ATE141585T1 - Neue klasse von verbindungen mit veränderlichem aktivitätsspektrum für capsaicinähnlichen reaktionen, ihre kompositionen und ihre anwendungen - Google Patents

Neue klasse von verbindungen mit veränderlichem aktivitätsspektrum für capsaicinähnlichen reaktionen, ihre kompositionen und ihre anwendungen

Info

Publication number: ATE141585T1
Authority: AT; Austria
Prior art keywords: compounds; capsaicin; compositions; new class; reactions
Prior art date: 1989-05-30

Application number

AT90907806T

Other languages

English (en)

Inventor

Peter M Blumberg

Original Assignee

Us Health

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-30

Filing date

1990-03-30

Publication date

1996-09-15

1990-03-30 Application filed by Us Health filed Critical Us Health

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE141585T1 publication Critical patent/ATE141585T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 2
238000001228 spectrum Methods 0.000 title abstract 2
238000006243 chemical reaction Methods 0.000 title 1
QGVLYPPODPLXMB-UBTYZVCOSA-N (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-5H-cyclopropa[3,4]benzo[1,2-e]azulen-5-one Chemical compound C1=C(CO)C[C@]2(O)C(=O)C(C)=C[C@H]2[C@@]2(O)[C@H](C)[C@@H](O)[C@@]3(O)C(C)(C)[C@H]3[C@@H]21 QGVLYPPODPLXMB-UBTYZVCOSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229930004069 diterpene Natural products 0.000 abstract 1
150000004141 diterpene derivatives Chemical class 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
QGVLYPPODPLXMB-QXYKVGAMSA-N phorbol Natural products C[C@@H]1[C@@H](O)[C@]2(O)[C@H]([C@H]3C=C(CO)C[C@@]4(O)[C@H](C=C(C)C4=O)[C@@]13O)C2(C)C QGVLYPPODPLXMB-QXYKVGAMSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/86—Ring systems containing bridged rings containing four rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT90907806T 1989-05-30 1990-03-30 Neue klasse von verbindungen mit veränderlichem aktivitätsspektrum für capsaicinähnlichen reaktionen, ihre kompositionen und ihre anwendungen ATE141585T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/358,073 US5021450A (en)	1989-05-30	1989-05-30	New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof

Publications (1)

Publication Number	Publication Date
ATE141585T1 true ATE141585T1 (de)	1996-09-15

Family

ID=23408188

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90907806T ATE141585T1 (de)	1989-05-30	1990-03-30	Neue klasse von verbindungen mit veränderlichem aktivitätsspektrum für capsaicinähnlichen reaktionen, ihre kompositionen und ihre anwendungen

Country Status (10)

Country	Link
US (1)	US5021450A (de)
EP (1)	EP0474672B1 (de)
JP (2)	JP2694479B2 (de)
AT (1)	ATE141585T1 (de)
AU (1)	AU644363B2 (de)
CA (1)	CA2057917C (de)
DE (1)	DE69028203T2 (de)
DK (1)	DK0474672T3 (de)
ES (1)	ES2093645T3 (de)
WO (1)	WO1990015055A1 (de)

Families Citing this family (39)

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Publication number	Priority date	Publication date	Assignee	Title
US5232684A (en) *	1990-06-29	1993-08-03	The United States Of America As Represented By The Department Of Health And Human Services	Labelled resiniferatoxin, compositions thereof, and methods for using the same
US5405875A (en) *	1991-04-08	1995-04-11	The United States Of America As Represented By The Department Of Health And Human Services	Method of inhibiting neoplasia and tumor promotion
US6063381A (en) *	1993-05-19	2000-05-16	Staggs; Jeff J.	Therapeutic uses of pungent botanicals and their related compounds
WO1998009620A1 (en) *	1996-09-05	1998-03-12	Research Development Foundation	INHIBITION OF NUCLEAR TRANSCRIPTION FACTOR NF-λB BY CAFFEIC ACID PHENETHYL ESTER (CAPE), DERIVATIVES OF CAPE, CAPSAICIN (8-METHYL-N-VANILLYL-6-NONENAMIDE) AND RESINIFERATOXIN
AU5460598A (en) *	1996-11-15	1998-06-03	United States Of America, Represented By The Secretary, Department Of Health And Human Services, The	Pharmaceutical compositions containing vanilloid agonists in combination with vanilloid antagonists
US6060060A (en) *	1997-01-31	2000-05-09	Bmb Patent Holding Corporation	Analgesic compositions from sweet peppers and methods of use thereof
EP1014957A4 (de) *	1997-08-28	2004-01-28	Afferon Corp	Behandlung der urininkontinenz
CA2309903C (en) *	1998-01-22	2012-03-27	The Regents Of The University Of California	Nucleic acid sequences encoding capsaicin receptor
US6790207B2 (en)	1998-06-04	2004-09-14	Curon Medical, Inc.	Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract
US20110071468A1 (en) *	1998-06-04	2011-03-24	Mederi Therapeutics, Inc.	Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction
US6802841B2 (en) *	1998-06-04	2004-10-12	Curon Medical, Inc.	Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction
US6086888A (en) *	1998-12-22	2000-07-11	Bmb Patent Holding Corporation	Analgesic compositions from sweet bell peppers and methods of use thereof
WO2000050387A1 (en) *	1999-02-22	2000-08-31	Pacific Corporation	Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof
KR100348819B1 (ko) *	1999-02-22	2002-08-17	주식회사 태평양	레시니페라톡신 약리기를 함유하여 강력한 바닐로이드수용체의 효현제 및 진통제로서 사용하는 바닐로이드동족체 및 이를 함유하는 약학적 조성물
EP1301484A2 (de) *	2000-07-20	2003-04-16	Neurogen Corporation	Capsaicin-rezeptor-liganden
HUP0500200A2 (hu) *	2002-01-17	2005-07-28	Neurogen Corporation	Szubsztituált kinazolin-4-ilamin analógok, mint kapszaicin modulátorok és ezeket tartalmazó gyógyszerkészítmények
MXPA05006670A (es) *	2002-12-18	2005-10-19	Algorx Pharmaceuticals Inc	Administracion de capsaicinoides.
US20040161481A1 (en) *	2002-12-18	2004-08-19	Algorx	Administration of capsaicinoids
US20050085652A1 (en) *	2003-04-08	2005-04-21	Algorx Pharmaceuticals, Inc.	Preparation and purification of synthetic capsaicin
AU2005309586A1 (en) *	2004-11-24	2006-06-01	Algorx Pharmaceuticals, Inc.	Capsaicinoid gel formulation and uses thereof
EP1924548B1 (de)	2005-07-13	2018-03-28	Salvia Sciences, Inc.	Ester-prodrugs von prostratin und verwandten phorbolverbindungen
US7943666B2 (en) *	2006-07-24	2011-05-17	Trinity Laboratories, Inc.	Esters of capsaicin for treating pain
US7645767B2 (en) *	2006-08-31	2010-01-12	Trinity Laboratories, Inc.	Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
WO2008052183A2 (en)	2006-10-27	2008-05-02	Bmb Patent Holding Corporation	Therapeutic compositions and methods of treatment with capsianoside-type compounds
US8067632B2 (en) *	2007-07-26	2011-11-29	The Board Of Trustees Of The Leland Stanford Junior University	Process to produce prostratin and structural or functional analogs thereof
US8987328B2 (en) *	2008-10-30	2015-03-24	Trinity Laboratories, Inc.	Esters of capsaicinoids as dietary supplements
EP2427056A4 (de) *	2009-05-07	2012-08-22	Univ Cincinnati	Verfahren zur verhinderung von ischämie während einer peripheren schmerzrezeptionsstimulation
US20120310140A1 (en)	2010-12-01	2012-12-06	Spinal Modulation, Inc.	Directed delivery of agents to neural anatomy
US9956166B2 (en)	2013-09-18	2018-05-01	Sorrento Therapeutics, Inc.	Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin
MX2019001455A (es)	2016-08-04	2019-06-20	Takasago Perfumery Co Ltd	Compuestos de sensacion de calor.
NZ752750A (en)	2016-11-02	2023-05-26	Centrexion Therapeutics Corp	Stable aqueous capsaicin injectable formulations and medical uses thereof
ES3018268T3 (en)	2017-07-20	2025-05-14	Centrexion Therapeutics Corp	Compositions and their use for treatment of pain using capsaicin
MX2020002692A (es)	2017-09-11	2020-10-14	Sorrento Therapeutics Inc	Formulacion de resiniferatoxina.
WO2020139797A1 (en)	2018-12-24	2020-07-02	Sorrento Therapeutics, Inc.	Methods for treating parkinson's disease by administering resiniferatoxin
JP7530365B2 (ja)	2019-01-22	2024-08-07	ソレント・セラピューティクス・インコーポレイテッド	レシニフェラトキシンを投与することによって変形性関節症疼痛を処置するための方法
CN111312928A (zh) *	2020-03-12	2020-06-19	昆明理工大学	一种热诱导改变带隙的半导体器件
CN115666551A (zh)	2020-03-30	2023-01-31	索伦托药业有限公司	通过施用树脂毒素治疗与covid-19相关的肺部炎性疾病
AU2021292420A1 (en)	2020-06-19	2023-02-09	Vivasor, Inc.	Administration of resiniferatoxin for treatment of bladder pain or bladder cancer
CA3207530A1 (en)	2021-02-11	2022-08-18	Sorrento Therapeutics, Inc.	Administration of resiniferatoxin for treatment of prostate cancer

Family Cites Families (2)

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Publication number	Priority date	Publication date	Assignee	Title
DE2902506A1 (de) *	1979-01-23	1980-07-24	Deutsches Krebsforsch	Verwendung von nicht oder nur gering irritierenden und/oder promovierenden diterpenalkoholen und von derivaten davon als antineoplastische mittel
US4939149A (en) *	1988-10-24	1990-07-03	The United States Of America As Represented By The Department Of Health And Human Services	Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization

1989
- 1989-05-30 US US07/358,073 patent/US5021450A/en not_active Expired - Lifetime
1990
- 1990-03-30 WO PCT/US1990/001767 patent/WO1990015055A1/en not_active Ceased
- 1990-03-30 AT AT90907806T patent/ATE141585T1/de not_active IP Right Cessation
- 1990-03-30 JP JP2507063A patent/JP2694479B2/ja not_active Expired - Fee Related
- 1990-03-30 DE DE69028203T patent/DE69028203T2/de not_active Expired - Fee Related
- 1990-03-30 DK DK90907806.5T patent/DK0474672T3/da active
- 1990-03-30 CA CA002057917A patent/CA2057917C/en not_active Expired - Fee Related
- 1990-03-30 AU AU55614/90A patent/AU644363B2/en not_active Ceased
- 1990-03-30 EP EP90907806A patent/EP0474672B1/de not_active Expired - Lifetime
- 1990-03-30 ES ES90907806T patent/ES2093645T3/es not_active Expired - Lifetime
1996
- 1996-07-09 JP JP8198456A patent/JP3028290B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2694479B2 (ja)	1997-12-24
AU5561490A (en)	1991-01-07
EP0474672A4 (en)	1992-06-17
JPH04503360A (ja)	1992-06-18
JP3028290B2 (ja)	2000-04-04
DE69028203D1 (de)	1996-09-26
EP0474672B1 (de)	1996-08-21
DE69028203T2 (de)	1997-03-06
CA2057917C (en)	2001-12-18
EP0474672A1 (de)	1992-03-18
JPH09165333A (ja)	1997-06-24
ES2093645T3 (es)	1997-01-01
US5021450A (en)	1991-06-04
WO1990015055A1 (en)	1990-12-13
CA2057917A1 (en)	1990-12-01
AU644363B2 (en)	1993-12-09
DK0474672T3 (da)	1996-10-28

Legal Events

Date	Code	Title	Description
2008-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE141585T1 (de)	1996-09-15	Neue klasse von verbindungen mit veränderlichem aktivitätsspektrum für capsaicinähnlichen reaktionen, ihre kompositionen und ihre anwendungen
ES2038236T3 (es)	1993-07-16	Proceso perfeccionado de microencapsulacion de separacion de fases.
DE3574702D1 (de)	1990-01-18	Antitumor-platin-komplexe.
ES542322A0 (es)	1985-12-16	Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina
MX9205573A (es)	1993-05-01	Nuevas 9-amino-7-(amino substituido)-6-desmetil-6-desoxitetraciclinas, metodo para su produccion y composicion farmaceutica que las contiene
ATE153667T1 (de)	1997-06-15	Herstellung von chiralen phospholanen aus chiralen zyklischen sulfaten von 1,4-diolen
BR0207583A (pt)	2004-04-27	Derivados de poliamida possuindo atividade antibacteriana, antifungo ou antitumor
MX9205532A (es)	1993-04-01	Nuevas 7-sustituidas-9-amino sustituidas 6-desmetil-6-desoxitetraciclinas, metodo para su producciony composicion farmaceutica que las contiene.
IL70585A0 (en)	1984-03-30	Substituted 4-aminomethylene-chromans and-chromenes,their preparation and pharmaceutical compositions containing them
ZA939065B (en)	1994-08-04	Use of 2-amino-6-N-propyl-amino-4,5,6,7-tetrahydrobenzothiazole as a pharmaceutical composition having an anti-depressant activity.
ATE35675T1 (de)	1988-07-15	Substituierte n-acetonylbenzamide und ihre verwendung als fungizide.
NO924832D0 (no)	1992-12-14	Vegetabilsk oljeblanding som inneholder kalsiumcitrat, samt fremgangsmaate for fremstilling av slik olje
DE68925080D1 (de)	1996-01-25	FR-901154- und FR-901155-Derivate, Verfahren zu ihrer Herstellung
PT649846E (pt)	2002-06-28	Derivados da galantamina processo para a sua preparacao e sua utilizacao como medicamentos
PT80817A (en)	1985-08-01	Process for the preparation of carbamates,thiocarbamates and dithiocarbamates and their substituted derivatives containing aromatic radicals
ATE226585T1 (de)	2002-11-15	Thiazolobenzoheterocyclen, ihre herstellung und diese enthaltende phatrmazeutische zubereitungen
IT8021166A0 (it)	1980-04-03	Semiacetali doppi ciclici dicomposti enediolici, composizioni e procedimenti per la loro preparazione.
ES2194033T3 (es)	2003-11-16	Amino-alquiloximas, un procedimiento para su preparacion, su uso como medicamentos y compuestos intermedios.
ATE107512T1 (de)	1994-07-15	Faserige cyanobakterien-extrakte, deren herstellungsverfahren und deren aktivität als wachstumsfaktor.
BE892302A (fr)	1982-06-16	Derives de carbamates, compositions insecticides, miticides ou nematocides contenant ces derives, ainsi que leur procede de preparation
BR0211480A (pt)	2004-08-17	Derivados de tetraidropiridazina e seu uso como pesticidas
PT94480A (pt)	1991-02-08	Processo para a preparacao de composicoes farmaceuticas contendo derivados de isoxazolin-3-ona uteis como antidepressivos
OA06446A (fr)	1981-07-31	Produits dérivés de l'aniline ayant une activité antifongique ainsi que leur proccédé de préparation.
FR2370045A1 (fr)	1978-06-02	O-(hydroxy-2 propyl) aldoximes substituees basiquement, leur procede de preparation et leur emploi comme medicaments
Viets	1977	Rheophile wassermilben (acari, hydrachnellae) aus Guatemala