ES2090970T3 - Procedimiento para la preparacion de derivados del taxano. - Google Patents

Procedimiento para la preparacion de derivados del taxano.

Info

Publication number
ES2090970T3
ES2090970T3 ES93904150T ES93904150T ES2090970T3 ES 2090970 T3 ES2090970 T3 ES 2090970T3 ES 93904150 T ES93904150 T ES 93904150T ES 93904150 T ES93904150 T ES 93904150T ES 2090970 T3 ES2090970 T3 ES 2090970T3
Authority
ES
Spain
Prior art keywords
iii
hydroxi
preparation
protective group
taxane derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93904150T
Other languages
English (en)
Inventor
Elie Fouque
Jean-Manuel Mas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2090970T3 publication Critical patent/ES2090970T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCESO DE PREPARACION DE DERIVADOS DE TAXANO DE FORMULA GENERAL (I) POR ESTERIFICACION A UNA TEMPERATURA COMPRENDIDA ENTRE 10 Y 60 (GRADOS) C DE UN DERIVADO DE BACATINA III O DE LA DESACETIL10-BACATINA III DE FORMULA GENERAL (II) MEDIANTE UN ACIDO DE FORMULA GENERAL (III) SEGUIDA DE LA SUSTITUCION DE LOS GRUPOS PROTECTORES G1, G2 Y R2 DEL PRODUCTO OBTENIDO POR ATOMOS DE HIDROGENO. EN LAS FORMULAS (I), (II) O (III): AR REPRESENTA UN RADICAL ARILO; R REPRESENTA HIDROGENO O ACETILO; R1 REPRESENTA BENZOILO O TER.BUTOXICARBONILO; G1 REPRESENTA UN GRUPO PROTECTOR HIDROXI, G2 REPRESENTA EL RADICAL ACETILO O UN GRUPO PROTECTOR DE LA FUNCION HIDROXI Y R2 REPRESENTA UN GRUPO PROTECTOR DE LA FUNCION HIDROXI.
ES93904150T 1992-02-07 1993-02-04 Procedimiento para la preparacion de derivados del taxano. Expired - Lifetime ES2090970T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201379A FR2687150B1 (fr) 1992-02-07 1992-02-07 Procede de preparation de derives du taxane.

Publications (1)

Publication Number Publication Date
ES2090970T3 true ES2090970T3 (es) 1996-10-16

Family

ID=9426424

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93904150T Expired - Lifetime ES2090970T3 (es) 1992-02-07 1993-02-04 Procedimiento para la preparacion de derivados del taxano.

Country Status (24)

Country Link
US (1) US6596880B1 (es)
EP (1) EP0625147B1 (es)
JP (1) JP3295879B2 (es)
KR (1) KR100254167B1 (es)
AT (1) ATE141920T1 (es)
AU (1) AU686095B2 (es)
CA (1) CA2126462C (es)
CZ (1) CZ283377B6 (es)
DE (1) DE69304309T2 (es)
DK (1) DK0625147T3 (es)
ES (1) ES2090970T3 (es)
FI (1) FI106959B (es)
FR (1) FR2687150B1 (es)
GR (1) GR3020894T3 (es)
HU (1) HU212577B (es)
MX (1) MX9300622A (es)
NO (1) NO305863B1 (es)
NZ (1) NZ249162A (es)
PL (1) PL175106B1 (es)
RU (1) RU2103266C1 (es)
SK (1) SK280012B6 (es)
TW (1) TW234122B (es)
WO (1) WO1993016059A1 (es)
ZA (1) ZA93823B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
CA2100808A1 (en) * 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
US5684175A (en) * 1993-02-05 1997-11-04 Napro Biotherapeutics, Inc. C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
US5948919A (en) * 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
JP3031715B2 (ja) * 1993-02-05 2000-04-10 ブリン モーアー カレッジ 様々なａ環側鎖を有するタキソール、類似体及び中間体の合成
EP0700910A1 (en) * 1994-09-06 1996-03-13 Shionogi & Co., Ltd. Process for isolation of taxol from Taxus sumatrana
US5580899A (en) * 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives
US5675025A (en) * 1995-06-07 1997-10-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US6051600A (en) * 1995-09-12 2000-04-18 Mayhew; Eric Liposomal hydrolysis-promoting hydrophobic taxane derivatives
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US5750737A (en) * 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
IL144976A0 (en) * 1999-05-17 2002-06-30 Bristol Myers Squibb Co A process for the preparation of paclitaxel
HK1047935A1 (zh) 2000-02-02 2003-03-14 佛罗里达州立大学研究基金有限公司 作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷
KR20010112395A (ko) 2000-02-02 2001-12-20 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 항종양제로서의 ｃ７ 카르보네이트 치환된 탁산
IT1319168B1 (it) * 2000-03-17 2003-09-26 Indena Spa Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.
US6452025B1 (en) 2001-04-25 2002-09-17 Napro Biotherapeutics, Inc. Three-step conversion of protected taxane ester to paclitaxel
EP1730522A2 (en) * 2004-03-29 2006-12-13 Howard Murad Methods for treating dermatological conditions in a patient
CN100586940C (zh) * 2007-01-26 2010-02-03 上海百灵医药科技有限公司 紫杉醇和多烯紫杉醇的半合成方法
KR101014438B1 (ko) * 2008-09-26 2011-02-14 동아제약주식회사 탁산 유도체의 제조방법
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
EP2697211A4 (en) * 2011-04-01 2014-08-13 Shilpa Medicare Ltd PROCESS FOR THE PREPARATION OF DOCETAXEL AND ITS HYDRATE
NZ700073A (en) 2012-04-04 2016-08-26 Halozyme Inc Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
WO2013188763A1 (en) 2012-06-15 2013-12-19 The Brigham And Women's Hospital, Inc. Compositions for treating cancer and methods for making the same
RU2016140160A (ru) 2014-04-03 2018-05-07 Инвиктус Онколоджи Пвт. Лтд. Супрамолекулярные комбинаторные лекарственные средства
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR336841A (fr) 1903-10-29 1904-03-18 James William Mander Perfectionnements apportés aux instruments employés pour le dessin
FR336840A (fr) 1903-10-29 1904-03-18 Emmanuel Saura Machine à piston diviseur
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol

Also Published As

Publication number Publication date
DK0625147T3 (da) 1996-11-11
TW234122B (es) 1994-11-11
FI106959B (fi) 2001-05-15
WO1993016059A1 (fr) 1993-08-19
EP0625147B1 (fr) 1996-08-28
ZA93823B (en) 1993-09-16
HUT68773A (en) 1995-07-28
EP0625147A1 (fr) 1994-11-23
KR100254167B1 (ko) 2000-05-01
DE69304309T2 (de) 1997-01-23
JP3295879B2 (ja) 2002-06-24
DE69304309D1 (de) 1996-10-02
JPH07503472A (ja) 1995-04-13
FI943643A7 (fi) 1994-08-05
NO305863B1 (no) 1999-08-09
KR950700267A (ko) 1995-01-16
NZ249162A (en) 1996-10-28
CA2126462C (fr) 2002-07-09
ATE141920T1 (de) 1996-09-15
MX9300622A (es) 1993-08-01
FI943643A0 (fi) 1994-08-05
NO942895D0 (es) 1994-08-04
CZ187094A3 (en) 1994-12-15
US6596880B1 (en) 2003-07-22
GR3020894T3 (en) 1996-11-30
AU686095B2 (en) 1998-02-05
FR2687150B1 (fr) 1995-04-28
FR2687150A1 (fr) 1993-08-13
HU212577B (en) 1996-08-29
HU9402289D0 (en) 1994-10-28
SK93094A3 (en) 1995-04-12
AU3504893A (en) 1993-09-03
RU94040356A (ru) 1997-05-27
NO942895L (no) 1994-08-04
CA2126462A1 (fr) 1993-08-19
RU2103266C1 (ru) 1998-01-27
PL175106B1 (pl) 1998-11-30
CZ283377B6 (cs) 1998-04-15
SK280012B6 (sk) 1999-07-12

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