ES2089736T3 - Derivados de bencilideno. - Google Patents

Derivados de bencilideno.

Info

Publication number
ES2089736T3
ES2089736T3 ES93308369T ES93308369T ES2089736T3 ES 2089736 T3 ES2089736 T3 ES 2089736T3 ES 93308369 T ES93308369 T ES 93308369T ES 93308369 T ES93308369 T ES 93308369T ES 2089736 T3 ES2089736 T3 ES 2089736T3
Authority
ES
Spain
Prior art keywords
derivatives
alkyl
alcoxy
bencilideno
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93308369T
Other languages
English (en)
Inventor
Saichi Matsumoto
Tatsuo Tsuri
Masanao Inagaki
Hirokuni Jyoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2089736T3 publication Critical patent/ES2089736T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
    • C07D291/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/46—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom
    • C07D333/48—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

DERIVADOS DE BENCILIDENO QUE TIENEN ACTIVIDADES ANTIINFLAMATORIAS, TIENEN LA SIGUIENTE FORMULA (I), EN LA QUE A ES -CH2 O -CH2CH2-, B ES UN ENLACE O -CH2-, -CHOH, -CO-, -O-, O A Y B PUEDEN TOMADOS JUNTOS FORMAR -CH=CH-; D>N UNO INDEPENDIENTEMENTE ES HIDROGENO, ALQUILO INFERIOR O ALCOXI INFERIOR; R3 ES HIDROGENO, ALQUILO INFERIOR, CICLOALQUILO, ALCOXI INFERIOR, ARILALQUILOXI, HETROARILALQUILOXI, ALQUILCARBONILO INFERIOR, ARILCARBONILO, CARBAMILO SUSTITUIDO O INSUSTITUIDO, O UN GRUPO DE LA FORMULA (CH2)N-R4 DONDE R4 ES HIDROGENO, HIDROXI, AMINO SUSTITUIDO O INSUSTITUIDO, ARILO, HETEROARILO, HIDROXICARBONILO, O ALQUILOXICARBONILO INFERIOR; N ES UN NUMERO ENTERO DE 0 A 3.
ES93308369T 1992-10-28 1993-10-20 Derivados de bencilideno. Expired - Lifetime ES2089736T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP28997292 1992-10-28

Publications (1)

Publication Number Publication Date
ES2089736T3 true ES2089736T3 (es) 1996-10-01

Family

ID=17750115

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93308369T Expired - Lifetime ES2089736T3 (es) 1992-10-28 1993-10-20 Derivados de bencilideno.

Country Status (14)

Country Link
US (1) US5418230A (es)
EP (1) EP0595546B1 (es)
KR (1) KR100281490B1 (es)
CN (1) CN1035614C (es)
AT (1) ATE135697T1 (es)
AU (1) AU675078B2 (es)
CA (1) CA2109498A1 (es)
DE (1) DE69301894T2 (es)
DK (1) DK0595546T3 (es)
ES (1) ES2089736T3 (es)
GR (1) GR3019395T3 (es)
HU (1) HU215924B (es)
NO (1) NO303828B1 (es)
TW (1) TW378207B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3507124B2 (ja) * 1993-05-26 2004-03-15 塩野義製薬株式会社 ベンジリデン誘導体の製造法
DE19700061A1 (de) * 1997-01-03 1998-07-09 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung von cyclischen N-Aminosulfonamiden
CA2306914A1 (en) 1997-10-24 1999-05-06 Shionogi & Co., Ltd. Antirheumatic
US6649645B1 (en) 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
CA2360066A1 (en) 1999-01-21 2000-07-27 Hidekazu Shodai A pharmaceutical composition containing a compound having a phenolic hydroxyl group with coloring change being controlled
NZ524252A (en) 2000-07-20 2004-03-26 Lauras As Cox-2 inhibitors for treating HIV and AIDS
WO2002080974A1 (en) * 2001-04-04 2002-10-17 Sankyo Company, Limited Novel medicinal use of cytokine production inhibitor
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
PT1572173E (pt) 2002-12-13 2010-05-10 Warner Lambert Co Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior
EP1708718A1 (en) 2004-01-22 2006-10-11 Pfizer Limited Triazole derivatives which inhibit vasopressin antagonistic activity
AU2007227457B2 (en) 2006-03-17 2013-03-28 Cardioxyl Pharmaceuticals, Inc. N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
CN102058885B (zh) 2006-12-22 2013-04-10 瑞蔻达蒂爱尔兰有限公司 采用α2δ配体和NSAID的下泌尿道疾病的联合治疗
GB0903493D0 (en) 2009-02-27 2009-04-08 Vantia Ltd New compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH066571B2 (ja) * 1985-05-09 1994-01-26 エーザイ株式会社 ２−ピロリドン誘導体
PT83152B (pt) * 1985-08-09 1989-03-30 Lilly Co Eli Processo para a preparacao de compostos di-t-butilfenoicos
ES2056983T3 (es) * 1988-03-21 1994-10-16 Boehringer Ingelheim Pharma Compuestos para inhibir la biosintesis de metabolitos de acido araquidonico derivados de lipoxigenasa.
NZ231534A (en) * 1988-11-29 1992-02-25 Warner Lambert Co 3,5-di-t-butyl-4-hydroxyphenyl-triazoles, oxadiazoles and thiadiazoles; anti-inflammatory compositions
US4895862A (en) * 1989-04-21 1990-01-23 American Home Products Corp. Novel benzyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents
IL96654A (en) * 1989-12-21 1995-06-29 Lilly Co Eli Hydroxybenzyl substituted sulfur containing heterocyclic derivatives their preparation and pharmaceutical compositions containing them
AU646722B2 (en) * 1991-01-21 1994-03-03 Shionogi Seiyaku Kabushiki Kaisha 3-benzylidene-1-carbamoyl-2-pyrrolidone analog

Also Published As

Publication number Publication date
DE69301894T2 (de) 1996-11-07
ATE135697T1 (de) 1996-04-15
HU9303053D0 (en) 1994-01-28
NO303828B1 (no) 1998-09-07
GR3019395T3 (en) 1996-06-30
CN1035614C (zh) 1997-08-13
KR100281490B1 (ko) 2001-02-15
EP0595546A1 (en) 1994-05-04
CN1092414A (zh) 1994-09-21
US5418230A (en) 1995-05-23
KR940009163A (ko) 1994-05-20
AU675078B2 (en) 1997-01-23
CA2109498A1 (en) 1994-04-29
HU215924B (hu) 1999-03-29
TW378207B (en) 2000-01-01
NO933870L (no) 1994-04-29
EP0595546B1 (en) 1996-03-20
DE69301894D1 (de) 1996-04-25
AU4910793A (en) 1994-05-12
DK0595546T3 (da) 1996-04-15
NO933870D0 (no) 1993-10-27
HUT70530A (en) 1995-10-30

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