ES2091852T3 - Acido piridil-dihidroxi-heptenoico sustituido y sus sales. - Google Patents

Acido piridil-dihidroxi-heptenoico sustituido y sus sales.

Info

Publication number
ES2091852T3
ES2091852T3 ES91120745T ES91120745T ES2091852T3 ES 2091852 T3 ES2091852 T3 ES 2091852T3 ES 91120745 T ES91120745 T ES 91120745T ES 91120745 T ES91120745 T ES 91120745T ES 2091852 T3 ES2091852 T3 ES 2091852T3
Authority
ES
Spain
Prior art keywords
dihidroxi
piridil
salts
substituted
heptenoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91120745T
Other languages
English (en)
Inventor
Rolf Dr Angerbauer
Peter Dr Fey
Walter Dr Hubsch
Thomas Dr Philipps
Hilmar Dr Bischoff
Dieter Dr Petzinna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4040026A external-priority patent/DE4040026A1/de
Priority claimed from IT002125A external-priority patent/ITMI912125A1/it
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2091852T3 publication Critical patent/ES2091852T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Valve Device For Special Equipments (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LOS ACIDOS DE PIRIDIL-DIHIDROXI-HETEN Y SUS SALES, DADO EL CASO EN UNA FORMA ISOMERICA SE PUEDEN ELABORAR AL HIDROLIZAR EL ESTER RACEMICO CORRESPONDIENTE EN CASO DE PRODUCTOS RACEMICOS O TRANSFORMANDO EL ESTER RACEMICO EN CASO DE LOS PRODUCTOS DE UNIDADES ESTEROISOMERICOS JUNTO CON AMINAS ENANTIOMERAS, SEPARANDO LAS AMIDAS DIASTEREOMERAS E HIDROLIZANDO ESTAS AMIDAS. ESTOS PRODUCTOS TIENEN EXCELENTES CUALIDADES FARMACOLOGICAS. SE PUEDEN EMPLEAR COMO INHIBIDORES DE REDUCTASE HMG-COA PARA EL TRATAMIENTO DE LA ESTEREOESCLEROSIS Y DE HIPERLIPOPROTEIN*ME.
ES91120745T 1990-12-14 1991-12-03 Acido piridil-dihidroxi-heptenoico sustituido y sus sales. Expired - Lifetime ES2091852T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4040026A DE4040026A1 (de) 1990-12-14 1990-12-14 Substituierte pyridyl-dihydroxy-heptensaeure und deren salze
IT002125A ITMI912125A1 (it) 1991-07-31 1991-07-31 Acidi piridil-diidrossi-eptenoici sostituiti e loro sali

Publications (1)

Publication Number Publication Date
ES2091852T3 true ES2091852T3 (es) 1996-11-16

Family

ID=25899340

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91120745T Expired - Lifetime ES2091852T3 (es) 1990-12-14 1991-12-03 Acido piridil-dihidroxi-heptenoico sustituido y sus sales.

Country Status (25)

Country Link
US (1) US5177080A (es)
EP (1) EP0491226B1 (es)
JP (1) JP2786363B2 (es)
KR (1) KR100192625B1 (es)
CN (3) CN1034073C (es)
AT (1) ATE141261T1 (es)
AU (1) AU652977B2 (es)
CA (1) CA2057444C (es)
CZ (1) CZ282642B6 (es)
DE (1) DE59108081D1 (es)
DK (1) DK0491226T3 (es)
ES (1) ES2091852T3 (es)
FI (1) FI101069B (es)
GR (1) GR3020826T3 (es)
HU (2) HU221293B1 (es)
IE (1) IE75691B1 (es)
IL (1) IL100327A (es)
LU (1) LU90230I2 (es)
MY (1) MY107492A (es)
NL (1) NL970033I1 (es)
NO (2) NO177140C (es)
NZ (1) NZ240946A (es)
PL (1) PL169757B1 (es)
PT (1) PT99776B (es)
SK (1) SK280115B6 (es)

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PT87929B (pt) * 1987-07-10 1995-03-01 Hoechst Ag Processo para a preparacao de derivados de acido 3-desmetil-mevalonico e de composicoes farmaceuticas que os contem
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HUT61282A (en) 1992-12-28
NO177140B (no) 1995-04-18
CN1329888A (zh) 2002-01-09
NO177140C (no) 1995-07-26
NO1998025I1 (no) 1998-10-22
CS360291A3 (en) 1992-06-17
FI915854A0 (fi) 1991-12-12
NO914696L (no) 1992-06-15
HU221293B1 (en) 2002-09-28
CN1034073C (zh) 1997-02-19
NZ240946A (en) 1993-09-27
NL970033I1 (nl) 1997-10-01
DK0491226T3 (da) 1997-01-06
PT99776A (pt) 1992-11-30
EP0491226A1 (de) 1992-06-24
IL100327A (en) 1995-12-08
HU211695A9 (en) 1995-12-28
CA2057444C (en) 1998-05-26
CA2057444A1 (en) 1992-06-15
US5177080A (en) 1993-01-05
CN1062350A (zh) 1992-07-01
MY107492A (en) 1995-12-30
KR100192625B1 (en) 2002-02-19
PL169757B1 (pl) 1996-08-30
AU652977B2 (en) 1994-09-15
IE75691B1 (en) 1997-09-10
IE914350A1 (en) 1992-06-17
JP2786363B2 (ja) 1998-08-13
CZ282642B6 (cs) 1997-08-13
NO914696D0 (no) 1991-11-29
PT99776B (pt) 1999-05-31
PL292764A1 (en) 1992-08-24
CN1113485A (zh) 1995-12-20
ATE141261T1 (de) 1996-08-15
FI915854A7 (fi) 1992-06-15
DE59108081D1 (de) 1996-09-19
LU90230I2 (fr) 1998-05-18
KR920012035A (ko) 1992-07-25
EP0491226B1 (de) 1996-08-14
AU8961591A (en) 1992-06-18
JPH04308573A (ja) 1992-10-30
HK1004552A1 (en) 1998-11-27
HU913945D0 (en) 1992-02-28
FI101069B (fi) 1998-04-15
SK280115B6 (sk) 1999-08-06
GR3020826T3 (en) 1996-11-30
CN1092641C (zh) 2002-10-16

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