ES2090147T3 - Emulsion de grasa. - Google Patents
Emulsion de grasa.Info
- Publication number
- ES2090147T3 ES2090147T3 ES90917270T ES90917270T ES2090147T3 ES 2090147 T3 ES2090147 T3 ES 2090147T3 ES 90917270 T ES90917270 T ES 90917270T ES 90917270 T ES90917270 T ES 90917270T ES 2090147 T3 ES2090147 T3 ES 2090147T3
- Authority
- ES
- Spain
- Prior art keywords
- emulsion
- polyene antifungal
- simple lipid
- fat emulsion
- antifungal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002960 lipid emulsion Substances 0.000 title abstract 2
- 230000000843 anti-fungal effect Effects 0.000 abstract 4
- 229940121375 antifungal agent Drugs 0.000 abstract 3
- 150000004291 polyenes Chemical class 0.000 abstract 3
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
- 206010029155 Nephropathy toxic Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- 229960003942 amphotericin b Drugs 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000002949 hemolytic effect Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000004530 micro-emulsion Substances 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 230000007694 nephrotoxicity Effects 0.000 abstract 1
- 231100000417 nephrotoxicity Toxicity 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 231100000004 severe toxicity Toxicity 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Edible Oils And Fats (AREA)
Abstract
UNA EMULSION DE GRASAS DESARROLLADA PARA SOLUCIONAR LOS INCONVENIENTES DE ANTIBIOTICOS ANTIFUNGICOS DE POLIENO QUE TIENEN TAL TOXICIDAD CONSIDERABLE QUE HAY QUE LIMITAR LA GAMA DE ADMINISTRACION DE LOS MISMOS CONCIBIENDO ADECUADAMENTE LA FORMA DE ADMINISTRACION, REDUCIENDO ASI LA TOXICIDAD HEMOLITICA Y NEFROTOXICIDAD Y FACILITANDO LA MIGRACION DE UNA MEDICINA HACIA PARTES INFECTADAS, SIN AFECTAR CONTRARIAMENTE A LA ACCION FARMACOLOGICA (ACCION ANTIFUNGICA) SOBRE UN NIVEL MOLECULAR. LA EMULSION COMPRENDE DE 0''005 A 5 % DE UN ANTIBIOTICO ANTIFUNGICO DE POLIENO, 0''5 A 30 % DE UN LIPIDO SIMPLE, Y UN FOSFOLIPIDO, EN UNA CANTIDAD DE 0''15 A 2 VECES TAN GRANDE COMO EL LIPIDO SIMPLE, EN EL QUE LA PROPORCION RELATIVA DE CADA INGREDIENTE SE CONTROLA PARA OBTENER UNA MICROEMULSION FINA DE UN DIAMETRO MEDIO DE PARTICULAS DE, AL MENOS, 10 NM HASTA 100 NM. ESTA EMULSION PUEDE REFORZAR CONSIDERABLEMENTE LA EFICACIA DE ANTIBIOTICOS ANTIFUNGICOS DE POLIENO TALES COMO AMFOTERICINA B, Y ES MUY UTIL PARA EL DESARROLLO DE MEDICINAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30862289 | 1989-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2090147T3 true ES2090147T3 (es) | 1996-10-16 |
Family
ID=17983265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90917270T Expired - Lifetime ES2090147T3 (es) | 1989-11-27 | 1990-11-26 | Emulsion de grasa. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0598116B1 (es) |
| JP (1) | JP2653245B2 (es) |
| KR (1) | KR0151704B1 (es) |
| AT (1) | ATE140622T1 (es) |
| CA (1) | CA2069635C (es) |
| DE (1) | DE69027941T2 (es) |
| ES (1) | ES2090147T3 (es) |
| WO (1) | WO1991007973A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436425B1 (en) | 1988-11-16 | 2002-08-20 | Mdv Technologies, Inc. | Method and non-gelling composition for inhibiting post-surgical adhesions |
| US5346703A (en) | 1990-08-07 | 1994-09-13 | Mediventures, Inc. | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
| US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5843470A (en) | 1995-10-06 | 1998-12-01 | Mdv Technologies, Inc. | Method and composition for inhibiting post-surgical adhesions |
| EP1039932A1 (en) * | 1997-12-23 | 2000-10-04 | Alliance Pharmaceutical Corporation | Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions |
| DE19825856A1 (de) * | 1998-06-10 | 1999-12-16 | Labtec Gmbh | Topische Arzneimittelzubereitung |
| IT1301807B1 (it) * | 1998-06-25 | 2000-07-07 | Tiberio Bruzzese | Formulazioni farmaceutiche iniettabili di derivati della partricina. |
| GB2511028A (en) * | 2012-12-18 | 2014-08-27 | Univ Manchester Metropolitan | Nano emulsions, methods of forming the same and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58222014A (ja) * | 1982-06-18 | 1983-12-23 | Taisho Pharmaceut Co Ltd | プロスタグランジンｅ↓１脂肪乳剤 |
| JPS59141518A (ja) * | 1983-02-03 | 1984-08-14 | Taisho Pharmaceut Co Ltd | プロスタグランジン脂肪乳剤 |
| JPS59216820A (ja) * | 1983-05-20 | 1984-12-06 | Taisho Pharmaceut Co Ltd | プロスタグランジン脂肪乳剤 |
| US4707470A (en) * | 1985-05-17 | 1987-11-17 | Smithkline Beckman Corporation | Polyene antibiotic emulsion formulation |
| JPS61291512A (ja) * | 1985-06-19 | 1986-12-22 | Kao Corp | 皮膚料 |
| IL78929A0 (en) * | 1985-07-29 | 1986-09-30 | Abbott Lab | Microemulsion compositions for parenteral administration |
| DE3625169A1 (de) * | 1986-07-25 | 1988-01-28 | Bayer Ag | Verwendung von haertbaren reaktionsmassen zur herstellung von datentraegern |
| IE60901B1 (en) * | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
| CA1338736C (fr) * | 1986-12-05 | 1996-11-26 | Roger Baurain | Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation |
| GB8714652D0 (en) * | 1987-06-23 | 1987-07-29 | Davis S S | Drug emulsion |
| AU598958B2 (en) * | 1987-11-12 | 1990-07-05 | Vestar, Inc. | Improved amphotericin b liposome preparation |
-
1990
- 1990-11-26 AT AT90917270T patent/ATE140622T1/de not_active IP Right Cessation
- 1990-11-26 ES ES90917270T patent/ES2090147T3/es not_active Expired - Lifetime
- 1990-11-26 EP EP90917270A patent/EP0598116B1/en not_active Expired - Lifetime
- 1990-11-26 KR KR1019920701233A patent/KR0151704B1/ko not_active Expired - Fee Related
- 1990-11-26 WO PCT/JP1990/001531 patent/WO1991007973A1/ja not_active Ceased
- 1990-11-26 DE DE69027941T patent/DE69027941T2/de not_active Expired - Fee Related
- 1990-11-26 JP JP3500269A patent/JP2653245B2/ja not_active Expired - Lifetime
- 1990-11-26 CA CA002069635A patent/CA2069635C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0598116A1 (en) | 1994-05-25 |
| DE69027941T2 (de) | 1997-01-23 |
| KR920703070A (ko) | 1992-12-17 |
| KR0151704B1 (ko) | 1998-10-15 |
| ATE140622T1 (de) | 1996-08-15 |
| EP0598116B1 (en) | 1996-07-24 |
| DE69027941D1 (de) | 1996-08-29 |
| EP0598116A4 (en) | 1992-07-30 |
| CA2069635A1 (en) | 1991-05-28 |
| JP2653245B2 (ja) | 1997-09-17 |
| CA2069635C (en) | 1998-05-05 |
| WO1991007973A1 (en) | 1991-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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