ES2090132T3 - Variantes de interleuquina-3(il-3) con cisteina añadida y sus modificaciones quimicas. - Google Patents

Variantes de interleuquina-3(il-3) con cisteina añadida y sus modificaciones quimicas.

Info

Publication number
ES2090132T3
ES2090132T3 ES90907849T ES90907849T ES2090132T3 ES 2090132 T3 ES2090132 T3 ES 2090132T3 ES 90907849 T ES90907849 T ES 90907849T ES 90907849 T ES90907849 T ES 90907849T ES 2090132 T3 ES2090132 T3 ES 2090132T3
Authority
ES
Spain
Prior art keywords
variants
cysteine
interleukin
modified
chemical modifications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90907849T
Other languages
English (en)
Inventor
Gray Shaw
Geertruida Veldman
Joseph Wooters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Application granted granted Critical
Publication of ES2090132T3 publication Critical patent/ES2090132T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE PRESENTAN VARIANTES AÑADIDAS DE CISTEINA ("CAVS") DE POLIPEPTIDOS QUE TIENEN UNO O MAS RESIDUOS DE CISTEINA SUSTITUIDOS POR RESIDUOS SELECCIONADOS DE AMINOACIDOS QUE OCURREN DE MANERA NATURAL O INSERTADOS EN LA SECUENCIA POLIPEPTIDA Y QUE PREFERIBLEMENTE SE HAN SEGUIDO MODIFICANDO ELIMINANDO CIERTOS AMINOACIDOS DE TERMINAL N. DICHAS CAVS SE PUEDEN SEGUIR MODIFICANDO SI SE ACOPLAN COMPUESTOS REACTIVOS SULFHIDRILICOS AL RESIDUO (S) DE CISTEINA INTRODUCIDO SIN PERDIDA DE BIOACTIVIDAD PARA PRODUCIR IL-3, G-CSF O EPO SELECCIONADOS HOMOGENEAMENTE MODIFICADOS Y COMPOSICIONES FARMACEUTICAS MEJORADAS QUE LAS CONTIENEN.
ES90907849T 1989-04-21 1990-04-19 Variantes de interleuquina-3(il-3) con cisteina añadida y sus modificaciones quimicas. Expired - Lifetime ES2090132T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/341,990 US5166322A (en) 1989-04-21 1989-04-21 Cysteine added variants of interleukin-3 and chemical modifications thereof

Publications (1)

Publication Number Publication Date
ES2090132T3 true ES2090132T3 (es) 1996-10-16

Family

ID=23339864

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90907849T Expired - Lifetime ES2090132T3 (es) 1989-04-21 1990-04-19 Variantes de interleuquina-3(il-3) con cisteina añadida y sus modificaciones quimicas.

Country Status (9)

Country Link
US (1) US5166322A (es)
EP (3) EP0469074B1 (es)
JP (1) JP2557144B2 (es)
AT (1) ATE140969T1 (es)
AU (1) AU5553790A (es)
DE (1) DE69027989T2 (es)
DK (1) DK0469074T3 (es)
ES (1) ES2090132T3 (es)
WO (1) WO1990012874A2 (es)

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ATE198353T1 (de) * 1988-08-24 2001-01-15 American Cyanamid Co Stabilisierung von somatotropinen durch modifikation von cystein-resten durch orts- spezifische mutagenese oder chemische derivatisierung
US4902502A (en) * 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
EP0458064B1 (en) * 1990-05-04 1998-02-25 American Cyanamid Company Stabilization of somatotropins by modification of cysteine residues
DK0575545T3 (da) * 1991-03-15 2003-09-15 Amgen Inc Pegylering af polypeptider
EP0679095A1 (en) * 1992-11-25 1995-11-02 Amgen Boulder Inc. Modified insulin-like growth factors

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WO1990012874A3 (en) 1991-01-10
US5166322A (en) 1992-11-24
EP0469074A1 (en) 1992-02-05
EP0469074B1 (en) 1996-07-31
EP0668353A1 (en) 1995-08-23
ATE140969T1 (de) 1996-08-15
DK0469074T3 (da) 1996-08-26
EP0668354A1 (en) 1995-08-23
JP2557144B2 (ja) 1996-11-27
DE69027989T2 (de) 1997-02-20
WO1990012874A2 (en) 1990-11-01
AU5553790A (en) 1990-11-16
DE69027989D1 (de) 1996-09-05
JPH04504801A (ja) 1992-08-27

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