ES2092067T3 - Procedimiento de purificacion de una proteina altamente glicosilada. - Google Patents

Procedimiento de purificacion de una proteina altamente glicosilada.

Info

Publication number
ES2092067T3
ES2092067T3 ES92400381T ES92400381T ES2092067T3 ES 2092067 T3 ES2092067 T3 ES 2092067T3 ES 92400381 T ES92400381 T ES 92400381T ES 92400381 T ES92400381 T ES 92400381T ES 2092067 T3 ES2092067 T3 ES 2092067T3
Authority
ES
Spain
Prior art keywords
protein
purification procedure
highly
highly glycosilated
glycosilated protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92400381T
Other languages
English (en)
Inventor
Hanno Kolbe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Transgene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene SA filed Critical Transgene SA
Application granted granted Critical
Publication of ES2092067T3 publication Critical patent/ES2092067T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/816—Enzyme separation or purification by solubility

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA INVENCION PROPONE UN PROCESO PARA PURIFICAR UNA PROTEINA FUERTEMENTE GLICOSILADA A PARTIR DE UNA PREPARACION BRUTA QUE COMPRENDE EL HECHO (I) DE AÑADIR A DICHA PREPARACION UN ION METALICA BIVALENTE EN CANTIDAD SUFICIENTE DE MANERA A FORMAR UNA MEZCLA QUE PRECIPITA Y (II), TRAS LA PRECIPITACION, DE RECOGER DICHA PROTEINA EN EL SUPERNADANTE DE LA MEZCLA.
ES92400381T 1991-02-15 1992-02-13 Procedimiento de purificacion de una proteina altamente glicosilada. Expired - Lifetime ES2092067T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9101830A FR2672895B1 (fr) 1991-02-15 1991-02-15 Procede de purification d'une proteine fortement glycosylee.

Publications (1)

Publication Number Publication Date
ES2092067T3 true ES2092067T3 (es) 1996-11-16

Family

ID=9409766

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92400381T Expired - Lifetime ES2092067T3 (es) 1991-02-15 1992-02-13 Procedimiento de purificacion de una proteina altamente glicosilada.

Country Status (9)

Country Link
US (1) US5276141A (es)
EP (1) EP0499541B1 (es)
JP (1) JP3376430B2 (es)
AT (1) ATE141283T1 (es)
CA (1) CA2061167C (es)
DE (1) DE69212660T2 (es)
DK (1) DK0499541T3 (es)
ES (1) ES2092067T3 (es)
FR (1) FR2672895B1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284874B1 (en) * 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
US5760189A (en) * 1995-06-02 1998-06-02 Genetics Institute, Inc. Protein recovery & purification methods
US5616693A (en) * 1996-07-01 1997-04-01 Alpha Therapeutic Corporation Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
BR0011817B1 (pt) * 1999-06-25 2011-11-01 processos para extrair proteìnas de membrana interna, para extrair proteìnas de membrana externa, para extrair proteìna p4 de membrana externa recombinante lipiadada (rp4), e, para extrair proteìna p6 de membrana externa recombinante lipidada (rp6).
AU1198701A (en) * 1999-10-13 2001-04-23 Lexicon Genetics Incorporated Novel human membrane proteins
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
JP2007535911A (ja) * 2003-12-30 2007-12-13 バハラ バイオテック インターナショナル リミテッド 組換えタンパク質の製造及び精製方法
US8748127B2 (en) * 2007-05-29 2014-06-10 Xiamen University Truncated L1 protein of human papillomavirus type 6
US20160130324A1 (en) 2014-10-31 2016-05-12 Shire Human Genetic Therapies, Inc. C1 Inhibitor Fusion Proteins and Uses Thereof
WO2017087882A1 (en) 2015-11-19 2017-05-26 Shire Human Genetic Therapies, Inc. Recombinant human c1 esterase inhibitor and uses thereof
CN113453712A (zh) * 2018-12-28 2021-09-28 特兰斯吉恩股份有限公司 M2缺陷型痘病毒

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947324A (en) * 1975-04-21 1976-03-30 G. D. Searle And Co. Method for isolating high purity peroxidase
JPS6098988A (ja) * 1983-11-01 1985-06-01 Chemo Sero Therapeut Res Inst Ｌｐｆ−ｈａの精製法
EP0213099A3 (de) * 1985-08-23 1989-07-19 Cederroth Nordic Aktiebolag Mittel mit antiphlogistischer, immunstimulierender und zytoprotektiver Wirkung, ihre Herstellung und pharmazeutische Verwendungen
US4798886A (en) * 1986-03-24 1989-01-17 Takeda Chemical Industries, Ltd. Mutual separation of proteins
FR2597344B1 (fr) * 1986-04-16 1989-06-23 Merieux Inst Perfectionnement au procede de purification d'antigenes proteiques de bacteries appartenant au genre bordetella, en vue de l'obtention d'un vaccin acellulaire.
IL85255A0 (en) * 1987-01-30 1988-07-31 Int Minerals & Chem Corp Recovery of somatotropin from dilute aqueous solutions
EP0321606B1 (de) * 1987-12-23 1993-09-29 IMMUNO Aktiengesellschaft Zelluläre amphipatische Proteine in aggregierten Formen und Verfahren zur Herstellung und Reinigung diese Proteine
US4992372A (en) * 1989-02-02 1991-02-12 Pokora Alexander R Method for removing impurities from peroxidase solutions
US5101014A (en) * 1989-02-10 1992-03-31 United States Of America Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis

Also Published As

Publication number Publication date
FR2672895B1 (fr) 1995-05-12
CA2061167A1 (fr) 1992-08-16
JPH04312600A (ja) 1992-11-04
EP0499541B1 (fr) 1996-08-14
EP0499541A1 (fr) 1992-08-19
DE69212660D1 (de) 1996-09-19
DE69212660T2 (de) 1997-03-13
FR2672895A1 (fr) 1992-08-21
CA2061167C (fr) 2002-06-11
ATE141283T1 (de) 1996-08-15
DK0499541T3 (da) 1996-12-02
JP3376430B2 (ja) 2003-02-10
US5276141A (en) 1994-01-04

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