ES2093645T3 - Nueva clase de compuestos que tienen un espectro variable de actividades para respuestas de tipo capsaicina, composiciones y usos de los mismos. - Google Patents

Nueva clase de compuestos que tienen un espectro variable de actividades para respuestas de tipo capsaicina, composiciones y usos de los mismos.

Info

Publication number
ES2093645T3
ES2093645T3 ES90907806T ES90907806T ES2093645T3 ES 2093645 T3 ES2093645 T3 ES 2093645T3 ES 90907806 T ES90907806 T ES 90907806T ES 90907806 T ES90907806 T ES 90907806T ES 2093645 T3 ES2093645 T3 ES 2093645T3
Authority
ES
Spain
Prior art keywords
compounds
capsaicin
activities
compositions
new class
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90907806T
Other languages
English (en)
Inventor
Peter M Blumberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of ES2093645T3 publication Critical patent/ES2093645T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/86—Ring systems containing bridged rings containing four rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UNA NUEVA CLASE DE COMPUESTOS QUE TIENE UN ESPECTRO VARIABLE DE ACTIVIDADES PARA RESPUESTAS DE TIPO CAPSAICINA, COMPOSICIONES DE LOS MISMOS, PROCESOS PARA PREPARAR LOS MISMOS, Y USOS DE LOS MISMOS. LOS COMPUESTOS DE LA INVENCION SE PREPARAN COMBINANDO DITERPENOS RELACIONADOS CON FORBOL Y ANALOGOS DE ACIDOS HOMOVANILICOS POR MEDIO DE LA ESTIRIFICACION EN EL GRUPO HIDROXI EXOCICLICO DEL DITERPENO. EJEMPLOS DE ESTOS COMPUESTOS INCLUYEN 20-HOMOVANILIL-MEZEREINA Y 20-HOMOVANILIL-12-DEXIFORBOL-13-FENIL-ACETATO.
ES90907806T 1989-05-30 1990-03-30 Nueva clase de compuestos que tienen un espectro variable de actividades para respuestas de tipo capsaicina, composiciones y usos de los mismos. Expired - Lifetime ES2093645T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/358,073 US5021450A (en) 1989-05-30 1989-05-30 New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof

Publications (1)

Publication Number Publication Date
ES2093645T3 true ES2093645T3 (es) 1997-01-01

Family

ID=23408188

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90907806T Expired - Lifetime ES2093645T3 (es) 1989-05-30 1990-03-30 Nueva clase de compuestos que tienen un espectro variable de actividades para respuestas de tipo capsaicina, composiciones y usos de los mismos.

Country Status (10)

Country Link
US (1) US5021450A (es)
EP (1) EP0474672B1 (es)
JP (2) JP2694479B2 (es)
AT (1) ATE141585T1 (es)
AU (1) AU644363B2 (es)
CA (1) CA2057917C (es)
DE (1) DE69028203T2 (es)
DK (1) DK0474672T3 (es)
ES (1) ES2093645T3 (es)
WO (1) WO1990015055A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232684A (en) * 1990-06-29 1993-08-03 The United States Of America As Represented By The Department Of Health And Human Services Labelled resiniferatoxin, compositions thereof, and methods for using the same
US5405875A (en) * 1991-04-08 1995-04-11 The United States Of America As Represented By The Department Of Health And Human Services Method of inhibiting neoplasia and tumor promotion
US6063381A (en) * 1993-05-19 2000-05-16 Staggs; Jeff J. Therapeutic uses of pungent botanicals and their related compounds
EP0998275A4 (en) * 1996-09-05 2003-05-02 Res Dev Foundation INHIBITION OF THE NUCLEAR TRANSCRIPTION FACTOR NF-kappaB BY THE PHENETHYLIC ESTER OF CAFEIC ACID, DERIVATIVES OF THIS ESTER, CAPSAICIN (8-METHYL-N-VANILLYLE-6-NONEAMIDE) AND RESINIFERATOXIN
AU5460598A (en) * 1996-11-15 1998-06-03 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Pharmaceutical compositions containing vanilloid agonists in combination with vanilloid antagonists
US6060060A (en) * 1997-01-31 2000-05-09 Bmb Patent Holding Corporation Analgesic compositions from sweet peppers and methods of use thereof
AU749201B2 (en) * 1997-08-28 2002-06-20 Afferon Corporation Urinary incontinence therapy
WO1999037675A1 (en) * 1998-01-22 1999-07-29 The Regents Of The University Of California Nucleic acid sequences encoding capsaicin receptors
US6790207B2 (en) 1998-06-04 2004-09-14 Curon Medical, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract
US20110071468A1 (en) * 1998-06-04 2011-03-24 Mederi Therapeutics, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction
US6802841B2 (en) * 1998-06-04 2004-10-12 Curon Medical, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction
US6086888A (en) * 1998-12-22 2000-07-11 Bmb Patent Holding Corporation Analgesic compositions from sweet bell peppers and methods of use thereof
KR100348819B1 (ko) * 1999-02-22 2002-08-17 주식회사 태평양 레시니페라톡신 약리기를 함유하여 강력한 바닐로이드수용체의 효현제 및 진통제로서 사용하는 바닐로이드동족체 및 이를 함유하는 약학적 조성물
WO2000050387A1 (en) * 1999-02-22 2000-08-31 Pacific Corporation Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof
WO2002008221A2 (en) * 2000-07-20 2002-01-31 Neurogen Corporation Capsaicin receptor ligands
CN1627944A (zh) * 2002-01-17 2005-06-15 神经能质公司 取代的喹唑啉－4－基胺类似物作为辣椒辣素调节剂
US20040191338A1 (en) * 2002-12-18 2004-09-30 Algorx Administration of capsaicinoids
CN102205127A (zh) * 2002-12-18 2011-10-05 阿尔乔医疗公司 类辣椒素的给药
EA008705B1 (ru) * 2003-04-08 2007-06-29 Алгоркс Фармасьютикалз, Инк. Получение и очистка синтетического капсаицина
CA2596194A1 (en) * 2004-11-24 2006-06-01 Algorx Pharmaceuticals, Inc. Capsaicinoid gel formulation and uses thereof
US8022103B2 (en) * 2005-07-13 2011-09-20 Salvia Sciences, Inc. Ester prodrugs of prostratin and related phorbol compounds
US7943666B2 (en) * 2006-07-24 2011-05-17 Trinity Laboratories, Inc. Esters of capsaicin for treating pain
US7645767B2 (en) * 2006-08-31 2010-01-12 Trinity Laboratories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
EP2096927B1 (en) 2006-10-27 2012-10-10 BMB Patent Holding Corporation Therapeutic compositions and methods of treatment with capsianoside-type compounds
US8067632B2 (en) 2007-07-26 2011-11-29 The Board Of Trustees Of The Leland Stanford Junior University Process to produce prostratin and structural or functional analogs thereof
US8987328B2 (en) * 2008-10-30 2015-03-24 Trinity Laboratories, Inc. Esters of capsaicinoids as dietary supplements
US9216171B2 (en) * 2009-05-07 2015-12-22 University Of Cincinnati Methods of preventing ischemic injury using peripheral nociceptive stimulation
WO2012075337A2 (en) 2010-12-01 2012-06-07 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
US9956166B2 (en) 2013-09-18 2018-05-01 Sorrento Therapeutics, Inc. Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin
US11059771B2 (en) 2016-08-04 2021-07-13 Takasago International Corporation Warming sensation compounds
ES3066533T3 (en) 2016-11-02 2026-05-13 Centrexion Therapeutics Corp Stable aqueous capsaicin injectable formulations and medical uses thereof
US20200206166A1 (en) 2017-07-20 2020-07-02 Centrexion Therapeutics Corporation Methods and compositions for treatment of pain using capsaicin
MX2020002692A (es) 2017-09-11 2020-10-14 Sorrento Therapeutics Inc Formulacion de resiniferatoxina.
CA3124499A1 (en) 2018-12-24 2020-07-02 Sorrento Therapeutics, Inc. Method for treating parkinson's disease by administering resiniferatoxin
SG11202107815UA (en) 2019-01-22 2021-08-30 Sorrento Therapeutics Inc Method for treating osteoarthritis pain by administering resiniferatoxin
CN111312928A (zh) * 2020-03-12 2020-06-19 昆明理工大学 一种热诱导改变带隙的半导体器件
JP2023519853A (ja) 2020-03-30 2023-05-15 ソレント・セラピューティクス・インコーポレイテッド レシニフェラトキシンを投与することによるｃｏｖｉｄ－１９と関連する肺炎症性疾患の処置
JP2023530975A (ja) 2020-06-19 2023-07-20 ソレント・セラピューティクス・インコーポレイテッド 膀胱痛または膀胱癌の処置のためのレシニフェラトキシンの投与
CN117120049A (zh) 2021-02-11 2023-11-24 索伦托药业有限公司 施用树脂毒素以治疗前列腺癌

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2902506A1 (de) * 1979-01-23 1980-07-24 Deutsches Krebsforsch Verwendung von nicht oder nur gering irritierenden und/oder promovierenden diterpenalkoholen und von derivaten davon als antineoplastische mittel
US4939149A (en) * 1988-10-24 1990-07-03 The United States Of America As Represented By The Department Of Health And Human Services Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization

Also Published As

Publication number Publication date
JP3028290B2 (ja) 2000-04-04
JPH09165333A (ja) 1997-06-24
JP2694479B2 (ja) 1997-12-24
DE69028203T2 (de) 1997-03-06
EP0474672A1 (en) 1992-03-18
JPH04503360A (ja) 1992-06-18
DE69028203D1 (de) 1996-09-26
US5021450A (en) 1991-06-04
CA2057917A1 (en) 1990-12-01
WO1990015055A1 (en) 1990-12-13
DK0474672T3 (da) 1996-10-28
EP0474672B1 (en) 1996-08-21
EP0474672A4 (en) 1992-06-17
AU644363B2 (en) 1993-12-09
CA2057917C (en) 2001-12-18
ATE141585T1 (de) 1996-09-15
AU5561490A (en) 1991-01-07

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