	Cell and tissue culture container
CN105859892A (zh) *	2016-06-08	2016-08-17	浙江大学	一种类胶原蛋白-人碱性成纤维细胞生长因子融合蛋白及其制备方法

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US4378347A (en) *	1980-06-30	1983-03-29	Franco Wayne P	Composition for treating the heart for myocardial infarction
US4296100A (en) *	1980-06-30	1981-10-20	Franco Wayne P	Method of treating the heart for myocardial infarction
US4588585A (en) *	1982-10-19	1986-05-13	Cetus Corporation	Human recombinant cysteine depleted interferon-β muteins
US4518584A (en) *	1983-04-15	1985-05-21	Cetus Corporation	Human recombinant interleukin-2 muteins
US4956455A (en) *	1984-03-05	1990-09-11	The Salk Institute For Biological Studies	Bovine fibroblast growth factor
US4785079A (en) *	1984-11-09	1988-11-15	The Salk Institute For Biological Studies	Isolation of fibroblast growth factor
US4959314A (en) *	1984-11-09	1990-09-25	Cetus Corporation	Cysteine-depleted muteins of biologically active proteins
US4902782A (en) *	1986-12-10	1990-02-20	The Salk Institute For Biological Studies	Isolation of fibroblast growth factor
AU629176B2 (en) *	1987-07-07	1992-10-01	Scios Nova Inc.	Recombinant fibroblast growth factors
JPH02504468A (ja) *	1987-11-24	1990-12-20	アムジエン・インコーポレーテツド	繊維芽細胞成長因子のアナログ
US5130418A (en) *	1989-05-02	1992-07-14	California Biotechnology Inc.	Method to stabilize basic fibroblast growth factor
ATE138687T1 (de) *	1990-11-23	1996-06-15	American Cyanamid Co	Chimeres fibroblasten-wachstumsfaktor
CA2259333A1 (en) *	1996-06-29	1998-01-08	Dieter Muller	Pharmaceutical administration form

1991
- 1991-11-04 AT AT91118725T patent/ATE138687T1/de not_active IP Right Cessation
- 1991-11-04 EP EP91118725A patent/EP0486862B1/en not_active Expired - Lifetime
- 1991-11-04 DE DE69119869T patent/DE69119869T2/de not_active Expired - Fee Related
- 1991-11-04 ES ES91118725T patent/ES2087207T3/es not_active Expired - Lifetime
- 1991-11-04 US US07/783,694 patent/US5310883A/en not_active Expired - Lifetime
- 1991-11-04 DK DK91118725.0T patent/DK0486862T3/da active
- 1991-11-07 IL IL9998491A patent/IL99984A/en active IP Right Grant
- 1991-11-18 NZ NZ240622A patent/NZ240622A/en not_active IP Right Cessation
- 1991-11-21 JP JP33156891A patent/JP3205578B2/ja not_active Expired - Fee Related
- 1991-11-21 PT PT99565A patent/PT99565B/pt not_active IP Right Cessation
- 1991-11-21 CA CA002055963A patent/CA2055963C/en not_active Expired - Fee Related
- 1991-11-22 KR KR1019910021053A patent/KR100205078B1/ko not_active Expired - Fee Related
- 1991-11-22 ZA ZA919260A patent/ZA919260B/xx unknown
- 1991-11-22 IE IE406891A patent/IE74956B1/en not_active IP Right Cessation
- 1991-11-22 AU AU88062/91A patent/AU646514B2/en not_active Ceased
1993
- 1993-02-26 US US08/023,757 patent/US5302702A/en not_active Expired - Lifetime
1994
- 1994-01-05 US US08/177,502 patent/US5371206A/en not_active Expired - Lifetime
1996
- 1996-06-17 GR GR950403456T patent/GR3020237T3/el unknown

Also Published As

Publication number	Publication date
KR920009848A (ko)	1992-06-25
ATE138687T1 (de)	1996-06-15
EP0486862A1 (en)	1992-05-27
AU8806291A (en)	1992-05-28
AU646514B2 (en)	1994-02-24
PT99565B (pt)	1999-04-30
US5371206A (en)	1994-12-06
CA2055963A1 (en)	1992-05-24
GR3020237T3 (en)	1996-09-30
IE914068A1 (en)	1992-06-03
EP0486862B1 (en)	1996-05-29
DE69119869D1 (de)	1996-07-04
KR100205078B1 (ko)	1999-06-15
US5302702A (en)	1994-04-12
DK0486862T3 (da)	1996-06-24
IL99984A (en)	1998-12-06
JP3205578B2 (ja)	2001-09-04
DE69119869T2 (de)	1996-12-12
JPH04330097A (ja)	1992-11-18
ZA919260B (en)	1992-08-26
ES2087207T3 (es)	1996-07-16
US5310883A (en)	1994-05-10
IL99984A0 (en)	1992-08-18
IE74956B1 (en)	1997-08-13
CA2055963C (en)	2002-11-12
NZ240622A (en)	1994-08-26

Legal Events

Date	Code	Title	Description
1992-10-30	BB1A	Laying open of patent application	Effective date: 19920601
1999-04-30	FG3A	Patent granted, date of granting	Effective date: 19990129
2004-01-30	PD3A	Change of proprietorship	Free format text: WYETH HOLDINGS CORPORATION US Effective date: 20031117
2004-01-30	TE3A	Change of address (patent)	Free format text: AMERICAN CYANAMID COMPANY US Effective date: 20031117
2006-09-29	MM3A	Annulment or lapse	Effective date: 20060731

Publication	Publication Date	Title
DE69119869D1 (de)	1996-07-04	Chimeres Fibroblasten-Wachstumsfaktor
BR1100321A (pt)	2000-03-21	Polipetìdeo utilizável como elemento de imunogenia, agente imunogênio, composição útil para a prevenção e/ou para o tratamento das afecções provocadas pelo vrs, sequência nucleotìdica, processo de pre uma proteìna
PT672145E (pt)	2003-08-29	Polipeptideos de interleucina-3(il-3) com multiplas mutacoes
DK1632574T3 (da)	2011-02-28	Fibroblast-vækstfaktor homologer
ATE458054T1 (de)	2010-03-15	Menschliches parathyroidhormon, modifikationen, herstellung und verwendung
IS2518B (is)	2009-06-15	Lífvirk peptíð, not fyrir þau og vinnsla þeirra
DE3850654D1 (de)	1994-08-18	Immunglobulin-e-kompetitor.
DK384084D0 (da)	1984-08-09	Vaeksthormonfrigoerende peptider samt fremgangsmaade til behandling af attedyr hermed
ATE98693T1 (de)	1994-01-15	Derivate des basischen mensch-/rinderfibroblastwachstumsfaktors.
EP1501936A4 (en)	2005-07-20	PROTEIN FAMILY OF CYTOKINE
SE9003374D0 (sv)	1990-10-22	A collagen binding protein as well as its preparation
SE8801723D0 (sv)	1988-05-06	Fibronectin binding protein as well as its preparation
FR2687156B1 (fr)	1994-04-01	Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives.
Seddon et al.	1995	DNA encoding chimeric fibroblast growth factors
AU6860294A (en)	1995-02-02	New chondrocyte proteins
ATE152127T1 (de)	1997-05-15	Muteine des menschlichen parathormons und ihre herstellung
GR3021408T3 (en)	1997-01-31	Cloning of a new member of the fibroblast growth factor (fgf) receptor family
Seddon et al.	1994	Chimeric fibroblast growth factors
ATE432985T1 (de)	2009-06-15	Polypeptide mit aktivität der stimulierung von neutrophilen